Gt2 - CB2 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 82.4

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.6
PAE mean: 15.4


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar TM2 S 69 2x39 G.H5 D 350 G.H5.22
Hydrophobic TM2 S 69 2x39 G.H5 D 350 G.H5.22
Van-der-waals TM2 S 69 2x39 G.H5 D 350 G.H5.22
Polar TM3 R 131 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 131 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 R 131 3x50 G.H5 C 351 G.H5.23
Hydrophobic ICL2 P 138 34x50 G.H5 I 343 G.H5.15
Hydrophobic ICL3 P 232 - G.H4 L 308 G.H4.16
Hydrophobic TM6 T 246 6x36 G.H5 L 353 G.H5.25
Van-der-waals TM6 T 246 6x36 G.H5 L 353 G.H5.25
Polar ICL3 R 236 - G.H5 A 338 G.H5.10
Hydrophobic ICL3 R 236 - G.H5 A 338 G.H5.10
Van-der-waals ICL3 R 236 - G.H5 A 338 G.H5.10
Polar C-term C 360 - G.H3 K 257 G.H3.16
Hydrophobic C-term C 360 - G.H3 K 257 G.H3.16
Van-der-waals C-term C 360 - G.H3 K 257 G.H3.16
Hydrophobic TM6 L 239 6x29 G.H5 F 354 G.H5.26
Van-der-waals TM6 L 239 6x29 G.H5 F 354 G.H5.26
Polar TM3 C 134 3x53 G.H5 L 348 G.H5.20
Hydrophobic TM3 C 134 3x53 G.H5 L 348 G.H5.20
Van-der-waals TM3 C 134 3x53 G.H5 L 348 G.H5.20
Van-der-waals ICL2 K 142 34x54 G.H5 N 347 G.H5.19
Polar ICL3 R 236 - G.S6 Y 320 G.S6.02
Aromatic ICL3 R 236 - G.S6 Y 320 G.S6.02
Hydrophobic ICL3 R 236 - G.S6 Y 320 G.S6.02
Van-der-waals ICL3 R 236 - G.S6 Y 320 G.S6.02
Polar ICL3 Q 230 - G.H4 D 297 G.H4.04
Van-der-waals ICL3 Q 230 - G.H4 D 297 G.H4.04
Hydrophobic TM6 L 239 6x29 G.H5 K 345 G.H5.17
Van-der-waals TM6 L 239 6x29 G.H5 K 345 G.H5.17
Polar ICL2 S 140 34x52 G.s2s3 D 193 G.s2s3.02
Hydrophobic TM4 T 146 4x38 G.HN D 28 G.HN.52
Van-der-waals TM4 T 146 4x38 G.HN D 28 G.HN.52
Polar TM3 C 134 3x53 G.H5 C 351 G.H5.23
Hydrophobic TM3 C 134 3x53 G.H5 C 351 G.H5.23
Van-der-waals TM3 C 134 3x53 G.H5 C 351 G.H5.23
Hydrophobic ICL2 A 143 34x55 G.hns1 K 32 G.hns1.03
Van-der-waals ICL2 A 143 34x55 G.hns1 K 32 G.hns1.03
Hydrophobic TM6 L 247 6x37 G.H5 L 353 G.H5.25
Van-der-waals TM5 L 223 5x72 G.H5 D 341 G.H5.13
Hydrophobic TM6 L 243 6x33 G.H5 L 348 G.H5.20
Van-der-waals TM6 L 243 6x33 G.H5 L 348 G.H5.20
Polar ICL3 Q 230 - G.H4 N 301 G.H4.08
Hydrophobic ICL3 Q 230 - G.H4 N 301 G.H4.08
Van-der-waals ICL3 Q 230 - G.H4 N 301 G.H4.08
Hydrophobic TM3 R 131 3x50 G.H5 L 353 G.H5.25
Van-der-waals TM3 R 131 3x50 G.H5 L 353 G.H5.25
Hydrophobic TM3 L 135 3x54 G.H5 I 344 G.H5.16
Hydrophobic TM2 Y 70 2x40 G.H5 D 350 G.H5.22
Van-der-waals TM2 Y 70 2x40 G.H5 D 350 G.H5.22
Hydrophobic ICL3 V 231 - G.S6 S 321 G.S6.03
Van-der-waals ICL3 V 231 - G.S6 S 321 G.S6.03
Hydrophobic ICL3 Q 230 - G.S6 M 323 G.S6.05
Van-der-waals ICL3 Q 230 - G.S6 M 323 G.S6.05
Hydrophobic ICL3 A 235 - G.h4s6 E 318 G.h4s6.12
Van-der-waals ICL3 A 235 - G.h4s6 E 318 G.h4s6.12
Hydrophobic TM3 R 131 3x50 G.H5 G 352 G.H5.24
Van-der-waals TM3 R 131 3x50 G.H5 G 352 G.H5.24
Hydrophobic ICL3 H 226 - G.H5 F 334 G.H5.06
Hydrophobic C-term L 355 - G.H2 K 209 G.H2.05
Hydrophobic H8 S 303 8x47 G.H5 G 352 G.H5.24
Hydrophobic C-term L 357 - G.H3 H 256 G.H3.15
Van-der-waals C-term L 357 - G.H3 H 256 G.H3.15
Polar TM3 C 134 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 C 134 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 C 134 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM7 R 302 7x56 G.H5 F 354 G.H5.26
Hydrophobic TM2 Y 70 2x40 G.H5 G 352 G.H5.24
Hydrophobic ICL2 K 142 34x54 G.hns1 A 31 G.hns1.02
Van-der-waals ICL2 K 142 34x54 G.hns1 A 31 G.hns1.02
Ionic TM5 H 219 5x68 G.H5 D 341 G.H5.13
Polar TM5 H 219 5x68 G.H5 D 341 G.H5.13
Hydrophobic TM5 H 219 5x68 G.H5 D 341 G.H5.13
Van-der-waals TM5 H 219 5x68 G.H5 D 341 G.H5.13
Hydrophobic ICL3 P 232 - G.S6 S 321 G.S6.03
Van-der-waals ICL3 P 232 - G.S6 S 321 G.S6.03
Hydrophobic ICL2 P 138 34x50 G.H5 I 344 G.H5.16
Van-der-waals ICL2 P 138 34x50 G.H5 I 344 G.H5.16
Hydrophobic C-term L 355 - G.H2 R 208 G.H2.04
Van-der-waals C-term L 355 - G.H2 R 208 G.H2.04
Hydrophobic ICL2 P 139 34x51 G.S3 L 194 G.S3.01
Van-der-waals ICL2 P 139 34x51 G.S3 L 194 G.S3.01
Hydrophobic TM2 S 69 2x39 G.H5 C 351 G.H5.23
Van-der-waals TM2 S 69 2x39 G.H5 C 351 G.H5.23
Hydrophobic ICL3 P 232 - G.H4 K 304 G.H4.12
Hydrophobic TM6 R 242 6x32 G.H5 F 354 G.H5.26
Van-der-waals TM6 R 242 6x32 G.H5 F 354 G.H5.26
Hydrophobic ICL2 Y 141 34x53 G.H5 N 347 G.H5.19
Ionic ICL3 R 229 - G.H4 D 297 G.H4.04
Polar ICL3 R 229 - G.H4 D 297 G.H4.04
Hydrophobic ICL3 R 229 - G.H4 D 297 G.H4.04
Van-der-waals ICL3 R 229 - G.H4 D 297 G.H4.04
Polar TM3 R 131 3x50 G.H5 L 348 G.H5.20
Ionic ICL2 K 142 34x54 G.H5 D 350 G.H5.22
Polar ICL2 K 142 34x54 G.H5 D 350 G.H5.22
Hydrophobic C-term L 357 - G.H3 S 252 G.H3.11
Van-der-waals C-term L 357 - G.H3 S 252 G.H3.11
Hydrophobic TM5 H 219 5x68 G.H5 I 344 G.H5.16
Van-der-waals TM5 H 219 5x68 G.H5 I 344 G.H5.16
Hydrophobic TM6 L 243 6x33 G.H5 L 353 G.H5.25
Van-der-waals TM6 L 243 6x33 G.H5 L 353 G.H5.25
Hydrophobic ICL3 V 231 - G.S6 H 322 G.S6.04
Van-der-waals ICL3 V 231 - G.S6 H 322 G.S6.04
Polar TM3 D 130 3x49 G.H5 C 351 G.H5.23
Hydrophobic TM3 D 130 3x49 G.H5 C 351 G.H5.23
Hydrophobic ICL2 P 139 34x51 G.s2s3 K 192 G.s2s3.01
Van-der-waals ICL2 P 139 34x51 G.s2s3 K 192 G.s2s3.01
Hydrophobic TM6 L 239 6x29 G.H5 L 348 G.H5.20
Polar ICL2 P 138 34x50 G.H5 N 347 G.H5.19
Van-der-waals ICL2 P 138 34x50 G.H5 N 347 G.H5.19
Ionic ICL3 R 236 - G.H5 D 341 G.H5.13
Polar ICL3 R 236 - G.H5 D 341 G.H5.13
Hydrophobic ICL3 R 236 - G.H5 D 341 G.H5.13
Van-der-waals ICL3 R 236 - G.H5 D 341 G.H5.13
Polar ICL3 R 236 - G.h4s6 E 318 G.h4s6.12
Van-der-waals ICL3 R 236 - G.h4s6 E 318 G.h4s6.12
Ionic TM2 K 67 2x37 G.H5 D 350 G.H5.22
Polar TM2 K 67 2x37 G.H5 D 350 G.H5.22
Hydrophobic TM2 K 67 2x37 G.H5 D 350 G.H5.22
Van-der-waals TM2 K 67 2x37 G.H5 D 350 G.H5.22
Polar ICL3 Q 230 - G.H4 K 304 G.H4.12
Hydrophobic ICL3 Q 230 - G.H4 K 304 G.H4.12
Van-der-waals ICL3 Q 230 - G.H4 K 304 G.H4.12
Polar ICL2 Y 141 34x53 G.H5 C 351 G.H5.23
Hydrophobic ICL2 Y 141 34x53 G.H5 C 351 G.H5.23
Van-der-waals ICL2 Y 141 34x53 G.H5 C 351 G.H5.23
Hydrophobic TM3 L 135 3x54 G.H5 L 348 G.H5.20