Gq -
CRF2 receptor complex model
GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 86.6
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.8
iPTM Score: 0.7
PAE mean: 10.2
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
Gβ,
Gγ,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Hydrophobic | TM3 | L | 209 | 3x54 | G.H5 | Y | 356 | G.H5.23 |
Hydrophobic | C-term | F | 402 | - | G.H3 | T | 257 | G.H3.11 |
Van-der-waals | C-term | F | 402 | - | G.H3 | T | 257 | G.H3.11 |
Hydrophobic | ICL2 | T | 216 | - | G.H5 | L | 349 | G.H5.16 |
Hydrophobic | TM7 | Y | 359 | 7x57 | G.H5 | Y | 356 | G.H5.23 |
Polar | C-term | I | 400 | - | G.H3 | Y | 261 | G.H3.15 |
Hydrophobic | C-term | I | 400 | - | G.H3 | Y | 261 | G.H3.15 |
Van-der-waals | C-term | I | 400 | - | G.H3 | Y | 261 | G.H3.15 |
Hydrophobic | TM3 | I | 213 | 3x58 | G.H5 | L | 358 | G.H5.25 |
Polar | TM6 | K | 310 | 6x40 | G.H5 | V | 359 | G.H5.26 |
Van-der-waals | TM6 | K | 310 | 6x40 | G.H5 | V | 359 | G.H5.26 |
Polar | ICL2 | Y | 217 | - | G.H5 | K | 345 | G.H5.12 |
Hydrophobic | ICL2 | Y | 217 | - | G.H5 | K | 345 | G.H5.12 |
Van-der-waals | ICL2 | Y | 217 | - | G.H5 | K | 345 | G.H5.12 |
Ionic | TM2 | R | 148 | 2x46 | G.H5 | E | 355 | G.H5.22 |
Polar | TM2 | R | 148 | 2x46 | G.H5 | E | 355 | G.H5.22 |
Hydrophobic | TM2 | R | 148 | 2x46 | G.H5 | E | 355 | G.H5.22 |
Van-der-waals | TM2 | R | 148 | 2x46 | G.H5 | E | 355 | G.H5.22 |
Hydrophobic | TM6 | A | 311 | 6x41 | G.H5 | L | 358 | G.H5.25 |
Van-der-waals | TM6 | A | 311 | 6x41 | G.H5 | L | 358 | G.H5.25 |
Hydrophobic | C-term | F | 402 | - | G.H3 | I | 258 | G.H3.12 |
Van-der-waals | C-term | F | 402 | - | G.H3 | I | 258 | G.H3.12 |
Polar | TM3 | A | 212 | 3x57 | G.H5 | N | 352 | G.H5.19 |
Hydrophobic | TM3 | A | 212 | 3x57 | G.H5 | N | 352 | G.H5.19 |
Van-der-waals | TM3 | A | 212 | 3x57 | G.H5 | N | 352 | G.H5.19 |
Hydrophobic | C-term | H | 403 | - | G.H2 | R | 214 | G.H2.05 |
Van-der-waals | C-term | H | 403 | - | G.H2 | R | 214 | G.H2.05 |
Hydrophobic | TM5 | L | 290 | 5x61 | G.H5 | V | 359 | G.H5.26 |
Ionic | TM5 | K | 293 | 5x64 | G.H5 | D | 346 | G.H5.13 |
Polar | TM5 | K | 293 | 5x64 | G.H5 | D | 346 | G.H5.13 |
Hydrophobic | TM5 | K | 293 | 5x64 | G.H5 | D | 346 | G.H5.13 |
Van-der-waals | TM5 | K | 293 | 5x64 | G.H5 | D | 346 | G.H5.13 |
Hydrophobic | C-term | F | 402 | - | G.H3 | L | 254 | G.H3.08 |
Aromatic | TM2 | R | 148 | 2x46 | G.H5 | Y | 356 | G.H5.23 |
Hydrophobic | TM2 | R | 148 | 2x46 | G.H5 | Y | 356 | G.H5.23 |
Van-der-waals | TM2 | R | 148 | 2x46 | G.H5 | Y | 356 | G.H5.23 |
Aromatic | C-term | F | 402 | - | G.H2 | W | 216 | G.H2.07 |
Hydrophobic | C-term | F | 402 | - | G.H2 | W | 216 | G.H2.07 |
Hydrophobic | ICL2 | Y | 217 | - | G.S3 | V | 199 | G.S3.01 |
Van-der-waals | ICL2 | Y | 217 | - | G.S3 | V | 199 | G.S3.01 |
Polar | C-term | H | 403 | - | G.H2 | R | 210 | G.H2.01 |
Hydrophobic | C-term | H | 403 | - | G.H2 | R | 210 | G.H2.01 |
Van-der-waals | C-term | H | 403 | - | G.H2 | R | 210 | G.H2.01 |
Hydrophobic | TM6 | L | 318 | 6x48 | G.H5 | Y | 356 | G.H5.23 |
Hydrophobic | ICL2 | T | 216 | - | G.H5 | I | 348 | G.H5.15 |
Van-der-waals | ICL2 | T | 216 | - | G.H5 | I | 348 | G.H5.15 |
Polar | TM3 | V | 214 | 3x59 | G.H5 | K | 345 | G.H5.12 |
Van-der-waals | TM3 | V | 214 | 3x59 | G.H5 | K | 345 | G.H5.12 |
Hydrophobic | TM3 | I | 213 | 3x58 | G.H5 | L | 353 | G.H5.20 |
Van-der-waals | TM3 | I | 213 | 3x58 | G.H5 | L | 353 | G.H5.20 |
Hydrophobic | C-term | P | 397 | - | G.H2 | I | 217 | G.H2.08 |
Hydrophobic | ICL2 | Y | 217 | - | G.S1 | L | 40 | G.S1.02 |
Hydrophobic | TM5 | L | 290 | 5x61 | G.H5 | L | 353 | G.H5.20 |
Polar | TM7 | F | 358 | 7x56 | G.H5 | N | 357 | G.H5.24 |
Hydrophobic | C-term | I | 393 | - | G.H3 | W | 263 | G.H3.17 |
Hydrophobic | TM6 | K | 307 | 6x37 | G.H5 | V | 359 | G.H5.26 |
Van-der-waals | TM6 | K | 307 | 6x37 | G.H5 | V | 359 | G.H5.26 |
Hydrophobic | ICL2 | Y | 217 | - | G.s2s3 | S | 198 | G.s2s3.02 |
Hydrophobic | ICL2 | Y | 217 | - | G.H5 | V | 344 | G.H5.11 |
Van-der-waals | ICL2 | Y | 217 | - | G.H5 | V | 344 | G.H5.11 |
Hydrophobic | C-term | I | 405 | - | G.H2 | R | 213 | G.H2.04 |
Van-der-waals | C-term | I | 405 | - | G.H2 | R | 213 | G.H2.04 |
Hydrophobic | TM2 | H | 152 | 2x50 | G.H5 | Y | 356 | G.H5.23 |
Hydrophobic | ICL2 | E | 220 | - | G.hns1 | R | 37 | G.hns1.02 |
Polar | ICL2 | R | 221 | - | G.s2s3 | Q | 197 | G.s2s3.01 |
Van-der-waals | ICL2 | R | 221 | - | G.s2s3 | Q | 197 | G.s2s3.01 |
Hydrophobic | TM5 | K | 293 | 5x64 | G.H5 | L | 349 | G.H5.16 |
Hydrophobic | TM3 | Y | 208 | 3x53 | G.H5 | Y | 356 | G.H5.23 |
Van-der-waals | TM3 | Y | 208 | 3x53 | G.H5 | Y | 356 | G.H5.23 |
Hydrophobic | C-term | I | 405 | - | G.H3 | T | 257 | G.H3.11 |
Van-der-waals | C-term | I | 405 | - | G.H3 | T | 257 | G.H3.11 |
Hydrophobic | C-term | I | 405 | - | G.H3 | L | 254 | G.H3.08 |
Van-der-waals | C-term | I | 405 | - | G.H3 | L | 254 | G.H3.08 |
Hydrophobic | C-term | F | 402 | - | G.h2s4 | F | 220 | G.h2s4.01 |
Van-der-waals | C-term | F | 402 | - | G.h2s4 | F | 220 | G.h2s4.01 |
Hydrophobic | TM4 | R | 223 | 4x42 | G.HN | R | 34 | G.HN.52 |
Van-der-waals | TM4 | R | 223 | 4x42 | G.HN | R | 34 | G.HN.52 |
Hydrophobic | TM3 | I | 213 | 3x58 | G.H5 | L | 349 | G.H5.16 |
Hydrophobic | ICL2 | Y | 217 | - | G.S3 | F | 201 | G.S3.03 |
Hydrophobic | ICL2 | Y | 217 | - | G.H5 | I | 348 | G.H5.15 |
Hydrophobic | ICL2 | T | 216 | - | G.H5 | K | 345 | G.H5.12 |
Van-der-waals | ICL2 | T | 216 | - | G.H5 | K | 345 | G.H5.12 |
Polar | ICL2 | R | 221 | - | G.s2s3 | S | 198 | G.s2s3.02 |
Hydrophobic | ICL2 | R | 221 | - | G.s2s3 | S | 198 | G.s2s3.02 |
Van-der-waals | ICL2 | R | 221 | - | G.s2s3 | S | 198 | G.s2s3.02 |
Polar | TM6 | K | 310 | 6x40 | G.H5 | N | 357 | G.H5.24 |
Van-der-waals | TM6 | K | 310 | 6x40 | G.H5 | N | 357 | G.H5.24 |
Hydrophobic | TM6 | L | 315 | 6x45 | G.H5 | L | 358 | G.H5.25 |
Hydrophobic | C-term | P | 397 | - | G.H2 | R | 214 | G.H2.05 |
Van-der-waals | C-term | P | 397 | - | G.H2 | R | 214 | G.H2.05 |
Aromatic | C-term | F | 402 | - | G.H3 | Y | 261 | G.H3.15 |
Hydrophobic | C-term | F | 402 | - | G.H3 | Y | 261 | G.H3.15 |
Van-der-waals | C-term | F | 402 | - | G.H3 | Y | 261 | G.H3.15 |
Polar | C-term | H | 403 | - | G.H2 | S | 211 | G.H2.02 |
Hydrophobic | C-term | H | 403 | - | G.H2 | S | 211 | G.H2.02 |
Van-der-waals | C-term | H | 403 | - | G.H2 | S | 211 | G.H2.02 |
Polar | ICL2 | Y | 217 | - | G.H5 | F | 341 | G.H5.08 |
Aromatic | ICL2 | Y | 217 | - | G.H5 | F | 341 | G.H5.08 |
Hydrophobic | ICL2 | Y | 217 | - | G.H5 | F | 341 | G.H5.08 |
Van-der-waals | ICL2 | Y | 217 | - | G.H5 | F | 341 | G.H5.08 |
Hydrophobic | TM5 | I | 289 | 5x60 | G.H5 | L | 349 | G.H5.16 |
Ionic | C-term | K | 406 | - | G.s4h3 | E | 245 | G.s4h3.14 |
Polar | C-term | K | 406 | - | G.s4h3 | E | 245 | G.s4h3.14 |
Hydrophobic | C-term | K | 406 | - | G.s4h3 | E | 245 | G.s4h3.14 |
Van-der-waals | C-term | K | 406 | - | G.s4h3 | E | 245 | G.s4h3.14 |
Polar | ICL2 | E | 220 | - | G.hns1 | R | 38 | G.hns1.03 |
Hydrophobic | ICL2 | E | 220 | - | G.hns1 | R | 38 | G.hns1.03 |
Polar | C-term | F | 402 | - | G.H2 | R | 213 | G.H2.04 |
Hydrophobic | C-term | F | 402 | - | G.H2 | R | 213 | G.H2.04 |
Van-der-waals | C-term | F | 402 | - | G.H2 | R | 213 | G.H2.04 |
Hydrophobic | C-term | I | 405 | - | G.H3 | A | 253 | G.H3.07 |