G13 -
D5 receptor complex model
GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 80.1
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.8
iPTM Score: 0.8
PAE mean: 13.8
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
Gβ,
Gγ,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Hydrophobic | TM5 | I | 259 | 5x72 | G.h4s6 | P | 341 | G.h4s6.20 |
Hydrophobic | TM3 | I | 142 | 3x54 | G.H5 | L | 371 | G.H5.20 |
Hydrophobic | ICL2 | F | 146 | 34x51 | G.H5 | V | 362 | G.H5.11 |
Polar | TM3 | A | 141 | 3x53 | G.H5 | N | 370 | G.H5.19 |
Hydrophobic | TM3 | A | 141 | 3x53 | G.H5 | N | 370 | G.H5.19 |
Van-der-waals | TM3 | A | 141 | 3x53 | G.H5 | N | 370 | G.H5.19 |
Polar | TM3 | R | 138 | 3x50 | G.H5 | L | 374 | G.H5.23 |
Hydrophobic | TM3 | R | 138 | 3x50 | G.H5 | L | 374 | G.H5.23 |
Van-der-waals | TM3 | R | 138 | 3x50 | G.H5 | L | 374 | G.H5.23 |
Hydrophobic | TM5 | I | 259 | 5x72 | G.H5 | H | 368 | G.H5.17 |
Van-der-waals | TM5 | I | 259 | 5x72 | G.H5 | H | 368 | G.H5.17 |
Hydrophobic | TM5 | A | 269 | 5x82 | G.H4 | K | 324 | G.H4.09 |
Polar | TM5 | A | 265 | 5x78 | G.H4 | R | 331 | G.H4.16 |
Hydrophobic | TM5 | A | 265 | 5x78 | G.H4 | R | 331 | G.H4.16 |
Van-der-waals | TM5 | A | 265 | 5x78 | G.H4 | R | 331 | G.H4.16 |
Hydrophobic | TM7 | F | 361 | 7x55 | G.H5 | L | 376 | G.H5.25 |
Polar | C-term | Y | 396 | - | G.h4s6 | R | 335 | G.h4s6.09 |
Hydrophobic | C-term | Y | 396 | - | G.h4s6 | R | 335 | G.h4s6.09 |
Van-der-waals | C-term | Y | 396 | - | G.h4s6 | R | 335 | G.h4s6.09 |
Hydrophobic | TM5 | A | 252 | 5x65 | G.H5 | L | 371 | G.H5.20 |
Ionic | TM5 | R | 258 | 5x71 | G.H5 | D | 364 | G.H5.13 |
Polar | TM5 | R | 258 | 5x71 | G.H5 | D | 364 | G.H5.13 |
Hydrophobic | TM5 | R | 258 | 5x71 | G.H5 | D | 364 | G.H5.13 |
Van-der-waals | TM5 | R | 258 | 5x71 | G.H5 | D | 364 | G.H5.13 |
Hydrophobic | C-term | V | 387 | - | G.H3 | R | 279 | G.H3.16 |
Van-der-waals | C-term | V | 387 | - | G.H3 | R | 279 | G.H3.16 |
Hydrophobic | C-term | I | 389 | - | G.H2 | E | 235 | G.H2.09 |
Van-der-waals | C-term | I | 389 | - | G.H2 | E | 235 | G.H2.09 |
Hydrophobic | ICL2 | F | 146 | 34x51 | G.S3 | V | 216 | G.S3.01 |
Van-der-waals | ICL2 | F | 146 | 34x51 | G.S3 | V | 216 | G.S3.01 |
Polar | ICL1 | A | 73 | 12x52 | G.hns1 | K | 46 | G.hns1.02 |
Polar | TM5 | Q | 255 | 5x68 | G.H5 | D | 364 | G.H5.13 |
Hydrophobic | TM5 | Q | 255 | 5x68 | G.H5 | D | 364 | G.H5.13 |
Van-der-waals | TM5 | Q | 255 | 5x68 | G.H5 | D | 364 | G.H5.13 |
Hydrophobic | TM5 | Q | 255 | 5x68 | G.H5 | L | 367 | G.H5.16 |
Van-der-waals | TM5 | Q | 255 | 5x68 | G.H5 | L | 367 | G.H5.16 |
Polar | TM6 | K | 293 | 6x32 | G.H5 | Q | 377 | G.H5.26 |
Hydrophobic | TM6 | K | 293 | 6x32 | G.H5 | Q | 377 | G.H5.26 |
Van-der-waals | TM6 | K | 293 | 6x32 | G.H5 | Q | 377 | G.H5.26 |
Polar | C-term | N | 388 | - | G.H3 | R | 279 | G.H3.16 |
Van-der-waals | C-term | N | 388 | - | G.H3 | R | 279 | G.H3.16 |
Aromatic | ICL2 | F | 146 | 34x51 | G.H5 | F | 359 | G.H5.08 |
Hydrophobic | ICL2 | F | 146 | 34x51 | G.H5 | F | 359 | G.H5.08 |
Van-der-waals | ICL2 | F | 146 | 34x51 | G.H5 | F | 359 | G.H5.08 |
Hydrophobic | H8 | A | 363 | 8x48 | G.H5 | Q | 377 | G.H5.26 |
Hydrophobic | TM5 | A | 269 | 5x82 | G.H4 | E | 328 | G.H4.13 |
Van-der-waals | TM5 | A | 269 | 5x82 | G.H4 | E | 328 | G.H4.13 |
Hydrophobic | TM3 | I | 142 | 3x54 | G.H5 | L | 374 | G.H5.23 |
Hydrophobic | ICL2 | K | 149 | 34x54 | G.hns1 | R | 47 | G.hns1.03 |
Polar | TM5 | L | 262 | 5x75 | G.H4 | R | 331 | G.H4.16 |
Ionic | C-term | E | 392 | - | G.H3 | R | 279 | G.H3.16 |
Polar | C-term | E | 392 | - | G.H3 | R | 279 | G.H3.16 |
Hydrophobic | C-term | E | 392 | - | G.H3 | R | 279 | G.H3.16 |
Van-der-waals | C-term | E | 392 | - | G.H3 | R | 279 | G.H3.16 |
Hydrophobic | TM3 | I | 142 | 3x54 | G.H5 | L | 367 | G.H5.16 |
Van-der-waals | TM3 | I | 142 | 3x54 | G.H5 | L | 367 | G.H5.16 |
Ionic | TM5 | R | 273 | 5x86 | G.hgh4 | E | 311 | G.hgh4.04 |
Polar | TM5 | R | 273 | 5x86 | G.hgh4 | E | 311 | G.hgh4.04 |
Hydrophobic | TM5 | R | 273 | 5x86 | G.hgh4 | E | 311 | G.hgh4.04 |
Van-der-waals | TM5 | R | 273 | 5x86 | G.hgh4 | E | 311 | G.hgh4.04 |
Polar | TM2 | N | 74 | 2x37 | G.H5 | Q | 373 | G.H5.22 |
Van-der-waals | TM2 | N | 74 | 2x37 | G.H5 | Q | 373 | G.H5.22 |
Hydrophobic | ICL2 | R | 150 | 34x55 | G.hns1 | R | 47 | G.hns1.03 |
Hydrophobic | TM5 | Q | 255 | 5x68 | G.H5 | L | 371 | G.H5.20 |
Polar | TM5 | Q | 270 | 5x83 | G.H4 | N | 332 | G.H4.17 |
Van-der-waals | TM5 | Q | 270 | 5x83 | G.H4 | N | 332 | G.H4.17 |
Hydrophobic | TM6 | T | 297 | 6x36 | G.H5 | M | 375 | G.H5.24 |
Van-der-waals | TM6 | T | 297 | 6x36 | G.H5 | M | 375 | G.H5.24 |
Ionic | TM5 | R | 258 | 5x71 | G.H5 | D | 361 | G.H5.10 |
Polar | TM5 | R | 258 | 5x71 | G.H5 | D | 361 | G.H5.10 |
Hydrophobic | TM5 | I | 251 | 5x64 | G.H5 | L | 367 | G.H5.16 |
Hydrophobic | H8 | N | 362 | 8x47 | G.H5 | L | 376 | G.H5.25 |
Hydrophobic | ICL2 | F | 146 | 34x51 | G.H5 | I | 366 | G.H5.15 |
Van-der-waals | ICL2 | F | 146 | 34x51 | G.H5 | I | 366 | G.H5.15 |
Polar | C-term | Y | 396 | - | G.H3 | E | 273 | G.H3.10 |
Hydrophobic | C-term | Y | 396 | - | G.H3 | E | 273 | G.H3.10 |
Van-der-waals | C-term | Y | 396 | - | G.H3 | E | 273 | G.H3.10 |
Hydrophobic | TM3 | I | 142 | 3x54 | G.H5 | N | 370 | G.H5.19 |
Hydrophobic | C-term | L | 393 | - | G.H2 | K | 231 | G.H2.05 |
Hydrophobic | TM5 | A | 266 | 5x79 | G.H4 | R | 331 | G.H4.16 |
Van-der-waals | TM5 | A | 266 | 5x79 | G.H4 | R | 331 | G.H4.16 |
Hydrophobic | ICL2 | P | 145 | 34x50 | G.H5 | K | 363 | G.H5.12 |
Hydrophobic | TM6 | K | 293 | 6x32 | G.H5 | M | 375 | G.H5.24 |
Van-der-waals | TM6 | K | 293 | 6x32 | G.H5 | M | 375 | G.H5.24 |
Hydrophobic | ICL2 | F | 146 | 34x51 | G.H5 | K | 363 | G.H5.12 |
Hydrophobic | ICL2 | K | 149 | 34x54 | G.H5 | I | 366 | G.H5.15 |
Hydrophobic | TM5 | R | 258 | 5x71 | G.H5 | R | 360 | G.H5.09 |
Van-der-waals | TM5 | R | 258 | 5x71 | G.H5 | R | 360 | G.H5.09 |
Hydrophobic | TM6 | V | 294 | 6x33 | G.H5 | M | 375 | G.H5.24 |
Van-der-waals | TM6 | V | 294 | 6x33 | G.H5 | M | 375 | G.H5.24 |
Polar | C-term | I | 389 | - | G.H2 | K | 231 | G.H2.05 |
Hydrophobic | C-term | I | 389 | - | G.H2 | K | 231 | G.H2.05 |
Van-der-waals | C-term | I | 389 | - | G.H2 | K | 231 | G.H2.05 |
Hydrophobic | ICL2 | P | 145 | 34x50 | G.H5 | I | 366 | G.H5.15 |
Van-der-waals | ICL2 | P | 145 | 34x50 | G.H5 | I | 366 | G.H5.15 |
Hydrophobic | TM6 | L | 298 | 6x37 | G.H5 | L | 374 | G.H5.23 |
Hydrophobic | TM5 | I | 248 | 5x61 | G.H5 | L | 374 | G.H5.23 |
Van-der-waals | TM5 | I | 248 | 5x61 | G.H5 | L | 374 | G.H5.23 |
Hydrophobic | TM5 | L | 262 | 5x75 | G.S6 | H | 344 | G.S6.03 |
Van-der-waals | TM5 | L | 262 | 5x75 | G.S6 | H | 344 | G.S6.03 |
Hydrophobic | TM7 | I | 358 | 7x52 | G.H5 | L | 376 | G.H5.25 |
Van-der-waals | TM7 | I | 358 | 7x52 | G.H5 | L | 376 | G.H5.25 |
Hydrophobic | ICL2 | F | 146 | 34x51 | G.S1 | V | 49 | G.S1.02 |
Hydrophobic | TM7 | Y | 359 | 7x53 | G.H5 | L | 376 | G.H5.25 |
Polar | ICL2 | R | 150 | 34x55 | G.s2s3 | N | 215 | G.s2s3.02 |
Hydrophobic | ICL2 | R | 150 | 34x55 | G.s2s3 | N | 215 | G.s2s3.02 |
Van-der-waals | ICL2 | R | 150 | 34x55 | G.s2s3 | N | 215 | G.s2s3.02 |
Polar | TM5 | Q | 270 | 5x83 | G.H4 | E | 328 | G.H4.13 |
Van-der-waals | TM5 | Q | 270 | 5x83 | G.H4 | E | 328 | G.H4.13 |