Gs - chemerin receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gs

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 79.1

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.4
PAE mean: 20.4


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL2 P 144 34x50 G.H5 R 385 G.H5.17
Hydrophobic ICL2 V 145 34x51 G.S3 V 217 G.S3.01
Polar H8 D 322 8x49 G.H5 E 392 G.H5.24
Hydrophobic H8 D 322 8x49 G.H5 E 392 G.H5.24
Polar ICL3 L 252 - G.H5 R 389 G.H5.21
Van-der-waals ICL3 L 252 - G.H5 R 389 G.H5.21
Polar ICL2 P 144 34x50 G.H5 Q 384 G.H5.16
Hydrophobic ICL2 P 144 34x50 G.H5 Q 384 G.H5.16
Van-der-waals ICL2 P 144 34x50 G.H5 Q 384 G.H5.16
Van-der-waals H8 Q 321 8x48 G.H5 E 392 G.H5.24
Hydrophobic TM5 N 250 5x68 G.S6 Y 360 G.S6.02
Van-der-waals TM5 N 250 5x68 G.S6 Y 360 G.S6.02
Polar ICL3 K 254 - G.h4s6 Y 358 G.h4s6.20
Hydrophobic ICL3 K 254 - G.h4s6 Y 358 G.h4s6.20
Van-der-waals ICL3 K 254 - G.h4s6 Y 358 G.h4s6.20
Polar ICL3 L 252 - G.h4s6 Y 358 G.h4s6.20
Hydrophobic ICL3 L 252 - G.h4s6 Y 358 G.h4s6.20
Van-der-waals ICL3 L 252 - G.h4s6 Y 358 G.h4s6.20
Polar TM5 N 250 5x68 G.H5 R 385 G.H5.17
Van-der-waals TM5 N 250 5x68 G.H5 R 385 G.H5.17
Polar ICL2 Q 148 34x54 G.S1 H 41 G.S1.02
Hydrophobic ICL2 Q 148 34x54 G.S1 H 41 G.S1.02
Van-der-waals ICL2 Q 148 34x54 G.S1 H 41 G.S1.02
Hydrophobic ICL2 V 145 34x51 G.s2s3 D 215 G.s2s3.01
Polar TM5 R 251 5x69 G.h4s6 Y 358 G.h4s6.20
Hydrophobic TM5 R 251 5x69 G.h4s6 Y 358 G.h4s6.20
Van-der-waals TM5 R 251 5x69 G.h4s6 Y 358 G.h4s6.20
Hydrophobic ICL3 T 255 - G.H5 R 389 G.H5.21
Van-der-waals ICL3 T 255 - G.H5 R 389 G.H5.21
Polar ICL2 N 149 34x55 G.s2s3 D 215 G.s2s3.01
Van-der-waals ICL2 N 149 34x55 G.s2s3 D 215 G.s2s3.01
Hydrophobic ICL2 R 151 34x57 G.H5 L 393 G.H5.25
Van-der-waals ICL2 R 151 34x57 G.H5 L 393 G.H5.25
Hydrophobic ICL2 Q 148 34x54 G.S3 V 217 G.S3.01
Hydrophobic ICL2 P 144 34x50 G.H5 L 388 G.H5.20
Hydrophobic TM3 S 140 3x53 G.H5 L 394 G.H5.26
Hydrophobic TM2 N 74 2x39 G.H5 L 393 G.H5.25
Polar ICL2 Q 148 34x54 G.H5 Q 384 G.H5.16
Hydrophobic ICL2 Q 148 34x54 G.H5 Q 384 G.H5.16
Van-der-waals ICL2 Q 148 34x54 G.H5 Q 384 G.H5.16
Polar TM2 N 74 2x39 G.H5 E 392 G.H5.24
Van-der-waals TM2 N 74 2x39 G.H5 E 392 G.H5.24
Hydrophobic TM6 P 258 6x33 G.H5 E 392 G.H5.24
Hydrophobic ICL3 K 254 - G.h4s6 G 355 G.h4s6.11
Van-der-waals ICL3 K 254 - G.h4s6 G 355 G.h4s6.11
Hydrophobic ICL1 K 70 - G.hns1 R 38 G.hns1.02
Hydrophobic TM3 S 140 3x53 G.H5 L 388 G.H5.20
Van-der-waals TM3 S 140 3x53 G.H5 L 388 G.H5.20
Ionic TM5 R 251 5x69 G.hgh4 D 323 G.hgh4.13
Polar TM5 R 251 5x69 G.hgh4 D 323 G.hgh4.13
Van-der-waals TM5 R 251 5x69 G.hgh4 D 323 G.hgh4.13
Polar ICL2 V 145 34x51 G.H5 Q 384 G.H5.16
Hydrophobic ICL2 V 145 34x51 G.H5 Q 384 G.H5.16
Van-der-waals ICL2 V 145 34x51 G.H5 Q 384 G.H5.16
Hydrophobic ICL2 N 149 34x55 G.s2s3 K 216 G.s2s3.02
Polar TM3 V 141 3x54 G.H5 R 385 G.H5.17
Hydrophobic TM3 V 141 3x54 G.H5 R 385 G.H5.17
Van-der-waals TM3 V 141 3x54 G.H5 R 385 G.H5.17
Hydrophobic ICL2 P 144 34x50 G.H5 D 381 G.H5.13
Van-der-waals ICL2 P 144 34x50 G.H5 D 381 G.H5.13
Polar ICL3 K 254 - G.h4s6 G 353 G.h4s6.09
Van-der-waals ICL3 K 254 - G.h4s6 G 353 G.h4s6.09
Polar ICL3 A 253 - G.h4s6 Y 358 G.h4s6.20
Van-der-waals ICL3 A 253 - G.h4s6 Y 358 G.h4s6.20
Hydrophobic TM3 V 141 3x54 G.H5 L 394 G.H5.26
Van-der-waals TM3 V 141 3x54 G.H5 L 394 G.H5.26
Hydrophobic TM5 K 246 5x64 G.H5 R 385 G.H5.17
Van-der-waals TM5 K 246 5x64 G.H5 R 385 G.H5.17
Polar ICL2 Q 148 34x54 G.hns1 A 39 G.hns1.03
Van-der-waals ICL2 Q 148 34x54 G.hns1 A 39 G.hns1.03
Hydrophobic ICL3 L 252 - G.H5 R 385 G.H5.17
Hydrophobic ICL3 L 252 - G.S6 Y 360 G.S6.02
Van-der-waals ICL3 L 252 - G.S6 Y 360 G.S6.02
Hydrophobic ICL2 V 145 34x51 G.H5 R 380 G.H5.12
Van-der-waals ICL2 V 145 34x51 G.H5 R 380 G.H5.12
Hydrophobic TM6 P 258 6x33 G.H5 L 394 G.H5.26
Van-der-waals TM6 P 258 6x33 G.H5 L 394 G.H5.26