GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 81.1
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.7
iPTM Score: 0.5
PAE mean: 17.4
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Polar | C-term | F | 340 | - | G.S2 | E | 196 | G.S2.03 |
Van-der-waals | C-term | F | 340 | - | G.S2 | E | 196 | G.S2.03 |
Polar | H8 | K | 294 | 8x49 | G.H5 | E | 379 | G.H5.24 |
Van-der-waals | H8 | K | 294 | 8x49 | G.H5 | E | 379 | G.H5.24 |
Hydrophobic | C-term | T | 337 | - | G.S2 | R | 198 | G.S2.05 |
Van-der-waals | C-term | T | 337 | - | G.S2 | R | 198 | G.S2.05 |
Hydrophobic | TM3 | V | 130 | 3x53 | G.H5 | Y | 378 | G.H5.23 |
Van-der-waals | TM3 | V | 130 | 3x53 | G.H5 | Y | 378 | G.H5.23 |
Polar | TM4 | R | 144 | 4x38 | G.H5 | Y | 378 | G.H5.23 |
Hydrophobic | ICL2 | T | 135 | 34x51 | G.S3 | V | 204 | G.S3.01 |
Hydrophobic | ICL2 | A | 134 | 34x50 | G.H5 | I | 370 | G.H5.15 |
Hydrophobic | ICL2 | Y | 138 | 34x54 | G.H5 | H | 374 | G.H5.19 |
Hydrophobic | ICL3 | F | 224 | - | G.H5 | R | 372 | G.H5.17 |
Van-der-waals | ICL3 | F | 224 | - | G.H5 | R | 372 | G.H5.17 |
Hydrophobic | ICL2 | T | 135 | 34x51 | G.H5 | I | 370 | G.H5.15 |
Polar | H8 | L | 293 | 8x48 | G.H5 | E | 379 | G.H5.24 |
Hydrophobic | H8 | L | 293 | 8x48 | G.H5 | E | 379 | G.H5.24 |
Van-der-waals | H8 | L | 293 | 8x48 | G.H5 | E | 379 | G.H5.24 |
Polar | TM3 | V | 131 | 3x54 | G.H5 | Q | 371 | G.H5.16 |
Hydrophobic | TM3 | V | 131 | 3x54 | G.H5 | Q | 371 | G.H5.16 |
Van-der-waals | TM3 | V | 131 | 3x54 | G.H5 | Q | 371 | G.H5.16 |
Polar | ICL2 | N | 139 | 34x55 | G.S1 | H | 43 | G.S1.02 |
Polar | ICL2 | A | 134 | 34x50 | G.H5 | H | 374 | G.H5.19 |
Hydrophobic | ICL2 | A | 134 | 34x50 | G.H5 | H | 374 | G.H5.19 |
Van-der-waals | ICL2 | A | 134 | 34x50 | G.H5 | H | 374 | G.H5.19 |
Hydrophobic | ICL2 | Y | 138 | 34x54 | G.H5 | I | 370 | G.H5.15 |
Polar | ICL3 | G | 223 | - | G.H5 | R | 372 | G.H5.17 |
Hydrophobic | C-term | S | 329 | - | G.HN | L | 32 | G.HN.47 |
Van-der-waals | C-term | S | 329 | - | G.HN | L | 32 | G.HN.47 |
Polar | TM3 | D | 126 | 3x49 | G.H5 | Y | 378 | G.H5.23 |
Hydrophobic | TM3 | D | 126 | 3x49 | G.H5 | Y | 378 | G.H5.23 |
Van-der-waals | TM3 | D | 126 | 3x49 | G.H5 | Y | 378 | G.H5.23 |
Hydrophobic | TM6 | I | 233 | 6x37 | G.H5 | L | 380 | G.H5.25 |
Hydrophobic | ICL2 | T | 135 | 34x51 | G.H5 | R | 367 | G.H5.12 |
Hydrophobic | C-term | M | 339 | - | G.H1 | V | 59 | G.H1.05 |
Polar | C-term | Q | 341 | - | G.hfs2 | S | 192 | G.hfs2.06 |
Van-der-waals | C-term | Q | 341 | - | G.hfs2 | S | 192 | G.hfs2.06 |
Polar | H8 | S | 292 | 8x47 | G.H5 | E | 379 | G.H5.24 |
Hydrophobic | H8 | S | 292 | 8x47 | G.H5 | E | 379 | G.H5.24 |
Van-der-waals | H8 | S | 292 | 8x47 | G.H5 | E | 379 | G.H5.24 |
Hydrophobic | TM3 | V | 131 | 3x54 | G.H5 | L | 380 | G.H5.25 |
Hydrophobic | C-term | L | 342 | - | G.S3 | F | 209 | G.S3.06 |
Hydrophobic | TM3 | V | 131 | 3x54 | G.H5 | L | 375 | G.H5.20 |
Van-der-waals | TM3 | V | 131 | 3x54 | G.H5 | L | 375 | G.H5.20 |
Hydrophobic | ICL2 | A | 137 | 34x53 | G.H5 | H | 374 | G.H5.19 |
Polar | ICL2 | N | 139 | 34x55 | G.hns1 | A | 41 | G.hns1.03 |
Hydrophobic | ICL2 | N | 139 | 34x55 | G.hns1 | A | 41 | G.hns1.03 |
Van-der-waals | ICL2 | N | 139 | 34x55 | G.hns1 | A | 41 | G.hns1.03 |
Hydrophobic | ICL3 | F | 224 | - | G.H5 | L | 375 | G.H5.20 |
Van-der-waals | ICL3 | F | 224 | - | G.H5 | L | 375 | G.H5.20 |
Hydrophobic | TM6 | I | 232 | 6x36 | G.H5 | L | 380 | G.H5.25 |
Hydrophobic | C-term | S | 331 | - | G.HN | E | 35 | G.HN.50 |
Hydrophobic | C-term | H | 332 | - | G.HN | A | 38 | G.HN.53 |
Van-der-waals | C-term | H | 332 | - | G.HN | A | 38 | G.HN.53 |
Hydrophobic | TM2 | T | 66 | 2x39 | G.H5 | Y | 378 | G.H5.23 |
Van-der-waals | TM2 | T | 66 | 2x39 | G.H5 | Y | 378 | G.H5.23 |
Hydrophobic | ICL2 | A | 142 | 34x58 | G.HN | L | 37 | G.HN.52 |
Van-der-waals | ICL2 | A | 142 | 34x58 | G.HN | L | 37 | G.HN.52 |
Hydrophobic | ICL2 | A | 134 | 34x50 | G.H5 | Q | 371 | G.H5.16 |
Van-der-waals | ICL2 | A | 134 | 34x50 | G.H5 | Q | 371 | G.H5.16 |
Hydrophobic | ICL3 | F | 224 | - | G.H5 | L | 381 | G.H5.26 |
Van-der-waals | ICL3 | F | 224 | - | G.H5 | L | 381 | G.H5.26 |
Polar | C-term | L | 342 | - | G.S2 | I | 194 | G.S2.01 |
Hydrophobic | C-term | L | 342 | - | G.S2 | I | 194 | G.S2.01 |
Van-der-waals | C-term | L | 342 | - | G.S2 | I | 194 | G.S2.01 |
Hydrophobic | C-term | T | 337 | - | G.h1ha | V | 67 | G.h1ha.01 |
Hydrophobic | C-term | M | 339 | - | G.H1 | R | 63 | G.H1.09 |
Van-der-waals | C-term | M | 339 | - | G.H1 | R | 63 | G.H1.09 |
Polar | TM3 | V | 130 | 3x53 | G.H5 | H | 374 | G.H5.19 |
Hydrophobic | TM3 | V | 130 | 3x53 | G.H5 | H | 374 | G.H5.19 |
Van-der-waals | TM3 | V | 130 | 3x53 | G.H5 | H | 374 | G.H5.19 |
Hydrophobic | TM5 | L | 218 | 5x65 | G.H5 | L | 375 | G.H5.20 |
Van-der-waals | TM5 | L | 218 | 5x65 | G.H5 | L | 375 | G.H5.20 |
Hydrophobic | TM5 | T | 217 | 5x64 | G.H5 | Q | 371 | G.H5.16 |
Polar | TM6 | S | 229 | 6x33 | G.H5 | L | 380 | G.H5.25 |
Hydrophobic | TM6 | S | 229 | 6x33 | G.H5 | L | 380 | G.H5.25 |
Van-der-waals | TM6 | S | 229 | 6x33 | G.H5 | L | 380 | G.H5.25 |
Hydrophobic | ICL2 | Y | 138 | 34x54 | G.hns1 | K | 40 | G.hns1.02 |
Van-der-waals | ICL2 | Y | 138 | 34x54 | G.hns1 | K | 40 | G.hns1.02 |
Polar | ICL3 | G | 222 | - | G.H5 | R | 372 | G.H5.17 |
Van-der-waals | ICL3 | G | 222 | - | G.H5 | R | 372 | G.H5.17 |
Hydrophobic | TM3 | R | 127 | 3x50 | G.H5 | Y | 378 | G.H5.23 |
Hydrophobic | TM6 | I | 232 | 6x36 | G.H5 | E | 379 | G.H5.24 |
Van-der-waals | TM6 | I | 232 | 6x36 | G.H5 | E | 379 | G.H5.24 |
Hydrophobic | TM3 | R | 127 | 3x50 | G.H5 | L | 380 | G.H5.25 |
Hydrophobic | C-term | Q | 341 | - | G.S2 | F | 195 | G.S2.02 |
Van-der-waals | C-term | Q | 341 | - | G.S2 | F | 195 | G.S2.02 |
Ionic | C-term | H | 332 | - | G.HN | E | 35 | G.HN.50 |
Polar | C-term | H | 332 | - | G.HN | E | 35 | G.HN.50 |
Hydrophobic | C-term | H | 332 | - | G.HN | E | 35 | G.HN.50 |
Van-der-waals | C-term | H | 332 | - | G.HN | E | 35 | G.HN.50 |
Aromatic | ICL2 | Y | 138 | 34x54 | G.S1 | H | 43 | G.S1.02 |
Hydrophobic | ICL2 | Y | 138 | 34x54 | G.S1 | H | 43 | G.S1.02 |
Van-der-waals | ICL2 | Y | 138 | 34x54 | G.S1 | H | 43 | G.S1.02 |