GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 85.1
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.8
iPTM Score: 0.8
PAE mean: 12.7
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Hydrophobic | H8 | G | 301 | 8x47 | G.H5 | G | 352 | G.H5.24 |
Hydrophobic | ICL2 | K | 138 | 34x55 | G.hns1 | K | 32 | G.hns1.03 |
Polar | H8 | E | 302 | 8x48 | G.H5 | Y | 354 | G.H5.26 |
Hydrophobic | H8 | E | 302 | 8x48 | G.H5 | Y | 354 | G.H5.26 |
Van-der-waals | H8 | E | 302 | 8x48 | G.H5 | Y | 354 | G.H5.26 |
Ionic | TM6 | K | 228 | 6x28 | G.h4s6 | D | 315 | G.h4s6.09 |
Polar | TM6 | K | 228 | 6x28 | G.h4s6 | D | 315 | G.h4s6.09 |
Van-der-waals | TM6 | K | 228 | 6x28 | G.h4s6 | D | 315 | G.h4s6.09 |
Hydrophobic | TM6 | L | 236 | 6x36 | G.H5 | G | 352 | G.H5.24 |
Van-der-waals | TM6 | L | 236 | 6x36 | G.H5 | G | 352 | G.H5.24 |
Polar | TM2 | S | 63 | 2x37 | G.H5 | E | 350 | G.H5.22 |
Hydrophobic | TM2 | S | 63 | 2x37 | G.H5 | E | 350 | G.H5.22 |
Van-der-waals | TM2 | S | 63 | 2x37 | G.H5 | E | 350 | G.H5.22 |
Van-der-waals | ICL2 | L | 137 | 34x54 | G.hns1 | A | 31 | G.hns1.02 |
Ionic | ICL1 | R | 60 | 12x49 | G.HN | D | 20 | G.HN.44 |
Polar | ICL2 | R | 140 | 34x57 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | ICL2 | R | 140 | 34x57 | G.H5 | C | 351 | G.H5.23 |
Van-der-waals | ICL2 | R | 140 | 34x57 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | TM6 | K | 229 | 6x29 | G.H5 | K | 345 | G.H5.17 |
Hydrophobic | ICL3 | R | 225 | - | G.H5 | F | 334 | G.H5.06 |
Van-der-waals | ICL3 | R | 225 | - | G.H5 | F | 334 | G.H5.06 |
Hydrophobic | TM5 | C | 224 | 5x68 | G.H5 | I | 344 | G.H5.16 |
Ionic | ICL2 | K | 138 | 34x55 | G.s2s3 | D | 193 | G.s2s3.02 |
Polar | ICL2 | K | 138 | 34x55 | G.s2s3 | D | 193 | G.s2s3.02 |
Van-der-waals | ICL2 | K | 138 | 34x55 | G.s2s3 | D | 193 | G.s2s3.02 |
Hydrophobic | ICL2 | A | 133 | 34x50 | G.H5 | I | 343 | G.H5.15 |
Polar | TM6 | K | 229 | 6x29 | G.h4s6 | D | 315 | G.h4s6.09 |
Hydrophobic | TM6 | K | 229 | 6x29 | G.h4s6 | D | 315 | G.h4s6.09 |
Van-der-waals | TM6 | K | 229 | 6x29 | G.h4s6 | D | 315 | G.h4s6.09 |
Hydrophobic | ICL3 | R | 225 | - | G.S6 | Y | 320 | G.S6.02 |
Hydrophobic | ICL2 | V | 134 | 34x51 | G.S3 | L | 194 | G.S3.01 |
Van-der-waals | ICL2 | V | 134 | 34x51 | G.S3 | L | 194 | G.S3.01 |
Polar | TM5 | C | 224 | 5x68 | G.H5 | D | 341 | G.H5.13 |
Hydrophobic | TM5 | C | 224 | 5x68 | G.H5 | D | 341 | G.H5.13 |
Van-der-waals | TM5 | C | 224 | 5x68 | G.H5 | D | 341 | G.H5.13 |
Polar | C-term | Y | 339 | - | G.h2s4 | E | 216 | G.h2s4.02 |
Hydrophobic | ICL2 | L | 137 | 34x54 | G.hns1 | K | 32 | G.hns1.03 |
Hydrophobic | C-term | A | 335 | - | G.H3 | W | 258 | G.H3.17 |
Polar | TM4 | V | 142 | 4x39 | G.HN | E | 28 | G.HN.52 |
Van-der-waals | TM4 | V | 142 | 4x39 | G.HN | E | 28 | G.HN.52 |
Hydrophobic | TM6 | I | 240 | 6x40 | G.H5 | L | 353 | G.H5.25 |
Ionic | ICL2 | R | 140 | 34x57 | G.H5 | E | 350 | G.H5.22 |
Polar | ICL2 | R | 140 | 34x57 | G.H5 | E | 350 | G.H5.22 |
Hydrophobic | ICL2 | R | 140 | 34x57 | G.H5 | E | 350 | G.H5.22 |
Van-der-waals | ICL2 | R | 140 | 34x57 | G.H5 | E | 350 | G.H5.22 |
Van-der-waals | ICL2 | V | 134 | 34x51 | G.s2s3 | K | 192 | G.s2s3.01 |
Hydrophobic | C-term | L | 352 | - | H.HA | Q | 79 | H.HA.17 |
Van-der-waals | C-term | L | 352 | - | H.HA | Q | 79 | H.HA.17 |
Polar | TM6 | N | 226 | 6x26 | G.h4s6 | E | 318 | G.h4s6.12 |
Hydrophobic | TM6 | N | 226 | 6x26 | G.h4s6 | E | 318 | G.h4s6.12 |
Van-der-waals | TM6 | N | 226 | 6x26 | G.h4s6 | E | 318 | G.h4s6.12 |
Van-der-waals | TM6 | A | 233 | 6x33 | G.H5 | L | 353 | G.H5.25 |
Polar | ICL3 | R | 225 | - | G.H5 | D | 341 | G.H5.13 |
Van-der-waals | ICL3 | R | 225 | - | G.H5 | D | 341 | G.H5.13 |
Hydrophobic | C-term | S | 342 | - | G.S2 | I | 184 | G.S2.01 |
Hydrophobic | TM4 | V | 142 | 4x39 | G.HN | R | 24 | G.HN.48 |
Van-der-waals | TM4 | V | 142 | 4x39 | G.HN | R | 24 | G.HN.48 |
Hydrophobic | TM3 | R | 126 | 3x50 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | TM6 | K | 229 | 6x29 | G.h4s6 | T | 316 | G.h4s6.10 |
Polar | TM2 | T | 65 | 2x39 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | TM2 | T | 65 | 2x39 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | TM6 | L | 236 | 6x36 | G.H5 | L | 353 | G.H5.25 |
Polar | ICL3 | R | 225 | - | G.S6 | T | 321 | G.S6.03 |
Hydrophobic | C-term | V | 350 | - | H.HA | S | 75 | H.HA.13 |
Van-der-waals | C-term | V | 350 | - | H.HA | S | 75 | H.HA.13 |
Polar | TM6 | R | 232 | 6x32 | G.H5 | Y | 354 | G.H5.26 |
Hydrophobic | TM6 | R | 232 | 6x32 | G.H5 | Y | 354 | G.H5.26 |
Van-der-waals | TM6 | R | 232 | 6x32 | G.H5 | Y | 354 | G.H5.26 |
Hydrophobic | TM5 | T | 220 | 5x64 | G.H5 | I | 344 | G.H5.16 |
Hydrophobic | C-term | I | 348 | - | G.hfs2 | V | 179 | G.hfs2.03 |
Hydrophobic | ICL2 | V | 134 | 34x51 | G.s2s3 | D | 193 | G.s2s3.02 |
Polar | ICL2 | R | 140 | 34x57 | G.H5 | N | 347 | G.H5.19 |
Hydrophobic | TM4 | T | 141 | 4x38 | G.HN | E | 28 | G.HN.52 |
Van-der-waals | TM4 | T | 141 | 4x38 | G.HN | E | 28 | G.HN.52 |
Polar | TM3 | R | 126 | 3x50 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | TM3 | R | 126 | 3x50 | G.H5 | C | 351 | G.H5.23 |
Van-der-waals | TM3 | R | 126 | 3x50 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | TM3 | V | 130 | 3x54 | G.H5 | I | 344 | G.H5.16 |
Van-der-waals | ICL3 | R | 225 | - | G.h4s6 | E | 318 | G.h4s6.12 |
Polar | TM4 | T | 143 | 4x40 | G.HN | R | 24 | G.HN.48 |
Hydrophobic | TM3 | V | 130 | 3x54 | G.H5 | L | 348 | G.H5.20 |
Van-der-waals | TM3 | V | 130 | 3x54 | G.H5 | L | 348 | G.H5.20 |
Hydrophobic | ICL2 | V | 134 | 34x51 | G.H5 | F | 336 | G.H5.08 |
Hydrophobic | ICL2 | A | 133 | 34x50 | G.H5 | I | 344 | G.H5.16 |
Van-der-waals | ICL2 | A | 133 | 34x50 | G.H5 | I | 344 | G.H5.16 |
Polar | C-term | S | 337 | - | G.h2s4 | E | 216 | G.h2s4.02 |
Hydrophobic | C-term | S | 337 | - | G.h2s4 | E | 216 | G.h2s4.02 |
Van-der-waals | C-term | S | 337 | - | G.h2s4 | E | 216 | G.h2s4.02 |
Hydrophobic | TM6 | I | 237 | 6x37 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | TM5 | L | 221 | 5x65 | G.H5 | I | 344 | G.H5.16 |
Hydrophobic | ICL2 | L | 137 | 34x54 | G.H5 | I | 343 | G.H5.15 |
Polar | TM6 | K | 229 | 6x29 | G.H5 | Y | 354 | G.H5.26 |
Hydrophobic | TM6 | K | 229 | 6x29 | G.H5 | Y | 354 | G.H5.26 |
Van-der-waals | TM6 | K | 229 | 6x29 | G.H5 | Y | 354 | G.H5.26 |
Hydrophobic | TM3 | A | 129 | 3x53 | G.H5 | C | 351 | G.H5.23 |
Van-der-waals | TM3 | A | 129 | 3x53 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | C-term | Q | 346 | - | G.S2 | V | 185 | G.S2.02 |
Van-der-waals | C-term | Q | 346 | - | G.S2 | V | 185 | G.S2.02 |
Polar | TM3 | A | 129 | 3x53 | G.H5 | N | 347 | G.H5.19 |
Hydrophobic | TM3 | A | 129 | 3x53 | G.H5 | N | 347 | G.H5.19 |
Van-der-waals | TM3 | A | 129 | 3x53 | G.H5 | N | 347 | G.H5.19 |
Polar | C-term | E | 347 | - | G.hfs2 | T | 182 | G.hfs2.06 |
Hydrophobic | ICL2 | L | 137 | 34x54 | G.S3 | L | 194 | G.S3.01 |
Van-der-waals | ICL2 | L | 137 | 34x54 | G.S3 | L | 194 | G.S3.01 |
Hydrophobic | TM5 | L | 221 | 5x65 | G.H5 | L | 348 | G.H5.20 |
Van-der-waals | TM5 | L | 221 | 5x65 | G.H5 | L | 348 | G.H5.20 |