G13 - CXCR2 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G12/13

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 84.7

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.8
iPTM Score: 0.7
PAE mean: 14.1


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Ionic ICL1 R 77 12x48 G.HN D 3 G.HN.03
Polar ICL1 R 77 12x48 G.HN D 3 G.HN.03
Hydrophobic TM3 I 148 3x54 G.H5 L 371 G.H5.20
Van-der-waals TM3 I 148 3x54 G.H5 L 371 G.H5.20
Hydrophobic C-term F 348 - G.H2 E 235 G.H2.09
Hydrophobic C-term S 353 - G.H2 K 231 G.H2.05
Hydrophobic TM6 A 249 6x33 G.H5 M 375 G.H5.24
Polar H8 Q 319 8x48 G.H5 L 376 G.H5.25
Hydrophobic H8 Q 319 8x48 G.H5 L 376 G.H5.25
Van-der-waals H8 Q 319 8x48 G.H5 L 376 G.H5.25
Hydrophobic C-term L 360 - G.S1 L 54 G.S1.07
Hydrophobic TM5 A 241 5x68 G.H5 D 364 G.H5.13
Van-der-waals TM5 A 241 5x68 G.H5 D 364 G.H5.13
Hydrophobic ICL3 M 243 - G.h4s6 P 341 G.h4s6.20
Hydrophobic TM5 A 241 5x68 G.H5 L 367 G.H5.16
Van-der-waals TM5 A 241 5x68 G.H5 L 367 G.H5.16
Hydrophobic ICL2 A 151 34x50 G.H5 L 367 G.H5.16
Hydrophobic TM1 Y 75 1x59 G.HN M 1 G.HN.01
Hydrophobic TM5 T 237 5x64 G.H5 L 367 G.H5.16
Van-der-waals TM5 T 237 5x64 G.H5 L 367 G.H5.16
Polar TM3 R 144 3x50 G.H5 L 374 G.H5.23
Van-der-waals TM3 R 144 3x50 G.H5 L 374 G.H5.23
Hydrophobic ICL3 M 243 - G.H5 D 364 G.H5.13
Hydrophobic ICL2 L 155 34x54 G.hns1 K 46 G.hns1.02
Van-der-waals ICL2 L 155 34x54 G.hns1 K 46 G.hns1.02
Hydrophobic ICL3 M 243 - G.H5 H 368 G.H5.17
Van-der-waals ICL3 M 243 - G.H5 H 368 G.H5.17
Hydrophobic ICL3 M 243 - G.H5 L 367 G.H5.16
Hydrophobic C-term L 360 - G.H2 F 234 G.H2.08
Hydrophobic C-term L 360 - G.H2 R 230 G.H2.04
Van-der-waals C-term L 360 - G.H2 R 230 G.H2.04
Hydrophobic C-term P 346 - G.H3 R 279 G.H3.16
Hydrophobic TM3 I 148 3x54 G.H5 M 375 G.H5.24
Hydrophobic ICL2 L 155 34x54 G.H5 I 366 G.H5.15
Hydrophobic TM6 Q 245 6x29 G.H5 H 368 G.H5.17
Polar ICL2 A 151 34x50 G.H5 N 370 G.H5.19
Hydrophobic TM3 R 144 3x50 G.H5 M 375 G.H5.24
Van-der-waals TM3 R 144 3x50 G.H5 M 375 G.H5.24
Hydrophobic TM3 I 148 3x54 G.H5 L 367 G.H5.16
Van-der-waals TM3 I 148 3x54 G.H5 L 367 G.H5.16
Hydrophobic ICL2 T 152 34x51 G.S3 V 216 G.S3.01
Hydrophobic ICL2 T 156 34x55 G.hns1 R 47 G.hns1.03
Van-der-waals ICL2 T 156 34x55 G.hns1 R 47 G.hns1.03
Hydrophobic C-term T 358 - G.H3 E 267 G.H3.04
Polar C-term S 353 - G.H2 E 229 G.H2.03
Hydrophobic C-term S 353 - G.H2 E 229 G.H2.03
Van-der-waals C-term S 353 - G.H2 E 229 G.H2.03
Polar C-term T 359 - G.H2 R 230 G.H2.04
Hydrophobic C-term T 359 - G.H2 R 230 G.H2.04
Van-der-waals C-term T 359 - G.H2 R 230 G.H2.04
Hydrophobic C-term F 348 - G.H3 V 280 G.H3.17
Van-der-waals C-term F 348 - G.H3 V 280 G.H3.17
Hydrophobic C-term F 348 - G.H3 R 279 G.H3.16
Hydrophobic TM2 T 83 2x39 G.H5 L 374 G.H5.23
Van-der-waals TM2 T 83 2x39 G.H5 L 374 G.H5.23
Hydrophobic C-term L 360 - G.H3 I 271 G.H3.08
Van-der-waals C-term L 360 - G.H3 I 271 G.H3.08
Hydrophobic ICL1 R 77 12x48 G.HN F 4 G.HN.04
Van-der-waals ICL1 R 77 12x48 G.HN F 4 G.HN.04
Polar C-term L 360 - G.s3h2 G 225 G.s3h2.02
Van-der-waals C-term L 360 - G.s3h2 G 225 G.s3h2.02
Hydrophobic ICL2 T 152 34x51 G.H5 I 366 G.H5.15
Hydrophobic TM6 R 248 6x32 G.H5 L 376 G.H5.25
Hydrophobic C-term L 360 - G.H2 W 233 G.H2.07
Hydrophobic TM6 I 253 6x37 G.H5 M 375 G.H5.24
Van-der-waals TM6 I 253 6x37 G.H5 M 375 G.H5.24
Polar C-term S 351 - G.H2 K 231 G.H2.05
Hydrophobic C-term S 351 - G.H2 K 231 G.H2.05
Van-der-waals C-term S 351 - G.H2 K 231 G.H2.05
Van-der-waals C-term L 360 - G.H1 K 61 G.H1.01
Hydrophobic TM6 Q 245 6x29 G.H5 L 376 G.H5.25
Van-der-waals TM6 Q 245 6x29 G.H5 L 376 G.H5.25
Hydrophobic H8 G 318 8x47 G.H5 L 376 G.H5.25
Hydrophobic TM5 L 238 5x65 G.H5 L 367 G.H5.16
Polar C-term S 347 - G.H3 R 279 G.H3.16
Van-der-waals C-term S 347 - G.H3 R 279 G.H3.16
Hydrophobic TM5 L 238 5x65 G.H5 L 371 G.H5.20
Van-der-waals TM5 L 238 5x65 G.H5 L 371 G.H5.20
Polar C-term T 358 - G.H2 R 230 G.H2.04
Hydrophobic C-term T 358 - G.H2 R 230 G.H2.04
Van-der-waals C-term T 358 - G.H2 R 230 G.H2.04
Ionic C-term H 355 - G.H2 E 229 G.H2.03
Hydrophobic C-term L 360 - G.s1h1 G 55 G.s1h1.01
Van-der-waals C-term L 360 - G.s1h1 G 55 G.s1h1.01
Hydrophobic TM6 A 249 6x33 G.H5 L 371 G.H5.20
Van-der-waals TM6 A 249 6x33 G.H5 L 371 G.H5.20
Hydrophobic ICL2 T 156 34x55 G.HN T 43 G.HN.52
Van-der-waals ICL2 T 156 34x55 G.HN T 43 G.HN.52
Hydrophobic H8 Q 319 8x48 G.H5 Q 377 G.H5.26
Van-der-waals H8 Q 319 8x48 G.H5 Q 377 G.H5.26
Polar ICL3 H 242 - G.H5 D 364 G.H5.13
Van-der-waals ICL3 H 242 - G.H5 D 364 G.H5.13
Hydrophobic ICL2 A 151 34x50 G.H5 I 366 G.H5.15
Polar C-term S 357 - G.H2 R 227 G.H2.01
Hydrophobic C-term T 359 - G.H2 R 227 G.H2.01
Van-der-waals C-term T 359 - G.H2 R 227 G.H2.01
Polar C-term L 360 - G.s3h2 Q 226 G.s3h2.03
Hydrophobic H8 G 318 8x47 G.H5 Q 377 G.H5.26
Van-der-waals H8 G 318 8x47 G.H5 Q 377 G.H5.26
Hydrophobic TM3 A 147 3x53 G.H5 L 374 G.H5.23
Van-der-waals TM3 A 147 3x53 G.H5 L 374 G.H5.23
Polar TM3 A 147 3x53 G.H5 N 370 G.H5.19
Hydrophobic TM3 A 147 3x53 G.H5 N 370 G.H5.19
Van-der-waals TM3 A 147 3x53 G.H5 N 370 G.H5.19
Hydrophobic C-term G 350 - G.H2 K 231 G.H2.05
Van-der-waals C-term G 350 - G.H2 K 231 G.H2.05
Hydrophobic H8 K 320 8x49 G.H5 Q 377 G.H5.26
Van-der-waals H8 K 320 8x49 G.H5 Q 377 G.H5.26