Gs -
C5a2 receptor complex model
GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 77.5
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.5
iPTM Score: 0.3
PAE mean: 25.4
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Polar | ICL2 | T | 144 | 34x55 | G.hns1 | A | 39 | G.hns1.03 |
Hydrophobic | ICL2 | P | 139 | 34x50 | G.H5 | R | 380 | G.H5.12 |
Hydrophobic | TM7 | F | 291 | 7x53 | G.H5 | E | 392 | G.H5.24 |
Van-der-waals | TM7 | F | 291 | 7x53 | G.H5 | E | 392 | G.H5.24 |
Hydrophobic | ICL2 | T | 144 | 34x55 | G.S1 | H | 41 | G.S1.02 |
Polar | TM3 | D | 131 | 3x49 | G.H5 | Y | 391 | G.H5.23 |
Van-der-waals | TM3 | D | 131 | 3x49 | G.H5 | Y | 391 | G.H5.23 |
Hydrophobic | TM3 | L | 132 | 3x50 | G.H5 | L | 393 | G.H5.25 |
Van-der-waals | TM3 | L | 132 | 3x50 | G.H5 | L | 393 | G.H5.25 |
Polar | TM3 | L | 137 | 3x55 | G.H5 | R | 380 | G.H5.12 |
Hydrophobic | TM3 | L | 137 | 3x55 | G.H5 | R | 380 | G.H5.12 |
Van-der-waals | TM3 | L | 137 | 3x55 | G.H5 | R | 380 | G.H5.12 |
Polar | TM3 | G | 138 | 3x56 | G.H5 | R | 380 | G.H5.12 |
Hydrophobic | TM3 | G | 138 | 3x56 | G.H5 | R | 380 | G.H5.12 |
Van-der-waals | TM3 | G | 138 | 3x56 | G.H5 | R | 380 | G.H5.12 |
Polar | TM6 | R | 232 | 6x34 | G.h4s6 | Y | 358 | G.h4s6.20 |
Hydrophobic | C-term | A | 310 | - | G.H5 | E | 392 | G.H5.24 |
Van-der-waals | C-term | A | 310 | - | G.H5 | E | 392 | G.H5.24 |
Hydrophobic | TM6 | R | 230 | 6x32 | G.H5 | L | 394 | G.H5.26 |
Van-der-waals | TM6 | R | 230 | 6x32 | G.H5 | L | 394 | G.H5.26 |
Ionic | C-term | E | 313 | - | G.h4s6 | R | 356 | G.h4s6.12 |
Polar | C-term | E | 313 | - | G.h4s6 | R | 356 | G.h4s6.12 |
Hydrophobic | C-term | E | 313 | - | G.h4s6 | R | 356 | G.h4s6.12 |
Van-der-waals | C-term | E | 313 | - | G.h4s6 | R | 356 | G.h4s6.12 |
Polar | C-term | Q | 317 | - | G.h2s4 | N | 239 | G.h2s4.02 |
Van-der-waals | C-term | Q | 317 | - | G.h2s4 | N | 239 | G.h2s4.02 |
Hydrophobic | TM3 | L | 132 | 3x50 | G.H5 | Y | 391 | G.H5.23 |
Hydrophobic | TM6 | L | 234 | 6x36 | G.H5 | E | 392 | G.H5.24 |
Van-der-waals | TM6 | L | 234 | 6x36 | G.H5 | E | 392 | G.H5.24 |
Polar | TM3 | L | 135 | 3x53 | G.H5 | R | 380 | G.H5.12 |
Van-der-waals | TM3 | L | 135 | 3x53 | G.H5 | R | 380 | G.H5.12 |
Polar | TM3 | A | 136 | 3x54 | G.H5 | R | 380 | G.H5.12 |
Hydrophobic | TM3 | A | 136 | 3x54 | G.H5 | R | 380 | G.H5.12 |
Van-der-waals | TM3 | A | 136 | 3x54 | G.H5 | R | 380 | G.H5.12 |
Hydrophobic | ICL2 | W | 141 | 34x52 | G.s2s3 | K | 216 | G.s2s3.02 |
Ionic | C-term | E | 313 | - | G.H5 | R | 389 | G.H5.21 |
Polar | TM6 | R | 232 | 6x34 | G.H5 | L | 393 | G.H5.25 |
Hydrophobic | TM6 | R | 232 | 6x34 | G.H5 | L | 393 | G.H5.25 |
Van-der-waals | TM6 | R | 232 | 6x34 | G.H5 | L | 393 | G.H5.25 |
Hydrophobic | ICL1 | R | 66 | - | G.hns1 | R | 38 | G.hns1.02 |
Polar | TM2 | V | 68 | 2x38 | G.H5 | Q | 390 | G.H5.22 |
Hydrophobic | TM3 | L | 135 | 3x53 | G.H5 | H | 387 | G.H5.19 |
Hydrophobic | ICL2 | W | 141 | 34x52 | G.S3 | V | 217 | G.S3.01 |
Van-der-waals | ICL2 | W | 141 | 34x52 | G.S3 | V | 217 | G.S3.01 |
Polar | TM2 | R | 67 | 2x37 | G.H5 | R | 389 | G.H5.21 |
Hydrophobic | ICL2 | V | 145 | 34x56 | G.HN | Q | 35 | G.HN.52 |
Van-der-waals | ICL2 | V | 145 | 34x56 | G.HN | Q | 35 | G.HN.52 |
Hydrophobic | TM3 | L | 128 | 3x46 | G.H5 | L | 393 | G.H5.25 |
Van-der-waals | TM3 | L | 128 | 3x46 | G.H5 | L | 393 | G.H5.25 |
Polar | TM3 | L | 135 | 3x53 | G.H5 | Q | 384 | G.H5.16 |
Hydrophobic | TM3 | L | 135 | 3x53 | G.H5 | Q | 384 | G.H5.16 |
Van-der-waals | TM3 | L | 135 | 3x53 | G.H5 | Q | 384 | G.H5.16 |
Hydrophobic | TM6 | G | 235 | 6x37 | G.H5 | L | 393 | G.H5.25 |
Van-der-waals | TM6 | G | 235 | 6x37 | G.H5 | L | 393 | G.H5.25 |
Hydrophobic | ICL2 | W | 141 | 34x52 | G.H5 | F | 376 | G.H5.08 |
Van-der-waals | ICL2 | W | 141 | 34x52 | G.H5 | F | 376 | G.H5.08 |
Polar | TM3 | A | 136 | 3x54 | G.H5 | Q | 384 | G.H5.16 |
Hydrophobic | TM3 | A | 136 | 3x54 | G.H5 | Q | 384 | G.H5.16 |
Van-der-waals | TM3 | A | 136 | 3x54 | G.H5 | Q | 384 | G.H5.16 |
Polar | TM6 | R | 232 | 6x34 | G.h4s6 | G | 355 | G.h4s6.11 |
Van-der-waals | TM6 | R | 232 | 6x34 | G.h4s6 | G | 355 | G.h4s6.11 |
Polar | TM2 | G | 69 | 2x39 | G.H5 | Y | 391 | G.H5.23 |
Hydrophobic | TM2 | G | 69 | 2x39 | G.H5 | Y | 391 | G.H5.23 |
Van-der-waals | TM2 | G | 69 | 2x39 | G.H5 | Y | 391 | G.H5.23 |
Hydrophobic | ICL2 | V | 145 | 34x56 | G.hns1 | A | 39 | G.hns1.03 |
Hydrophobic | TM3 | L | 132 | 3x50 | G.H5 | L | 388 | G.H5.20 |
Van-der-waals | TM3 | L | 132 | 3x50 | G.H5 | L | 388 | G.H5.20 |
Hydrophobic | ICL2 | A | 140 | 34x51 | G.H5 | F | 376 | G.H5.08 |
Van-der-waals | ICL2 | A | 140 | 34x51 | G.H5 | F | 376 | G.H5.08 |
Hydrophobic | TM6 | I | 238 | 6x40 | G.H5 | L | 393 | G.H5.25 |
Polar | TM2 | V | 68 | 2x38 | G.H5 | Y | 391 | G.H5.23 |
Hydrophobic | TM2 | V | 68 | 2x38 | G.H5 | Y | 391 | G.H5.23 |
Van-der-waals | TM2 | V | 68 | 2x38 | G.H5 | Y | 391 | G.H5.23 |
Hydrophobic | TM2 | V | 68 | 2x38 | G.H5 | H | 387 | G.H5.19 |
Hydrophobic | ICL2 | S | 143 | 34x54 | G.hns1 | A | 39 | G.hns1.03 |
Polar | TM6 | R | 232 | 6x34 | G.H5 | L | 394 | G.H5.26 |
Hydrophobic | TM6 | R | 232 | 6x34 | G.H5 | L | 394 | G.H5.26 |
Van-der-waals | TM6 | R | 232 | 6x34 | G.H5 | L | 394 | G.H5.26 |
Hydrophobic | ICL2 | A | 140 | 34x51 | G.S3 | V | 217 | G.S3.01 |
Van-der-waals | ICL2 | A | 140 | 34x51 | G.S3 | V | 217 | G.S3.01 |
Hydrophobic | TM2 | G | 69 | 2x39 | G.H5 | H | 387 | G.H5.19 |
Polar | TM2 | W | 72 | 2x42 | G.H5 | Y | 391 | G.H5.23 |
Aromatic | TM2 | W | 72 | 2x42 | G.H5 | Y | 391 | G.H5.23 |
Hydrophobic | TM2 | W | 72 | 2x42 | G.H5 | Y | 391 | G.H5.23 |
Van-der-waals | TM2 | W | 72 | 2x42 | G.H5 | Y | 391 | G.H5.23 |
Polar | ICL2 | T | 144 | 34x55 | G.hns1 | R | 38 | G.hns1.02 |
Hydrophobic | ICL2 | T | 144 | 34x55 | G.hns1 | R | 38 | G.hns1.02 |
Van-der-waals | ICL2 | T | 144 | 34x55 | G.hns1 | R | 38 | G.hns1.02 |
Hydrophobic | TM6 | R | 230 | 6x32 | G.h4s6 | Y | 358 | G.h4s6.20 |
Van-der-waals | TM6 | R | 230 | 6x32 | G.h4s6 | Y | 358 | G.h4s6.20 |
Van-der-waals | TM6 | R | 232 | 6x34 | G.H5 | R | 389 | G.H5.21 |
Hydrophobic | TM3 | L | 128 | 3x46 | G.H5 | Y | 391 | G.H5.23 |
Van-der-waals | C-term | L | 311 | - | G.H5 | E | 392 | G.H5.24 |
Hydrophobic | ICL2 | A | 140 | 34x51 | G.H5 | R | 380 | G.H5.12 |
Van-der-waals | ICL2 | A | 140 | 34x51 | G.H5 | R | 380 | G.H5.12 |
Polar | ICL2 | W | 141 | 34x52 | G.s2s3 | D | 215 | G.s2s3.01 |
Hydrophobic | ICL2 | W | 141 | 34x52 | G.s2s3 | D | 215 | G.s2s3.01 |
Van-der-waals | ICL2 | W | 141 | 34x52 | G.s2s3 | D | 215 | G.s2s3.01 |
Van-der-waals | C-term | L | 311 | - | G.H5 | Q | 390 | G.H5.22 |
Polar | ICL1 | R | 65 | - | G.hns1 | R | 38 | G.hns1.02 |
Hydrophobic | ICL1 | R | 65 | - | G.hns1 | R | 38 | G.hns1.02 |
Van-der-waals | ICL1 | R | 65 | - | G.hns1 | R | 38 | G.hns1.02 |
Hydrophobic | TM2 | L | 73 | 2x43 | G.H5 | Y | 391 | G.H5.23 |
Van-der-waals | TM2 | L | 73 | 2x43 | G.H5 | Y | 391 | G.H5.23 |
Polar | TM4 | R | 147 | 4x38 | G.H5 | H | 387 | G.H5.19 |
Aromatic | TM4 | R | 147 | 4x38 | G.H5 | H | 387 | G.H5.19 |
Hydrophobic | TM4 | R | 147 | 4x38 | G.H5 | H | 387 | G.H5.19 |
Van-der-waals | TM4 | R | 147 | 4x38 | G.H5 | H | 387 | G.H5.19 |
Polar | TM2 | G | 69 | 2x39 | G.H5 | Q | 390 | G.H5.22 |
Hydrophobic | TM2 | G | 69 | 2x39 | G.H5 | Q | 390 | G.H5.22 |
Van-der-waals | TM2 | G | 69 | 2x39 | G.H5 | Q | 390 | G.H5.22 |
Hydrophobic | TM2 | R | 67 | 2x37 | G.H5 | Q | 390 | G.H5.22 |
Van-der-waals | TM2 | R | 67 | 2x37 | G.H5 | Q | 390 | G.H5.22 |
Polar | TM4 | R | 147 | 4x38 | G.H5 | Y | 391 | G.H5.23 |
Van-der-waals | TM4 | R | 147 | 4x38 | G.H5 | Y | 391 | G.H5.23 |