Gz - CRF1 receptor complex model

GPCR CLASS (FAMILY)

B1 (Secretin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 81.5

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.6
PAE mean: 16.5


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM4 K 250 4x64 G.S3 L 195 G.S3.01
Van-der-waals TM4 K 250 4x64 G.S3 L 195 G.S3.01
Polar TM2 Q 173 2x68 G.H5 N 347 G.H5.18
Van-der-waals TM2 Q 173 2x68 G.H5 N 347 G.H5.18
Polar ECL1 V 180 - G.H5 I 352 G.H5.23
Hydrophobic ECL1 V 180 - G.H5 I 352 G.H5.23
Van-der-waals ECL1 V 180 - G.H5 I 352 G.H5.23
Hydrophobic TM4 G 249 4x63 G.H5 I 345 G.H5.16
Van-der-waals TM4 G 249 4x63 G.H5 I 345 G.H5.16
Hydrophobic TM4 W 246 4x60 G.H5 L 349 G.H5.20
Van-der-waals TM4 W 246 4x60 G.H5 L 349 G.H5.20
Hydrophobic TM4 K 250 4x64 G.s2s3 K 193 G.s2s3.01
Van-der-waals TM4 K 250 4x64 G.s2s3 K 193 G.s2s3.01
Polar TM6 F 330 6x56 G.h4s6 E 319 G.h4s6.12
Hydrophobic TM6 F 330 6x56 G.h4s6 E 319 G.h4s6.12
Van-der-waals TM6 F 330 6x56 G.h4s6 E 319 G.h4s6.12
Polar TM4 A 245 4x59 G.H5 N 348 G.H5.19
Van-der-waals TM4 A 245 4x59 G.H5 N 348 G.H5.19
Polar ECL1 H 181 - G.H5 Y 351 G.H5.22
Hydrophobic TM6 L 323 6x49 G.H5 C 355 G.H5.26
Van-der-waals TM6 L 323 6x49 G.H5 C 355 G.H5.26
Polar C-term P 398 - G.H5 Y 351 G.H5.22
Hydrophobic C-term P 398 - G.H5 Y 351 G.H5.22
Van-der-waals C-term P 398 - G.H5 Y 351 G.H5.22
Hydrophobic TM4 W 246 4x60 G.H5 L 354 G.H5.25
Polar TM2 V 172 2x67 G.hns1 R 31 G.hns1.02
Hydrophobic TM2 V 172 2x67 G.hns1 R 31 G.hns1.02
Van-der-waals TM2 V 172 2x67 G.hns1 R 31 G.hns1.02
Polar TM2 V 171 2x66 G.hns1 R 31 G.hns1.02
Hydrophobic TM2 V 171 2x66 G.hns1 R 31 G.hns1.02
Van-der-waals TM2 V 171 2x66 G.hns1 R 31 G.hns1.02
Hydrophobic TM2 W 169 2x64 G.h2s4 G 218 G.h2s4.03
Van-der-waals TM2 W 169 2x64 G.h2s4 G 218 G.h2s4.03
Hydrophobic TM4 W 246 4x60 G.H5 I 352 G.H5.23
Hydrophobic TM6 L 323 6x49 G.H5 L 349 G.H5.20
Hydrophobic TM2 V 172 2x67 G.hns1 Q 30 G.hns1.01
Van-der-waals TM2 V 172 2x67 G.hns1 Q 30 G.hns1.01
Hydrophobic TM4 I 242 4x56 G.H5 L 354 G.H5.25
Hydrophobic ECL1 M 176 - G.H5 Y 351 G.H5.22
Polar TM2 R 151 2x46 G.HN D 20 G.HN.44
Hydrophobic TM2 R 151 2x46 G.HN D 20 G.HN.44
Van-der-waals TM2 R 151 2x46 G.HN D 20 G.HN.44
Hydrophobic TM4 K 250 4x64 G.H5 I 344 G.H5.15
Hydrophobic TM6 L 322 6x48 G.H5 I 345 G.H5.16
Hydrophobic TM4 G 249 4x63 G.H5 I 344 G.H5.15
Van-der-waals TM4 G 249 4x63 G.H5 I 344 G.H5.15
Hydrophobic TM6 F 331 6x57 G.H4 E 309 G.H4.16
Polar TM4 K 250 4x64 G.H5 T 341 G.H5.12
Van-der-waals TM4 K 250 4x64 G.H5 T 341 G.H5.12
Ionic TM4 Y 253 4x67 G.hns1 R 32 G.hns1.03
Polar TM4 Y 253 4x67 G.hns1 R 32 G.hns1.03
Hydrophobic TM4 Y 253 4x67 G.hns1 R 32 G.hns1.03
Van-der-waals TM4 Y 253 4x67 G.hns1 R 32 G.hns1.03
Hydrophobic TM6 T 326 6x52 G.H5 I 345 G.H5.16
Hydrophobic TM7 N 348 7x41 G.H5 L 354 G.H5.25
Polar TM2 V 171 2x66 G.HN S 27 G.HN.51
Van-der-waals TM2 V 171 2x66 G.HN S 27 G.HN.51
Polar ECL1 V 180 - G.H5 Y 351 G.H5.22
Aromatic ECL1 V 180 - G.H5 Y 351 G.H5.22
Hydrophobic ECL1 V 180 - G.H5 Y 351 G.H5.22
Van-der-waals ECL1 V 180 - G.H5 Y 351 G.H5.22
Ionic TM6 T 326 6x52 G.H5 D 342 G.H5.13
Polar TM6 T 326 6x52 G.H5 D 342 G.H5.13
Hydrophobic TM6 T 326 6x52 G.H5 D 342 G.H5.13
Van-der-waals TM6 T 326 6x52 G.H5 D 342 G.H5.13
Hydrophobic TM7 F 344 7x37 G.H5 L 354 G.H5.25
Polar TM2 T 175 2x70 G.hns1 R 31 G.hns1.02
Hydrophobic TM2 T 175 2x70 G.hns1 R 31 G.hns1.02
Van-der-waals TM2 T 175 2x70 G.hns1 R 31 G.hns1.02
Polar ECL1 S 177 - G.H5 Y 351 G.H5.22
Hydrophobic ECL1 S 177 - G.H5 Y 351 G.H5.22
Van-der-waals ECL1 S 177 - G.H5 Y 351 G.H5.22
Ionic TM4 D 254 4x68 G.s2s3 E 194 G.s2s3.02
Polar TM4 D 254 4x68 G.s2s3 E 194 G.s2s3.02
Hydrophobic TM4 D 254 4x68 G.s2s3 E 194 G.s2s3.02
Van-der-waals TM4 D 254 4x68 G.s2s3 E 194 G.s2s3.02
Aromatic TM2 R 151 2x46 G.HN R 24 G.HN.48
Hydrophobic TM2 R 151 2x46 G.HN R 24 G.HN.48
Van-der-waals TM2 R 151 2x46 G.HN R 24 G.HN.48
Hydrophobic TM4 I 242 4x56 G.H5 I 352 G.H5.23
Van-der-waals TM4 I 242 4x56 G.H5 I 352 G.H5.23