Gz - CCR10 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 82.6

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 13.0


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar TM3 A 141 3x53 G.H5 N 348 G.H5.19
Van-der-waals TM3 A 141 3x53 G.H5 N 348 G.H5.19
Hydrophobic TM6 A 245 6x33 G.H5 L 354 G.H5.25
Polar TM6 R 242 6x30 G.H5 Q 346 G.H5.17
Hydrophobic TM3 I 142 3x54 G.H5 I 345 G.H5.16
Hydrophobic ICL3 R 238 - G.S6 Y 321 G.S6.02
Polar ICL3 R 238 - G.H5 D 342 G.H5.13
Hydrophobic ICL3 R 238 - G.H5 D 342 G.H5.13
Van-der-waals ICL3 R 238 - G.H5 D 342 G.H5.13
Polar ICL3 G 239 - G.H5 Q 346 G.H5.17
Hydrophobic ICL3 G 239 - G.H5 Q 346 G.H5.17
Van-der-waals ICL3 G 239 - G.H5 Q 346 G.H5.17
Polar ICL1 A 73 12x51 G.H5 Y 351 G.H5.22
Polar ICL2 A 148 - G.hns1 R 31 G.hns1.02
Hydrophobic ICL2 A 148 - G.hns1 R 31 G.hns1.02
Van-der-waals ICL2 A 148 - G.hns1 R 31 G.hns1.02
Hydrophobic ICL2 A 145 - G.H5 I 344 G.H5.15
Van-der-waals ICL2 A 145 - G.H5 I 344 G.H5.15
Hydrophobic TM6 V 248 6x36 G.H5 L 354 G.H5.25
Van-der-waals TM6 V 248 6x36 G.H5 L 354 G.H5.25
Hydrophobic TM4 P 155 4x39 G.HN R 24 G.HN.48
Hydrophobic ICL2 P 147 - G.H5 I 344 G.H5.15
Van-der-waals ICL2 P 147 - G.H5 I 344 G.H5.15
Hydrophobic TM3 I 142 3x54 G.H5 N 348 G.H5.19
Polar H8 G 314 8x47 G.H5 G 353 G.H5.24
Hydrophobic H8 G 314 8x47 G.H5 G 353 G.H5.24
Hydrophobic ICL2 L 146 - G.hns1 R 32 G.hns1.03
Polar ICL3 R 238 - G.H5 Q 346 G.H5.17
Van-der-waals ICL3 R 238 - G.H5 Q 346 G.H5.17
Polar ICL2 G 149 - G.hns1 R 31 G.hns1.02
Hydrophobic ICL2 G 149 - G.hns1 R 31 G.hns1.02
Van-der-waals ICL2 G 149 - G.hns1 R 31 G.hns1.02
Polar TM2 S 75 2x37 G.H5 Y 351 G.H5.22
Hydrophobic TM2 S 75 2x37 G.H5 Y 351 G.H5.22
Van-der-waals TM2 S 75 2x37 G.H5 Y 351 G.H5.22
Polar TM3 R 138 3x50 G.H5 I 352 G.H5.23
Hydrophobic TM3 R 138 3x50 G.H5 I 352 G.H5.23
Van-der-waals TM3 R 138 3x50 G.H5 I 352 G.H5.23
Hydrophobic H8 G 314 8x47 G.H5 C 355 G.H5.26
Polar ICL2 R 151 - G.HN Q 28 G.HN.52
Hydrophobic ICL2 R 151 - G.HN Q 28 G.HN.52
Hydrophobic ICL2 A 145 - G.H5 T 341 G.H5.12
Van-der-waals ICL2 A 145 - G.H5 T 341 G.H5.12
Hydrophobic TM4 T 154 4x38 G.HN R 24 G.HN.48
Polar ICL2 G 149 - G.H5 Y 351 G.H5.22
Hydrophobic TM6 L 252 6x40 G.H5 L 354 G.H5.25
Hydrophobic TM6 P 240 6x28 G.H5 Q 346 G.H5.17
Hydrophobic TM5 T 233 5x64 G.H5 I 345 G.H5.16
Hydrophobic TM3 I 142 3x54 G.H5 L 349 G.H5.20
Polar ICL2 P 147 - G.hns1 R 31 G.hns1.02
Hydrophobic ICL2 P 147 - G.hns1 R 31 G.hns1.02
Van-der-waals ICL2 P 147 - G.hns1 R 31 G.hns1.02
Hydrophobic ICL2 P 152 - G.HN R 24 G.HN.48
Hydrophobic ICL3 R 238 - G.h4s6 E 319 G.h4s6.12
Van-der-waals ICL3 R 238 - G.h4s6 E 319 G.h4s6.12
Polar TM6 E 241 6x29 G.H5 C 355 G.H5.26
Hydrophobic TM6 E 241 6x29 G.H5 C 355 G.H5.26
Van-der-waals TM6 E 241 6x29 G.H5 C 355 G.H5.26
Hydrophobic ICL2 P 147 - G.S1 I 34 G.S1.02
Van-der-waals ICL2 P 147 - G.S1 I 34 G.S1.02
Hydrophobic TM5 L 234 5x65 G.H5 I 345 G.H5.16
Hydrophobic H8 R 316 8x49 G.H5 Y 351 G.H5.22
Van-der-waals H8 R 316 8x49 G.H5 Y 351 G.H5.22
Polar ICL2 R 151 - G.hns1 R 31 G.hns1.02
Hydrophobic ICL2 R 151 - G.hns1 R 31 G.hns1.02
Van-der-waals ICL2 R 151 - G.hns1 R 31 G.hns1.02
Polar H8 L 315 8x48 G.H5 C 355 G.H5.26
Hydrophobic H8 L 315 8x48 G.H5 C 355 G.H5.26
Van-der-waals H8 L 315 8x48 G.H5 C 355 G.H5.26
Hydrophobic TM6 A 245 6x33 G.H5 C 355 G.H5.26
Hydrophobic ICL2 P 147 - G.S3 L 195 G.S3.01
Hydrophobic ICL2 P 152 - G.HN S 27 G.HN.51
Van-der-waals ICL2 P 152 - G.HN S 27 G.HN.51
Hydrophobic TM6 P 240 6x28 G.h4s6 T 317 G.h4s6.10
Hydrophobic TM5 A 237 5x68 G.H5 D 342 G.H5.13
Van-der-waals TM5 A 237 5x68 G.H5 D 342 G.H5.13
Polar TM3 R 138 3x50 G.H5 G 353 G.H5.24
Hydrophobic TM3 I 142 3x54 G.H5 I 352 G.H5.23
Van-der-waals TM3 I 142 3x54 G.H5 I 352 G.H5.23
Hydrophobic TM5 A 237 5x68 G.H5 I 345 G.H5.16
Hydrophobic ICL2 L 146 - G.S3 L 195 G.S3.01
Van-der-waals ICL2 L 146 - G.S3 L 195 G.S3.01
Polar ICL2 A 148 - G.H5 N 348 G.H5.19
Hydrophobic ICL2 A 148 - G.H5 N 348 G.H5.19
Van-der-waals ICL2 A 148 - G.H5 N 348 G.H5.19
Hydrophobic TM6 A 245 6x33 G.H5 L 349 G.H5.20
Van-der-waals TM6 A 245 6x33 G.H5 L 349 G.H5.20
Hydrophobic ICL2 A 148 - G.H5 Y 351 G.H5.22
Van-der-waals ICL2 A 148 - G.H5 Y 351 G.H5.22
Hydrophobic TM3 A 141 3x53 G.H5 I 352 G.H5.23
Hydrophobic TM3 R 138 3x50 G.H5 L 354 G.H5.25
Van-der-waals TM3 R 138 3x50 G.H5 L 354 G.H5.25
Ionic TM6 E 241 6x29 G.H5 K 350 G.H5.21
Polar TM6 E 241 6x29 G.H5 K 350 G.H5.21
Hydrophobic TM6 E 241 6x29 G.H5 K 350 G.H5.21
Van-der-waals TM6 E 241 6x29 G.H5 K 350 G.H5.21
Hydrophobic TM5 L 230 5x61 G.H5 L 354 G.H5.25
Polar TM6 E 241 6x29 G.H5 Q 346 G.H5.17
Hydrophobic TM6 E 241 6x29 G.H5 Q 346 G.H5.17
Van-der-waals TM6 E 241 6x29 G.H5 Q 346 G.H5.17
Hydrophobic ICL2 L 146 - G.H5 I 344 G.H5.15
Van-der-waals ICL2 L 146 - G.H5 I 344 G.H5.15
Hydrophobic TM6 R 244 6x32 G.H5 C 355 G.H5.26
Van-der-waals TM6 R 244 6x32 G.H5 C 355 G.H5.26
Polar ICL3 G 239 - G.h4s6 E 319 G.h4s6.12
Hydrophobic ICL3 G 239 - G.h4s6 E 319 G.h4s6.12
Van-der-waals ICL3 G 239 - G.h4s6 E 319 G.h4s6.12
Polar ICL2 L 146 - G.H5 N 348 G.H5.19
Van-der-waals ICL2 L 146 - G.H5 N 348 G.H5.19
Hydrophobic TM6 P 240 6x28 G.h4s6 E 316 G.h4s6.09
Van-der-waals TM6 P 240 6x28 G.h4s6 E 316 G.h4s6.09
Hydrophobic TM5 L 234 5x65 G.H5 L 349 G.H5.20
Hydrophobic TM6 V 249 6x37 G.H5 L 354 G.H5.25