Gi2 -
CB2 receptor complex model
GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 87.2
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.8
iPTM Score: 0.7
PAE mean: 12.8
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
Gβ,
Gγ,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Hydrophobic | TM5 | H | 219 | 5x68 | G.H5 | I | 345 | G.H5.16 |
Van-der-waals | TM5 | H | 219 | 5x68 | G.H5 | I | 345 | G.H5.16 |
Hydrophobic | TM2 | S | 69 | 2x39 | G.H5 | C | 352 | G.H5.23 |
Van-der-waals | TM2 | S | 69 | 2x39 | G.H5 | C | 352 | G.H5.23 |
Polar | ICL3 | R | 236 | - | G.h4s6 | K | 315 | G.h4s6.08 |
Van-der-waals | ICL3 | R | 236 | - | G.h4s6 | K | 315 | G.h4s6.08 |
Hydrophobic | ICL3 | V | 231 | - | G.H4 | Q | 305 | G.H4.12 |
Hydrophobic | ICL2 | P | 138 | 34x50 | G.H5 | I | 345 | G.H5.16 |
Van-der-waals | ICL2 | P | 138 | 34x50 | G.H5 | I | 345 | G.H5.16 |
Hydrophobic | ICL2 | Y | 141 | 34x53 | G.H5 | N | 348 | G.H5.19 |
Polar | ICL2 | Y | 141 | 34x53 | G.H5 | C | 352 | G.H5.23 |
Hydrophobic | ICL2 | Y | 141 | 34x53 | G.H5 | C | 352 | G.H5.23 |
Van-der-waals | ICL2 | Y | 141 | 34x53 | G.H5 | C | 352 | G.H5.23 |
Hydrophobic | TM3 | C | 134 | 3x53 | G.H5 | C | 352 | G.H5.23 |
Ionic | ICL2 | K | 142 | 34x54 | G.H5 | D | 351 | G.H5.22 |
Polar | ICL2 | K | 142 | 34x54 | G.H5 | D | 351 | G.H5.22 |
Polar | H8 | S | 303 | 8x47 | G.H5 | G | 353 | G.H5.24 |
Hydrophobic | H8 | S | 303 | 8x47 | G.H5 | G | 353 | G.H5.24 |
Polar | TM3 | C | 134 | 3x53 | G.H5 | N | 348 | G.H5.19 |
Hydrophobic | TM3 | C | 134 | 3x53 | G.H5 | N | 348 | G.H5.19 |
Van-der-waals | TM3 | C | 134 | 3x53 | G.H5 | N | 348 | G.H5.19 |
Hydrophobic | TM6 | L | 239 | 6x29 | G.H5 | L | 349 | G.H5.20 |
Van-der-waals | TM6 | L | 239 | 6x29 | G.H5 | L | 349 | G.H5.20 |
Hydrophobic | TM6 | L | 239 | 6x29 | G.H5 | I | 345 | G.H5.16 |
Van-der-waals | TM6 | L | 239 | 6x29 | G.H5 | I | 345 | G.H5.16 |
Ionic | TM5 | H | 219 | 5x68 | G.H5 | D | 342 | G.H5.13 |
Polar | TM5 | H | 219 | 5x68 | G.H5 | D | 342 | G.H5.13 |
Hydrophobic | TM5 | H | 219 | 5x68 | G.H5 | D | 342 | G.H5.13 |
Van-der-waals | TM5 | H | 219 | 5x68 | G.H5 | D | 342 | G.H5.13 |
Hydrophobic | ICL3 | H | 226 | - | G.H5 | F | 335 | G.H5.06 |
Van-der-waals | ICL3 | H | 226 | - | G.H5 | F | 335 | G.H5.06 |
Polar | TM2 | Y | 70 | 2x40 | G.H5 | G | 353 | G.H5.24 |
Hydrophobic | TM2 | Y | 70 | 2x40 | G.H5 | G | 353 | G.H5.24 |
Van-der-waals | TM2 | Y | 70 | 2x40 | G.H5 | G | 353 | G.H5.24 |
Ionic | ICL3 | R | 236 | - | G.h4s6 | E | 319 | G.h4s6.12 |
Polar | ICL3 | R | 236 | - | G.h4s6 | E | 319 | G.h4s6.12 |
Van-der-waals | ICL3 | R | 236 | - | G.h4s6 | E | 319 | G.h4s6.12 |
Polar | H8 | G | 304 | 8x48 | G.H5 | F | 355 | G.H5.26 |
Hydrophobic | ICL2 | P | 138 | 34x50 | G.H5 | T | 341 | G.H5.12 |
Hydrophobic | ICL2 | P | 139 | 34x51 | G.S3 | L | 195 | G.S3.01 |
Van-der-waals | ICL2 | P | 139 | 34x51 | G.S3 | L | 195 | G.S3.01 |
Hydrophobic | ICL2 | A | 143 | 34x55 | G.hns1 | R | 32 | G.hns1.03 |
Hydrophobic | TM6 | L | 239 | 6x29 | G.H5 | F | 355 | G.H5.26 |
Hydrophobic | TM3 | R | 131 | 3x50 | G.H5 | L | 354 | G.H5.25 |
Van-der-waals | TM3 | R | 131 | 3x50 | G.H5 | L | 354 | G.H5.25 |
Hydrophobic | TM3 | L | 135 | 3x54 | G.H5 | I | 345 | G.H5.16 |
Van-der-waals | TM3 | L | 135 | 3x54 | G.H5 | I | 345 | G.H5.16 |
Polar | TM3 | D | 130 | 3x49 | G.H5 | C | 352 | G.H5.23 |
Hydrophobic | TM3 | D | 130 | 3x49 | G.H5 | C | 352 | G.H5.23 |
Van-der-waals | TM3 | D | 130 | 3x49 | G.H5 | C | 352 | G.H5.23 |
Hydrophobic | ICL2 | P | 139 | 34x51 | G.H5 | I | 344 | G.H5.15 |
Hydrophobic | TM3 | R | 131 | 3x50 | G.H5 | G | 353 | G.H5.24 |
Hydrophobic | ICL3 | M | 234 | - | G.h4s6 | E | 319 | G.h4s6.12 |
Van-der-waals | ICL3 | M | 234 | - | G.h4s6 | E | 319 | G.h4s6.12 |
Polar | ICL2 | P | 138 | 34x50 | G.H5 | N | 348 | G.H5.19 |
Van-der-waals | ICL2 | P | 138 | 34x50 | G.H5 | N | 348 | G.H5.19 |
Ionic | ICL3 | H | 226 | - | G.H5 | D | 338 | G.H5.09 |
Polar | ICL3 | H | 226 | - | G.H5 | D | 338 | G.H5.09 |
Hydrophobic | ICL3 | H | 226 | - | G.H5 | D | 338 | G.H5.09 |
Van-der-waals | ICL3 | H | 226 | - | G.H5 | D | 338 | G.H5.09 |
Hydrophobic | TM6 | L | 247 | 6x37 | G.H5 | L | 354 | G.H5.25 |
Hydrophobic | TM6 | L | 243 | 6x33 | G.H5 | L | 349 | G.H5.20 |
Polar | TM3 | R | 131 | 3x50 | G.H5 | C | 352 | G.H5.23 |
Hydrophobic | TM3 | R | 131 | 3x50 | G.H5 | C | 352 | G.H5.23 |
Van-der-waals | TM3 | R | 131 | 3x50 | G.H5 | C | 352 | G.H5.23 |
Hydrophobic | ICL3 | H | 226 | - | G.H5 | Q | 334 | G.H5.05 |
Polar | ICL3 | R | 236 | - | G.h4s6 | T | 317 | G.h4s6.10 |
Hydrophobic | ICL3 | R | 236 | - | G.h4s6 | T | 317 | G.h4s6.10 |
Van-der-waals | ICL3 | R | 236 | - | G.h4s6 | T | 317 | G.h4s6.10 |
Ionic | TM2 | K | 67 | 2x37 | G.H5 | D | 351 | G.H5.22 |
Polar | TM2 | K | 67 | 2x37 | G.H5 | D | 351 | G.H5.22 |
Hydrophobic | TM2 | K | 67 | 2x37 | G.H5 | D | 351 | G.H5.22 |
Van-der-waals | TM2 | K | 67 | 2x37 | G.H5 | D | 351 | G.H5.22 |
Hydrophobic | TM5 | L | 223 | 5x72 | G.H5 | A | 339 | G.H5.10 |
Polar | TM5 | S | 222 | 5x71 | G.H5 | D | 338 | G.H5.09 |
Van-der-waals | TM5 | S | 222 | 5x71 | G.H5 | D | 338 | G.H5.09 |
Hydrophobic | TM5 | H | 219 | 5x68 | G.H5 | T | 341 | G.H5.12 |
Hydrophobic | TM5 | L | 223 | 5x72 | G.H5 | D | 338 | G.H5.09 |
Hydrophobic | ICL2 | P | 138 | 34x50 | G.H5 | I | 344 | G.H5.15 |
Van-der-waals | ICL2 | P | 138 | 34x50 | G.H5 | I | 344 | G.H5.15 |
Hydrophobic | TM6 | T | 246 | 6x36 | G.H5 | L | 354 | G.H5.25 |
Van-der-waals | TM6 | T | 246 | 6x36 | G.H5 | L | 354 | G.H5.25 |
Polar | TM2 | S | 69 | 2x39 | G.H5 | D | 351 | G.H5.22 |
Van-der-waals | TM2 | S | 69 | 2x39 | G.H5 | D | 351 | G.H5.22 |
Polar | ICL3 | R | 236 | - | G.h4s6 | D | 316 | G.h4s6.09 |
Hydrophobic | ICL3 | R | 236 | - | G.h4s6 | D | 316 | G.h4s6.09 |
Van-der-waals | ICL3 | R | 236 | - | G.h4s6 | D | 316 | G.h4s6.09 |
Van-der-waals | C-term | T | 338 | - | G.H3 | K | 258 | G.H3.16 |
Hydrophobic | TM5 | L | 223 | 5x72 | G.H5 | D | 342 | G.H5.13 |
Van-der-waals | TM5 | L | 223 | 5x72 | G.H5 | D | 342 | G.H5.13 |
Hydrophobic | TM5 | L | 223 | 5x72 | G.S6 | Y | 321 | G.S6.02 |
Hydrophobic | ICL3 | R | 236 | - | G.H5 | K | 346 | G.H5.17 |
Van-der-waals | ICL3 | R | 236 | - | G.H5 | K | 346 | G.H5.17 |
Hydrophobic | TM2 | Y | 70 | 2x40 | G.H5 | D | 351 | G.H5.22 |
Van-der-waals | TM2 | Y | 70 | 2x40 | G.H5 | D | 351 | G.H5.22 |
Aromatic | TM6 | R | 242 | 6x32 | G.H5 | F | 355 | G.H5.26 |
Hydrophobic | TM6 | R | 242 | 6x32 | G.H5 | F | 355 | G.H5.26 |
Van-der-waals | TM6 | R | 242 | 6x32 | G.H5 | F | 355 | G.H5.26 |
Polar | TM3 | R | 131 | 3x50 | G.H5 | L | 349 | G.H5.20 |
Polar | ICL3 | R | 236 | - | G.h4s6 | K | 318 | G.h4s6.11 |
Hydrophobic | ICL3 | R | 236 | - | G.h4s6 | K | 318 | G.h4s6.11 |
Van-der-waals | ICL3 | R | 236 | - | G.h4s6 | K | 318 | G.h4s6.11 |
Ionic | ICL3 | R | 229 | - | G.H4 | D | 298 | G.H4.04 |
Polar | ICL3 | R | 229 | - | G.H4 | D | 298 | G.H4.04 |
Hydrophobic | ICL3 | R | 229 | - | G.H4 | D | 298 | G.H4.04 |
Van-der-waals | ICL3 | R | 229 | - | G.H4 | D | 298 | G.H4.04 |
Hydrophobic | C-term | C | 360 | - | G.hgh4 | P | 289 | G.hgh4.03 |
Van-der-waals | TM7 | R | 302 | 7x56 | G.H5 | F | 355 | G.H5.26 |
Hydrophobic | TM6 | L | 243 | 6x33 | G.H5 | L | 354 | G.H5.25 |
Hydrophobic | C-term | C | 360 | - | G.HG | I | 286 | G.HG.17 |
Van-der-waals | C-term | C | 360 | - | G.HG | I | 286 | G.HG.17 |
Polar | TM3 | C | 134 | 3x53 | G.H5 | L | 349 | G.H5.20 |
Hydrophobic | TM3 | C | 134 | 3x53 | G.H5 | L | 349 | G.H5.20 |