Ggust - CCR9 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 81.6

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 13.1


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar TM3 A 147 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 A 147 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 A 147 3x53 G.H5 N 347 G.H5.19
Hydrophobic C-term L 367 - G.H2 R 208 G.H2.04
Hydrophobic C-term K 354 - G.h4s6 K 313 G.h4s6.04
Van-der-waals C-term K 354 - G.h4s6 K 313 G.h4s6.04
Hydrophobic H8 G 321 8x47 G.H5 G 352 G.H5.24
Hydrophobic H8 R 323 8x49 G.H5 K 349 G.H5.21
Hydrophobic TM3 A 147 3x53 G.H5 C 351 G.H5.23
Van-der-waals TM3 A 147 3x53 G.H5 C 351 G.H5.23
Hydrophobic ICL2 M 152 34x51 G.H5 I 343 G.H5.15
Hydrophobic TM3 D 143 3x49 G.H5 C 351 G.H5.23
Hydrophobic TM6 S 248 6x29 G.H5 F 354 G.H5.26
Van-der-waals TM6 S 248 6x29 G.H5 F 354 G.H5.26
Polar ICL2 T 156 34x55 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 T 156 34x55 G.hns1 R 32 G.hns1.03
Ionic ICL3 K 246 - G.h4s6 E 318 G.h4s6.12
Polar ICL3 K 246 - G.h4s6 E 318 G.h4s6.12
Hydrophobic ICL3 K 246 - G.h4s6 E 318 G.h4s6.12
Van-der-waals ICL3 K 246 - G.h4s6 E 318 G.h4s6.12
Hydrophobic TM6 A 252 6x33 G.H5 L 348 G.H5.20
Hydrophobic TM5 L 241 5x65 G.H5 L 348 G.H5.20
Polar ICL3 K 246 - G.H5 D 341 G.H5.13
Hydrophobic ICL3 K 246 - G.H5 D 341 G.H5.13
Van-der-waals ICL3 K 246 - G.H5 D 341 G.H5.13
Polar H8 E 322 8x48 G.H5 F 354 G.H5.26
Hydrophobic H8 E 322 8x48 G.H5 F 354 G.H5.26
Van-der-waals H8 E 322 8x48 G.H5 F 354 G.H5.26
Hydrophobic ICL2 A 151 34x50 G.H5 I 344 G.H5.16
Van-der-waals ICL2 A 151 34x50 G.H5 I 344 G.H5.16
Hydrophobic C-term L 367 - G.H3 I 253 G.H3.12
Van-der-waals C-term L 367 - G.H3 I 253 G.H3.12
Polar ICL2 H 155 34x54 G.hns1 A 31 G.hns1.02
Hydrophobic ICL2 H 155 34x54 G.hns1 A 31 G.hns1.02
Polar TM2 T 81 2x37 G.H5 D 350 G.H5.22
Hydrophobic TM2 T 81 2x37 G.H5 D 350 G.H5.22
Van-der-waals TM2 T 81 2x37 G.H5 D 350 G.H5.22
Hydrophobic ICL2 M 152 34x51 G.H5 F 336 G.H5.08
Van-der-waals ICL2 M 152 34x51 G.H5 F 336 G.H5.08
Polar ICL2 A 151 34x50 G.H5 N 347 G.H5.19
Polar ICL2 H 155 34x54 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 H 155 34x54 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 H 155 34x54 G.hns1 R 32 G.hns1.03
Hydrophobic TM6 V 255 6x36 G.H5 L 353 G.H5.25
Hydrophobic ICL2 H 155 34x54 G.S1 V 34 G.S1.02
Ionic ICL2 R 153 34x52 G.s2s3 D 193 G.s2s3.02
Polar ICL2 R 153 34x52 G.s2s3 D 193 G.s2s3.02
Hydrophobic ICL2 R 153 34x52 G.s2s3 D 193 G.s2s3.02
Van-der-waals ICL2 R 153 34x52 G.s2s3 D 193 G.s2s3.02
Hydrophobic ICL2 H 155 34x54 G.H5 I 343 G.H5.15
Hydrophobic C-term A 366 - G.H3 L 249 G.H3.08
Polar C-term A 366 - G.H2 R 208 G.H2.04
Van-der-waals C-term A 366 - G.H2 R 208 G.H2.04
Hydrophobic C-term L 367 - G.H3 S 252 G.H3.11
Polar TM6 A 252 6x33 G.H5 L 353 G.H5.25
Van-der-waals TM6 A 252 6x33 G.H5 L 353 G.H5.25
Hydrophobic TM6 T 256 6x37 G.H5 L 353 G.H5.25
Polar C-term E 350 - G.h4s6 K 313 G.h4s6.04
Van-der-waals C-term E 350 - G.h4s6 K 313 G.h4s6.04
Hydrophobic H8 G 321 8x47 G.H5 F 354 G.H5.26
Polar C-term K 354 - G.H3 N 255 G.H3.14
Hydrophobic C-term K 354 - G.H3 N 255 G.H3.14
Van-der-waals C-term K 354 - G.H3 N 255 G.H3.14
Hydrophobic C-term L 367 - G.H3 L 249 G.H3.08
Hydrophobic ICL2 H 155 34x54 G.S3 L 194 G.S3.01
Aromatic TM6 K 251 6x32 G.H5 F 354 G.H5.26
Hydrophobic TM6 K 251 6x32 G.H5 F 354 G.H5.26
Van-der-waals TM6 K 251 6x32 G.H5 F 354 G.H5.26
Hydrophobic TM6 S 248 6x29 G.H5 K 345 G.H5.17
Hydrophobic ICL2 M 152 34x51 G.H5 T 340 G.H5.12
Van-der-waals ICL2 M 152 34x51 G.H5 T 340 G.H5.12
Van-der-waals ICL3 K 246 - G.H5 I 342 G.H5.14
Ionic H8 R 323 8x49 G.H5 D 350 G.H5.22
Polar H8 R 323 8x49 G.H5 D 350 G.H5.22
Hydrophobic H8 R 323 8x49 G.H5 D 350 G.H5.22
Van-der-waals H8 R 323 8x49 G.H5 D 350 G.H5.22
Polar TM2 T 83 2x39 G.H5 C 351 G.H5.23
Hydrophobic TM2 T 83 2x39 G.H5 C 351 G.H5.23
Van-der-waals TM2 T 83 2x39 G.H5 C 351 G.H5.23
Hydrophobic C-term K 354 - G.h4s6 L 312 G.h4s6.03
Van-der-waals C-term K 354 - G.h4s6 L 312 G.h4s6.03
Hydrophobic ICL2 H 155 34x54 G.S1 T 33 G.S1.01
Hydrophobic TM3 I 148 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 I 148 3x54 G.H5 L 348 G.H5.20
Hydrophobic C-term L 369 - G.H2 K 209 G.H2.05
Van-der-waals C-term L 369 - G.H2 K 209 G.H2.05
Hydrophobic ICL2 A 151 34x50 G.H5 I 343 G.H5.15
Polar ICL2 T 156 34x55 G.s2s3 D 193 G.s2s3.02
Van-der-waals ICL2 T 156 34x55 G.s2s3 D 193 G.s2s3.02
Polar C-term K 354 - G.H3 C 254 G.H3.13
Polar TM3 R 144 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 144 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 R 144 3x50 G.H5 C 351 G.H5.23
Hydrophobic C-term M 358 - G.h4s6 L 312 G.h4s6.03
Van-der-waals C-term M 358 - G.h4s6 L 312 G.h4s6.03
Ionic TM4 E 159 4x36 G.hns1 R 32 G.hns1.03
Polar TM4 E 159 4x36 G.hns1 R 32 G.hns1.03
Hydrophobic TM4 E 159 4x36 G.hns1 R 32 G.hns1.03
Van-der-waals TM4 E 159 4x36 G.hns1 R 32 G.hns1.03
Hydrophobic C-term L 367 - G.H2 W 211 G.H2.07
Hydrophobic TM4 E 159 4x36 G.HN E 28 G.HN.52
Van-der-waals TM4 E 159 4x36 G.HN E 28 G.HN.52
Hydrophobic TM4 R 158 4x35 G.hns1 A 31 G.hns1.02
Ionic TM4 R 158 4x35 G.H5 D 350 G.H5.22
Polar TM4 R 158 4x35 G.H5 D 350 G.H5.22
Van-der-waals TM4 R 158 4x35 G.H5 D 350 G.H5.22
Polar ICL3 K 246 - G.S6 Y 320 G.S6.02
Hydrophobic ICL3 K 246 - G.S6 Y 320 G.S6.02
Van-der-waals ICL3 K 246 - G.S6 Y 320 G.S6.02
Hydrophobic ICL2 M 152 34x51 G.S3 L 194 G.S3.01
Van-der-waals ICL2 M 152 34x51 G.S3 L 194 G.S3.01
Hydrophobic TM3 R 144 3x50 G.H5 L 353 G.H5.25
Van-der-waals TM3 R 144 3x50 G.H5 L 353 G.H5.25
Hydrophobic TM3 I 148 3x54 G.H5 L 353 G.H5.25