G12 - CCR8 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G12/13

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 80.2

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.6
PAE mean: 16.2


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL2 V 139 34x51 G.H5 I 370 G.H5.15
Polar H8 E 305 8x48 G.H5 Q 381 G.H5.26
Hydrophobic H8 E 305 8x48 G.H5 Q 381 G.H5.26
Van-der-waals H8 E 305 8x48 G.H5 Q 381 G.H5.26
Hydrophobic TM7 A 301 7x54 G.H5 L 380 G.H5.25
Hydrophobic TM6 K 235 6x32 G.H5 M 379 G.H5.24
Van-der-waals TM6 K 235 6x32 G.H5 M 379 G.H5.24
Polar ICL2 K 143 34x55 G.hns1 R 56 G.hns1.03
Hydrophobic ICL2 K 143 34x55 G.hns1 R 56 G.hns1.03
Van-der-waals ICL2 K 143 34x55 G.hns1 R 56 G.hns1.03
Polar ICL2 A 138 34x50 G.H5 N 374 G.H5.19
Hydrophobic TM5 L 225 5x65 G.H5 L 375 G.H5.20
Van-der-waals TM5 L 225 5x65 G.H5 L 375 G.H5.20
Polar TM6 N 232 6x29 G.H5 Q 381 G.H5.26
Van-der-waals TM6 N 232 6x29 G.H5 Q 381 G.H5.26
Van-der-waals ICL1 K 64 12x48 G.H5 L 380 G.H5.25
Hydrophobic ICL2 V 139 34x51 G.S1 V 58 G.S1.02
Van-der-waals ICL2 V 139 34x51 G.S1 V 58 G.S1.02
Hydrophobic TM3 V 135 3x54 G.H5 L 375 G.H5.20
Polar H8 K 306 8x49 G.H5 L 380 G.H5.25
Hydrophobic H8 K 306 8x49 G.H5 L 380 G.H5.25
Van-der-waals H8 K 306 8x49 G.H5 L 380 G.H5.25
Hydrophobic ICL2 A 138 34x50 G.H5 I 370 G.H5.15
Van-der-waals ICL2 A 138 34x50 G.H5 I 370 G.H5.15
Polar TM3 A 134 3x53 G.H5 N 374 G.H5.19
Hydrophobic TM3 A 134 3x53 G.H5 N 374 G.H5.19
Van-der-waals TM3 A 134 3x53 G.H5 N 374 G.H5.19
Hydrophobic ICL2 V 139 34x51 G.H5 K 367 G.H5.12
Hydrophobic TM6 A 236 6x33 G.H5 L 375 G.H5.20
Ionic H8 K 306 8x49 G.H5 D 377 G.H5.22
Polar H8 K 306 8x49 G.H5 D 377 G.H5.22
Hydrophobic TM3 V 135 3x54 G.H5 I 378 G.H5.23
Van-der-waals TM3 V 135 3x54 G.H5 I 378 G.H5.23
Hydrophobic TM3 V 135 3x54 G.H5 L 371 G.H5.16
Van-der-waals TM3 V 135 3x54 G.H5 L 371 G.H5.16
Polar ICL1 R 67 12x51 G.hns1 R 55 G.hns1.02
Hydrophobic ICL2 L 142 34x54 G.S1 V 58 G.S1.02
Hydrophobic TM6 A 236 6x33 G.H5 M 379 G.H5.24
Van-der-waals TM6 A 236 6x33 G.H5 M 379 G.H5.24
Hydrophobic ICL2 A 138 34x50 G.H5 L 371 G.H5.16
Hydrophobic ICL2 L 142 34x54 G.hns1 R 56 G.hns1.03
Polar H8 F 307 8x50 G.H5 L 380 G.H5.25
Hydrophobic TM6 L 239 6x36 G.H5 M 379 G.H5.24
Hydrophobic TM7 Y 300 7x53 G.H5 L 380 G.H5.25
Van-der-waals TM7 Y 300 7x53 G.H5 L 380 G.H5.25
Hydrophobic ICL3 N 230 - G.H5 Q 372 G.H5.17
Van-der-waals ICL3 N 230 - G.H5 Q 372 G.H5.17
Polar ICL2 R 145 34x57 G.H5 N 374 G.H5.19
Hydrophobic ICL2 L 142 34x54 G.H5 I 370 G.H5.15
Van-der-waals ICL2 L 142 34x54 G.H5 I 370 G.H5.15
Hydrophobic ICL2 V 139 34x51 G.H5 F 363 G.H5.08
Polar H8 E 305 8x48 G.H5 L 380 G.H5.25
Van-der-waals H8 E 305 8x48 G.H5 L 380 G.H5.25
Hydrophobic TM3 R 131 3x50 G.H5 I 378 G.H5.23
Van-der-waals TM3 R 131 3x50 G.H5 I 378 G.H5.23
Hydrophobic ICL2 L 142 34x54 G.hns1 R 55 G.hns1.02
Van-der-waals ICL2 L 142 34x54 G.hns1 R 55 G.hns1.02
Hydrophobic TM3 A 134 3x53 G.H5 I 378 G.H5.23
Hydrophobic H8 G 304 8x47 G.H5 L 380 G.H5.25
Van-der-waals H8 G 304 8x47 G.H5 L 380 G.H5.25
Hydrophobic TM6 N 232 6x29 G.H5 M 379 G.H5.24
Hydrophobic TM5 C 228 5x68 G.H5 L 371 G.H5.16
Van-der-waals TM5 C 228 5x68 G.H5 L 371 G.H5.16
Polar H8 K 306 8x49 G.H5 Q 381 G.H5.26
Hydrophobic H8 K 306 8x49 G.H5 Q 381 G.H5.26
Van-der-waals H8 K 306 8x49 G.H5 Q 381 G.H5.26
Hydrophobic ICL2 V 139 34x51 G.S3 I 221 G.S3.01
Van-der-waals ICL2 V 139 34x51 G.S3 I 221 G.S3.01
Hydrophobic H8 G 304 8x47 G.H5 M 379 G.H5.24
Van-der-waals H8 G 304 8x47 G.H5 M 379 G.H5.24