Gq - CCR3 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gq/11

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 84.6

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.8
iPTM Score: 0.7
PAE mean: 12.8


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM3 I 135 3x54 G.H5 L 353 G.H5.20
Van-der-waals TM3 I 135 3x54 G.H5 L 353 G.H5.20
Hydrophobic TM6 A 237 6x33 G.H5 V 359 G.H5.26
Hydrophobic TM6 A 237 6x33 G.H5 L 353 G.H5.20
Hydrophobic ICL2 R 143 34x55 G.hns1 R 38 G.hns1.03
Hydrophobic TM3 I 135 3x54 G.H5 L 349 G.H5.16
Hydrophobic ICL2 L 142 34x54 G.H5 I 348 G.H5.15
Hydrophobic TM3 R 131 3x50 G.H5 L 358 G.H5.25
Van-der-waals TM3 R 131 3x50 G.H5 L 358 G.H5.25
Hydrophobic TM5 C 229 5x68 G.H5 L 349 G.H5.16
Van-der-waals TM5 C 229 5x68 G.H5 L 349 G.H5.16
Hydrophobic TM5 L 226 5x65 G.H5 L 349 G.H5.16
Hydrophobic H8 G 305 8x47 G.H5 V 359 G.H5.26
Polar H8 E 306 8x48 G.H5 V 359 G.H5.26
Hydrophobic H8 E 306 8x48 G.H5 V 359 G.H5.26
Van-der-waals H8 E 306 8x48 G.H5 V 359 G.H5.26
Hydrophobic TM2 I 67 2x37 G.H5 E 355 G.H5.22
Van-der-waals TM2 I 67 2x37 G.H5 E 355 G.H5.22
Polar ICL2 R 145 34x57 G.H5 Y 356 G.H5.23
Hydrophobic ICL2 R 145 34x57 G.H5 Y 356 G.H5.23
Van-der-waals ICL2 R 145 34x57 G.H5 Y 356 G.H5.23
Polar H8 G 305 8x47 G.H5 N 357 G.H5.24
Hydrophobic H8 G 305 8x47 G.H5 N 357 G.H5.24
Van-der-waals H8 G 305 8x47 G.H5 N 357 G.H5.24
Hydrophobic TM5 L 226 5x65 G.H5 L 353 G.H5.20
Van-der-waals TM5 L 226 5x65 G.H5 L 353 G.H5.20
Polar ICL2 R 143 34x55 G.s2s3 S 198 G.s2s3.02
Hydrophobic ICL2 R 143 34x55 G.s2s3 S 198 G.s2s3.02
Van-der-waals ICL2 R 143 34x55 G.s2s3 S 198 G.s2s3.02
Hydrophobic TM6 K 236 6x32 G.H5 V 359 G.H5.26
Van-der-waals TM6 K 236 6x32 G.H5 V 359 G.H5.26
Hydrophobic TM6 L 240 6x36 G.H5 N 357 G.H5.24
Van-der-waals TM6 L 240 6x36 G.H5 N 357 G.H5.24
Polar TM6 A 237 6x33 G.H5 L 358 G.H5.25
Hydrophobic TM6 A 237 6x33 G.H5 L 358 G.H5.25
Van-der-waals TM6 A 237 6x33 G.H5 L 358 G.H5.25
Hydrophobic ICL2 A 138 34x50 G.H5 I 348 G.H5.15
Hydrophobic ICL2 V 139 34x51 G.H5 F 341 G.H5.08
Polar TM3 A 134 3x53 G.H5 N 352 G.H5.19
Hydrophobic TM3 A 134 3x53 G.H5 N 352 G.H5.19
Van-der-waals TM3 A 134 3x53 G.H5 N 352 G.H5.19
Hydrophobic TM3 I 135 3x54 G.H5 L 358 G.H5.25
Van-der-waals TM3 I 135 3x54 G.H5 L 358 G.H5.25
Polar TM3 D 130 3x49 G.H5 Y 356 G.H5.23
Hydrophobic TM3 D 130 3x49 G.H5 Y 356 G.H5.23
Van-der-waals TM3 D 130 3x49 G.H5 Y 356 G.H5.23
Polar ICL1 R 66 12x51 G.hns1 R 37 G.hns1.02
Polar ICL3 S 231 - G.H5 Q 350 G.H5.17
Hydrophobic ICL3 S 231 - G.H5 Q 350 G.H5.17
Van-der-waals ICL3 S 231 - G.H5 Q 350 G.H5.17
Ionic H8 R 307 8x49 G.H5 E 355 G.H5.22
Polar H8 R 307 8x49 G.H5 E 355 G.H5.22
Hydrophobic ICL3 S 231 - G.h4s6 I 323 G.h4s6.20
Van-der-waals ICL3 S 231 - G.h4s6 I 323 G.h4s6.20
Polar TM7 Y 301 7x53 G.H5 N 357 G.H5.24
Hydrophobic TM7 Y 301 7x53 G.H5 N 357 G.H5.24
Van-der-waals TM7 Y 301 7x53 G.H5 N 357 G.H5.24
Polar TM3 R 131 3x50 G.H5 Y 356 G.H5.23
Hydrophobic TM3 R 131 3x50 G.H5 Y 356 G.H5.23
Van-der-waals TM3 R 131 3x50 G.H5 Y 356 G.H5.23
Hydrophobic ICL2 L 142 34x54 G.S1 L 40 G.S1.02
Hydrophobic TM6 L 240 6x36 G.H5 L 358 G.H5.25
Van-der-waals TM6 L 240 6x36 G.H5 L 358 G.H5.25
Polar TM7 A 302 7x54 G.H5 N 357 G.H5.24
Hydrophobic TM7 A 302 7x54 G.H5 N 357 G.H5.24
Hydrophobic ICL2 V 139 34x51 G.S3 V 199 G.S3.01
Van-der-waals ICL2 V 139 34x51 G.S3 V 199 G.S3.01
Ionic ICL2 R 145 34x57 G.H5 E 355 G.H5.22
Polar ICL2 R 145 34x57 G.H5 E 355 G.H5.22
Van-der-waals ICL2 R 145 34x57 G.H5 E 355 G.H5.22
Hydrophobic TM6 K 233 6x29 G.H5 V 359 G.H5.26
Hydrophobic TM3 A 134 3x53 G.H5 Y 356 G.H5.23
Van-der-waals TM3 A 134 3x53 G.H5 Y 356 G.H5.23
Polar H8 F 308 8x50 G.H5 N 357 G.H5.24
Hydrophobic H8 F 308 8x50 G.H5 N 357 G.H5.24
Hydrophobic TM2 T 69 2x39 G.H5 E 355 G.H5.22
Hydrophobic TM6 I 241 6x37 G.H5 L 358 G.H5.25
Hydrophobic TM2 T 69 2x39 G.H5 Y 356 G.H5.23
Van-der-waals TM2 T 69 2x39 G.H5 Y 356 G.H5.23
Hydrophobic TM5 T 225 5x64 G.H5 L 349 G.H5.16
Hydrophobic ICL3 P 230 - G.S6 Y 325 G.S6.02
Hydrophobic ICL3 P 230 - G.H5 D 346 G.H5.13
Van-der-waals ICL3 P 230 - G.H5 D 346 G.H5.13
Polar ICL2 R 145 34x57 G.H5 N 352 G.H5.19
Polar TM5 C 229 5x68 G.H5 D 346 G.H5.13
Van-der-waals TM5 C 229 5x68 G.H5 D 346 G.H5.13
Ionic TM6 K 233 6x29 G.h4s6 D 321 G.h4s6.12
Polar TM6 K 233 6x29 G.h4s6 D 321 G.h4s6.12
Hydrophobic TM6 K 233 6x29 G.h4s6 D 321 G.h4s6.12
Van-der-waals TM6 K 233 6x29 G.h4s6 D 321 G.h4s6.12