Go - CCR8 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 83.1

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.8
iPTM Score: 0.7
PAE mean: 13.6


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type
GPCR
Segment

AA

Number
Generic
number

segment

AA

Number
Generic
number
Hydrophobic H8 K 306 8x49 G.H5 G 350 G.H5.22
Hydrophobic TM5 L 225 5x65 G.H5 L 348 G.H5.20
Van-der-waals TM5 L 225 5x65 G.H5 L 348 G.H5.20
Hydrophobic TM3 R 131 3x50 G.H5 L 353 G.H5.25
Van-der-waals TM3 R 131 3x50 G.H5 L 353 G.H5.25
Van-der-waals ICL3 N 230 - G.H5 A 345 G.H5.17
Polar ICL3 N 230 - G.H5 Y 354 G.H5.26
Van-der-waals ICL3 N 230 - G.H5 Y 354 G.H5.26
Hydrophobic C-term L 355 - G.H2 K 210 G.H2.05
Van-der-waals C-term L 355 - G.H2 K 210 G.H2.05
Polar ICL2 R 145 34x57 G.H5 N 347 G.H5.19
Van-der-waals ICL2 R 145 34x57 G.H5 N 347 G.H5.19
Polar TM6 N 232 6x29 G.h4s6 E 318 G.h4s6.12
Hydrophobic TM6 A 236 6x33 G.H5 L 348 G.H5.20
Hydrophobic TM6 L 239 6x36 G.H5 L 353 G.H5.25
Van-der-waals TM6 L 239 6x36 G.H5 L 353 G.H5.25
Polar H8 E 305 8x48 G.h4s6 N 316 G.h4s6.10
Hydrophobic TM6 V 243 6x40 G.H5 L 353 G.H5.25
Hydrophobic TM3 V 135 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 V 135 3x54 G.H5 L 348 G.H5.20
Hydrophobic ICL2 A 138 34x50 G.H5 I 344 G.H5.16
Hydrophobic ICL2 L 142 34x54 G.hns1 K 32 G.hns1.03
Polar H8 G 304 8x47 G.H5 G 352 G.H5.24
Hydrophobic H8 G 304 8x47 G.H5 G 352 G.H5.24
Van-der-waals H8 G 304 8x47 G.H5 G 352 G.H5.24
Hydrophobic TM5 C 228 5x68 G.H5 I 344 G.H5.16
Polar ICL3 Q 229 - G.H5 D 341 G.H5.13
Van-der-waals ICL3 Q 229 - G.H5 D 341 G.H5.13
Hydrophobic ICL2 V 139 34x51 G.s2s3 N 194 G.s2s3.02
Hydrophobic ICL3 N 230 - G.h4s6 E 318 G.h4s6.12
Van-der-waals ICL3 N 230 - G.h4s6 E 318 G.h4s6.12
Polar TM3 A 134 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 A 134 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 A 134 3x53 G.H5 N 347 G.H5.19
Polar TM3 R 131 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 131 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 R 131 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 A 134 3x53 G.H5 C 351 G.H5.23
Polar TM6 N 232 6x29 G.H5 Y 354 G.H5.26
Hydrophobic TM6 N 232 6x29 G.H5 Y 354 G.H5.26
Van-der-waals TM6 N 232 6x29 G.H5 Y 354 G.H5.26
Hydrophobic H8 K 306 8x49 G.H5 R 349 G.H5.21
Polar TM2 T 70 2x39 G.H5 C 351 G.H5.23
Hydrophobic TM2 T 70 2x39 G.H5 C 351 G.H5.23
Hydrophobic TM5 Q 224 5x64 G.H5 I 344 G.H5.16
Polar ICL2 K 143 34x55 G.s2s3 N 194 G.s2s3.02
Van-der-waals ICL2 K 143 34x55 G.s2s3 N 194 G.s2s3.02
Polar TM6 N 232 6x29 G.h4s6 P 315 G.h4s6.09
Van-der-waals TM6 N 232 6x29 G.h4s6 P 315 G.h4s6.09
Hydrophobic TM6 L 239 6x36 G.H5 Y 354 G.H5.26
Van-der-waals TM6 L 239 6x36 G.H5 Y 354 G.H5.26
Hydrophobic TM3 V 135 3x54 G.H5 I 344 G.H5.16
Van-der-waals TM3 V 135 3x54 G.H5 I 344 G.H5.16
Hydrophobic ICL3 Q 229 - G.S6 Y 320 G.S6.02
Ionic H8 E 305 8x48 G.H5 R 349 G.H5.21
Van-der-waals TM6 A 236 6x33 G.H5 L 353 G.H5.25
Hydrophobic ICL2 L 142 34x54 G.S3 L 195 G.S3.01
Van-der-waals ICL2 L 142 34x54 G.S3 L 195 G.S3.01
Hydrophobic TM6 V 240 6x37 G.H5 L 353 G.H5.25
Hydrophobic ICL2 K 143 34x55 G.hns1 K 32 G.hns1.03
Hydrophobic ICL2 V 139 34x51 G.H5 F 336 G.H5.08
Polar H8 E 305 8x48 G.H5 Y 354 G.H5.26
Polar TM5 C 228 5x68 G.H5 D 341 G.H5.13
Hydrophobic TM5 C 228 5x68 G.H5 D 341 G.H5.13
Van-der-waals TM5 C 228 5x68 G.H5 D 341 G.H5.13
Polar ICL2 R 145 34x57 G.H5 C 351 G.H5.23
Hydrophobic ICL2 R 145 34x57 G.H5 C 351 G.H5.23
Van-der-waals ICL2 R 145 34x57 G.H5 C 351 G.H5.23
Hydrophobic ICL2 V 139 34x51 G.S3 L 195 G.S3.01
Polar TM6 H 231 6x28 G.h4s6 E 318 G.h4s6.12
Hydrophobic TM6 H 231 6x28 G.h4s6 E 318 G.h4s6.12
Van-der-waals TM6 H 231 6x28 G.h4s6 E 318 G.h4s6.12
Hydrophobic TM6 K 235 6x32 G.H5 Y 354 G.H5.26
Van-der-waals TM6 K 235 6x32 G.H5 Y 354 G.H5.26
Hydrophobic ICL2 A 138 34x50 G.H5 I 343 G.H5.15
Hydrophobic ICL2 L 142 34x54 G.H5 I 343 G.H5.15