G14 -
CCK1 receptor complex model
GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 86.8
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.8
iPTM Score: 0.7
PAE mean: 10.4
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
Gβ,
Gγ,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Hydrophobic | ICL3 | I | 296 | - | G.H5 | F | 335 | G.H5.06 |
Van-der-waals | ICL3 | I | 296 | - | G.H5 | F | 335 | G.H5.06 |
Hydrophobic | ICL3 | R | 297 | - | G.S6 | F | 324 | G.S6.05 |
Polar | TM6 | N | 304 | 6x26 | G.H5 | Q | 346 | G.H5.17 |
Hydrophobic | TM6 | N | 304 | 6x26 | G.H5 | Q | 346 | G.H5.17 |
Van-der-waals | TM6 | N | 304 | 6x26 | G.H5 | Q | 346 | G.H5.17 |
Hydrophobic | TM4 | T | 154 | 4x38 | G.hns1 | R | 33 | G.hns1.02 |
Van-der-waals | TM4 | T | 154 | 4x38 | G.hns1 | R | 33 | G.hns1.02 |
Polar | C-term | G | 406 | - | G.HN | K | 29 | G.HN.51 |
Van-der-waals | C-term | G | 406 | - | G.HN | K | 29 | G.HN.51 |
Hydrophobic | TM6 | V | 311 | 6x33 | G.H5 | L | 349 | G.H5.20 |
Hydrophobic | C-term | Y | 418 | - | G.H3 | W | 259 | G.H3.17 |
Van-der-waals | C-term | Y | 418 | - | G.H3 | W | 259 | G.H3.17 |
Hydrophobic | ICL2 | Q | 153 | 34x57 | G.H5 | F | 352 | G.H5.23 |
Van-der-waals | ICL2 | Q | 153 | 34x57 | G.H5 | F | 352 | G.H5.23 |
Hydrophobic | ICL2 | L | 147 | 34x51 | G.H5 | F | 337 | G.H5.08 |
Van-der-waals | ICL2 | L | 147 | 34x51 | G.H5 | F | 337 | G.H5.08 |
Hydrophobic | TM6 | M | 314 | 6x36 | G.H5 | L | 354 | G.H5.25 |
Van-der-waals | TM6 | M | 314 | 6x36 | G.H5 | L | 354 | G.H5.25 |
Hydrophobic | TM2 | T | 76 | 2x39 | G.H5 | E | 351 | G.H5.22 |
Van-der-waals | TM2 | T | 76 | 2x39 | G.H5 | E | 351 | G.H5.22 |
Hydrophobic | TM5 | L | 236 | 5x65 | G.H5 | L | 349 | G.H5.20 |
Hydrophobic | ICL2 | L | 147 | 34x51 | G.H5 | I | 344 | G.H5.15 |
Van-der-waals | ICL2 | L | 147 | 34x51 | G.H5 | I | 344 | G.H5.15 |
Polar | H8 | R | 376 | 8x49 | G.H5 | R | 350 | G.H5.21 |
Hydrophobic | H8 | R | 376 | 8x49 | G.H5 | R | 350 | G.H5.21 |
Van-der-waals | H8 | R | 376 | 8x49 | G.H5 | R | 350 | G.H5.21 |
Hydrophobic | TM3 | R | 139 | 3x50 | G.H5 | L | 354 | G.H5.25 |
Van-der-waals | TM3 | R | 139 | 3x50 | G.H5 | L | 354 | G.H5.25 |
Polar | TM3 | A | 142 | 3x53 | G.H5 | N | 348 | G.H5.19 |
Hydrophobic | TM3 | A | 142 | 3x53 | G.H5 | N | 348 | G.H5.19 |
Van-der-waals | TM3 | A | 142 | 3x53 | G.H5 | N | 348 | G.H5.19 |
Hydrophobic | ICL2 | P | 146 | 34x50 | G.H5 | K | 341 | G.H5.12 |
Hydrophobic | C-term | M | 421 | - | G.h2s4 | F | 216 | G.h2s4.01 |
Van-der-waals | C-term | M | 421 | - | G.h2s4 | F | 216 | G.h2s4.01 |
Hydrophobic | ICL3 | I | 296 | - | G.S6 | Y | 321 | G.S6.02 |
Hydrophobic | TM3 | E | 138 | 3x49 | G.H5 | F | 352 | G.H5.23 |
Hydrophobic | C-term | M | 421 | - | G.H2 | I | 213 | G.H2.08 |
Ionic | TM5 | E | 235 | 5x64 | G.H5 | K | 341 | G.H5.12 |
Polar | TM5 | E | 235 | 5x64 | G.H5 | K | 341 | G.H5.12 |
Polar | ICL3 | N | 299 | - | G.H4 | Q | 310 | G.H4.16 |
Hydrophobic | ICL3 | N | 299 | - | G.H4 | Q | 310 | G.H4.16 |
Van-der-waals | ICL3 | N | 299 | - | G.H4 | Q | 310 | G.H4.16 |
Hydrophobic | ICL3 | N | 299 | - | G.h4s6 | V | 319 | G.h4s6.20 |
Hydrophobic | ICL3 | R | 297 | - | G.H4 | L | 306 | G.H4.12 |
Hydrophobic | ICL3 | S | 298 | - | G.S6 | I | 320 | G.S6.01 |
Van-der-waals | ICL3 | S | 298 | - | G.S6 | I | 320 | G.S6.01 |
Hydrophobic | TM3 | I | 143 | 3x54 | G.H5 | L | 354 | G.H5.25 |
Hydrophobic | ICL3 | S | 298 | - | G.h4s6 | V | 319 | G.h4s6.20 |
Hydrophobic | TM6 | V | 311 | 6x33 | G.H5 | L | 354 | G.H5.25 |
Van-der-waals | TM6 | V | 311 | 6x33 | G.H5 | L | 354 | G.H5.25 |
Polar | TM3 | R | 139 | 3x50 | G.H5 | F | 352 | G.H5.23 |
Hydrophobic | TM3 | R | 139 | 3x50 | G.H5 | F | 352 | G.H5.23 |
Van-der-waals | TM3 | R | 139 | 3x50 | G.H5 | F | 352 | G.H5.23 |
Hydrophobic | TM3 | I | 143 | 3x54 | G.H5 | N | 348 | G.H5.19 |
Polar | ICL3 | N | 299 | - | G.S6 | I | 320 | G.S6.01 |
Van-der-waals | ICL3 | N | 299 | - | G.S6 | I | 320 | G.S6.01 |
Hydrophobic | C-term | M | 421 | - | G.H3 | Y | 257 | G.H3.15 |
Van-der-waals | C-term | M | 421 | - | G.H3 | Y | 257 | G.H3.15 |
Hydrophobic | C-term | L | 413 | - | G.H3 | P | 258 | G.H3.16 |
Hydrophobic | ICL2 | L | 147 | 34x51 | G.S1 | L | 36 | G.S1.02 |
Hydrophobic | ICL2 | L | 147 | 34x51 | G.S3 | I | 195 | G.S3.01 |
Van-der-waals | ICL2 | L | 147 | 34x51 | G.S3 | I | 195 | G.S3.01 |
Polar | H8 | K | 375 | 8x48 | G.H5 | V | 355 | G.H5.26 |
Hydrophobic | H8 | K | 375 | 8x48 | G.H5 | V | 355 | G.H5.26 |
Ionic | ICL3 | A | 293 | - | G.H4 | R | 299 | G.H4.05 |
Polar | ICL3 | A | 293 | - | G.H4 | R | 299 | G.H4.05 |
Hydrophobic | ICL3 | A | 293 | - | G.H4 | R | 299 | G.H4.05 |
Van-der-waals | ICL3 | A | 293 | - | G.H4 | R | 299 | G.H4.05 |
Hydrophobic | ICL3 | S | 298 | - | G.S6 | Y | 321 | G.S6.02 |
Hydrophobic | C-term | L | 413 | - | G.H3 | W | 259 | G.H3.17 |
Van-der-waals | C-term | L | 413 | - | G.H3 | W | 259 | G.H3.17 |
Hydrophobic | TM3 | A | 142 | 3x53 | G.H5 | F | 352 | G.H5.23 |
Van-der-waals | TM3 | A | 142 | 3x53 | G.H5 | F | 352 | G.H5.23 |
Hydrophobic | ICL2 | V | 151 | 34x55 | G.hns1 | R | 34 | G.hns1.03 |
Van-der-waals | ICL2 | V | 151 | 34x55 | G.hns1 | R | 34 | G.hns1.03 |
Polar | ICL3 | R | 297 | - | G.S6 | S | 322 | G.S6.03 |
Van-der-waals | ICL3 | R | 297 | - | G.S6 | S | 322 | G.S6.03 |
Polar | TM3 | R | 139 | 3x50 | G.H5 | N | 353 | G.H5.24 |
Van-der-waals | TM3 | R | 139 | 3x50 | G.H5 | N | 353 | G.H5.24 |
Ionic | TM6 | K | 308 | 6x30 | G.H5 | D | 342 | G.H5.13 |
Polar | TM6 | K | 308 | 6x30 | G.H5 | D | 342 | G.H5.13 |
Ionic | ICL3 | R | 297 | - | G.H4 | D | 303 | G.H4.09 |
Polar | ICL3 | R | 297 | - | G.H4 | D | 303 | G.H4.09 |
Van-der-waals | ICL3 | R | 297 | - | G.H4 | D | 303 | G.H4.09 |
Ionic | ICL3 | A | 293 | - | G.H4 | R | 302 | G.H4.08 |
Polar | ICL3 | A | 293 | - | G.H4 | R | 302 | G.H4.08 |
Hydrophobic | ICL3 | A | 293 | - | G.H4 | R | 302 | G.H4.08 |
Van-der-waals | ICL3 | A | 293 | - | G.H4 | R | 302 | G.H4.08 |
Hydrophobic | TM6 | L | 315 | 6x37 | G.H5 | L | 354 | G.H5.25 |
Polar | H8 | N | 374 | 8x47 | G.H5 | N | 353 | G.H5.24 |
Hydrophobic | H8 | N | 374 | 8x47 | G.H5 | N | 353 | G.H5.24 |
Van-der-waals | H8 | N | 374 | 8x47 | G.H5 | N | 353 | G.H5.24 |
Hydrophobic | ICL2 | R | 150 | 34x54 | G.S1 | L | 36 | G.S1.02 |
Van-der-waals | ICL2 | R | 150 | 34x54 | G.S1 | L | 36 | G.S1.02 |
Hydrophobic | C-term | S | 417 | - | G.H3 | P | 258 | G.H3.16 |
Hydrophobic | ICL3 | I | 296 | - | G.H5 | A | 338 | G.H5.09 |
Hydrophobic | TM2 | T | 76 | 2x39 | G.H5 | N | 353 | G.H5.24 |
Hydrophobic | ICL2 | P | 146 | 34x50 | G.H5 | I | 344 | G.H5.15 |
Hydrophobic | TM3 | I | 143 | 3x54 | G.H5 | L | 349 | G.H5.20 |
Van-der-waals | TM3 | I | 143 | 3x54 | G.H5 | L | 349 | G.H5.20 |
Hydrophobic | TM6 | K | 308 | 6x30 | G.H5 | Q | 346 | G.H5.17 |
Van-der-waals | TM6 | K | 308 | 6x30 | G.H5 | Q | 346 | G.H5.17 |
Hydrophobic | ICL3 | N | 294 | - | G.S6 | H | 323 | G.S6.04 |
Van-der-waals | ICL3 | N | 294 | - | G.S6 | H | 323 | G.S6.04 |
Hydrophobic | TM2 | V | 75 | 2x38 | G.H5 | F | 352 | G.H5.23 |
Hydrophobic | C-term | Y | 418 | - | G.H2 | I | 213 | G.H2.08 |
Polar | TM2 | T | 76 | 2x39 | G.H5 | F | 352 | G.H5.23 |
Hydrophobic | TM2 | T | 76 | 2x39 | G.H5 | F | 352 | G.H5.23 |
Hydrophobic | ICL2 | R | 150 | 34x54 | G.H5 | I | 344 | G.H5.15 |
Polar | TM2 | T | 74 | 2x37 | G.H5 | E | 351 | G.H5.22 |
Hydrophobic | TM2 | T | 74 | 2x37 | G.H5 | E | 351 | G.H5.22 |
Hydrophobic | TM3 | I | 143 | 3x54 | G.H5 | L | 345 | G.H5.16 |
Van-der-waals | TM3 | I | 143 | 3x54 | G.H5 | L | 345 | G.H5.16 |
Polar | TM2 | N | 77 | 2x40 | G.H5 | N | 353 | G.H5.24 |
Van-der-waals | TM2 | N | 77 | 2x40 | G.H5 | N | 353 | G.H5.24 |