Gi3 -
CB1 receptor complex model
GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 76.8
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 12.5
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Polar | ICL3 | Q | 314 | - | G.h4s6 | E | 318 | G.h4s6.12 |
Van-der-waals | ICL3 | Q | 314 | - | G.h4s6 | E | 318 | G.h4s6.12 |
Hydrophobic | ICL3 | I | 317 | - | G.H4 | Q | 304 | G.H4.12 |
Hydrophobic | TM6 | M | 337 | 6x29 | G.H5 | I | 344 | G.H5.16 |
Van-der-waals | TM6 | M | 337 | 6x29 | G.H5 | I | 344 | G.H5.16 |
Hydrophobic | ICL2 | R | 226 | 34x55 | G.hns1 | K | 32 | G.hns1.03 |
Van-der-waals | ICL2 | R | 226 | 34x55 | G.hns1 | K | 32 | G.hns1.03 |
Hydrophobic | ICL2 | L | 222 | 34x51 | G.H5 | I | 343 | G.H5.15 |
Ionic | TM5 | R | 311 | 5x75 | G.H5 | D | 337 | G.H5.09 |
Polar | TM5 | R | 311 | 5x75 | G.H5 | D | 337 | G.H5.09 |
Hydrophobic | TM5 | R | 311 | 5x75 | G.H5 | D | 337 | G.H5.09 |
Van-der-waals | TM5 | R | 311 | 5x75 | G.H5 | D | 337 | G.H5.09 |
Hydrophobic | ICL2 | K | 225 | 34x54 | G.hns1 | A | 31 | G.hns1.02 |
Polar | ICL2 | P | 221 | 34x50 | G.H5 | N | 347 | G.H5.19 |
Van-der-waals | ICL2 | P | 221 | 34x50 | G.H5 | N | 347 | G.H5.19 |
Hydrophobic | TM6 | L | 341 | 6x33 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | N-term | Y | 30 | - | G.HN | G | 2 | G.HN.02 |
Van-der-waals | N-term | Y | 30 | - | G.HN | G | 2 | G.HN.02 |
Hydrophobic | C-term | V | 442 | - | G.hgh4 | E | 289 | G.hgh4.04 |
Van-der-waals | C-term | V | 442 | - | G.hgh4 | E | 289 | G.hgh4.04 |
Hydrophobic | TM5 | M | 308 | 5x72 | G.H5 | D | 341 | G.H5.13 |
Van-der-waals | TM5 | M | 308 | 5x72 | G.H5 | D | 341 | G.H5.13 |
Polar | TM6 | Q | 334 | 6x26 | G.h4s6 | K | 317 | G.h4s6.11 |
Polar | N-term | I | 28 | - | G.HN | G | 2 | G.HN.02 |
Hydrophobic | N-term | I | 28 | - | G.HN | G | 2 | G.HN.02 |
Van-der-waals | N-term | I | 28 | - | G.HN | G | 2 | G.HN.02 |
Ionic | ICL3 | R | 331 | - | G.H4 | E | 308 | G.H4.16 |
Polar | ICL3 | R | 331 | - | G.H4 | E | 308 | G.H4.16 |
Hydrophobic | ICL3 | R | 331 | - | G.H4 | E | 308 | G.H4.16 |
Van-der-waals | ICL3 | R | 331 | - | G.H4 | E | 308 | G.H4.16 |
Hydrophobic | TM6 | L | 341 | 6x33 | G.H5 | L | 348 | G.H5.20 |
Polar | TM6 | T | 344 | 6x36 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | TM6 | T | 344 | 6x36 | G.H5 | L | 353 | G.H5.25 |
Van-der-waals | TM6 | T | 344 | 6x36 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | TM2 | S | 152 | 2x39 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | TM5 | M | 308 | 5x72 | G.H5 | D | 337 | G.H5.09 |
Hydrophobic | TM5 | R | 311 | 5x75 | G.H5 | Q | 333 | G.H5.05 |
Van-der-waals | TM5 | R | 311 | 5x75 | G.H5 | Q | 333 | G.H5.05 |
Hydrophobic | TM3 | R | 214 | 3x50 | G.H5 | L | 353 | G.H5.25 |
Van-der-waals | TM3 | R | 214 | 3x50 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | ICL3 | I | 318 | - | G.S6 | F | 323 | G.S6.05 |
Hydrophobic | ICL3 | I | 317 | - | G.H4 | A | 301 | G.H4.08 |
Van-der-waals | ICL3 | I | 317 | - | G.H4 | A | 301 | G.H4.08 |
Polar | N-term | I | 28 | - | G.HN | T | 4 | G.HN.10 |
Hydrophobic | N-term | I | 28 | - | G.HN | T | 4 | G.HN.10 |
Van-der-waals | N-term | I | 28 | - | G.HN | T | 4 | G.HN.10 |
Hydrophobic | TM2 | R | 150 | 2x37 | G.H5 | E | 350 | G.H5.22 |
Hydrophobic | TM5 | H | 304 | 5x68 | G.H5 | I | 344 | G.H5.16 |
Hydrophobic | TM6 | L | 341 | 6x33 | G.H5 | Y | 354 | G.H5.26 |
Polar | N-term | I | 28 | - | G.HN | C | 3 | G.HN.09 |
Hydrophobic | N-term | I | 28 | - | G.HN | C | 3 | G.HN.09 |
Van-der-waals | N-term | I | 28 | - | G.HN | C | 3 | G.HN.09 |
Polar | N-term | Q | 29 | - | G.HN | G | 2 | G.HN.02 |
Hydrophobic | N-term | Q | 29 | - | G.HN | G | 2 | G.HN.02 |
Van-der-waals | N-term | Q | 29 | - | G.HN | G | 2 | G.HN.02 |
Polar | ICL3 | S | 316 | - | G.H4 | Q | 304 | G.H4.12 |
Hydrophobic | ICL3 | T | 313 | - | G.H5 | F | 334 | G.H5.06 |
Van-der-waals | ICL3 | T | 313 | - | G.H5 | F | 334 | G.H5.06 |
Polar | ICL3 | R | 331 | - | G.H4 | C | 305 | G.H4.13 |
Hydrophobic | ICL3 | R | 331 | - | G.H4 | C | 305 | G.H4.13 |
Hydrophobic | ICL3 | I | 317 | - | G.H4 | C | 305 | G.H4.13 |
Van-der-waals | ICL3 | I | 317 | - | G.H4 | C | 305 | G.H4.13 |
Hydrophobic | C-term | I | 450 | - | G.hgh4 | T | 291 | G.hgh4.06 |
Van-der-waals | C-term | I | 450 | - | G.hgh4 | T | 291 | G.hgh4.06 |
Hydrophobic | TM3 | I | 218 | 3x54 | G.H5 | I | 344 | G.H5.16 |
Hydrophobic | TM6 | M | 337 | 6x29 | G.H5 | K | 345 | G.H5.17 |
Van-der-waals | TM6 | M | 337 | 6x29 | G.H5 | K | 345 | G.H5.17 |
Hydrophobic | N-term | I | 28 | - | G.HN | M | 1 | G.HN.01 |
Van-der-waals | N-term | I | 28 | - | G.HN | M | 1 | G.HN.01 |
Ionic | TM5 | H | 304 | 5x68 | G.H5 | D | 341 | G.H5.13 |
Polar | TM5 | H | 304 | 5x68 | G.H5 | D | 341 | G.H5.13 |
Hydrophobic | TM5 | H | 304 | 5x68 | G.H5 | D | 341 | G.H5.13 |
Van-der-waals | TM5 | H | 304 | 5x68 | G.H5 | D | 341 | G.H5.13 |
Polar | N-term | Y | 30 | - | G.HN | T | 4 | G.HN.10 |
Hydrophobic | N-term | Y | 30 | - | G.HN | T | 4 | G.HN.10 |
Van-der-waals | N-term | Y | 30 | - | G.HN | T | 4 | G.HN.10 |
Ionic | ICL2 | K | 225 | 34x54 | G.H5 | E | 350 | G.H5.22 |
Polar | ICL2 | K | 225 | 34x54 | G.H5 | E | 350 | G.H5.22 |
Hydrophobic | ICL2 | K | 225 | 34x54 | G.H5 | E | 350 | G.H5.22 |
Van-der-waals | ICL2 | K | 225 | 34x54 | G.H5 | E | 350 | G.H5.22 |
Hydrophobic | TM6 | I | 348 | 6x40 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | ICL3 | K | 315 | - | G.H4 | E | 308 | G.H4.16 |
Ionic | ICL2 | R | 226 | 34x55 | G.HN | E | 28 | G.HN.52 |
Polar | ICL2 | R | 226 | 34x55 | G.HN | E | 28 | G.HN.52 |
Hydrophobic | ICL2 | R | 226 | 34x55 | G.HN | E | 28 | G.HN.52 |
Van-der-waals | ICL2 | R | 226 | 34x55 | G.HN | E | 28 | G.HN.52 |
Hydrophobic | ICL3 | I | 319 | - | G.H4 | A | 301 | G.H4.08 |
Ionic | ICL3 | R | 331 | - | G.H4 | D | 309 | G.H4.17 |
Polar | ICL3 | R | 331 | - | G.H4 | D | 309 | G.H4.17 |
Hydrophobic | ICL3 | R | 331 | - | G.H4 | D | 309 | G.H4.17 |
Van-der-waals | ICL3 | R | 331 | - | G.H4 | D | 309 | G.H4.17 |
Hydrophobic | TM3 | I | 218 | 3x54 | G.H5 | L | 348 | G.H5.20 |
Hydrophobic | TM6 | Q | 334 | 6x26 | G.h4s6 | E | 318 | G.h4s6.12 |
Polar | N-term | Q | 29 | - | G.HN | T | 4 | G.HN.10 |
Hydrophobic | N-term | Q | 29 | - | G.HN | T | 4 | G.HN.10 |
Van-der-waals | N-term | Q | 29 | - | G.HN | T | 4 | G.HN.10 |
Hydrophobic | ICL3 | T | 313 | - | G.S6 | Y | 320 | G.S6.02 |
Van-der-waals | ICL3 | T | 313 | - | G.S6 | Y | 320 | G.S6.02 |
Hydrophobic | ICL3 | I | 318 | - | G.H4 | A | 301 | G.H4.08 |
Hydrophobic | TM6 | L | 345 | 6x37 | G.H5 | L | 353 | G.H5.25 |
Van-der-waals | TM6 | L | 345 | 6x37 | G.H5 | L | 353 | G.H5.25 |
Polar | TM2 | S | 152 | 2x39 | G.H5 | E | 350 | G.H5.22 |
Hydrophobic | TM2 | S | 152 | 2x39 | G.H5 | E | 350 | G.H5.22 |
Van-der-waals | TM2 | S | 152 | 2x39 | G.H5 | E | 350 | G.H5.22 |
Hydrophobic | TM6 | M | 337 | 6x29 | G.H5 | Y | 354 | G.H5.26 |
Van-der-waals | TM6 | M | 337 | 6x29 | G.H5 | Y | 354 | G.H5.26 |
Hydrophobic | C-term | C | 449 | - | G.H4 | C | 305 | G.H4.13 |
Hydrophobic | ICL2 | P | 221 | 34x50 | G.H5 | I | 344 | G.H5.16 |
Van-der-waals | ICL2 | P | 221 | 34x50 | G.H5 | I | 344 | G.H5.16 |
Polar | N-term | Q | 29 | - | G.HN | M | 1 | G.HN.01 |
Hydrophobic | N-term | Q | 29 | - | G.HN | M | 1 | G.HN.01 |
Van-der-waals | N-term | Q | 29 | - | G.HN | M | 1 | G.HN.01 |
Hydrophobic | ICL3 | T | 313 | - | G.H5 | D | 337 | G.H5.09 |
Polar | TM6 | Q | 334 | 6x26 | G.h4s6 | K | 314 | G.h4s6.08 |
Hydrophobic | TM6 | Q | 334 | 6x26 | G.h4s6 | K | 314 | G.h4s6.08 |
Van-der-waals | TM6 | Q | 334 | 6x26 | G.h4s6 | K | 314 | G.h4s6.08 |
Hydrophobic | TM3 | D | 213 | 3x49 | G.H5 | C | 351 | G.H5.23 |
Van-der-waals | TM3 | D | 213 | 3x49 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | ICL2 | Y | 224 | 34x53 | G.H5 | N | 347 | G.H5.19 |
Van-der-waals | ICL2 | Y | 224 | 34x53 | G.H5 | N | 347 | G.H5.19 |
Hydrophobic | N-term | Y | 30 | - | G.HN | C | 3 | G.HN.09 |
Van-der-waals | N-term | Y | 30 | - | G.HN | C | 3 | G.HN.09 |
Hydrophobic | N-term | D | 27 | - | G.HN | T | 4 | G.HN.10 |
Van-der-waals | N-term | D | 27 | - | G.HN | T | 4 | G.HN.10 |
Hydrophobic | TM5 | M | 308 | 5x72 | G.H5 | A | 338 | G.H5.10 |
Polar | TM3 | R | 214 | 3x50 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | TM3 | R | 214 | 3x50 | G.H5 | C | 351 | G.H5.23 |
Van-der-waals | TM3 | R | 214 | 3x50 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | TM5 | M | 308 | 5x72 | G.S6 | Y | 320 | G.S6.02 |
Aromatic | TM6 | R | 340 | 6x32 | G.H5 | Y | 354 | G.H5.26 |
Hydrophobic | TM6 | R | 340 | 6x32 | G.H5 | Y | 354 | G.H5.26 |
Van-der-waals | TM6 | R | 340 | 6x32 | G.H5 | Y | 354 | G.H5.26 |
Polar | TM3 | S | 217 | 3x53 | G.H5 | N | 347 | G.H5.19 |
Hydrophobic | TM3 | S | 217 | 3x53 | G.H5 | N | 347 | G.H5.19 |
Van-der-waals | TM3 | S | 217 | 3x53 | G.H5 | N | 347 | G.H5.19 |
Hydrophobic | ICL2 | L | 222 | 34x51 | G.S3 | L | 194 | G.S3.01 |
Hydrophobic | TM5 | H | 304 | 5x68 | G.H5 | T | 340 | G.H5.12 |
Hydrophobic | ICL2 | P | 221 | 34x50 | G.H5 | I | 343 | G.H5.15 |
Hydrophobic | ICL2 | R | 226 | 34x55 | G.hns1 | A | 31 | G.hns1.02 |
Van-der-waals | ICL2 | R | 226 | 34x55 | G.hns1 | A | 31 | G.hns1.02 |
Polar | N-term | Q | 29 | - | G.HN | C | 3 | G.HN.09 |
Hydrophobic | N-term | Q | 29 | - | G.HN | C | 3 | G.HN.09 |
Hydrophobic | TM6 | M | 337 | 6x29 | G.H5 | L | 348 | G.H5.20 |
Polar | TM3 | R | 214 | 3x50 | G.H5 | G | 352 | G.H5.24 |
Polar | TM3 | S | 217 | 3x53 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | TM3 | S | 217 | 3x53 | G.H5 | C | 351 | G.H5.23 |
Van-der-waals | TM3 | S | 217 | 3x53 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | ICL2 | Y | 224 | 34x53 | G.H5 | E | 350 | G.H5.22 |
Polar | N-term | D | 32 | - | G.HN | S | 6 | G.HN.30 |
Hydrophobic | N-term | D | 32 | - | G.HN | S | 6 | G.HN.30 |
Van-der-waals | N-term | D | 32 | - | G.HN | S | 6 | G.HN.30 |
Hydrophobic | H8 | S | 401 | 8x47 | G.H5 | G | 352 | G.H5.24 |
Hydrophobic | TM5 | G | 312 | 5x76 | G.H5 | F | 334 | G.H5.06 |