GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 63.7
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.5
iPTM Score: 0.4
PAE mean: 19.7
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Polar | TM6 | G | 2649 | 6x34 | G.H5 | L | 380 | G.H5.25 |
Hydrophobic | TM6 | G | 2649 | 6x34 | G.H5 | L | 380 | G.H5.25 |
Van-der-waals | TM6 | G | 2649 | 6x34 | G.H5 | L | 380 | G.H5.25 |
Aromatic | C-term | R | 2752 | - | G.S2 | F | 195 | G.S2.02 |
Hydrophobic | C-term | R | 2752 | - | G.S2 | F | 195 | G.S2.02 |
Van-der-waals | C-term | R | 2752 | - | G.S2 | F | 195 | G.S2.02 |
Hydrophobic | C-term | V | 2890 | - | G.H1 | R | 63 | G.H1.09 |
Van-der-waals | C-term | V | 2890 | - | G.H1 | R | 63 | G.H1.09 |
Hydrophobic | C-term | V | 2888 | - | G.S2 | R | 198 | G.S2.05 |
Van-der-waals | C-term | V | 2888 | - | G.S2 | R | 198 | G.S2.05 |
Polar | C-term | G | 2756 | - | G.H2 | Q | 223 | G.H2.09 |
Hydrophobic | C-term | G | 2756 | - | G.H2 | Q | 223 | G.H2.09 |
Van-der-waals | C-term | G | 2756 | - | G.H2 | Q | 223 | G.H2.09 |
Polar | ICL2 | N | 2565 | - | G.H5 | Y | 378 | G.H5.23 |
Van-der-waals | ICL2 | N | 2565 | - | G.H5 | Y | 378 | G.H5.23 |
Polar | TM5 | H | 2643 | 5x67 | G.H5 | R | 372 | G.H5.17 |
Aromatic | TM5 | H | 2643 | 5x67 | G.H5 | R | 372 | G.H5.17 |
Hydrophobic | TM5 | H | 2643 | 5x67 | G.H5 | R | 372 | G.H5.17 |
Van-der-waals | TM5 | H | 2643 | 5x67 | G.H5 | R | 372 | G.H5.17 |
Hydrophobic | C-term | A | 2996 | - | G.S6 | Y | 347 | G.S6.02 |
Hydrophobic | C-term | M | 2997 | - | G.H4 | R | 329 | G.H4.12 |
Van-der-waals | C-term | M | 2997 | - | G.H4 | R | 329 | G.H4.12 |
Hydrophobic | C-term | L | 2882 | - | G.S2 | V | 201 | G.S2.08 |
Van-der-waals | C-term | L | 2882 | - | G.S2 | V | 201 | G.S2.08 |
Aromatic | ICL3 | Y | 2645 | - | G.h4s6 | Y | 345 | G.h4s6.20 |
Hydrophobic | ICL3 | Y | 2645 | - | G.h4s6 | Y | 345 | G.h4s6.20 |
Van-der-waals | ICL3 | Y | 2645 | - | G.h4s6 | Y | 345 | G.h4s6.20 |
Hydrophobic | C-term | A | 2996 | - | G.S6 | C | 346 | G.S6.01 |
Van-der-waals | C-term | A | 2996 | - | G.S6 | C | 346 | G.S6.01 |
Hydrophobic | ICL3 | Y | 2645 | - | G.H5 | L | 381 | G.H5.26 |
Ionic | TM5 | H | 2643 | 5x67 | G.H5 | D | 368 | G.H5.13 |
Polar | TM5 | H | 2643 | 5x67 | G.H5 | D | 368 | G.H5.13 |
Hydrophobic | TM5 | H | 2643 | 5x67 | G.H5 | D | 368 | G.H5.13 |
Van-der-waals | TM5 | H | 2643 | 5x67 | G.H5 | D | 368 | G.H5.13 |
Polar | TM6 | I | 2650 | 6x35 | G.H5 | L | 380 | G.H5.25 |
Hydrophobic | TM6 | I | 2650 | 6x35 | G.H5 | L | 380 | G.H5.25 |
Van-der-waals | TM6 | I | 2650 | 6x35 | G.H5 | L | 380 | G.H5.25 |
Hydrophobic | C-term | R | 2730 | - | G.H3 | W | 268 | G.H3.17 |
Van-der-waals | C-term | R | 2730 | - | G.H3 | W | 268 | G.H3.17 |
Hydrophobic | ICL2 | V | 2563 | - | G.S3 | V | 204 | G.S3.01 |
Hydrophobic | ICL3 | G | 2646 | - | G.H5 | L | 381 | G.H5.26 |
Van-der-waals | ICL3 | G | 2646 | - | G.H5 | L | 381 | G.H5.26 |
Hydrophobic | C-term | V | 2884 | - | G.H1 | H | 66 | G.H1.12 |
Van-der-waals | C-term | V | 2884 | - | G.H1 | H | 66 | G.H1.12 |
Hydrophobic | TM3 | M | 2559 | 3x57 | G.H5 | L | 380 | G.H5.25 |
Van-der-waals | TM3 | M | 2559 | 3x57 | G.H5 | L | 380 | G.H5.25 |
Hydrophobic | C-term | L | 2762 | - | G.H3 | N | 266 | G.H3.15 |
Van-der-waals | C-term | L | 2762 | - | G.H3 | N | 266 | G.H3.15 |
Hydrophobic | C-term | V | 2890 | - | G.h1ha | V | 67 | G.h1ha.01 |
Polar | C-term | K | 2930 | - | G.s6h5 | V | 354 | G.s6h5.04 |
Hydrophobic | C-term | K | 2930 | - | G.s6h5 | V | 354 | G.s6h5.04 |
Van-der-waals | C-term | K | 2930 | - | G.s6h5 | V | 354 | G.s6h5.04 |
Hydrophobic | C-term | T | 2886 | - | G.h1ha | V | 67 | G.h1ha.01 |
Polar | C-term | L | 2751 | - | G.S2 | R | 198 | G.S2.05 |
Hydrophobic | C-term | L | 2751 | - | G.S2 | R | 198 | G.S2.05 |
Van-der-waals | C-term | L | 2751 | - | G.S2 | R | 198 | G.S2.05 |
Polar | ICL2 | N | 2565 | - | G.H5 | H | 374 | G.H5.19 |
Hydrophobic | ICL2 | N | 2565 | - | G.H5 | H | 374 | G.H5.19 |
Van-der-waals | ICL2 | N | 2565 | - | G.H5 | H | 374 | G.H5.19 |
Hydrophobic | C-term | V | 2995 | - | G.S6 | P | 348 | G.S6.03 |
Hydrophobic | H8 | Q | 2706 | 8x48 | G.H5 | E | 379 | G.H5.24 |
Van-der-waals | H8 | Q | 2706 | 8x48 | G.H5 | E | 379 | G.H5.24 |
Hydrophobic | C-term | M | 2750 | - | G.S2 | T | 197 | G.S2.04 |
Hydrophobic | C-term | L | 2755 | - | G.H2 | C | 224 | G.H2.10 |
Van-der-waals | C-term | L | 2755 | - | G.H2 | C | 224 | G.H2.10 |
Van-der-waals | C-term | S | 2758 | - | G.H2 | R | 219 | G.H2.05 |
Hydrophobic | C-term | L | 2762 | - | G.h2s4 | F | 225 | G.h2s4.01 |
Hydrophobic | C-term | V | 2999 | - | G.h4s6 | T | 337 | G.h4s6.03 |
Hydrophobic | TM6 | I | 2650 | 6x35 | G.H5 | L | 381 | G.H5.26 |
Polar | ICL2 | R | 2564 | - | G.H5 | H | 374 | G.H5.19 |
Hydrophobic | ICL2 | R | 2564 | - | G.H5 | H | 374 | G.H5.19 |
Van-der-waals | ICL2 | R | 2564 | - | G.H5 | H | 374 | G.H5.19 |
Hydrophobic | TM3 | L | 2560 | 3x58 | G.H5 | L | 375 | G.H5.20 |
Polar | C-term | A | 2731 | - | G.h2s4 | D | 227 | G.h2s4.03 |
Hydrophobic | C-term | A | 2731 | - | G.h2s4 | D | 227 | G.h2s4.03 |
Van-der-waals | C-term | A | 2731 | - | G.h2s4 | D | 227 | G.h2s4.03 |
Hydrophobic | C-term | L | 2762 | - | G.H2 | R | 218 | G.H2.04 |
Hydrophobic | C-term | V | 2888 | - | G.S2 | F | 199 | G.S2.06 |
Polar | H8 | E | 2707 | 8x49 | G.H5 | E | 379 | G.H5.24 |
Hydrophobic | H8 | E | 2707 | 8x49 | G.H5 | E | 379 | G.H5.24 |
Van-der-waals | H8 | E | 2707 | 8x49 | G.H5 | E | 379 | G.H5.24 |
Hydrophobic | C-term | P | 2936 | - | G.hgh4 | A | 315 | G.hgh4.18 |
Van-der-waals | C-term | P | 2936 | - | G.hgh4 | A | 315 | G.hgh4.18 |
Hydrophobic | C-term | T | 2735 | - | G.hns1 | Y | 39 | G.hns1.01 |
Hydrophobic | C-term | V | 2888 | - | G.h1ha | V | 67 | G.h1ha.01 |
Van-der-waals | C-term | V | 2888 | - | G.h1ha | V | 67 | G.h1ha.01 |
Hydrophobic | C-term | V | 2888 | - | G.S2 | T | 197 | G.S2.04 |
Aromatic | TM5 | H | 2643 | 5x67 | G.S6 | Y | 347 | G.S6.02 |
Hydrophobic | TM5 | H | 2643 | 5x67 | G.S6 | Y | 347 | G.S6.02 |
Van-der-waals | TM5 | H | 2643 | 5x67 | G.S6 | Y | 347 | G.S6.02 |
Hydrophobic | C-term | E | 2757 | - | G.H2 | Q | 223 | G.H2.09 |
Van-der-waals | C-term | E | 2757 | - | G.H2 | Q | 223 | G.H2.09 |
Hydrophobic | TM6 | L | 2653 | 6x38 | G.H5 | L | 380 | G.H5.25 |
Hydrophobic | ICL2 | V | 2563 | - | G.H5 | R | 367 | G.H5.12 |
Van-der-waals | ICL2 | V | 2563 | - | G.H5 | R | 367 | G.H5.12 |
Hydrophobic | C-term | A | 2760 | - | G.H2 | I | 222 | G.H2.08 |
Van-der-waals | C-term | A | 2760 | - | G.H2 | I | 222 | G.H2.08 |
Ionic | TM5 | R | 2640 | 5x64 | G.H5 | D | 368 | G.H5.13 |
Polar | TM5 | R | 2640 | 5x64 | G.H5 | D | 368 | G.H5.13 |
Van-der-waals | ICL3 | G | 2646 | - | G.H5 | L | 380 | G.H5.25 |
Hydrophobic | C-term | T | 2886 | - | G.H1 | H | 66 | G.H1.12 |
Van-der-waals | C-term | T | 2886 | - | G.H1 | H | 66 | G.H1.12 |
Hydrophobic | C-term | N | 2993 | - | G.S6 | H | 349 | G.S6.04 |
Hydrophobic | C-term | S | 2758 | - | G.H2 | Q | 223 | G.H2.09 |
Van-der-waals | C-term | S | 2758 | - | G.H2 | Q | 223 | G.H2.09 |
Polar | TM3 | T | 2561 | 3x59 | G.H5 | Q | 371 | G.H5.16 |
Van-der-waals | TM3 | T | 2561 | 3x59 | G.H5 | Q | 371 | G.H5.16 |
Hydrophobic | C-term | L | 2882 | - | G.s2s3 | D | 202 | G.s2s3.01 |
Hydrophobic | C-term | M | 2750 | - | G.S2 | E | 196 | G.S2.03 |
Van-der-waals | C-term | M | 2750 | - | G.S2 | E | 196 | G.S2.03 |
Hydrophobic | ICL2 | V | 2563 | - | G.H5 | F | 363 | G.H5.08 |
Polar | C-term | K | 2930 | - | G.H5 | T | 356 | G.H5.01 |
Hydrophobic | C-term | K | 2930 | - | G.H5 | T | 356 | G.H5.01 |
Van-der-waals | C-term | K | 2930 | - | G.H5 | T | 356 | G.H5.01 |
Hydrophobic | C-term | M | 2997 | - | G.hgh4 | D | 310 | G.hgh4.13 |
Van-der-waals | C-term | M | 2997 | - | G.hgh4 | D | 310 | G.hgh4.13 |
Polar | TM3 | E | 2562 | 3x60 | G.H5 | Q | 371 | G.H5.16 |
Hydrophobic | TM3 | E | 2562 | 3x60 | G.H5 | Q | 371 | G.H5.16 |
Van-der-waals | TM3 | E | 2562 | 3x60 | G.H5 | Q | 371 | G.H5.16 |
Polar | ICL2 | V | 2563 | - | G.H5 | H | 374 | G.H5.19 |
Polar | TM5 | R | 2640 | 5x64 | G.H5 | Q | 371 | G.H5.16 |
Hydrophobic | TM5 | R | 2640 | 5x64 | G.H5 | Q | 371 | G.H5.16 |
Van-der-waals | TM5 | R | 2640 | 5x64 | G.H5 | Q | 371 | G.H5.16 |
Hydrophobic | C-term | Y | 2935 | - | G.hgh4 | D | 314 | G.hgh4.17 |
Ionic | H8 | K | 2710 | 8x52 | G.H5 | E | 379 | G.H5.24 |
Polar | H8 | K | 2710 | 8x52 | G.H5 | E | 379 | G.H5.24 |
Hydrophobic | H8 | K | 2710 | 8x52 | G.H5 | E | 379 | G.H5.24 |
Van-der-waals | H8 | K | 2710 | 8x52 | G.H5 | E | 379 | G.H5.24 |
Hydrophobic | ICL2 | V | 2563 | - | G.H5 | I | 370 | G.H5.15 |
Van-der-waals | ICL2 | V | 2563 | - | G.H5 | I | 370 | G.H5.15 |
Hydrophobic | C-term | L | 2734 | - | G.h2s4 | N | 226 | G.h2s4.02 |
Van-der-waals | C-term | L | 2734 | - | G.h2s4 | N | 226 | G.h2s4.02 |
Hydrophobic | C-term | G | 2994 | - | G.S6 | H | 349 | G.S6.04 |
Van-der-waals | C-term | G | 2994 | - | G.S6 | H | 349 | G.S6.04 |
Ionic | C-term | H | 2991 | - | G.hgh4 | D | 314 | G.hgh4.17 |
Polar | C-term | H | 2991 | - | G.hgh4 | D | 314 | G.hgh4.17 |
Hydrophobic | C-term | Y | 2935 | - | G.hgh4 | A | 315 | G.hgh4.18 |
Van-der-waals | C-term | Y | 2935 | - | G.hgh4 | A | 315 | G.hgh4.18 |
Hydrophobic | H8 | E | 2707 | 8x49 | G.H5 | Y | 378 | G.H5.23 |
Van-der-waals | H8 | E | 2707 | 8x49 | G.H5 | Y | 378 | G.H5.23 |
Hydrophobic | TM6 | I | 2650 | 6x35 | G.H5 | L | 375 | G.H5.20 |
Hydrophobic | C-term | L | 2755 | - | G.S2 | I | 194 | G.S2.01 |
Polar | ICL2 | N | 2565 | - | G.H5 | Q | 377 | G.H5.22 |
Hydrophobic | C-term | M | 2997 | - | G.H4 | L | 333 | G.H4.16 |
Van-der-waals | C-term | M | 2997 | - | G.H4 | L | 333 | G.H4.16 |
Hydrophobic | ICL3 | Y | 2645 | - | G.H5 | R | 372 | G.H5.17 |
Van-der-waals | ICL3 | Y | 2645 | - | G.H5 | R | 372 | G.H5.17 |
Hydrophobic | ICL2 | V | 2563 | - | G.H5 | Q | 371 | G.H5.16 |
Hydrophobic | C-term | L | 2882 | - | G.H5 | R | 360 | G.H5.05 |
Hydrophobic | C-term | V | 2884 | - | G.S2 | Q | 200 | G.S2.07 |
Van-der-waals | C-term | V | 2884 | - | G.S2 | Q | 200 | G.S2.07 |
Hydrophobic | C-term | L | 2892 | - | H.HA | E | 74 | H.HA.03 |
Hydrophobic | C-term | I | 2765 | - | G.H3 | S | 262 | G.H3.11 |
Hydrophobic | C-term | S | 2758 | - | G.H2 | I | 222 | G.H2.08 |
Van-der-waals | C-term | S | 2758 | - | G.H2 | I | 222 | G.H2.08 |
Polar | C-term | R | 2730 | - | G.H3 | R | 267 | G.H3.16 |
Hydrophobic | ICL2 | D | 2567 | - | G.H5 | Y | 378 | G.H5.23 |
Van-der-waals | ICL2 | D | 2567 | - | G.H5 | Y | 378 | G.H5.23 |
Hydrophobic | TM3 | M | 2559 | 3x57 | G.H5 | L | 375 | G.H5.20 |
Polar | C-term | L | 2755 | - | G.H2 | Q | 223 | G.H2.09 |
Hydrophobic | C-term | L | 2755 | - | G.H2 | Q | 223 | G.H2.09 |
Van-der-waals | C-term | L | 2755 | - | G.H2 | Q | 223 | G.H2.09 |
Polar | C-term | T | 2886 | - | G.h1ha | N | 68 | G.h1ha.02 |
Hydrophobic | C-term | T | 2886 | - | G.h1ha | N | 68 | G.h1ha.02 |
Van-der-waals | C-term | T | 2886 | - | G.h1ha | N | 68 | G.h1ha.02 |
Hydrophobic | C-term | L | 2762 | - | G.H2 | W | 221 | G.H2.07 |
Ionic | C-term | E | 2757 | - | G.H2 | R | 219 | G.H2.05 |
Polar | C-term | E | 2757 | - | G.H2 | R | 219 | G.H2.05 |
Hydrophobic | C-term | E | 2757 | - | G.H2 | R | 219 | G.H2.05 |
Van-der-waals | C-term | E | 2757 | - | G.H2 | R | 219 | G.H2.05 |
Hydrophobic | TM3 | M | 2559 | 3x57 | G.H5 | Y | 378 | G.H5.23 |
Van-der-waals | TM3 | M | 2559 | 3x57 | G.H5 | Y | 378 | G.H5.23 |
Ionic | C-term | K | 2930 | - | G.s6h5 | D | 355 | G.s6h5.05 |
Polar | C-term | K | 2930 | - | G.s6h5 | D | 355 | G.s6h5.05 |
Van-der-waals | C-term | K | 2930 | - | G.s6h5 | D | 355 | G.s6h5.05 |
Hydrophobic | C-term | L | 2734 | - | G.h2s4 | D | 227 | G.h2s4.03 |
Van-der-waals | C-term | L | 2734 | - | G.h2s4 | D | 227 | G.h2s4.03 |