Gt1 -
CCK1 receptor complex model
GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 83.3
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 13.2
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Hydrophobic | TM2 | T | 76 | 2x39 | G.H5 | C | 347 | G.H5.23 |
Van-der-waals | TM2 | T | 76 | 2x39 | G.H5 | C | 347 | G.H5.23 |
Hydrophobic | TM6 | L | 315 | 6x37 | G.H5 | L | 349 | G.H5.25 |
Ionic | H8 | R | 376 | 8x49 | G.H5 | D | 346 | G.H5.22 |
Polar | H8 | R | 376 | 8x49 | G.H5 | D | 346 | G.H5.22 |
Van-der-waals | H8 | R | 376 | 8x49 | G.H5 | D | 346 | G.H5.22 |
Polar | ICL2 | Q | 148 | 34x52 | G.s2s3 | D | 189 | G.s2s3.02 |
Van-der-waals | ICL2 | Q | 148 | 34x52 | G.s2s3 | D | 189 | G.s2s3.02 |
Ionic | ICL2 | R | 150 | 34x54 | G.H5 | E | 342 | G.H5.18 |
Polar | ICL2 | R | 150 | 34x54 | G.H5 | E | 342 | G.H5.18 |
Van-der-waals | ICL2 | R | 150 | 34x54 | G.H5 | E | 342 | G.H5.18 |
Hydrophobic | TM3 | A | 142 | 3x53 | G.H5 | C | 347 | G.H5.23 |
Van-der-waals | TM3 | A | 142 | 3x53 | G.H5 | C | 347 | G.H5.23 |
Hydrophobic | ICL2 | R | 150 | 34x54 | G.H5 | I | 339 | G.H5.15 |
Polar | TM2 | T | 74 | 2x37 | G.H5 | D | 346 | G.H5.22 |
Hydrophobic | C-term | L | 413 | - | G.H2 | R | 204 | G.H2.04 |
Polar | C-term | Y | 418 | - | G.H3 | E | 241 | G.H3.04 |
Van-der-waals | C-term | Y | 418 | - | G.H3 | E | 241 | G.H3.04 |
Ionic | C-term | H | 420 | - | G.s4h3 | E | 235 | G.s4h3.13 |
Polar | C-term | H | 420 | - | G.s4h3 | E | 235 | G.s4h3.13 |
Hydrophobic | C-term | H | 420 | - | G.s4h3 | E | 235 | G.s4h3.13 |
Van-der-waals | C-term | H | 420 | - | G.s4h3 | E | 235 | G.s4h3.13 |
Hydrophobic | ICL2 | P | 146 | 34x50 | G.H5 | T | 336 | G.H5.12 |
Hydrophobic | ICL2 | V | 151 | 34x55 | G.hns1 | R | 28 | G.hns1.03 |
Van-der-waals | ICL2 | V | 151 | 34x55 | G.hns1 | R | 28 | G.hns1.03 |
Hydrophobic | TM3 | I | 143 | 3x54 | G.H5 | L | 349 | G.H5.25 |
Van-der-waals | TM3 | I | 143 | 3x54 | G.H5 | L | 349 | G.H5.25 |
Van-der-waals | ICL3 | A | 250 | - | G.H4 | K | 300 | G.H4.12 |
Polar | TM6 | N | 304 | 6x26 | G.h4s6 | E | 314 | G.h4s6.12 |
Hydrophobic | TM6 | N | 304 | 6x26 | G.h4s6 | E | 314 | G.h4s6.12 |
Van-der-waals | TM6 | N | 304 | 6x26 | G.h4s6 | E | 314 | G.h4s6.12 |
Hydrophobic | C-term | L | 413 | - | G.H3 | S | 248 | G.H3.11 |
Van-der-waals | C-term | L | 413 | - | G.H3 | S | 248 | G.H3.11 |
Hydrophobic | ICL3 | S | 300 | - | G.h4s6 | R | 310 | G.h4s6.08 |
Van-der-waals | ICL3 | S | 300 | - | G.h4s6 | R | 310 | G.h4s6.08 |
Hydrophobic | TM6 | K | 308 | 6x30 | G.H5 | F | 350 | G.H5.26 |
Hydrophobic | TM6 | V | 311 | 6x33 | G.H5 | L | 349 | G.H5.25 |
Van-der-waals | TM6 | V | 311 | 6x33 | G.H5 | L | 349 | G.H5.25 |
Hydrophobic | C-term | Y | 418 | - | G.s4h3 | V | 236 | G.s4h3.14 |
Van-der-waals | C-term | Y | 418 | - | G.s4h3 | V | 236 | G.s4h3.14 |
Hydrophobic | ICL2 | P | 146 | 34x50 | G.H5 | I | 339 | G.H5.15 |
Hydrophobic | TM5 | L | 236 | 5x65 | G.H5 | I | 340 | G.H5.16 |
Polar | TM2 | T | 76 | 2x39 | G.H5 | D | 346 | G.H5.22 |
Polar | TM3 | A | 142 | 3x53 | G.H5 | N | 343 | G.H5.19 |
Hydrophobic | TM3 | A | 142 | 3x53 | G.H5 | N | 343 | G.H5.19 |
Van-der-waals | TM3 | A | 142 | 3x53 | G.H5 | N | 343 | G.H5.19 |
Hydrophobic | TM6 | V | 311 | 6x33 | G.H5 | L | 344 | G.H5.20 |
Hydrophobic | ICL2 | L | 147 | 34x51 | G.S3 | L | 190 | G.S3.01 |
Van-der-waals | ICL2 | L | 147 | 34x51 | G.S3 | L | 190 | G.S3.01 |
Hydrophobic | TM6 | A | 307 | 6x29 | G.H5 | F | 350 | G.H5.26 |
Van-der-waals | TM6 | A | 307 | 6x29 | G.H5 | F | 350 | G.H5.26 |
Hydrophobic | ICL3 | I | 296 | - | G.H4 | V | 301 | G.H4.13 |
Van-der-waals | ICL3 | I | 296 | - | G.H4 | V | 301 | G.H4.13 |
Polar | H8 | R | 376 | 8x49 | G.H5 | K | 345 | G.H5.21 |
Hydrophobic | H8 | R | 376 | 8x49 | G.H5 | K | 345 | G.H5.21 |
Van-der-waals | H8 | R | 376 | 8x49 | G.H5 | K | 345 | G.H5.21 |
Polar | TM3 | R | 139 | 3x50 | G.H5 | C | 347 | G.H5.23 |
Hydrophobic | TM3 | R | 139 | 3x50 | G.H5 | C | 347 | G.H5.23 |
Van-der-waals | TM3 | R | 139 | 3x50 | G.H5 | C | 347 | G.H5.23 |
Polar | C-term | Y | 418 | - | G.H2 | R | 201 | G.H2.01 |
Hydrophobic | C-term | Y | 418 | - | G.H2 | R | 201 | G.H2.01 |
Van-der-waals | C-term | Y | 418 | - | G.H2 | R | 201 | G.H2.01 |
Aromatic | C-term | F | 416 | - | G.H3 | H | 244 | G.H3.07 |
Hydrophobic | C-term | F | 416 | - | G.H3 | H | 244 | G.H3.07 |
Van-der-waals | C-term | F | 416 | - | G.H3 | H | 244 | G.H3.07 |
Hydrophobic | C-term | Y | 418 | - | G.H3 | H | 244 | G.H3.07 |
Polar | ICL2 | R | 150 | 34x54 | G.hns1 | A | 27 | G.hns1.02 |
Hydrophobic | ICL2 | R | 150 | 34x54 | G.hns1 | A | 27 | G.hns1.02 |
Van-der-waals | ICL2 | R | 150 | 34x54 | G.hns1 | A | 27 | G.hns1.02 |
Hydrophobic | TM5 | L | 236 | 5x65 | G.H5 | L | 344 | G.H5.20 |
Hydrophobic | TM6 | N | 304 | 6x26 | G.H5 | K | 341 | G.H5.17 |
Hydrophobic | ICL2 | L | 147 | 34x51 | G.H5 | F | 332 | G.H5.08 |
Hydrophobic | TM6 | M | 314 | 6x36 | G.H5 | L | 349 | G.H5.25 |
Van-der-waals | TM6 | M | 314 | 6x36 | G.H5 | L | 349 | G.H5.25 |
Polar | H8 | N | 374 | 8x47 | G.H5 | G | 348 | G.H5.24 |
Hydrophobic | H8 | N | 374 | 8x47 | G.H5 | G | 348 | G.H5.24 |
Van-der-waals | H8 | N | 374 | 8x47 | G.H5 | G | 348 | G.H5.24 |
Hydrophobic | ICL2 | P | 146 | 34x50 | G.H5 | I | 340 | G.H5.16 |
Polar | TM3 | R | 139 | 3x50 | G.H5 | G | 348 | G.H5.24 |
Hydrophobic | ICL2 | V | 151 | 34x55 | G.HN | E | 24 | G.HN.52 |
Van-der-waals | ICL2 | V | 151 | 34x55 | G.HN | E | 24 | G.HN.52 |
Hydrophobic | TM6 | N | 304 | 6x26 | G.H5 | F | 350 | G.H5.26 |
Van-der-waals | TM6 | N | 304 | 6x26 | G.H5 | F | 350 | G.H5.26 |
Ionic | TM6 | K | 308 | 6x30 | G.H5 | D | 337 | G.H5.13 |
Polar | TM6 | K | 308 | 6x30 | G.H5 | D | 337 | G.H5.13 |
Van-der-waals | TM6 | K | 308 | 6x30 | G.H5 | D | 337 | G.H5.13 |
Hydrophobic | TM6 | V | 311 | 6x33 | G.H5 | F | 350 | G.H5.26 |
Hydrophobic | ICL2 | L | 147 | 34x51 | G.H5 | I | 339 | G.H5.15 |
Van-der-waals | ICL2 | L | 147 | 34x51 | G.H5 | I | 339 | G.H5.15 |
Hydrophobic | TM3 | I | 143 | 3x54 | G.H5 | L | 344 | G.H5.20 |
Van-der-waals | TM3 | I | 143 | 3x54 | G.H5 | L | 344 | G.H5.20 |
Polar | ICL3 | N | 294 | - | G.H4 | D | 294 | G.H4.05 |
Van-der-waals | ICL3 | N | 294 | - | G.H4 | D | 294 | G.H4.05 |
Hydrophobic | TM3 | I | 143 | 3x54 | G.H5 | I | 340 | G.H5.16 |
Hydrophobic | TM3 | R | 139 | 3x50 | G.H5 | L | 349 | G.H5.25 |
Van-der-waals | TM3 | R | 139 | 3x50 | G.H5 | L | 349 | G.H5.25 |
Hydrophobic | C-term | M | 421 | - | G.hgh4 | P | 284 | G.hgh4.03 |