Ggust - CXCR3 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 83.5

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.8
iPTM Score: 0.7
PAE mean: 11.8


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM3 I 153 3x54 G.H5 I 344 G.H5.16
Hydrophobic TM3 I 153 3x54 G.H5 L 353 G.H5.25
Hydrophobic ICL2 Y 160 34x54 G.S3 L 194 G.S3.01
Van-der-waals ICL2 Y 160 34x54 G.S3 L 194 G.S3.01
Polar ICL2 R 161 34x55 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 R 161 34x55 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 R 161 34x55 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 T 157 34x51 G.H5 F 336 G.H5.08
Hydrophobic TM5 L 242 5x65 G.H5 I 344 G.H5.16
Hydrophobic ICL2 T 157 34x51 G.H5 T 340 G.H5.12
Van-der-waals ICL2 T 157 34x51 G.H5 T 340 G.H5.12
Ionic ICL2 R 161 34x55 G.H5 E 346 G.H5.18
Hydrophobic TM6 L 256 6x36 G.H5 L 353 G.H5.25
Van-der-waals TM6 L 256 6x36 G.H5 L 353 G.H5.25
Polar TM2 T 88 2x39 G.H5 C 351 G.H5.23
Hydrophobic TM2 T 88 2x39 G.H5 C 351 G.H5.23
Hydrophobic TM3 I 153 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 I 153 3x54 G.H5 L 348 G.H5.20
Polar ICL2 Q 158 34x52 G.s2s3 D 193 G.s2s3.02
Hydrophobic ICL2 Q 158 34x52 G.s2s3 D 193 G.s2s3.02
Ionic TM6 R 249 6x29 G.h4s6 D 316 G.h4s6.10
Polar TM6 R 249 6x29 G.h4s6 D 316 G.h4s6.10
Van-der-waals TM6 R 249 6x29 G.h4s6 D 316 G.h4s6.10
Polar TM6 A 253 6x33 G.H5 L 353 G.H5.25
Van-der-waals TM6 A 253 6x33 G.H5 L 353 G.H5.25
Hydrophobic H8 V 323 8x48 G.H5 K 349 G.H5.21
Hydrophobic TM5 V 241 5x64 G.H5 I 344 G.H5.16
Hydrophobic TM5 L 242 5x65 G.H5 L 348 G.H5.20
Hydrophobic H8 K 324 8x49 G.H5 K 349 G.H5.21
Van-der-waals H8 K 324 8x49 G.H5 K 349 G.H5.21
Polar ICL3 Q 248 - G.h4s6 E 315 G.h4s6.09
Hydrophobic ICL3 Q 248 - G.h4s6 E 315 G.h4s6.09
Van-der-waals ICL3 Q 248 - G.h4s6 E 315 G.h4s6.09
Polar TM3 R 149 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 149 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 R 149 3x50 G.H5 C 351 G.H5.23
Hydrophobic ICL3 G 247 - G.h4s6 E 318 G.h4s6.12
Van-der-waals ICL3 G 247 - G.h4s6 E 318 G.h4s6.12
Polar ICL3 Q 248 - G.h4s6 E 318 G.h4s6.12
Hydrophobic ICL3 Q 248 - G.h4s6 E 318 G.h4s6.12
Van-der-waals ICL3 Q 248 - G.h4s6 E 318 G.h4s6.12
Polar TM6 R 252 6x32 G.H5 F 354 G.H5.26
Hydrophobic TM6 R 252 6x32 G.H5 F 354 G.H5.26
Van-der-waals TM6 R 252 6x32 G.H5 F 354 G.H5.26
Polar C-term Y 365 - G.s4h3 E 239 G.s4h3.13
Hydrophobic C-term Y 365 - G.s4h3 E 239 G.s4h3.13
Van-der-waals C-term Y 365 - G.s4h3 E 239 G.s4h3.13
Hydrophobic ICL2 R 162 34x56 G.hns1 R 32 G.hns1.03
Hydrophobic TM6 A 253 6x33 G.H5 L 348 G.H5.20
Polar ICL2 R 161 34x55 G.hns1 A 31 G.hns1.02
Hydrophobic ICL2 R 161 34x55 G.hns1 A 31 G.hns1.02
Van-der-waals ICL2 R 161 34x55 G.hns1 A 31 G.hns1.02
Hydrophobic ICL3 R 246 - G.S6 Y 320 G.S6.02
Polar TM3 N 152 3x53 G.H5 C 351 G.H5.23
Hydrophobic TM3 N 152 3x53 G.H5 C 351 G.H5.23
Hydrophobic ICL2 Y 160 34x54 G.H5 I 343 G.H5.15
Van-der-waals ICL2 Y 160 34x54 G.H5 I 343 G.H5.15
Ionic C-term E 359 - G.H2 K 209 G.H2.05
Polar C-term E 359 - G.H2 K 209 G.H2.05
Van-der-waals C-term E 359 - G.H2 K 209 G.H2.05
Hydrophobic ICL2 Y 160 34x54 G.S1 V 34 G.S1.02
Hydrophobic TM5 S 245 5x68 G.H5 D 341 G.H5.13
Van-der-waals TM5 S 245 5x68 G.H5 D 341 G.H5.13
Hydrophobic ICL2 A 156 34x50 G.H5 I 344 G.H5.16
Polar ICL3 Q 248 - G.h4s6 K 314 G.h4s6.08
Hydrophobic ICL3 Q 248 - G.h4s6 K 314 G.h4s6.08
Van-der-waals ICL3 Q 248 - G.h4s6 K 314 G.h4s6.08
Polar H8 V 323 8x48 G.H5 F 354 G.H5.26
Hydrophobic H8 V 323 8x48 G.H5 F 354 G.H5.26
Van-der-waals H8 V 323 8x48 G.H5 F 354 G.H5.26
Ionic H8 K 324 8x49 G.H5 D 350 G.H5.22
Polar H8 K 324 8x49 G.H5 D 350 G.H5.22
Hydrophobic H8 K 324 8x49 G.H5 D 350 G.H5.22
Van-der-waals H8 K 324 8x49 G.H5 D 350 G.H5.22
Ionic H8 E 327 8x52 G.H5 K 349 G.H5.21
Polar H8 G 322 8x47 G.H5 G 352 G.H5.24
Hydrophobic H8 G 322 8x47 G.H5 G 352 G.H5.24
Hydrophobic ICL2 T 157 34x51 G.S3 L 194 G.S3.01
Van-der-waals ICL2 T 157 34x51 G.S3 L 194 G.S3.01
Hydrophobic TM3 R 149 3x50 G.H5 L 353 G.H5.25
Van-der-waals TM3 R 149 3x50 G.H5 L 353 G.H5.25
Hydrophobic ICL2 Y 160 34x54 G.S1 T 33 G.S1.01
Hydrophobic TM6 R 249 6x29 G.H5 F 354 G.H5.26
Van-der-waals TM6 R 249 6x29 G.H5 F 354 G.H5.26
Hydrophobic ICL2 A 156 34x50 G.H5 I 343 G.H5.15
Polar ICL3 R 246 - G.H5 D 341 G.H5.13
Van-der-waals ICL3 R 246 - G.H5 D 341 G.H5.13
Hydrophobic ICL2 Y 160 34x54 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 Y 160 34x54 G.hns1 R 32 G.hns1.03
Polar TM3 N 152 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 N 152 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 N 152 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM6 V 257 6x37 G.H5 L 353 G.H5.25