Gs - CCR10 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gs

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 81.6

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 13.7


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM5 L 234 5x65 G.H5 L 388 G.H5.20
Hydrophobic TM3 R 138 3x50 G.H5 L 393 G.H5.25
Polar TM3 A 141 3x53 G.H5 H 387 G.H5.19
Hydrophobic TM3 A 141 3x53 G.H5 H 387 G.H5.19
Van-der-waals TM3 A 141 3x53 G.H5 H 387 G.H5.19
Hydrophobic ICL2 L 146 - G.H5 F 376 G.H5.08
Van-der-waals ICL2 L 146 - G.H5 F 376 G.H5.08
Polar H8 F 317 8x50 G.H5 E 392 G.H5.24
Hydrophobic H8 F 317 8x50 G.H5 E 392 G.H5.24
Van-der-waals H8 F 317 8x50 G.H5 E 392 G.H5.24
Hydrophobic ICL2 L 146 - G.S1 H 41 G.S1.02
Van-der-waals ICL2 L 146 - G.S1 H 41 G.S1.02
Polar TM3 D 137 3x49 G.H5 Y 391 G.H5.23
Hydrophobic TM3 D 137 3x49 G.H5 Y 391 G.H5.23
Van-der-waals TM3 D 137 3x49 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 A 145 - G.H5 I 383 G.H5.15
Van-der-waals ICL2 A 145 - G.H5 I 383 G.H5.15
Hydrophobic ICL2 P 147 - G.S3 V 217 G.S3.01
Hydrophobic TM3 I 142 3x54 G.H5 L 393 G.H5.25
Van-der-waals TM3 I 142 3x54 G.H5 L 393 G.H5.25
Hydrophobic ICL2 G 149 - G.hns1 A 39 G.hns1.03
Hydrophobic TM5 L 230 5x61 G.H5 L 393 G.H5.25
Polar ICL3 R 238 - G.H5 R 385 G.H5.17
Van-der-waals ICL3 R 238 - G.H5 R 385 G.H5.17
Hydrophobic ICL2 L 146 - G.H5 C 379 G.H5.11
Hydrophobic TM6 E 241 6x29 G.H5 L 394 G.H5.26
Van-der-waals TM6 E 241 6x29 G.H5 L 394 G.H5.26
Hydrophobic TM3 A 141 3x53 G.H5 Y 391 G.H5.23
Van-der-waals TM3 A 141 3x53 G.H5 Y 391 G.H5.23
Polar H8 Q 319 8x52 G.H5 R 389 G.H5.21
Hydrophobic TM3 I 142 3x54 G.H5 L 388 G.H5.20
Van-der-waals TM3 I 142 3x54 G.H5 L 388 G.H5.20
Polar TM3 R 138 3x50 G.H5 E 392 G.H5.24
Hydrophobic ICL2 L 146 - G.H5 I 383 G.H5.15
Van-der-waals ICL2 L 146 - G.H5 I 383 G.H5.15
Hydrophobic ICL2 L 146 - G.H5 R 380 G.H5.12
Van-der-waals ICL2 L 146 - G.H5 R 380 G.H5.12
Hydrophobic ICL2 A 148 - G.s2s3 K 216 G.s2s3.02
Van-der-waals ICL2 A 148 - G.s2s3 K 216 G.s2s3.02
Ionic TM6 E 241 6x29 G.H5 R 385 G.H5.17
Van-der-waals TM6 E 241 6x29 G.H5 R 385 G.H5.17
Hydrophobic TM3 I 142 3x54 G.H5 H 387 G.H5.19
Polar TM6 A 245 6x33 G.H5 L 393 G.H5.25
Van-der-waals TM6 A 245 6x33 G.H5 L 393 G.H5.25
Polar H8 R 316 8x49 G.H5 E 392 G.H5.24
Hydrophobic H8 R 316 8x49 G.H5 E 392 G.H5.24
Van-der-waals H8 R 316 8x49 G.H5 E 392 G.H5.24
Hydrophobic TM6 P 240 6x28 G.H5 R 385 G.H5.17
Hydrophobic ICL2 L 146 - G.S3 F 219 G.S3.03
Hydrophobic ICL2 P 150 - G.hns1 A 39 G.hns1.03
Hydrophobic ICL2 A 145 - G.H5 H 387 G.H5.19
Hydrophobic ICL2 L 146 - G.S3 V 217 G.S3.01
Polar TM6 E 241 6x29 G.h4s6 Y 358 G.h4s6.20
Hydrophobic TM6 E 241 6x29 G.h4s6 Y 358 G.h4s6.20
Van-der-waals TM6 E 241 6x29 G.h4s6 Y 358 G.h4s6.20
Hydrophobic TM6 R 244 6x32 G.H5 L 394 G.H5.26
Van-der-waals TM6 R 244 6x32 G.H5 L 394 G.H5.26
Hydrophobic TM2 S 75 2x37 G.H5 Q 390 G.H5.22
Van-der-waals TM2 S 75 2x37 G.H5 Q 390 G.H5.22
Hydrophobic TM6 L 252 6x40 G.H5 L 393 G.H5.25
Polar H8 L 315 8x48 G.H5 L 394 G.H5.26
Hydrophobic H8 L 315 8x48 G.H5 L 394 G.H5.26
Van-der-waals H8 L 315 8x48 G.H5 L 394 G.H5.26
Hydrophobic ICL2 A 148 - G.S3 V 217 G.S3.01
Polar H8 L 315 8x48 G.H5 E 392 G.H5.24
Van-der-waals H8 L 315 8x48 G.H5 E 392 G.H5.24
Polar TM2 T 77 2x39 G.H5 Y 391 G.H5.23
Hydrophobic TM2 T 77 2x39 G.H5 Y 391 G.H5.23
Van-der-waals TM2 T 77 2x39 G.H5 Y 391 G.H5.23
Polar TM3 I 142 3x54 G.H5 Q 384 G.H5.16
Hydrophobic TM3 I 142 3x54 G.H5 Q 384 G.H5.16
Van-der-waals TM3 I 142 3x54 G.H5 Q 384 G.H5.16
Hydrophobic TM6 V 248 6x36 G.H5 L 393 G.H5.25
Polar ICL2 R 151 - G.H5 H 387 G.H5.19
Hydrophobic ICL2 R 151 - G.H5 H 387 G.H5.19
Van-der-waals ICL2 R 151 - G.H5 H 387 G.H5.19
Hydrophobic ICL3 G 239 - G.H5 R 385 G.H5.17
Van-der-waals ICL3 G 239 - G.H5 R 385 G.H5.17
Hydrophobic ICL2 P 150 - G.HN Q 35 G.HN.52
Hydrophobic ICL2 P 152 - G.HN Q 35 G.HN.52
Hydrophobic TM6 A 245 6x33 G.H5 L 388 G.H5.20
Van-der-waals TM6 A 245 6x33 G.H5 L 388 G.H5.20
Hydrophobic H8 G 314 8x47 G.H5 E 392 G.H5.24
Van-der-waals H8 G 314 8x47 G.H5 E 392 G.H5.24
Polar TM3 R 138 3x50 G.H5 Y 391 G.H5.23
Hydrophobic TM3 R 138 3x50 G.H5 Y 391 G.H5.23
Van-der-waals TM3 R 138 3x50 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 A 145 - G.H5 Q 384 G.H5.16
Van-der-waals ICL2 A 145 - G.H5 Q 384 G.H5.16
Hydrophobic ICL2 A 145 - G.H5 R 380 G.H5.12
Van-der-waals ICL3 R 238 - G.H5 D 381 G.H5.13
Hydrophobic TM6 V 249 6x37 G.H5 L 393 G.H5.25