G12 -
D1 receptor complex model
GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 81.5
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.8
iPTM Score: 0.7
PAE mean: 13.4
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
Gβ,
Gγ,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Hydrophobic | ICL2 | F | 129 | 34x51 | G.S3 | I | 221 | G.S3.01 |
Van-der-waals | ICL2 | F | 129 | 34x51 | G.S3 | I | 221 | G.S3.01 |
Polar | ICL2 | R | 133 | 34x55 | G.s2s3 | K | 220 | G.s2s3.02 |
Van-der-waals | ICL2 | R | 133 | 34x55 | G.s2s3 | K | 220 | G.s2s3.02 |
Polar | TM5 | Q | 242 | 5x86 | G.H4 | Q | 333 | G.H4.13 |
Hydrophobic | TM5 | Q | 242 | 5x86 | G.H4 | Q | 333 | G.H4.13 |
Ionic | TM2 | K | 57 | 2x37 | G.H5 | D | 377 | G.H5.22 |
Polar | TM2 | K | 57 | 2x37 | G.H5 | D | 377 | G.H5.22 |
Van-der-waals | TM2 | K | 57 | 2x37 | G.H5 | D | 377 | G.H5.22 |
Aromatic | ICL2 | F | 129 | 34x51 | G.H5 | F | 363 | G.H5.08 |
Hydrophobic | ICL2 | F | 129 | 34x51 | G.H5 | F | 363 | G.H5.08 |
Van-der-waals | ICL2 | F | 129 | 34x51 | G.H5 | F | 363 | G.H5.08 |
Hydrophobic | ICL2 | P | 128 | 34x50 | G.H5 | I | 370 | G.H5.15 |
Van-der-waals | ICL2 | P | 128 | 34x50 | G.H5 | I | 370 | G.H5.15 |
Polar | TM5 | Q | 242 | 5x86 | G.hgh4 | R | 318 | G.hgh4.06 |
Hydrophobic | TM5 | Q | 242 | 5x86 | G.hgh4 | R | 318 | G.hgh4.06 |
Van-der-waals | TM5 | Q | 242 | 5x86 | G.hgh4 | R | 318 | G.hgh4.06 |
Hydrophobic | C-term | V | 388 | - | G.S6 | L | 346 | G.S6.01 |
Hydrophobic | TM5 | Q | 224 | 5x68 | G.H5 | L | 371 | G.H5.16 |
Polar | H8 | R | 338 | 8x51 | G.H5 | L | 380 | G.H5.25 |
Van-der-waals | H8 | R | 338 | 8x51 | G.H5 | L | 380 | G.H5.25 |
Hydrophobic | C-term | I | 363 | - | G.H3 | T | 279 | G.H3.11 |
Van-der-waals | C-term | I | 363 | - | G.H3 | T | 279 | G.H3.11 |
Polar | ICL2 | R | 133 | 34x55 | G.hns1 | R | 56 | G.hns1.03 |
Hydrophobic | ICL2 | R | 133 | 34x55 | G.hns1 | R | 56 | G.hns1.03 |
Van-der-waals | ICL2 | R | 133 | 34x55 | G.hns1 | R | 56 | G.hns1.03 |
Ionic | TM5 | R | 227 | 5x71 | G.H5 | D | 368 | G.H5.13 |
Polar | TM5 | R | 227 | 5x71 | G.H5 | D | 368 | G.H5.13 |
Van-der-waals | TM5 | R | 227 | 5x71 | G.H5 | D | 368 | G.H5.13 |
Hydrophobic | ICL2 | P | 128 | 34x50 | G.H5 | L | 371 | G.H5.16 |
Hydrophobic | C-term | V | 388 | - | G.H4 | V | 332 | G.H4.12 |
Ionic | C-term | E | 359 | - | G.H3 | K | 284 | G.H3.16 |
Polar | C-term | E | 359 | - | G.H3 | K | 284 | G.H3.16 |
Hydrophobic | C-term | E | 359 | - | G.H3 | K | 284 | G.H3.16 |
Van-der-waals | C-term | E | 359 | - | G.H3 | K | 284 | G.H3.16 |
Polar | TM5 | Q | 242 | 5x86 | G.H4 | R | 337 | G.H4.17 |
Van-der-waals | TM5 | Q | 242 | 5x86 | G.H4 | R | 337 | G.H4.17 |
Polar | C-term | Y | 389 | - | G.S6 | L | 346 | G.S6.01 |
Hydrophobic | C-term | Y | 389 | - | G.S6 | L | 346 | G.S6.01 |
Van-der-waals | C-term | Y | 389 | - | G.S6 | L | 346 | G.S6.01 |
Hydrophobic | C-term | V | 388 | - | G.S6 | H | 348 | G.S6.03 |
Hydrophobic | TM5 | I | 228 | 5x72 | G.H5 | Q | 372 | G.H5.17 |
Polar | C-term | N | 386 | - | G.h4s6 | R | 342 | G.h4s6.11 |
Hydrophobic | C-term | N | 386 | - | G.h4s6 | R | 342 | G.h4s6.11 |
Van-der-waals | C-term | N | 386 | - | G.h4s6 | R | 342 | G.h4s6.11 |
Polar | C-term | L | 390 | - | G.S6 | H | 348 | G.S6.03 |
Hydrophobic | C-term | L | 390 | - | G.S6 | H | 348 | G.S6.03 |
Van-der-waals | C-term | L | 390 | - | G.S6 | H | 348 | G.S6.03 |
Hydrophobic | TM5 | A | 221 | 5x65 | G.H5 | L | 375 | G.H5.20 |
Van-der-waals | TM5 | A | 221 | 5x65 | G.H5 | L | 375 | G.H5.20 |
Hydrophobic | H8 | N | 334 | 8x47 | G.H5 | L | 380 | G.H5.25 |
Hydrophobic | TM5 | I | 220 | 5x64 | G.H5 | L | 371 | G.H5.16 |
Hydrophobic | TM3 | I | 125 | 3x54 | G.H5 | N | 374 | G.H5.19 |
Polar | ICL1 | S | 56 | 12x52 | G.hns1 | R | 55 | G.hns1.02 |
Hydrophobic | TM7 | F | 333 | 7x55 | G.H5 | L | 380 | G.H5.25 |
Hydrophobic | TM6 | K | 269 | 6x32 | G.H5 | M | 379 | G.H5.24 |
Polar | TM5 | A | 238 | 5x82 | G.H4 | Q | 333 | G.H4.13 |
Hydrophobic | TM5 | A | 238 | 5x82 | G.H4 | Q | 333 | G.H4.13 |
Van-der-waals | TM5 | A | 238 | 5x82 | G.H4 | Q | 333 | G.H4.13 |
Hydrophobic | TM5 | Q | 224 | 5x68 | G.H5 | Q | 372 | G.H5.17 |
Polar | TM6 | K | 269 | 6x32 | G.H5 | Q | 381 | G.H5.26 |
Hydrophobic | TM6 | K | 269 | 6x32 | G.H5 | Q | 381 | G.H5.26 |
Van-der-waals | TM6 | K | 269 | 6x32 | G.H5 | Q | 381 | G.H5.26 |
Hydrophobic | TM5 | K | 239 | 5x83 | G.H4 | Q | 333 | G.H4.13 |
Hydrophobic | C-term | V | 388 | - | G.H4 | D | 336 | G.H4.16 |
Van-der-waals | C-term | V | 388 | - | G.H4 | D | 336 | G.H4.16 |
Hydrophobic | ICL2 | F | 129 | 34x51 | G.S1 | V | 58 | G.S1.02 |
Hydrophobic | TM6 | V | 270 | 6x33 | G.H5 | M | 379 | G.H5.24 |
Van-der-waals | TM6 | V | 270 | 6x33 | G.H5 | M | 379 | G.H5.24 |
Hydrophobic | C-term | C | 385 | - | G.h4s6 | R | 342 | G.h4s6.11 |
Hydrophobic | C-term | I | 358 | - | G.H3 | L | 285 | G.H3.17 |
Hydrophobic | C-term | I | 391 | - | G.H5 | F | 361 | G.H5.06 |
Van-der-waals | C-term | I | 391 | - | G.H5 | F | 361 | G.H5.06 |
Hydrophobic | TM3 | I | 125 | 3x54 | G.H5 | L | 375 | G.H5.20 |
Van-der-waals | TM3 | I | 125 | 3x54 | G.H5 | L | 375 | G.H5.20 |
Hydrophobic | TM3 | I | 125 | 3x54 | G.H5 | I | 378 | G.H5.23 |
Van-der-waals | TM3 | I | 125 | 3x54 | G.H5 | I | 378 | G.H5.23 |
Hydrophobic | C-term | I | 358 | - | G.H3 | K | 284 | G.H3.16 |
Hydrophobic | TM2 | V | 58 | 2x38 | G.hns1 | R | 55 | G.hns1.02 |
Van-der-waals | TM2 | V | 58 | 2x38 | G.hns1 | R | 55 | G.hns1.02 |
Polar | C-term | H | 393 | - | G.S6 | F | 350 | G.S6.05 |
Polar | TM5 | Q | 224 | 5x68 | G.H5 | D | 368 | G.H5.13 |
Hydrophobic | TM5 | Q | 224 | 5x68 | G.H5 | D | 368 | G.H5.13 |
Van-der-waals | TM5 | Q | 224 | 5x68 | G.H5 | D | 368 | G.H5.13 |
Hydrophobic | C-term | H | 393 | - | G.S6 | H | 349 | G.S6.04 |
Polar | C-term | N | 355 | - | G.H3 | K | 284 | G.H3.16 |
Hydrophobic | C-term | Y | 389 | - | G.h4s6 | P | 345 | G.h4s6.20 |
Van-der-waals | C-term | Y | 389 | - | G.h4s6 | P | 345 | G.h4s6.20 |
Hydrophobic | ICL2 | F | 129 | 34x51 | G.H5 | K | 367 | G.H5.12 |
Hydrophobic | TM3 | R | 121 | 3x50 | G.H5 | I | 378 | G.H5.23 |
Van-der-waals | TM3 | R | 121 | 3x50 | G.H5 | I | 378 | G.H5.23 |
Hydrophobic | TM5 | A | 238 | 5x82 | G.H4 | R | 329 | G.H4.09 |
Van-der-waals | TM5 | A | 238 | 5x82 | G.H4 | R | 329 | G.H4.09 |
Polar | C-term | Y | 389 | - | G.S6 | H | 348 | G.S6.03 |
Hydrophobic | C-term | Y | 389 | - | G.S6 | H | 348 | G.S6.03 |
Van-der-waals | C-term | Y | 389 | - | G.S6 | H | 348 | G.S6.03 |
Hydrophobic | C-term | Y | 389 | - | G.S6 | F | 347 | G.S6.02 |
Hydrophobic | C-term | I | 391 | - | G.S6 | F | 347 | G.S6.02 |
Polar | C-term | A | 357 | - | G.H3 | K | 284 | G.H3.16 |
Van-der-waals | C-term | A | 357 | - | G.H3 | K | 284 | G.H3.16 |
Hydrophobic | ICL2 | P | 128 | 34x50 | G.H5 | K | 367 | G.H5.12 |
Polar | C-term | L | 387 | - | G.S6 | L | 346 | G.S6.01 |
Hydrophobic | TM5 | Q | 224 | 5x68 | G.H5 | L | 375 | G.H5.20 |
Polar | C-term | L | 387 | - | G.h4s6 | R | 339 | G.h4s6.08 |
Hydrophobic | ICL2 | E | 132 | 34x54 | G.H5 | I | 370 | G.H5.15 |
Hydrophobic | TM3 | I | 125 | 3x54 | G.H5 | L | 371 | G.H5.16 |
Van-der-waals | TM3 | I | 125 | 3x54 | G.H5 | L | 371 | G.H5.16 |
Hydrophobic | ICL2 | F | 129 | 34x51 | G.H5 | I | 370 | G.H5.15 |
Van-der-waals | ICL2 | F | 129 | 34x51 | G.H5 | I | 370 | G.H5.15 |
Polar | TM3 | A | 124 | 3x53 | G.H5 | N | 374 | G.H5.19 |
Hydrophobic | TM3 | A | 124 | 3x53 | G.H5 | N | 374 | G.H5.19 |
Van-der-waals | TM3 | A | 124 | 3x53 | G.H5 | N | 374 | G.H5.19 |
Hydrophobic | TM7 | I | 330 | 7x52 | G.H5 | L | 380 | G.H5.25 |
Van-der-waals | TM7 | I | 330 | 7x52 | G.H5 | L | 380 | G.H5.25 |
Hydrophobic | TM6 | T | 273 | 6x36 | G.H5 | M | 379 | G.H5.24 |
Van-der-waals | TM6 | T | 273 | 6x36 | G.H5 | M | 379 | G.H5.24 |
Hydrophobic | ICL2 | F | 129 | 34x51 | G.H5 | V | 366 | G.H5.11 |