Gq -
C5a2 receptor complex model
GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 79.5
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.6
iPTM Score: 0.3
PAE mean: 23.6
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Hydrophobic | TM4 | R | 173 | 4x65 | G.H5 | V | 359 | G.H5.26 |
Van-der-waals | TM4 | R | 173 | 4x65 | G.H5 | V | 359 | G.H5.26 |
Polar | N-term | V | 6 | - | G.S6 | I | 324 | G.S6.01 |
Van-der-waals | N-term | V | 6 | - | G.S6 | I | 324 | G.S6.01 |
Polar | N-term | N | 3 | - | G.h4s6 | N | 317 | G.h4s6.08 |
Hydrophobic | N-term | N | 3 | - | G.h4s6 | N | 317 | G.h4s6.08 |
Van-der-waals | N-term | N | 3 | - | G.h4s6 | N | 317 | G.h4s6.08 |
Hydrophobic | N-term | Y | 13 | - | G.H5 | E | 335 | G.H5.02 |
Polar | ECL2 | H | 179 | - | G.s2s3 | S | 198 | G.s2s3.02 |
Hydrophobic | ECL2 | H | 179 | - | G.s2s3 | S | 198 | G.s2s3.02 |
Van-der-waals | ECL2 | H | 179 | - | G.s2s3 | S | 198 | G.s2s3.02 |
Hydrophobic | TM7 | L | 266 | 7x27 | G.H5 | K | 354 | G.H5.21 |
Van-der-waals | TM7 | L | 266 | 7x27 | G.H5 | K | 354 | G.H5.21 |
Hydrophobic | TM6 | L | 252 | 6x54 | G.H5 | L | 358 | G.H5.25 |
Polar | ECL2 | H | 176 | - | G.s2s3 | S | 198 | G.s2s3.02 |
Hydrophobic | ECL2 | H | 176 | - | G.s2s3 | S | 198 | G.s2s3.02 |
Van-der-waals | ECL2 | H | 176 | - | G.s2s3 | S | 198 | G.s2s3.02 |
Hydrophobic | TM7 | L | 266 | 7x27 | G.H5 | L | 351 | G.H5.18 |
Van-der-waals | TM7 | L | 266 | 7x27 | G.H5 | L | 351 | G.H5.18 |
Hydrophobic | N-term | L | 24 | - | G.H5 | F | 339 | G.H5.06 |
Van-der-waals | N-term | L | 24 | - | G.H5 | F | 339 | G.H5.06 |
Hydrophobic | ECL2 | V | 187 | 45x51 | G.H5 | Y | 356 | G.H5.23 |
Van-der-waals | ECL2 | V | 187 | 45x51 | G.H5 | Y | 356 | G.H5.23 |
Hydrophobic | N-term | L | 16 | - | G.H5 | F | 339 | G.H5.06 |
Hydrophobic | ECL2 | E | 178 | - | G.H5 | L | 349 | G.H5.16 |
Polar | ECL2 | E | 178 | - | G.s2s3 | S | 198 | G.s2s3.02 |
Hydrophobic | ECL2 | E | 178 | - | G.s2s3 | S | 198 | G.s2s3.02 |
Van-der-waals | ECL2 | E | 178 | - | G.s2s3 | S | 198 | G.s2s3.02 |
Polar | TM7 | E | 273 | 7x34 | G.H5 | N | 357 | G.H5.24 |
Hydrophobic | TM7 | E | 273 | 7x34 | G.H5 | N | 357 | G.H5.24 |
Van-der-waals | TM7 | E | 273 | 7x34 | G.H5 | N | 357 | G.H5.24 |
Polar | N-term | V | 6 | - | G.S6 | S | 326 | G.S6.03 |
Van-der-waals | N-term | V | 6 | - | G.S6 | S | 326 | G.S6.03 |
Ionic | N-term | E | 9 | - | G.H4 | R | 306 | G.H4.08 |
Polar | N-term | E | 9 | - | G.H4 | R | 306 | G.H4.08 |
Hydrophobic | N-term | E | 9 | - | G.H4 | R | 306 | G.H4.08 |
Van-der-waals | N-term | E | 9 | - | G.H4 | R | 306 | G.H4.08 |
Hydrophobic | TM6 | L | 256 | 6x58 | G.H5 | L | 358 | G.H5.25 |
Van-der-waals | TM6 | L | 256 | 6x58 | G.H5 | L | 358 | G.H5.25 |
Ionic | TM5 | E | 197 | 5x36 | G.H5 | K | 354 | G.H5.21 |
Van-der-waals | N-term | Y | 10 | - | G.H5 | A | 343 | G.H5.10 |
Polar | ECL2 | Y | 190 | - | G.H5 | E | 355 | G.H5.22 |
Van-der-waals | ECL2 | Y | 190 | - | G.H5 | E | 355 | G.H5.22 |
Polar | N-term | Y | 10 | - | G.H5 | V | 340 | G.H5.07 |
Hydrophobic | N-term | Y | 10 | - | G.H5 | V | 340 | G.H5.07 |
Van-der-waals | N-term | Y | 10 | - | G.H5 | V | 340 | G.H5.07 |
Ionic | ECL2 | E | 178 | - | G.H5 | K | 345 | G.H5.12 |
Polar | ECL2 | E | 178 | - | G.H5 | K | 345 | G.H5.12 |
Hydrophobic | ECL2 | E | 178 | - | G.H5 | K | 345 | G.H5.12 |
Van-der-waals | ECL2 | E | 178 | - | G.H5 | K | 345 | G.H5.12 |
Polar | ECL2 | F | 180 | - | G.H5 | K | 345 | G.H5.12 |
Hydrophobic | ECL2 | F | 180 | - | G.H5 | K | 345 | G.H5.12 |
Van-der-waals | ECL2 | F | 180 | - | G.H5 | K | 345 | G.H5.12 |
Polar | ECL2 | Q | 185 | - | G.H5 | Y | 356 | G.H5.23 |
Hydrophobic | ECL2 | Q | 185 | - | G.H5 | Y | 356 | G.H5.23 |
Van-der-waals | ECL2 | Q | 185 | - | G.H5 | Y | 356 | G.H5.23 |
Polar | N-term | N | 3 | - | G.H4 | V | 314 | G.H4.16 |
Hydrophobic | N-term | N | 3 | - | G.H4 | V | 314 | G.H4.16 |
Van-der-waals | N-term | N | 3 | - | G.H4 | V | 314 | G.H4.16 |
Hydrophobic | N-term | V | 21 | - | G.H5 | F | 339 | G.H5.06 |
Van-der-waals | N-term | V | 21 | - | G.H5 | F | 339 | G.H5.06 |
Hydrophobic | ECL2 | C | 186 | 45x50 | G.H5 | Y | 356 | G.H5.23 |
Polar | TM7 | A | 264 | 7x25 | G.h4s6 | D | 321 | G.h4s6.12 |
Hydrophobic | TM7 | A | 264 | 7x25 | G.h4s6 | D | 321 | G.h4s6.12 |
Van-der-waals | TM7 | A | 264 | 7x25 | G.h4s6 | D | 321 | G.h4s6.12 |
Polar | TM4 | R | 173 | 4x65 | G.H5 | L | 358 | G.H5.25 |
Van-der-waals | TM4 | R | 173 | 4x65 | G.H5 | L | 358 | G.H5.25 |
Hydrophobic | ECL3 | A | 260 | - | G.H5 | K | 354 | G.H5.21 |
Aromatic | ECL2 | F | 180 | - | G.H1 | H | 63 | G.H1.12 |
Hydrophobic | ECL2 | F | 180 | - | G.H1 | H | 63 | G.H1.12 |
Van-der-waals | ECL2 | F | 180 | - | G.H1 | H | 63 | G.H1.12 |
Polar | ECL2 | G | 192 | - | G.hns1 | R | 37 | G.hns1.02 |
Hydrophobic | ECL2 | G | 192 | - | G.hns1 | R | 37 | G.hns1.02 |
Van-der-waals | ECL2 | G | 192 | - | G.hns1 | R | 37 | G.hns1.02 |
Hydrophobic | ECL2 | H | 179 | - | G.H5 | K | 345 | G.H5.12 |
Hydrophobic | ECL2 | V | 187 | 45x51 | G.H5 | L | 353 | G.H5.20 |
Polar | ECL2 | G | 191 | - | G.hns1 | R | 37 | G.hns1.02 |
Hydrophobic | ECL2 | G | 191 | - | G.hns1 | R | 37 | G.hns1.02 |
Van-der-waals | ECL2 | G | 191 | - | G.hns1 | R | 37 | G.hns1.02 |
Hydrophobic | TM7 | L | 270 | 7x31 | G.H5 | Q | 350 | G.H5.17 |
Van-der-waals | TM7 | L | 270 | 7x31 | G.H5 | Q | 350 | G.H5.17 |
Aromatic | N-term | Y | 8 | - | G.S6 | H | 327 | G.S6.04 |
Hydrophobic | N-term | Y | 8 | - | G.S6 | H | 327 | G.S6.04 |
Van-der-waals | N-term | Y | 8 | - | G.S6 | H | 327 | G.S6.04 |
Polar | ECL2 | Q | 177 | - | G.s2s3 | Q | 197 | G.s2s3.01 |
Hydrophobic | ECL2 | Q | 177 | - | G.s2s3 | Q | 197 | G.s2s3.01 |
Van-der-waals | ECL2 | Q | 177 | - | G.s2s3 | Q | 197 | G.s2s3.01 |
Polar | ECL2 | V | 188 | 45x52 | G.H5 | E | 355 | G.H5.22 |
Hydrophobic | ECL2 | V | 188 | 45x52 | G.H5 | E | 355 | G.H5.22 |
Van-der-waals | ECL2 | V | 188 | 45x52 | G.H5 | E | 355 | G.H5.22 |
Hydrophobic | ECL2 | F | 180 | - | G.H5 | A | 342 | G.H5.09 |
Polar | ECL2 | G | 191 | - | G.H5 | E | 355 | G.H5.22 |
Hydrophobic | ECL3 | N | 262 | - | G.h3s5 | S | 267 | G.h3s5.03 |
Van-der-waals | ECL3 | N | 262 | - | G.h3s5 | S | 267 | G.h3s5.03 |
Hydrophobic | TM5 | S | 193 | 5x32 | G.hns1 | R | 37 | G.hns1.02 |
Van-der-waals | TM5 | S | 193 | 5x32 | G.hns1 | R | 37 | G.hns1.02 |
Polar | N-term | D | 22 | - | G.H5 | A | 343 | G.H5.10 |
Hydrophobic | N-term | D | 22 | - | G.H5 | A | 343 | G.H5.10 |
Van-der-waals | N-term | D | 22 | - | G.H5 | A | 343 | G.H5.10 |
Polar | ECL2 | V | 188 | 45x52 | G.H5 | Y | 356 | G.H5.23 |
Hydrophobic | ECL2 | H | 176 | - | G.H5 | L | 353 | G.H5.20 |
Hydrophobic | N-term | E | 9 | - | G.S6 | F | 328 | G.S6.05 |
Hydrophobic | TM7 | A | 264 | 7x25 | G.h4s6 | I | 323 | G.h4s6.20 |
Polar | N-term | E | 9 | - | G.H4 | Q | 303 | G.H4.05 |
Van-der-waals | N-term | E | 9 | - | G.H4 | Q | 303 | G.H4.05 |
Hydrophobic | ECL2 | F | 180 | - | G.H1 | I | 62 | G.H1.11 |
Polar | N-term | Y | 13 | - | G.H5 | N | 336 | G.H5.03 |
Hydrophobic | N-term | Y | 13 | - | G.H5 | N | 336 | G.H5.03 |
Van-der-waals | N-term | Y | 13 | - | G.H5 | N | 336 | G.H5.03 |
Hydrophobic | TM7 | V | 277 | 7x38 | G.H5 | V | 359 | G.H5.26 |
Polar | ECL3 | N | 262 | - | G.H5 | L | 351 | G.H5.18 |
Hydrophobic | ECL3 | N | 262 | - | G.H5 | L | 351 | G.H5.18 |
Van-der-waals | ECL3 | N | 262 | - | G.H5 | L | 351 | G.H5.18 |
Polar | TM7 | E | 273 | 7x34 | G.H5 | L | 358 | G.H5.25 |
Hydrophobic | TM7 | E | 273 | 7x34 | G.H5 | L | 358 | G.H5.25 |
Van-der-waals | TM7 | E | 273 | 7x34 | G.H5 | L | 358 | G.H5.25 |
Polar | ECL2 | H | 176 | - | G.H5 | Y | 356 | G.H5.23 |
Hydrophobic | ECL2 | H | 176 | - | G.H5 | Y | 356 | G.H5.23 |
Van-der-waals | ECL2 | H | 176 | - | G.H5 | Y | 356 | G.H5.23 |
Polar | ECL2 | H | 179 | - | G.S2 | L | 196 | G.S2.08 |
Hydrophobic | ECL2 | H | 179 | - | G.S2 | L | 196 | G.S2.08 |
Van-der-waals | ECL2 | H | 179 | - | G.S2 | L | 196 | G.S2.08 |
Hydrophobic | TM6 | Y | 249 | 6x51 | G.H5 | L | 358 | G.H5.25 |
Hydrophobic | ECL2 | H | 176 | - | G.S3 | V | 199 | G.S3.01 |
Hydrophobic | N-term | S | 7 | - | G.S6 | F | 328 | G.S6.05 |
Polar | ECL2 | Q | 177 | - | G.s2s3 | S | 198 | G.s2s3.02 |
Hydrophobic | ECL2 | Q | 177 | - | G.s2s3 | S | 198 | G.s2s3.02 |
Van-der-waals | ECL2 | Q | 177 | - | G.s2s3 | S | 198 | G.s2s3.02 |
Hydrophobic | N-term | V | 21 | - | G.H5 | R | 338 | G.H5.05 |
Van-der-waals | N-term | V | 21 | - | G.H5 | R | 338 | G.H5.05 |
Polar | ECL3 | N | 262 | - | G.h2s4 | T | 224 | G.h2s4.05 |
Polar | N-term | D | 22 | - | G.H5 | A | 342 | G.H5.09 |
Hydrophobic | N-term | D | 22 | - | G.H5 | A | 342 | G.H5.09 |
Van-der-waals | N-term | D | 22 | - | G.H5 | A | 342 | G.H5.09 |
Polar | ECL2 | D | 189 | - | G.H5 | E | 355 | G.H5.22 |
Hydrophobic | ECL2 | D | 189 | - | G.H5 | E | 355 | G.H5.22 |
Van-der-waals | ECL2 | D | 189 | - | G.H5 | E | 355 | G.H5.22 |
Polar | N-term | D | 4 | - | G.S6 | I | 324 | G.S6.01 |
Van-der-waals | TM1 | R | 35 | 1x32 | G.H5 | Q | 350 | G.H5.17 |
Hydrophobic | N-term | D | 22 | - | G.H5 | F | 339 | G.H5.06 |
Van-der-waals | N-term | D | 22 | - | G.H5 | F | 339 | G.H5.06 |
Polar | N-term | S | 7 | - | G.S6 | S | 326 | G.S6.03 |
Hydrophobic | N-term | S | 7 | - | G.S6 | S | 326 | G.S6.03 |
Van-der-waals | N-term | S | 7 | - | G.S6 | S | 326 | G.S6.03 |
Hydrophobic | ECL2 | F | 180 | - | G.S2 | L | 196 | G.S2.08 |
Van-der-waals | ECL2 | F | 180 | - | G.S2 | L | 196 | G.S2.08 |
Polar | TM6 | Y | 249 | 6x51 | G.H5 | V | 359 | G.H5.26 |
Van-der-waals | TM6 | Y | 249 | 6x51 | G.H5 | V | 359 | G.H5.26 |
Polar | TM6 | A | 259 | 6x61 | G.H5 | K | 354 | G.H5.21 |
Hydrophobic | TM6 | A | 259 | 6x61 | G.H5 | K | 354 | G.H5.21 |
Van-der-waals | TM6 | A | 259 | 6x61 | G.H5 | K | 354 | G.H5.21 |
Hydrophobic | ECL3 | P | 261 | - | G.h3s5 | N | 266 | G.h3s5.02 |
Hydrophobic | N-term | Y | 13 | - | G.H5 | F | 339 | G.H5.06 |
Hydrophobic | N-term | S | 7 | - | G.H4 | L | 310 | G.H4.12 |
Van-der-waals | N-term | S | 7 | - | G.H4 | L | 310 | G.H4.12 |
Polar | ECL3 | N | 262 | - | G.h3s5 | N | 266 | G.h3s5.02 |
Hydrophobic | ECL3 | N | 262 | - | G.h3s5 | N | 266 | G.h3s5.02 |
Van-der-waals | ECL3 | N | 262 | - | G.h3s5 | N | 266 | G.h3s5.02 |
Polar | ECL3 | N | 262 | - | G.S5 | S | 268 | G.S5.01 |
Hydrophobic | ECL3 | N | 262 | - | G.S5 | S | 268 | G.S5.01 |
Van-der-waals | ECL3 | N | 262 | - | G.S5 | S | 268 | G.S5.01 |
Polar | ECL2 | H | 179 | - | G.s2s3 | Q | 197 | G.s2s3.01 |
Hydrophobic | ECL2 | H | 179 | - | G.s2s3 | Q | 197 | G.s2s3.01 |
Van-der-waals | ECL2 | H | 179 | - | G.s2s3 | Q | 197 | G.s2s3.01 |
Polar | TM6 | L | 256 | 6x58 | G.H5 | K | 354 | G.H5.21 |
Hydrophobic | TM6 | L | 256 | 6x58 | G.H5 | K | 354 | G.H5.21 |
Van-der-waals | TM6 | L | 256 | 6x58 | G.H5 | K | 354 | G.H5.21 |
Polar | N-term | Y | 10 | - | G.HG | K | 276 | G.HG.01 |
Van-der-waals | N-term | Y | 10 | - | G.HG | K | 276 | G.HG.01 |
Ionic | ECL2 | R | 183 | - | G.H5 | D | 346 | G.H5.13 |
Polar | ECL2 | R | 183 | - | G.H5 | D | 346 | G.H5.13 |
Van-der-waals | ECL2 | R | 183 | - | G.H5 | D | 346 | G.H5.13 |
Hydrophobic | TM3 | I | 114 | 3x32 | G.H5 | V | 359 | G.H5.26 |
Van-der-waals | TM3 | I | 114 | 3x32 | G.H5 | V | 359 | G.H5.26 |
Polar | N-term | Y | 8 | - | G.S6 | S | 326 | G.S6.03 |
Hydrophobic | N-term | Y | 8 | - | G.S6 | S | 326 | G.S6.03 |
Van-der-waals | N-term | Y | 8 | - | G.S6 | S | 326 | G.S6.03 |
Van-der-waals | N-term | S | 5 | - | G.S6 | I | 324 | G.S6.01 |
Polar | TM6 | T | 257 | 6x59 | G.H5 | K | 354 | G.H5.21 |
Van-der-waals | TM6 | T | 257 | 6x59 | G.H5 | K | 354 | G.H5.21 |
Van-der-waals | ECL2 | E | 178 | - | G.H5 | D | 346 | G.H5.13 |
Hydrophobic | N-term | S | 5 | - | G.H4 | V | 314 | G.H4.16 |
Van-der-waals | N-term | S | 5 | - | G.H4 | V | 314 | G.H4.16 |
Polar | N-term | N | 3 | - | G.H4 | D | 315 | G.H4.17 |
Aromatic | N-term | Y | 10 | - | G.H5 | F | 339 | G.H5.06 |
Hydrophobic | N-term | Y | 10 | - | G.H5 | F | 339 | G.H5.06 |
Van-der-waals | N-term | Y | 10 | - | G.H5 | F | 339 | G.H5.06 |
Hydrophobic | TM6 | G | 253 | 6x55 | G.H5 | L | 358 | G.H5.25 |
Polar | ECL2 | G | 192 | - | G.H5 | E | 355 | G.H5.22 |
Polar | N-term | Y | 10 | - | G.S6 | H | 327 | G.S6.04 |
Hydrophobic | N-term | Y | 10 | - | G.S6 | H | 327 | G.S6.04 |
Van-der-waals | N-term | Y | 10 | - | G.S6 | H | 327 | G.S6.04 |
Polar | N-term | Y | 8 | - | G.S6 | F | 328 | G.S6.05 |