GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 78.9
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.7
iPTM Score: 0.6
PAE mean: 15.5
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Polar | C-term | L | 358 | - | G.S2 | E | 194 | G.S2.03 |
Van-der-waals | C-term | L | 358 | - | G.S2 | E | 194 | G.S2.03 |
Hydrophobic | H8 | G | 314 | 8x47 | G.H5 | N | 372 | G.H5.24 |
Hydrophobic | TM3 | A | 141 | 3x53 | G.H5 | Y | 367 | G.H5.19 |
Van-der-waals | TM3 | A | 141 | 3x53 | G.H5 | Y | 367 | G.H5.19 |
Hydrophobic | TM6 | V | 248 | 6x36 | G.H5 | L | 373 | G.H5.25 |
Van-der-waals | TM6 | V | 248 | 6x36 | G.H5 | L | 373 | G.H5.25 |
Van-der-waals | TM6 | R | 244 | 6x32 | G.h4s6 | R | 335 | G.h4s6.17 |
Polar | ICL2 | R | 151 | - | G.H5 | Y | 367 | G.H5.19 |
Aromatic | ICL2 | R | 151 | - | G.H5 | Y | 367 | G.H5.19 |
Hydrophobic | ICL2 | R | 151 | - | G.H5 | Y | 367 | G.H5.19 |
Van-der-waals | ICL2 | R | 151 | - | G.H5 | Y | 367 | G.H5.19 |
Polar | H8 | Q | 319 | 8x52 | G.h4s6 | K | 332 | G.h4s6.14 |
Hydrophobic | TM6 | R | 244 | 6x32 | G.H5 | L | 374 | G.H5.26 |
Van-der-waals | TM6 | R | 244 | 6x32 | G.H5 | L | 374 | G.H5.26 |
Hydrophobic | ICL2 | A | 145 | - | G.H5 | V | 363 | G.H5.15 |
Van-der-waals | ICL2 | A | 145 | - | G.H5 | V | 363 | G.H5.15 |
Polar | ICL2 | P | 147 | - | G.S3 | T | 202 | G.S3.01 |
Hydrophobic | ICL2 | P | 147 | - | G.S3 | T | 202 | G.S3.01 |
Van-der-waals | ICL2 | P | 147 | - | G.S3 | T | 202 | G.S3.01 |
Hydrophobic | TM5 | L | 234 | 5x65 | G.H5 | L | 364 | G.H5.16 |
Hydrophobic | C-term | W | 360 | - | G.S2 | Y | 195 | G.S2.04 |
Polar | TM7 | Y | 310 | 7x53 | G.H5 | N | 372 | G.H5.24 |
Hydrophobic | ICL2 | G | 149 | - | G.hns1 | G | 41 | G.hns1.03 |
Hydrophobic | H8 | L | 315 | 8x48 | G.h4s6 | R | 335 | G.h4s6.17 |
Van-der-waals | H8 | L | 315 | 8x48 | G.h4s6 | R | 335 | G.h4s6.17 |
Hydrophobic | ICL2 | P | 147 | - | G.H5 | F | 356 | G.H5.08 |
Van-der-waals | ICL2 | P | 147 | - | G.H5 | F | 356 | G.H5.08 |
Hydrophobic | TM6 | E | 241 | 6x29 | G.H5 | L | 374 | G.H5.26 |
Van-der-waals | TM6 | E | 241 | 6x29 | G.H5 | L | 374 | G.H5.26 |
Hydrophobic | TM3 | R | 138 | 3x50 | G.H5 | L | 373 | G.H5.25 |
Hydrophobic | TM3 | I | 142 | 3x54 | G.H5 | I | 371 | G.H5.23 |
Van-der-waals | TM3 | I | 142 | 3x54 | G.H5 | I | 371 | G.H5.23 |
Hydrophobic | TM6 | E | 241 | 6x29 | G.H5 | A | 365 | G.H5.17 |
Van-der-waals | TM6 | E | 241 | 6x29 | G.H5 | A | 365 | G.H5.17 |
Hydrophobic | TM5 | A | 237 | 5x68 | G.H5 | L | 364 | G.H5.16 |
Van-der-waals | TM5 | A | 237 | 5x68 | G.H5 | L | 364 | G.H5.16 |
Polar | H8 | L | 315 | 8x48 | G.H5 | L | 374 | G.H5.26 |
Hydrophobic | H8 | L | 315 | 8x48 | G.H5 | L | 374 | G.H5.26 |
Van-der-waals | H8 | L | 315 | 8x48 | G.H5 | L | 374 | G.H5.26 |
Hydrophobic | ICL2 | P | 147 | - | G.H5 | R | 360 | G.H5.12 |
Hydrophobic | ICL2 | A | 145 | - | G.H5 | Y | 367 | G.H5.19 |
Van-der-waals | ICL2 | A | 145 | - | G.H5 | Y | 367 | G.H5.19 |
Hydrophobic | C-term | L | 346 | - | G.H2 | K | 217 | G.H2.05 |
Hydrophobic | TM6 | A | 245 | 6x33 | G.H5 | L | 368 | G.H5.20 |
Van-der-waals | TM6 | A | 245 | 6x33 | G.H5 | L | 368 | G.H5.20 |
Ionic | ICL2 | R | 151 | - | G.H5 | E | 370 | G.H5.22 |
Polar | ICL2 | R | 151 | - | G.H5 | E | 370 | G.H5.22 |
Hydrophobic | ICL2 | R | 151 | - | G.H5 | E | 370 | G.H5.22 |
Van-der-waals | ICL2 | R | 151 | - | G.H5 | E | 370 | G.H5.22 |
Hydrophobic | TM3 | I | 142 | 3x54 | G.H5 | L | 364 | G.H5.16 |
Van-der-waals | TM3 | I | 142 | 3x54 | G.H5 | L | 364 | G.H5.16 |
Hydrophobic | TM6 | P | 240 | 6x28 | G.h4s6 | R | 338 | G.h4s6.20 |
Polar | C-term | L | 358 | - | G.S2 | C | 196 | G.S2.05 |
Hydrophobic | C-term | W | 360 | - | H.HA | E | 74 | H.HA.03 |
Van-der-waals | C-term | W | 360 | - | H.HA | E | 74 | H.HA.03 |
Hydrophobic | TM6 | V | 249 | 6x37 | G.H5 | L | 373 | G.H5.25 |
Hydrophobic | C-term | T | 355 | - | G.S2 | I | 192 | G.S2.01 |
Van-der-waals | C-term | T | 355 | - | G.S2 | I | 192 | G.S2.01 |
Hydrophobic | TM5 | L | 234 | 5x65 | G.H5 | L | 368 | G.H5.20 |
Hydrophobic | TM3 | R | 144 | 3x56 | G.H5 | Y | 367 | G.H5.19 |
Hydrophobic | ICL2 | P | 150 | - | G.hns1 | R | 40 | G.hns1.02 |
Van-der-waals | ICL2 | P | 150 | - | G.hns1 | R | 40 | G.hns1.02 |
Hydrophobic | C-term | W | 360 | - | G.h1ha | A | 68 | G.h1ha.02 |
Polar | TM3 | R | 138 | 3x50 | G.H5 | N | 372 | G.H5.24 |
Polar | H8 | R | 316 | 8x49 | G.H5 | D | 369 | G.H5.21 |
Hydrophobic | ICL2 | P | 147 | - | G.S1 | L | 43 | G.S1.02 |
Van-der-waals | ICL2 | P | 147 | - | G.S1 | L | 43 | G.S1.02 |
Hydrophobic | ICL2 | P | 150 | - | G.HN | K | 37 | G.HN.52 |
Van-der-waals | ICL2 | P | 150 | - | G.HN | K | 37 | G.HN.52 |
Hydrophobic | ICL2 | P | 150 | - | G.hns1 | G | 41 | G.hns1.03 |
Polar | ICL2 | R | 151 | - | G.hns1 | R | 40 | G.hns1.02 |
Van-der-waals | ICL2 | R | 151 | - | G.hns1 | R | 40 | G.hns1.02 |
Hydrophobic | TM3 | I | 142 | 3x54 | G.H5 | L | 373 | G.H5.25 |
Hydrophobic | H8 | G | 314 | 8x47 | G.H5 | L | 374 | G.H5.26 |
Van-der-waals | H8 | G | 314 | 8x47 | G.H5 | L | 374 | G.H5.26 |
Polar | TM3 | R | 138 | 3x50 | G.H5 | I | 371 | G.H5.23 |
Hydrophobic | TM3 | R | 138 | 3x50 | G.H5 | I | 371 | G.H5.23 |
Van-der-waals | TM3 | R | 138 | 3x50 | G.H5 | I | 371 | G.H5.23 |
Hydrophobic | TM3 | A | 141 | 3x53 | G.H5 | I | 371 | G.H5.23 |
Aromatic | C-term | W | 360 | - | G.H1 | R | 63 | G.H1.09 |
Hydrophobic | C-term | W | 360 | - | G.H1 | R | 63 | G.H1.09 |
Van-der-waals | C-term | W | 360 | - | G.H1 | R | 63 | G.H1.09 |
Hydrophobic | ICL2 | L | 146 | - | G.H5 | R | 360 | G.H5.12 |
Van-der-waals | ICL2 | L | 146 | - | G.H5 | R | 360 | G.H5.12 |
Hydrophobic | TM5 | L | 230 | 5x61 | G.H5 | L | 373 | G.H5.25 |
Polar | TM6 | A | 245 | 6x33 | G.H5 | L | 373 | G.H5.25 |
Polar | C-term | H | 356 | - | G.S2 | I | 192 | G.S2.01 |
Hydrophobic | TM2 | T | 77 | 2x39 | G.H5 | I | 371 | G.H5.23 |
Van-der-waals | TM2 | T | 77 | 2x39 | G.H5 | I | 371 | G.H5.23 |
Van-der-waals | TM6 | E | 241 | 6x29 | G.h4s6 | R | 335 | G.h4s6.17 |
Polar | TM5 | A | 236 | 5x67 | G.H5 | R | 360 | G.H5.12 |
Polar | ICL3 | R | 238 | - | G.H5 | D | 361 | G.H5.13 |
Hydrophobic | ICL3 | R | 238 | - | G.H5 | D | 361 | G.H5.13 |
Van-der-waals | ICL3 | R | 238 | - | G.H5 | D | 361 | G.H5.13 |
Hydrophobic | TM3 | I | 142 | 3x54 | G.H5 | L | 368 | G.H5.20 |
Van-der-waals | TM3 | I | 142 | 3x54 | G.H5 | L | 368 | G.H5.20 |
Hydrophobic | C-term | T | 353 | - | G.H2 | K | 218 | G.H2.06 |
Hydrophobic | TM6 | L | 252 | 6x40 | G.H5 | L | 373 | G.H5.25 |
Hydrophobic | ICL3 | R | 238 | - | G.H5 | K | 357 | G.H5.09 |
Van-der-waals | ICL3 | R | 238 | - | G.H5 | K | 357 | G.H5.09 |
Polar | C-term | H | 356 | - | G.S2 | E | 194 | G.S2.03 |
Van-der-waals | C-term | H | 356 | - | G.S2 | E | 194 | G.S2.03 |
Polar | ICL2 | S | 153 | - | G.hns1 | R | 40 | G.hns1.02 |
Hydrophobic | ICL2 | S | 153 | - | G.hns1 | R | 40 | G.hns1.02 |
Van-der-waals | ICL2 | S | 153 | - | G.hns1 | R | 40 | G.hns1.02 |
Hydrophobic | C-term | S | 357 | - | G.S2 | E | 194 | G.S2.03 |
Ionic | H8 | R | 316 | 8x49 | G.H5 | E | 370 | G.H5.22 |
Van-der-waals | H8 | R | 316 | 8x49 | G.H5 | E | 370 | G.H5.22 |
Ionic | TM6 | E | 241 | 6x29 | G.h4s6 | R | 338 | G.h4s6.20 |
Polar | TM6 | E | 241 | 6x29 | G.h4s6 | R | 338 | G.h4s6.20 |
Hydrophobic | TM6 | E | 241 | 6x29 | G.h4s6 | R | 338 | G.h4s6.20 |
Van-der-waals | TM6 | E | 241 | 6x29 | G.h4s6 | R | 338 | G.h4s6.20 |
Hydrophobic | C-term | L | 358 | - | G.S2 | Y | 195 | G.S2.04 |