GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 84.0
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 14.1
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Hydrophobic | TM6 | Q | 236 | 6x29 | G.H5 | L | 381 | G.H5.26 |
Van-der-waals | TM6 | Q | 236 | 6x29 | G.H5 | L | 381 | G.H5.26 |
Hydrophobic | TM2 | T | 74 | 2x39 | G.H5 | Y | 378 | G.H5.23 |
Van-der-waals | TM2 | T | 74 | 2x39 | G.H5 | Y | 378 | G.H5.23 |
Hydrophobic | C-term | L | 350 | - | G.H4 | F | 327 | G.H4.10 |
Van-der-waals | C-term | L | 350 | - | G.H4 | F | 327 | G.H4.10 |
Hydrophobic | ICL3 | M | 234 | - | G.H5 | L | 375 | G.H5.20 |
Van-der-waals | ICL3 | M | 234 | - | G.H5 | L | 375 | G.H5.20 |
Polar | TM6 | Q | 236 | 6x29 | G.h4s6 | Y | 345 | G.h4s6.20 |
Polar | TM3 | A | 138 | 3x53 | G.H5 | H | 374 | G.H5.19 |
Hydrophobic | TM3 | A | 138 | 3x53 | G.H5 | H | 374 | G.H5.19 |
Van-der-waals | TM3 | A | 138 | 3x53 | G.H5 | H | 374 | G.H5.19 |
Polar | C-term | N | 349 | - | G.hgh4 | T | 306 | G.hgh4.09 |
Van-der-waals | C-term | N | 349 | - | G.hgh4 | T | 306 | G.hgh4.09 |
Hydrophobic | TM3 | I | 139 | 3x54 | G.H5 | L | 375 | G.H5.20 |
Van-der-waals | TM3 | I | 139 | 3x54 | G.H5 | L | 375 | G.H5.20 |
Hydrophobic | ICL2 | L | 146 | 34x54 | G.hns1 | K | 40 | G.hns1.02 |
Polar | C-term | L | 350 | - | G.H4 | R | 334 | G.H4.17 |
Hydrophobic | C-term | L | 350 | - | G.H4 | R | 334 | G.H4.17 |
Van-der-waals | C-term | L | 350 | - | G.H4 | R | 334 | G.H4.17 |
Polar | TM3 | R | 135 | 3x50 | G.H5 | Y | 378 | G.H5.23 |
Hydrophobic | TM3 | R | 135 | 3x50 | G.H5 | Y | 378 | G.H5.23 |
Van-der-waals | TM3 | R | 135 | 3x50 | G.H5 | Y | 378 | G.H5.23 |
Hydrophobic | ICL2 | T | 143 | 34x51 | G.H5 | F | 363 | G.H5.08 |
Hydrophobic | ICL3 | M | 234 | - | G.H5 | R | 372 | G.H5.17 |
Van-der-waals | ICL3 | M | 234 | - | G.H5 | R | 372 | G.H5.17 |
Hydrophobic | TM6 | A | 240 | 6x33 | G.H5 | L | 375 | G.H5.20 |
Hydrophobic | C-term | Y | 339 | - | G.h4s6 | G | 342 | G.h4s6.11 |
Van-der-waals | C-term | Y | 339 | - | G.h4s6 | G | 342 | G.h4s6.11 |
Polar | ICL3 | H | 233 | - | G.H5 | R | 372 | G.H5.17 |
Hydrophobic | C-term | Y | 339 | - | G.h4s6 | G | 340 | G.h4s6.09 |
Van-der-waals | C-term | Y | 339 | - | G.h4s6 | G | 340 | G.h4s6.09 |
Hydrophobic | ICL2 | A | 142 | 34x50 | G.H5 | Q | 371 | G.H5.16 |
Van-der-waals | ICL2 | A | 142 | 34x50 | G.H5 | Q | 371 | G.H5.16 |
Hydrophobic | TM6 | V | 243 | 6x36 | G.H5 | L | 380 | G.H5.25 |
Van-der-waals | TM6 | V | 243 | 6x36 | G.H5 | L | 380 | G.H5.25 |
Hydrophobic | C-term | L | 350 | - | G.hgh4 | Y | 305 | G.hgh4.08 |
Van-der-waals | C-term | L | 350 | - | G.hgh4 | Y | 305 | G.hgh4.08 |
Hydrophobic | TM3 | R | 135 | 3x50 | G.H5 | L | 380 | G.H5.25 |
Hydrophobic | H8 | G | 309 | 8x47 | G.H5 | E | 379 | G.H5.24 |
Van-der-waals | H8 | G | 309 | 8x47 | G.H5 | E | 379 | G.H5.24 |
Hydrophobic | ICL3 | M | 234 | - | G.H5 | Q | 371 | G.H5.16 |
Polar | TM6 | A | 240 | 6x33 | G.H5 | L | 380 | G.H5.25 |
Hydrophobic | TM6 | A | 240 | 6x33 | G.H5 | L | 380 | G.H5.25 |
Van-der-waals | TM6 | A | 240 | 6x33 | G.H5 | L | 380 | G.H5.25 |
Hydrophobic | TM6 | R | 239 | 6x32 | G.H5 | L | 381 | G.H5.26 |
Van-der-waals | TM6 | R | 239 | 6x32 | G.H5 | L | 381 | G.H5.26 |
Hydrophobic | C-term | S | 343 | - | G.h4s6 | T | 337 | G.h4s6.03 |
Van-der-waals | C-term | S | 343 | - | G.h4s6 | T | 337 | G.h4s6.03 |
Polar | H8 | F | 312 | 8x50 | G.H5 | E | 379 | G.H5.24 |
Van-der-waals | H8 | F | 312 | 8x50 | G.H5 | E | 379 | G.H5.24 |
Hydrophobic | ICL3 | M | 234 | - | G.H5 | D | 368 | G.H5.13 |
Van-der-waals | ICL3 | M | 234 | - | G.H5 | D | 368 | G.H5.13 |
Hydrophobic | ICL2 | L | 146 | 34x54 | G.HN | L | 37 | G.HN.52 |
Van-der-waals | ICL2 | L | 146 | 34x54 | G.HN | L | 37 | G.HN.52 |
Polar | H8 | N | 311 | 8x49 | G.H5 | E | 379 | G.H5.24 |
Hydrophobic | H8 | N | 311 | 8x49 | G.H5 | E | 379 | G.H5.24 |
Van-der-waals | H8 | N | 311 | 8x49 | G.H5 | E | 379 | G.H5.24 |
Hydrophobic | H8 | Q | 310 | 8x48 | G.H5 | L | 381 | G.H5.26 |
Van-der-waals | H8 | Q | 310 | 8x48 | G.H5 | L | 381 | G.H5.26 |
Hydrophobic | C-term | Y | 339 | - | G.h4s6 | K | 343 | G.h4s6.12 |
Van-der-waals | C-term | Y | 339 | - | G.h4s6 | K | 343 | G.h4s6.12 |
Hydrophobic | TM5 | T | 228 | 5x64 | G.H5 | Q | 371 | G.H5.16 |
Van-der-waals | TM5 | T | 228 | 5x64 | G.H5 | Q | 371 | G.H5.16 |
Hydrophobic | TM6 | I | 244 | 6x37 | G.H5 | L | 380 | G.H5.25 |
Hydrophobic | ICL2 | L | 146 | 34x54 | G.hns1 | A | 41 | G.hns1.03 |
Polar | ICL2 | R | 144 | 34x52 | G.s2s3 | D | 202 | G.s2s3.01 |
Van-der-waals | ICL2 | R | 144 | 34x52 | G.s2s3 | D | 202 | G.s2s3.01 |
Polar | H8 | Q | 310 | 8x48 | G.H5 | E | 379 | G.H5.24 |
Van-der-waals | H8 | Q | 310 | 8x48 | G.H5 | E | 379 | G.H5.24 |
Polar | ICL2 | Q | 148 | 34x56 | G.hns1 | K | 40 | G.hns1.02 |
Hydrophobic | ICL2 | Q | 148 | 34x56 | G.hns1 | K | 40 | G.hns1.02 |
Van-der-waals | ICL2 | Q | 148 | 34x56 | G.hns1 | K | 40 | G.hns1.02 |
Hydrophobic | C-term | S | 342 | - | G.h4s6 | Y | 345 | G.h4s6.20 |
Hydrophobic | TM3 | A | 138 | 3x53 | G.H5 | Y | 378 | G.H5.23 |
Van-der-waals | TM3 | A | 138 | 3x53 | G.H5 | Y | 378 | G.H5.23 |
Polar | ICL2 | Q | 148 | 34x56 | G.HN | L | 37 | G.HN.52 |
Hydrophobic | ICL2 | Q | 148 | 34x56 | G.HN | L | 37 | G.HN.52 |
Van-der-waals | ICL2 | Q | 148 | 34x56 | G.HN | L | 37 | G.HN.52 |
Polar | C-term | Y | 339 | - | G.h4s6 | D | 341 | G.h4s6.10 |
Hydrophobic | C-term | Y | 339 | - | G.h4s6 | D | 341 | G.h4s6.10 |
Van-der-waals | C-term | Y | 339 | - | G.h4s6 | D | 341 | G.h4s6.10 |
Hydrophobic | C-term | L | 350 | - | G.H4 | D | 330 | G.H4.13 |
Van-der-waals | C-term | L | 350 | - | G.H4 | D | 330 | G.H4.13 |
Hydrophobic | C-term | L | 350 | - | G.hgh4 | E | 301 | G.hgh4.04 |
Polar | TM3 | D | 134 | 3x49 | G.H5 | Y | 378 | G.H5.23 |
Hydrophobic | TM3 | D | 134 | 3x49 | G.H5 | Y | 378 | G.H5.23 |
Van-der-waals | TM3 | D | 134 | 3x49 | G.H5 | Y | 378 | G.H5.23 |
Hydrophobic | TM2 | S | 72 | 2x37 | G.H5 | Q | 377 | G.H5.22 |
Hydrophobic | ICL2 | T | 143 | 34x51 | G.H5 | R | 367 | G.H5.12 |
Polar | ICL2 | T | 143 | 34x51 | G.S1 | H | 43 | G.S1.02 |
Hydrophobic | ICL2 | T | 143 | 34x51 | G.S1 | H | 43 | G.S1.02 |
Van-der-waals | ICL2 | T | 143 | 34x51 | G.S1 | H | 43 | G.S1.02 |
Hydrophobic | TM3 | I | 139 | 3x54 | G.H5 | L | 380 | G.H5.25 |
Hydrophobic | TM5 | L | 229 | 5x65 | G.H5 | L | 375 | G.H5.20 |
Van-der-waals | TM5 | L | 229 | 5x65 | G.H5 | L | 375 | G.H5.20 |
Polar | H8 | N | 311 | 8x49 | G.H5 | K | 376 | G.H5.21 |
Van-der-waals | H8 | N | 311 | 8x49 | G.H5 | K | 376 | G.H5.21 |
Polar | TM2 | T | 74 | 2x39 | G.H5 | Q | 377 | G.H5.22 |
Van-der-waals | TM2 | T | 74 | 2x39 | G.H5 | Q | 377 | G.H5.22 |
Hydrophobic | ICL2 | A | 142 | 34x50 | G.H5 | H | 374 | G.H5.19 |
Hydrophobic | ICL2 | T | 147 | 34x55 | G.H5 | H | 374 | G.H5.19 |
Van-der-waals | ICL2 | T | 147 | 34x55 | G.H5 | H | 374 | G.H5.19 |
Hydrophobic | C-term | V | 346 | - | G.H4 | L | 333 | G.H4.16 |
Hydrophobic | C-term | L | 350 | - | G.H4 | L | 331 | G.H4.14 |
Polar | TM3 | I | 139 | 3x54 | G.H5 | Q | 371 | G.H5.16 |
Hydrophobic | TM3 | I | 139 | 3x54 | G.H5 | Q | 371 | G.H5.16 |
Van-der-waals | TM3 | I | 139 | 3x54 | G.H5 | Q | 371 | G.H5.16 |
Hydrophobic | ICL2 | T | 143 | 34x51 | G.S3 | V | 204 | G.S3.01 |
Van-der-waals | ICL2 | T | 143 | 34x51 | G.S3 | V | 204 | G.S3.01 |
Hydrophobic | ICL2 | A | 142 | 34x50 | G.H5 | I | 370 | G.H5.15 |
Van-der-waals | ICL2 | A | 142 | 34x50 | G.H5 | I | 370 | G.H5.15 |
Hydrophobic | ICL2 | T | 143 | 34x51 | G.H5 | I | 370 | G.H5.15 |
Polar | ICL2 | Q | 148 | 34x56 | G.HN | R | 36 | G.HN.51 |
Hydrophobic | ICL2 | Q | 148 | 34x56 | G.HN | R | 36 | G.HN.51 |
Van-der-waals | ICL2 | Q | 148 | 34x56 | G.HN | R | 36 | G.HN.51 |
Hydrophobic | C-term | V | 346 | - | G.h4s6 | T | 337 | G.h4s6.03 |
Hydrophobic | ICL2 | R | 144 | 34x52 | G.S3 | V | 204 | G.S3.01 |