Golf -
D1 receptor complex model
GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 78.8
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.7
iPTM Score: 0.8
PAE mean: 12.1
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Hydrophobic | ICL2 | F | 129 | 34x51 | G.H5 | R | 367 | G.H5.12 |
Van-der-waals | ICL2 | F | 129 | 34x51 | G.H5 | R | 367 | G.H5.12 |
Hydrophobic | C-term | L | 432 | - | G.S2 | V | 201 | G.S2.08 |
Polar | TM5 | Q | 224 | 5x68 | G.H5 | R | 372 | G.H5.17 |
Hydrophobic | TM5 | Q | 224 | 5x68 | G.H5 | R | 372 | G.H5.17 |
Van-der-waals | TM5 | Q | 224 | 5x68 | G.H5 | R | 372 | G.H5.17 |
Hydrophobic | TM5 | A | 238 | 5x82 | G.H4 | D | 330 | G.H4.13 |
Van-der-waals | TM5 | A | 238 | 5x82 | G.H4 | D | 330 | G.H4.13 |
Polar | TM5 | K | 239 | 5x83 | G.h4s6 | T | 337 | G.h4s6.03 |
Hydrophobic | TM5 | K | 239 | 5x83 | G.h4s6 | T | 337 | G.h4s6.03 |
Van-der-waals | TM5 | K | 239 | 5x83 | G.h4s6 | T | 337 | G.h4s6.03 |
Hydrophobic | TM5 | I | 228 | 5x72 | G.H5 | R | 372 | G.H5.17 |
Van-der-waals | TM5 | I | 228 | 5x72 | G.H5 | R | 372 | G.H5.17 |
Hydrophobic | ICL1 | S | 56 | 12x52 | G.HN | R | 36 | G.HN.51 |
Van-der-waals | ICL1 | S | 56 | 12x52 | G.HN | R | 36 | G.HN.51 |
Aromatic | ICL2 | F | 129 | 34x51 | G.H5 | F | 363 | G.H5.08 |
Hydrophobic | ICL2 | F | 129 | 34x51 | G.H5 | F | 363 | G.H5.08 |
Van-der-waals | ICL2 | F | 129 | 34x51 | G.H5 | F | 363 | G.H5.08 |
Ionic | H8 | R | 338 | 8x51 | G.H5 | E | 379 | G.H5.24 |
Polar | H8 | R | 338 | 8x51 | G.H5 | E | 379 | G.H5.24 |
Hydrophobic | ICL2 | P | 128 | 34x50 | G.H5 | R | 367 | G.H5.12 |
Hydrophobic | TM5 | Q | 224 | 5x68 | G.H5 | L | 375 | G.H5.20 |
Van-der-waals | TM5 | Q | 224 | 5x68 | G.H5 | L | 375 | G.H5.20 |
Polar | ICL1 | S | 56 | 12x52 | G.hns1 | K | 40 | G.hns1.02 |
Van-der-waals | ICL1 | S | 56 | 12x52 | G.hns1 | K | 40 | G.hns1.02 |
Polar | TM5 | A | 238 | 5x82 | G.H4 | R | 334 | G.H4.17 |
Hydrophobic | TM5 | A | 238 | 5x82 | G.H4 | R | 334 | G.H4.17 |
Van-der-waals | TM5 | A | 238 | 5x82 | G.H4 | R | 334 | G.H4.17 |
Polar | TM6 | T | 273 | 6x36 | G.H5 | E | 379 | G.H5.24 |
Hydrophobic | TM6 | T | 273 | 6x36 | G.H5 | E | 379 | G.H5.24 |
Van-der-waals | TM6 | T | 273 | 6x36 | G.H5 | E | 379 | G.H5.24 |
Polar | TM5 | Q | 242 | 5x86 | G.H4 | R | 334 | G.H4.17 |
Hydrophobic | TM5 | Q | 242 | 5x86 | G.H4 | R | 334 | G.H4.17 |
Van-der-waals | TM5 | Q | 242 | 5x86 | G.H4 | R | 334 | G.H4.17 |
Hydrophobic | C-term | I | 435 | - | G.H1 | H | 66 | G.H1.12 |
Van-der-waals | C-term | I | 435 | - | G.H1 | H | 66 | G.H1.12 |
Polar | TM5 | Q | 242 | 5x86 | G.hgh4 | E | 301 | G.hgh4.04 |
Hydrophobic | TM5 | Q | 242 | 5x86 | G.hgh4 | E | 301 | G.hgh4.04 |
Hydrophobic | TM5 | A | 221 | 5x65 | G.H5 | L | 375 | G.H5.20 |
Hydrophobic | ICL2 | F | 129 | 34x51 | G.H5 | I | 370 | G.H5.15 |
Van-der-waals | ICL2 | F | 129 | 34x51 | G.H5 | I | 370 | G.H5.15 |
Ionic | C-term | D | 429 | - | G.H5 | R | 360 | G.H5.05 |
Polar | C-term | D | 429 | - | G.H5 | R | 360 | G.H5.05 |
Van-der-waals | C-term | D | 429 | - | G.H5 | R | 360 | G.H5.05 |
Hydrophobic | TM4 | P | 137 | 4x39 | G.HN | L | 37 | G.HN.52 |
Hydrophobic | TM5 | I | 220 | 5x64 | G.H5 | Q | 371 | G.H5.16 |
Van-der-waals | TM5 | I | 220 | 5x64 | G.H5 | Q | 371 | G.H5.16 |
Hydrophobic | TM6 | T | 273 | 6x36 | G.H5 | L | 380 | G.H5.25 |
Van-der-waals | TM6 | T | 273 | 6x36 | G.H5 | L | 380 | G.H5.25 |
Polar | ICL2 | R | 133 | 34x55 | G.s2s3 | K | 203 | G.s2s3.02 |
Hydrophobic | ICL2 | R | 133 | 34x55 | G.s2s3 | K | 203 | G.s2s3.02 |
Van-der-waals | ICL2 | R | 133 | 34x55 | G.s2s3 | K | 203 | G.s2s3.02 |
Hydrophobic | TM5 | I | 217 | 5x61 | G.H5 | L | 380 | G.H5.25 |
Van-der-waals | TM5 | I | 217 | 5x61 | G.H5 | L | 380 | G.H5.25 |
Ionic | ICL2 | E | 132 | 34x54 | G.S1 | H | 43 | G.S1.02 |
Polar | ICL2 | E | 132 | 34x54 | G.S1 | H | 43 | G.S1.02 |
Hydrophobic | ICL2 | E | 132 | 34x54 | G.S1 | H | 43 | G.S1.02 |
Van-der-waals | ICL2 | E | 132 | 34x54 | G.S1 | H | 43 | G.S1.02 |
Polar | TM5 | Q | 224 | 5x68 | G.H5 | D | 368 | G.H5.13 |
Hydrophobic | TM5 | Q | 224 | 5x68 | G.H5 | D | 368 | G.H5.13 |
Van-der-waals | TM5 | Q | 224 | 5x68 | G.H5 | D | 368 | G.H5.13 |
Hydrophobic | TM3 | A | 124 | 3x53 | G.H5 | Y | 378 | G.H5.23 |
Hydrophobic | TM5 | L | 231 | 5x75 | G.S6 | Y | 347 | G.S6.02 |
Hydrophobic | TM3 | I | 125 | 3x54 | G.H5 | L | 380 | G.H5.25 |
Polar | TM6 | K | 269 | 6x32 | G.H5 | L | 381 | G.H5.26 |
Hydrophobic | TM6 | K | 269 | 6x32 | G.H5 | L | 381 | G.H5.26 |
Van-der-waals | TM6 | K | 269 | 6x32 | G.H5 | L | 381 | G.H5.26 |
Hydrophobic | TM6 | L | 274 | 6x37 | G.H5 | L | 380 | G.H5.25 |
Van-der-waals | TM6 | L | 274 | 6x37 | G.H5 | L | 380 | G.H5.25 |
Polar | TM2 | T | 59 | 2x39 | G.H5 | Y | 378 | G.H5.23 |
Hydrophobic | C-term | V | 430 | - | G.s2s3 | D | 202 | G.s2s3.01 |
Hydrophobic | C-term | I | 358 | - | G.H3 | R | 267 | G.H3.16 |
Van-der-waals | C-term | I | 358 | - | G.H3 | R | 267 | G.H3.16 |
Polar | TM5 | Q | 224 | 5x68 | G.H5 | Q | 371 | G.H5.16 |
Hydrophobic | TM5 | Q | 224 | 5x68 | G.H5 | Q | 371 | G.H5.16 |
Van-der-waals | TM5 | Q | 224 | 5x68 | G.H5 | Q | 371 | G.H5.16 |
Hydrophobic | C-term | P | 437 | - | G.h1ha | N | 68 | G.h1ha.02 |
Hydrophobic | TM3 | I | 125 | 3x54 | G.H5 | Y | 378 | G.H5.23 |
Aromatic | ICL2 | F | 129 | 34x51 | G.S1 | H | 43 | G.S1.02 |
Hydrophobic | ICL2 | F | 129 | 34x51 | G.S1 | H | 43 | G.S1.02 |
Van-der-waals | ICL2 | F | 129 | 34x51 | G.S1 | H | 43 | G.S1.02 |
Polar | H8 | A | 335 | 8x48 | G.H5 | E | 379 | G.H5.24 |
Ionic | TM5 | R | 227 | 5x71 | G.H5 | D | 368 | G.H5.13 |
Polar | TM5 | R | 227 | 5x71 | G.H5 | D | 368 | G.H5.13 |
Van-der-waals | TM5 | R | 227 | 5x71 | G.H5 | D | 368 | G.H5.13 |
Polar | TM5 | H | 237 | 5x81 | G.hgh4 | T | 306 | G.hgh4.09 |
Van-der-waals | TM5 | H | 237 | 5x81 | G.hgh4 | T | 306 | G.hgh4.09 |
Ionic | TM5 | H | 237 | 5x81 | G.H4 | D | 330 | G.H4.13 |
Hydrophobic | TM5 | I | 225 | 5x69 | G.H5 | L | 381 | G.H5.26 |
Van-der-waals | TM5 | I | 225 | 5x69 | G.H5 | L | 381 | G.H5.26 |
Ionic | ICL2 | E | 132 | 34x54 | G.H5 | H | 374 | G.H5.19 |
Hydrophobic | C-term | L | 432 | - | G.s2s3 | D | 202 | G.s2s3.01 |
Van-der-waals | C-term | L | 432 | - | G.s2s3 | D | 202 | G.s2s3.01 |
Hydrophobic | TM3 | I | 125 | 3x54 | G.H5 | H | 374 | G.H5.19 |
Hydrophobic | TM5 | I | 228 | 5x72 | G.H5 | L | 381 | G.H5.26 |
Hydrophobic | ICL2 | F | 129 | 34x51 | G.S3 | F | 206 | G.S3.03 |
Hydrophobic | C-term | L | 432 | - | G.H5 | R | 360 | G.H5.05 |
Hydrophobic | TM5 | A | 234 | 5x78 | G.H4 | R | 329 | G.H4.12 |
Hydrophobic | TM6 | V | 270 | 6x33 | G.H5 | L | 380 | G.H5.25 |
Van-der-waals | TM6 | V | 270 | 6x33 | G.H5 | L | 380 | G.H5.25 |
Hydrophobic | ICL2 | F | 129 | 34x51 | G.S3 | V | 204 | G.S3.01 |
Van-der-waals | ICL2 | F | 129 | 34x51 | G.S3 | V | 204 | G.S3.01 |
Hydrophobic | TM5 | A | 234 | 5x78 | G.H4 | L | 333 | G.H4.16 |
Polar | TM5 | C | 241 | 5x85 | G.hgh4 | T | 306 | G.hgh4.09 |
Hydrophobic | ICL2 | F | 129 | 34x51 | G.H5 | C | 366 | G.H5.11 |
Hydrophobic | TM5 | L | 231 | 5x75 | G.S6 | P | 348 | G.S6.03 |
Hydrophobic | TM5 | A | 235 | 5x79 | G.h4s6 | T | 337 | G.h4s6.03 |
Van-der-waals | TM5 | A | 235 | 5x79 | G.h4s6 | T | 337 | G.h4s6.03 |
Hydrophobic | TM5 | A | 235 | 5x79 | G.H4 | L | 333 | G.H4.16 |
Ionic | TM5 | R | 233 | 5x77 | G.hgh4 | D | 310 | G.hgh4.13 |
Polar | TM3 | I | 125 | 3x54 | G.H5 | Q | 371 | G.H5.16 |
Hydrophobic | TM3 | I | 125 | 3x54 | G.H5 | Q | 371 | G.H5.16 |
Van-der-waals | TM3 | I | 125 | 3x54 | G.H5 | Q | 371 | G.H5.16 |
Aromatic | TM3 | R | 121 | 3x50 | G.H5 | Y | 378 | G.H5.23 |
Hydrophobic | TM3 | R | 121 | 3x50 | G.H5 | Y | 378 | G.H5.23 |
Polar | TM5 | H | 237 | 5x81 | G.hgh4 | P | 308 | G.hgh4.11 |
Hydrophobic | TM5 | H | 237 | 5x81 | G.hgh4 | P | 308 | G.hgh4.11 |
Van-der-waals | TM5 | H | 237 | 5x81 | G.hgh4 | P | 308 | G.hgh4.11 |
Hydrophobic | TM5 | I | 228 | 5x72 | G.h4s6 | Y | 345 | G.h4s6.20 |
Van-der-waals | TM5 | I | 228 | 5x72 | G.h4s6 | Y | 345 | G.h4s6.20 |
Hydrophobic | TM3 | I | 125 | 3x54 | G.H5 | L | 375 | G.H5.20 |
Polar | TM3 | A | 124 | 3x53 | G.H5 | H | 374 | G.H5.19 |
Hydrophobic | TM3 | A | 124 | 3x53 | G.H5 | H | 374 | G.H5.19 |
Van-der-waals | TM3 | A | 124 | 3x53 | G.H5 | H | 374 | G.H5.19 |
Hydrophobic | ICL2 | P | 128 | 34x50 | G.H5 | H | 374 | G.H5.19 |
Hydrophobic | TM5 | K | 239 | 5x83 | G.H4 | R | 334 | G.H4.17 |
Hydrophobic | ICL2 | P | 128 | 34x50 | G.H5 | I | 370 | G.H5.15 |
Van-der-waals | ICL2 | P | 128 | 34x50 | G.H5 | I | 370 | G.H5.15 |
Hydrophobic | TM5 | K | 239 | 5x83 | G.h4s6 | A | 338 | G.h4s6.04 |
Hydrophobic | TM5 | C | 241 | 5x85 | G.hgh4 | Y | 305 | G.hgh4.08 |
Hydrophobic | C-term | I | 358 | - | G.H3 | W | 268 | G.H3.17 |
Polar | ICL3 | T | 244 | - | G.hgh4 | N | 304 | G.hgh4.07 |
Hydrophobic | ICL3 | T | 244 | - | G.hgh4 | N | 304 | G.hgh4.07 |
Polar | ICL2 | R | 133 | 34x55 | G.s2s3 | D | 202 | G.s2s3.01 |
Hydrophobic | TM4 | T | 136 | 4x38 | G.HN | L | 37 | G.HN.52 |
Hydrophobic | TM5 | H | 237 | 5x81 | G.hgh4 | V | 307 | G.hgh4.10 |
Ionic | TM6 | K | 269 | 6x32 | G.H5 | E | 379 | G.H5.24 |
Polar | TM6 | K | 269 | 6x32 | G.H5 | E | 379 | G.H5.24 |