Gi2 - calcitonin receptor-like receptor complex model

GPCR CLASS (FAMILY)

B1 (Secretin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 79.6

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.6
PAE mean: 16.3


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM5 L 316 5x61 G.H5 L 354 G.H5.25
Hydrophobic TM5 L 316 5x61 G.H5 L 349 G.H5.20
Ionic ICL2 E 248 - G.hns1 R 32 G.hns1.03
Polar ICL2 E 248 - G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 E 248 - G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 E 248 - G.hns1 R 32 G.hns1.03
Ionic ICL1 K 167 12x48 G.HN D 20 G.HN.44
Hydrophobic ICL2 V 245 - G.H5 I 345 G.H5.16
Van-der-waals ICL2 V 245 - G.H5 I 345 G.H5.16
Hydrophobic TM5 V 315 5x60 G.H5 I 345 G.H5.16
Hydrophobic TM3 I 241 3x58 G.H5 L 349 G.H5.20
Van-der-waals TM3 I 241 3x58 G.H5 L 349 G.H5.20
Hydrophobic TM6 I 340 6x44 G.H5 L 354 G.H5.25
Van-der-waals TM6 I 340 6x44 G.H5 L 354 G.H5.25
Polar ICL2 K 249 - G.HN R 24 G.HN.48
Van-der-waals ICL2 K 249 - G.HN R 24 G.HN.48
Hydrophobic TM3 I 241 3x58 G.H5 I 345 G.H5.16
Hydrophobic TM6 L 341 6x45 G.H5 L 354 G.H5.25
Van-der-waals TM6 L 341 6x45 G.H5 L 354 G.H5.25
Hydrophobic TM3 L 237 3x54 G.H5 C 352 G.H5.23
Van-der-waals TM3 L 237 3x54 G.H5 C 352 G.H5.23
Hydrophobic ICL2 V 245 - G.H5 I 344 G.H5.15
Van-der-waals ICL2 V 245 - G.H5 I 344 G.H5.15
Ionic TM5 K 319 5x64 G.H5 D 342 G.H5.13
Polar TM5 K 319 5x64 G.H5 D 342 G.H5.13
Hydrophobic TM5 K 319 5x64 G.H5 D 342 G.H5.13
Van-der-waals TM5 K 319 5x64 G.H5 D 342 G.H5.13
Polar ICL3 Q 325 - G.h4s6 D 316 G.h4s6.09
Van-der-waals ICL3 Q 325 - G.h4s6 D 316 G.h4s6.09
Hydrophobic TM3 L 237 3x54 G.H5 L 354 G.H5.25
Ionic ICL2 K 249 - G.HN E 28 G.HN.52
Polar ICL2 K 249 - G.HN E 28 G.HN.52
Hydrophobic ICL2 K 249 - G.HN E 28 G.HN.52
Van-der-waals ICL2 K 249 - G.HN E 28 G.HN.52
Hydrophobic ICL2 F 246 - G.H5 I 344 G.H5.15
Van-der-waals ICL2 F 246 - G.H5 I 344 G.H5.15
Polar TM3 L 240 3x57 G.H5 N 348 G.H5.19
Hydrophobic TM3 L 240 3x57 G.H5 N 348 G.H5.19
Van-der-waals TM3 L 240 3x57 G.H5 N 348 G.H5.19
Hydrophobic TM6 A 337 6x41 G.H5 L 354 G.H5.25
Hydrophobic ICL2 F 246 - G.S3 L 195 G.S3.01
Van-der-waals ICL2 F 246 - G.S3 L 195 G.S3.01
Aromatic ICL2 F 246 - G.H5 F 337 G.H5.08
Hydrophobic ICL2 F 246 - G.H5 F 337 G.H5.08
Van-der-waals ICL2 F 246 - G.H5 F 337 G.H5.08
Polar TM2 R 173 2x46 G.H5 D 351 G.H5.22
Hydrophobic TM2 R 173 2x46 G.H5 D 351 G.H5.22
Van-der-waals TM2 R 173 2x46 G.H5 D 351 G.H5.22
Aromatic TM6 K 333 6x37 G.H5 F 355 G.H5.26
Hydrophobic TM5 K 319 5x64 G.H5 I 345 G.H5.16
Van-der-waals TM5 K 319 5x64 G.H5 I 345 G.H5.16
Hydrophobic ICL2 V 245 - G.H5 T 341 G.H5.12
Polar ICL3 T 323 - G.h4s6 E 319 G.h4s6.12
Hydrophobic ICL3 T 323 - G.h4s6 E 319 G.h4s6.12
Van-der-waals ICL3 T 323 - G.h4s6 E 319 G.h4s6.12
Hydrophobic TM2 R 173 2x46 G.H5 C 352 G.H5.23
Polar ICL2 V 245 - G.H5 N 348 G.H5.19
Hydrophobic TM5 L 320 5x65 G.H5 F 355 G.H5.26
Van-der-waals TM5 L 320 5x65 G.H5 F 355 G.H5.26
Hydrophobic ICL2 F 246 - G.H5 T 341 G.H5.12
Van-der-waals ICL2 F 246 - G.H5 T 341 G.H5.12