G12 -
CT receptor complex model
GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 83.6
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.8
iPTM Score: 0.8
PAE mean: 13.6
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
Gβ,
Gγ,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Polar | C-term | I | 468 | - | H.HA | D | 110 | H.HA.24 |
Hydrophobic | C-term | I | 468 | - | H.HA | D | 110 | H.HA.24 |
Van-der-waals | C-term | I | 468 | - | H.HA | D | 110 | H.HA.24 |
Polar | C-term | Q | 470 | - | H.HA | N | 100 | H.HA.14 |
Ionic | TM5 | K | 326 | 5x64 | G.H5 | D | 368 | G.H5.13 |
Polar | TM5 | K | 326 | 5x64 | G.H5 | D | 368 | G.H5.13 |
Hydrophobic | TM5 | K | 326 | 5x64 | G.H5 | D | 368 | G.H5.13 |
Van-der-waals | TM5 | K | 326 | 5x64 | G.H5 | D | 368 | G.H5.13 |
Hydrophobic | TM3 | L | 247 | 3x57 | G.H5 | N | 374 | G.H5.19 |
Van-der-waals | TM3 | L | 247 | 3x57 | G.H5 | N | 374 | G.H5.19 |
Hydrophobic | C-term | I | 467 | - | H.HA | A | 111 | H.HA.25 |
Polar | C-term | S | 473 | - | H.HA | D | 99 | H.HA.13 |
Hydrophobic | C-term | S | 473 | - | H.HA | D | 99 | H.HA.13 |
Van-der-waals | C-term | S | 473 | - | H.HA | D | 99 | H.HA.13 |
Ionic | TM2 | R | 180 | 2x46 | G.H5 | D | 377 | G.H5.22 |
Polar | TM2 | R | 180 | 2x46 | G.H5 | D | 377 | G.H5.22 |
Hydrophobic | TM2 | R | 180 | 2x46 | G.H5 | D | 377 | G.H5.22 |
Van-der-waals | TM2 | R | 180 | 2x46 | G.H5 | D | 377 | G.H5.22 |
Hydrophobic | TM6 | L | 348 | 6x45 | G.H5 | I | 378 | G.H5.23 |
Hydrophobic | C-term | I | 442 | - | G.H2 | Q | 236 | G.H2.05 |
Van-der-waals | C-term | I | 442 | - | G.H2 | Q | 236 | G.H2.05 |
Hydrophobic | C-term | I | 442 | - | G.H2 | Q | 240 | G.H2.09 |
Van-der-waals | C-term | I | 442 | - | G.H2 | Q | 240 | G.H2.09 |
Hydrophobic | C-term | I | 468 | - | H.HB | M | 132 | H.HB.10 |
Hydrophobic | TM5 | T | 330 | 5x68 | G.h4s6 | P | 345 | G.h4s6.20 |
Hydrophobic | TM3 | I | 248 | 3x58 | G.H5 | L | 375 | G.H5.20 |
Hydrophobic | C-term | I | 467 | - | H.HA | L | 115 | H.HA.29 |
Hydrophobic | C-term | I | 467 | - | H.hdhe | F | 173 | H.hdhe.01 |
Van-der-waals | C-term | I | 467 | - | H.hdhe | F | 173 | H.hdhe.01 |
Hydrophobic | C-term | I | 440 | - | G.H3 | K | 284 | G.H3.16 |
Hydrophobic | C-term | Q | 470 | - | H.HA | G | 104 | H.HA.18 |
Van-der-waals | C-term | Q | 470 | - | H.HA | G | 104 | H.HA.18 |
Polar | C-term | H | 444 | - | G.H2 | Q | 236 | G.H2.05 |
Polar | C-term | L | 465 | - | G.s4h3 | R | 265 | G.s4h3.12 |
Ionic | C-term | D | 437 | - | G.H3 | K | 284 | G.H3.16 |
Hydrophobic | C-term | D | 437 | - | G.H3 | K | 284 | G.H3.16 |
Van-der-waals | C-term | D | 437 | - | G.H3 | K | 284 | G.H3.16 |
Polar | H8 | N | 396 | 8x48 | G.H5 | L | 380 | G.H5.25 |
Hydrophobic | C-term | C | 443 | - | G.H2 | K | 237 | G.H2.06 |
Hydrophobic | H8 | N | 395 | 8x47 | G.H5 | L | 380 | G.H5.25 |
Polar | C-term | N | 466 | - | H.HA | K | 114 | H.HA.28 |
Hydrophobic | C-term | N | 466 | - | H.HA | K | 114 | H.HA.28 |
Van-der-waals | C-term | N | 466 | - | H.HA | K | 114 | H.HA.28 |
Hydrophobic | TM3 | I | 248 | 3x58 | G.H5 | L | 371 | G.H5.16 |
Van-der-waals | TM3 | I | 248 | 3x58 | G.H5 | L | 371 | G.H5.16 |
Hydrophobic | C-term | Q | 470 | - | H.HA | V | 107 | H.HA.21 |
Van-der-waals | C-term | Q | 470 | - | H.HA | V | 107 | H.HA.21 |
Hydrophobic | C-term | I | 467 | - | H.HA | K | 114 | H.HA.28 |
Van-der-waals | C-term | I | 467 | - | H.HA | K | 114 | H.HA.28 |
Hydrophobic | TM5 | K | 326 | 5x64 | G.H5 | L | 371 | G.H5.16 |
Hydrophobic | C-term | E | 469 | - | H.HA | V | 107 | H.HA.21 |
Hydrophobic | C-term | I | 467 | - | H.HA | D | 110 | H.HA.24 |
Van-der-waals | C-term | I | 467 | - | H.HA | D | 110 | H.HA.24 |
Hydrophobic | TM6 | A | 344 | 6x41 | G.H5 | M | 379 | G.H5.24 |
Hydrophobic | C-term | L | 465 | - | H.HA | L | 115 | H.HA.29 |
Van-der-waals | C-term | L | 465 | - | H.HA | L | 115 | H.HA.29 |
Hydrophobic | TM3 | I | 248 | 3x58 | G.H5 | I | 378 | G.H5.23 |
Van-der-waals | TM3 | I | 248 | 3x58 | G.H5 | I | 378 | G.H5.23 |
Hydrophobic | C-term | I | 440 | - | G.H3 | L | 285 | G.H3.17 |
Van-der-waals | C-term | I | 440 | - | G.H3 | L | 285 | G.H3.17 |
Ionic | C-term | E | 469 | - | G.s4h3 | R | 265 | G.s4h3.12 |
Polar | C-term | E | 469 | - | G.s4h3 | R | 265 | G.s4h3.12 |
Hydrophobic | C-term | E | 469 | - | G.s4h3 | R | 265 | G.s4h3.12 |
Van-der-waals | C-term | E | 469 | - | G.s4h3 | R | 265 | G.s4h3.12 |
Hydrophobic | ICL2 | F | 253 | - | G.H5 | V | 366 | G.H5.11 |
Hydrophobic | ICL2 | K | 256 | - | G.hns1 | R | 55 | G.hns1.02 |
Van-der-waals | ICL2 | K | 256 | - | G.hns1 | R | 55 | G.hns1.02 |
Hydrophobic | TM5 | L | 323 | 5x61 | G.H5 | M | 379 | G.H5.24 |
Hydrophobic | H8 | N | 396 | 8x48 | G.H5 | Q | 381 | G.H5.26 |
Van-der-waals | H8 | N | 396 | 8x48 | G.H5 | Q | 381 | G.H5.26 |
Hydrophobic | C-term | E | 469 | - | G.s4h3 | M | 262 | G.s4h3.09 |
Van-der-waals | C-term | E | 469 | - | G.s4h3 | M | 262 | G.s4h3.09 |
Hydrophobic | C-term | Q | 470 | - | H.HA | K | 103 | H.HA.17 |
Hydrophobic | C-term | A | 474 | - | G.hfs2 | K | 209 | G.hfs2.06 |
Van-der-waals | C-term | A | 474 | - | G.hfs2 | K | 209 | G.hfs2.06 |
Hydrophobic | C-term | I | 467 | - | H.HA | V | 107 | H.HA.21 |
Hydrophobic | ICL2 | V | 252 | - | G.H5 | L | 371 | G.H5.16 |
Hydrophobic | TM3 | L | 244 | 3x54 | G.H5 | I | 378 | G.H5.23 |
Van-der-waals | TM3 | L | 244 | 3x54 | G.H5 | I | 378 | G.H5.23 |
Van-der-waals | C-term | I | 468 | - | H.HA | V | 107 | H.HA.21 |
Hydrophobic | ICL2 | V | 252 | - | G.H5 | I | 370 | G.H5.15 |
Van-der-waals | ICL2 | V | 252 | - | G.H5 | I | 370 | G.H5.15 |
Polar | C-term | E | 471 | - | H.HA | K | 103 | H.HA.17 |
Van-der-waals | C-term | E | 471 | - | H.HA | K | 103 | H.HA.17 |
Hydrophobic | ICL2 | F | 253 | - | G.H5 | K | 367 | G.H5.12 |
Van-der-waals | ICL2 | F | 253 | - | G.H5 | K | 367 | G.H5.12 |
Polar | C-term | N | 466 | - | G.s4h3 | R | 265 | G.s4h3.12 |
Van-der-waals | C-term | N | 466 | - | G.s4h3 | R | 265 | G.s4h3.12 |
Polar | C-term | I | 438 | - | G.H3 | K | 284 | G.H3.16 |
Hydrophobic | C-term | I | 438 | - | G.H3 | K | 284 | G.H3.16 |
Van-der-waals | C-term | I | 438 | - | G.H3 | K | 284 | G.H3.16 |
Hydrophobic | TM7 | I | 390 | 7x56 | G.H5 | L | 380 | G.H5.25 |
Van-der-waals | TM7 | I | 390 | 7x56 | G.H5 | L | 380 | G.H5.25 |
Hydrophobic | TM6 | I | 347 | 6x44 | G.H5 | L | 380 | G.H5.25 |
Hydrophobic | TM5 | L | 323 | 5x61 | G.H5 | L | 375 | G.H5.20 |
Ionic | ICL2 | E | 255 | - | G.hns1 | R | 55 | G.hns1.02 |
Polar | ICL2 | E | 255 | - | G.hns1 | R | 55 | G.hns1.02 |
Hydrophobic | ICL2 | E | 255 | - | G.hns1 | R | 55 | G.hns1.02 |
Van-der-waals | ICL2 | E | 255 | - | G.hns1 | R | 55 | G.hns1.02 |
Aromatic | ICL2 | F | 253 | - | G.H5 | F | 363 | G.H5.08 |
Hydrophobic | ICL2 | F | 253 | - | G.H5 | F | 363 | G.H5.08 |
Van-der-waals | ICL2 | F | 253 | - | G.H5 | F | 363 | G.H5.08 |
Hydrophobic | ICL2 | V | 252 | - | G.H5 | K | 367 | G.H5.12 |
Hydrophobic | TM7 | Y | 391 | 7x57 | G.H5 | L | 380 | G.H5.25 |
Hydrophobic | C-term | C | 443 | - | G.H2 | Q | 236 | G.H2.05 |
Van-der-waals | C-term | C | 443 | - | G.H2 | Q | 236 | G.H2.05 |
Hydrophobic | C-term | L | 465 | - | H.HA | K | 114 | H.HA.28 |
Van-der-waals | C-term | L | 465 | - | H.HA | K | 114 | H.HA.28 |
Hydrophobic | ICL2 | F | 253 | - | G.H5 | I | 370 | G.H5.15 |
Polar | C-term | S | 473 | - | H.HA | K | 103 | H.HA.17 |
Van-der-waals | C-term | S | 473 | - | H.HA | K | 103 | H.HA.17 |
Hydrophobic | C-term | I | 442 | - | G.H2 | K | 237 | G.H2.06 |
Van-der-waals | C-term | I | 442 | - | G.H2 | K | 237 | G.H2.06 |
Polar | C-term | Q | 470 | - | H.hdhe | G | 176 | H.hdhe.04 |
Van-der-waals | C-term | Q | 470 | - | H.hdhe | G | 176 | H.hdhe.04 |
Hydrophobic | TM5 | K | 326 | 5x64 | G.H5 | L | 375 | G.H5.20 |
Polar | C-term | G | 436 | - | G.H3 | K | 284 | G.H3.16 |
Van-der-waals | C-term | G | 436 | - | G.H3 | K | 284 | G.H3.16 |
Hydrophobic | C-term | Q | 470 | - | G.s4h3 | M | 262 | G.s4h3.09 |
Hydrophobic | ICL2 | F | 253 | - | G.S3 | I | 221 | G.S3.01 |
Van-der-waals | ICL2 | F | 253 | - | G.S3 | I | 221 | G.S3.01 |
Hydrophobic | TM5 | V | 322 | 5x60 | G.H5 | L | 371 | G.H5.16 |