Gi1 - D5 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 75.7

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 12.7


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic C-term L 393 - G.h2s4 F 215 G.h2s4.01
Ionic ICL2 R 150 34x55 G.s2s3 D 193 G.s2s3.02
Polar ICL2 R 150 34x55 G.s2s3 D 193 G.s2s3.02
Hydrophobic ICL2 R 150 34x55 G.s2s3 D 193 G.s2s3.02
Van-der-waals ICL2 R 150 34x55 G.s2s3 D 193 G.s2s3.02
Polar TM6 T 297 6x36 G.H5 G 352 G.H5.24
Hydrophobic TM6 T 297 6x36 G.H5 G 352 G.H5.24
Van-der-waals TM6 T 297 6x36 G.H5 G 352 G.H5.24
Ionic TM6 K 290 6x29 G.h4s6 E 318 G.h4s6.12
Hydrophobic C-term V 387 - G.H3 K 257 G.H3.16
Polar TM5 R 273 5x86 G.hgh4 S 293 G.hgh4.08
Hydrophobic TM5 R 273 5x86 G.hgh4 S 293 G.hgh4.08
Van-der-waals TM5 R 273 5x86 G.hgh4 S 293 G.hgh4.08
Hydrophobic ICL2 F 146 34x51 G.H5 F 336 G.H5.08
Van-der-waals ICL2 F 146 34x51 G.H5 F 336 G.H5.08
Hydrophobic C-term I 400 - G.s4h3 D 237 G.s4h3.11
Hydrophobic C-term L 393 - G.H2 I 212 G.H2.08
Hydrophobic TM5 Q 255 5x68 G.H5 I 344 G.H5.16
Hydrophobic ICL2 P 145 34x50 G.H5 I 344 G.H5.16
Hydrophobic TM5 I 259 5x72 G.h4s6 E 318 G.h4s6.12
Van-der-waals TM5 I 259 5x72 G.h4s6 E 318 G.h4s6.12
Hydrophobic TM5 A 266 5x79 G.H4 A 301 G.H4.08
Polar ICL2 R 150 34x55 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 R 150 34x55 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 R 150 34x55 G.hns1 R 32 G.hns1.03
Hydrophobic ICL1 R 69 12x48 G.HN L 23 G.HN.47
Van-der-waals ICL1 R 69 12x48 G.HN L 23 G.HN.47
Hydrophobic C-term I 389 - G.h2s4 F 215 G.h2s4.01
Hydrophobic TM4 T 153 4x38 G.HN E 28 G.HN.52
Hydrophobic ICL2 F 146 34x51 G.H5 T 340 G.H5.12
Van-der-waals ICL2 F 146 34x51 G.H5 T 340 G.H5.12
Hydrophobic TM5 A 252 5x65 G.H5 L 348 G.H5.20
Hydrophobic TM5 R 258 5x71 G.H5 D 337 G.H5.09
Hydrophobic TM6 L 298 6x37 G.H5 L 353 G.H5.25
Van-der-waals TM6 L 298 6x37 G.H5 L 353 G.H5.25
Hydrophobic TM3 I 142 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 I 142 3x54 G.H5 L 348 G.H5.20
Hydrophobic TM5 I 248 5x61 G.H5 L 353 G.H5.25
Van-der-waals TM5 I 248 5x61 G.H5 L 353 G.H5.25
Hydrophobic TM5 I 251 5x64 G.H5 I 344 G.H5.16
Polar ICL2 K 149 34x54 G.hns1 A 31 G.hns1.02
Hydrophobic ICL2 K 149 34x54 G.hns1 A 31 G.hns1.02
Van-der-waals ICL2 K 149 34x54 G.hns1 A 31 G.hns1.02
Polar TM5 Q 255 5x68 G.H5 D 341 G.H5.13
Hydrophobic TM5 Q 255 5x68 G.H5 D 341 G.H5.13
Van-der-waals TM5 Q 255 5x68 G.H5 D 341 G.H5.13
Polar TM5 Q 270 5x83 G.H4 Y 302 G.H4.10
Hydrophobic TM5 Q 270 5x83 G.H4 Y 302 G.H4.10
Van-der-waals TM5 Q 270 5x83 G.H4 Y 302 G.H4.10
Hydrophobic C-term S 390 - G.H2 I 212 G.H2.08
Polar TM6 K 293 6x32 G.H5 F 354 G.H5.26
Hydrophobic TM6 K 293 6x32 G.H5 F 354 G.H5.26
Van-der-waals TM6 K 293 6x32 G.H5 F 354 G.H5.26
Polar TM4 Q 154 4x39 G.HN E 28 G.HN.52
Van-der-waals TM4 Q 154 4x39 G.HN E 28 G.HN.52
Hydrophobic TM3 I 142 3x54 G.H5 I 344 G.H5.16
Hydrophobic ICL2 K 149 34x54 G.H5 I 343 G.H5.15
Hydrophobic TM3 R 138 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 R 138 3x50 G.H5 C 351 G.H5.23
Polar ICL1 R 69 12x48 G.HN S 16 G.HN.40
Van-der-waals ICL1 R 69 12x48 G.HN S 16 G.HN.40
Polar TM4 Q 154 4x39 G.HN R 24 G.HN.48
Hydrophobic TM4 Q 154 4x39 G.HN R 24 G.HN.48
Van-der-waals TM4 Q 154 4x39 G.HN R 24 G.HN.48
Hydrophobic TM5 A 269 5x82 G.H4 A 301 G.H4.08
Van-der-waals TM5 A 269 5x82 G.H4 A 301 G.H4.08
Ionic ICL1 R 72 12x51 G.HN D 20 G.HN.44
Polar ICL1 R 72 12x51 G.HN D 20 G.HN.44
Hydrophobic ICL1 R 72 12x51 G.HN D 20 G.HN.44
Van-der-waals ICL1 R 72 12x51 G.HN D 20 G.HN.44
Hydrophobic C-term L 393 - G.H2 W 211 G.H2.07
Hydrophobic ICL2 F 146 34x51 G.S3 L 194 G.S3.01
Van-der-waals ICL2 F 146 34x51 G.S3 L 194 G.S3.01
Hydrophobic C-term I 389 - G.H3 W 258 G.H3.17
Van-der-waals C-term I 389 - G.H3 W 258 G.H3.17
Polar TM3 A 141 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 A 141 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 A 141 3x53 G.H5 N 347 G.H5.19
Hydrophobic ICL2 F 146 34x51 G.s2s3 K 192 G.s2s3.01
Van-der-waals ICL2 F 146 34x51 G.s2s3 K 192 G.s2s3.01
Hydrophobic ICL2 F 146 34x51 G.H5 I 343 G.H5.15
Van-der-waals ICL2 F 146 34x51 G.H5 I 343 G.H5.15
Hydrophobic TM5 I 259 5x72 G.S6 Y 320 G.S6.02
Polar TM5 Q 270 5x83 G.H4 C 305 G.H4.13
Hydrophobic TM5 Q 270 5x83 G.H4 C 305 G.H4.13
Van-der-waals TM5 Q 270 5x83 G.H4 C 305 G.H4.13
Ionic TM5 R 258 5x71 G.H5 D 341 G.H5.13
Polar TM5 R 258 5x71 G.H5 D 341 G.H5.13
Hydrophobic TM5 R 258 5x71 G.H5 D 341 G.H5.13
Van-der-waals TM5 R 258 5x71 G.H5 D 341 G.H5.13
Hydrophobic TM3 I 142 3x54 G.H5 L 353 G.H5.25
Hydrophobic C-term I 411 - G.hfs2 T 182 G.hfs2.06
Hydrophobic TM6 V 294 6x33 G.H5 L 353 G.H5.25
Van-der-waals TM6 V 294 6x33 G.H5 L 353 G.H5.25
Hydrophobic ICL2 K 149 34x54 G.S3 L 194 G.S3.01
Hydrophobic TM3 I 142 3x54 G.H5 C 351 G.H5.23
Polar ICL2 K 149 34x54 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 K 149 34x54 G.hns1 R 32 G.hns1.03
Polar TM5 L 262 5x75 G.H4 Q 304 G.H4.12
Van-der-waals TM5 L 262 5x75 G.H4 Q 304 G.H4.12
Hydrophobic C-term M 414 - H.HA Y 69 H.HA.07
Van-der-waals C-term M 414 - H.HA Y 69 H.HA.07
Ionic C-term E 385 - G.H3 K 257 G.H3.16
Polar C-term E 385 - G.H3 K 257 G.H3.16
Van-der-waals C-term E 385 - G.H3 K 257 G.H3.16
Hydrophobic ICL2 P 145 34x50 G.H5 I 343 G.H5.15
Van-der-waals ICL2 P 145 34x50 G.H5 I 343 G.H5.15
Hydrophobic TM5 A 266 5x79 G.H4 Q 304 G.H4.12
Van-der-waals TM5 A 266 5x79 G.H4 Q 304 G.H4.12
Ionic ICL1 R 69 12x48 G.HN D 20 G.HN.44
Polar ICL1 R 69 12x48 G.HN D 20 G.HN.44
Van-der-waals ICL1 R 69 12x48 G.HN D 20 G.HN.44
Hydrophobic C-term H 412 - G.hfs2 V 179 G.hfs2.03
Van-der-waals C-term H 412 - G.hfs2 V 179 G.hfs2.03
Van-der-waals TM4 T 153 4x38 G.hns1 R 32 G.hns1.03
Polar TM5 R 273 5x86 G.hgh4 G 292 G.hgh4.07
Hydrophobic TM5 R 273 5x86 G.hgh4 G 292 G.hgh4.07
Van-der-waals TM5 R 273 5x86 G.hgh4 G 292 G.hgh4.07
Hydrophobic TM3 I 142 3x54 G.H5 N 347 G.H5.19
Polar TM5 A 266 5x79 G.H4 C 305 G.H4.13
Hydrophobic TM5 A 266 5x79 G.H4 C 305 G.H4.13
Van-der-waals TM5 A 266 5x79 G.H4 C 305 G.H4.13
Hydrophobic TM5 I 259 5x72 G.H5 F 354 G.H5.26
Hydrophobic TM2 M 75 2x38 G.HN R 24 G.HN.48
Polar TM5 R 273 5x86 G.hgh4 A 291 G.hgh4.06
Hydrophobic TM5 R 273 5x86 G.hgh4 A 291 G.hgh4.06
Van-der-waals TM5 R 273 5x86 G.hgh4 A 291 G.hgh4.06
Hydrophobic C-term M 414 - G.hfs2 V 179 G.hfs2.03
Van-der-waals C-term M 414 - G.hfs2 V 179 G.hfs2.03
Hydrophobic TM5 I 256 5x69 G.H5 F 354 G.H5.26
Van-der-waals TM5 I 256 5x69 G.H5 F 354 G.H5.26
Hydrophobic TM5 I 248 5x61 G.H5 L 348 G.H5.20
Hydrophobic TM6 T 297 6x36 G.H5 L 353 G.H5.25
Van-der-waals TM6 T 297 6x36 G.H5 L 353 G.H5.25
Hydrophobic C-term Y 396 - G.H3 K 248 G.H3.07
Hydrophobic C-term I 389 - G.H2 I 212 G.H2.08
Van-der-waals C-term I 389 - G.H2 I 212 G.H2.08
Ionic TM5 R 273 5x86 G.H4 E 298 G.H4.05
Polar TM5 R 273 5x86 G.H4 E 298 G.H4.05
Hydrophobic TM5 R 273 5x86 G.H4 E 298 G.H4.05
Van-der-waals TM5 R 273 5x86 G.H4 E 298 G.H4.05
Hydrophobic ICL1 R 69 12x48 G.HN I 19 G.HN.43
Van-der-waals ICL1 R 69 12x48 G.HN I 19 G.HN.43