Gs - D5 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gs

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 81.2

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.8
iPTM Score: 0.8
PAE mean: 12.7


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Aromatic ICL2 F 146 34x51 G.H5 F 376 G.H5.08
Hydrophobic ICL2 F 146 34x51 G.H5 F 376 G.H5.08
Van-der-waals ICL2 F 146 34x51 G.H5 F 376 G.H5.08
Hydrophobic TM5 I 259 5x72 G.H5 R 385 G.H5.17
Van-der-waals TM5 I 259 5x72 G.H5 R 385 G.H5.17
Polar TM2 T 76 2x39 G.H5 Y 391 G.H5.23
Hydrophobic TM2 T 76 2x39 G.H5 Y 391 G.H5.23
Van-der-waals TM2 T 76 2x39 G.H5 Y 391 G.H5.23
Hydrophobic TM5 A 252 5x65 G.H5 L 388 G.H5.20
Hydrophobic ICL2 K 149 34x54 G.H5 I 383 G.H5.15
Hydrophobic C-term A 417 - G.s4h3 E 259 G.s4h3.10
Hydrophobic ICL2 F 146 34x51 G.S3 V 217 G.S3.01
Hydrophobic C-term P 415 - G.s4h3 D 260 G.s4h3.11
Van-der-waals C-term P 415 - G.s4h3 D 260 G.s4h3.11
Hydrophobic TM6 V 294 6x33 G.H5 L 393 G.H5.25
Van-der-waals TM6 V 294 6x33 G.H5 L 393 G.H5.25
Polar TM5 Q 255 5x68 G.H5 Q 384 G.H5.16
Van-der-waals TM5 Q 255 5x68 G.H5 Q 384 G.H5.16
Aromatic TM3 R 138 3x50 G.H5 Y 391 G.H5.23
Hydrophobic TM3 R 138 3x50 G.H5 Y 391 G.H5.23
Van-der-waals TM3 R 138 3x50 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 F 146 34x51 G.H5 R 380 G.H5.12
Van-der-waals ICL2 F 146 34x51 G.H5 R 380 G.H5.12
Hydrophobic TM5 Q 255 5x68 G.H5 L 388 G.H5.20
Hydrophobic TM5 I 259 5x72 G.h4s6 Y 358 G.h4s6.20
Van-der-waals TM5 I 259 5x72 G.h4s6 Y 358 G.h4s6.20
Hydrophobic TM5 A 265 5x78 G.H4 R 342 G.H4.12
Van-der-waals TM5 A 265 5x78 G.H4 R 342 G.H4.12
Polar TM2 N 74 2x37 G.H5 Q 390 G.H5.22
Hydrophobic TM2 N 74 2x37 G.H5 Q 390 G.H5.22
Van-der-waals TM2 N 74 2x37 G.H5 Q 390 G.H5.22
Hydrophobic ICL2 K 149 34x54 G.S1 H 41 G.S1.02
Hydrophobic TM5 A 266 5x79 G.H4 R 347 G.H4.17
Polar C-term S 395 - G.H5 R 389 G.H5.21
Hydrophobic C-term S 395 - G.H5 R 389 G.H5.21
Van-der-waals C-term S 395 - G.H5 R 389 G.H5.21
Hydrophobic ICL2 Y 148 34x53 G.H5 H 387 G.H5.19
Hydrophobic ICL2 F 146 34x51 G.H5 C 379 G.H5.11
Hydrophobic C-term P 415 - G.s4h3 E 259 G.s4h3.10
Hydrophobic TM3 I 142 3x54 G.H5 H 387 G.H5.19
Hydrophobic TM3 I 142 3x54 G.H5 Y 391 G.H5.23
Hydrophobic TM5 C 272 5x85 G.hgh4 R 317 G.hgh4.07
Van-der-waals TM5 C 272 5x85 G.hgh4 R 317 G.hgh4.07
Hydrophobic C-term I 394 - G.H5 Q 390 G.H5.22
Polar TM6 T 297 6x36 G.H5 E 392 G.H5.24
Hydrophobic TM6 T 297 6x36 G.H5 E 392 G.H5.24
Van-der-waals TM6 T 297 6x36 G.H5 E 392 G.H5.24
Polar C-term N 397 - G.h4s6 R 356 G.h4s6.12
Polar TM3 I 142 3x54 G.H5 Q 384 G.H5.16
Hydrophobic TM3 I 142 3x54 G.H5 Q 384 G.H5.16
Van-der-waals TM3 I 142 3x54 G.H5 Q 384 G.H5.16
Hydrophobic ICL2 F 146 34x51 G.H5 I 383 G.H5.15
Van-der-waals ICL2 F 146 34x51 G.H5 I 383 G.H5.15
Hydrophobic TM3 I 142 3x54 G.H5 L 393 G.H5.25
Polar C-term S 395 - G.h4s6 R 356 G.h4s6.12
Hydrophobic ICL2 P 145 34x50 G.H5 I 383 G.H5.15
Van-der-waals ICL2 P 145 34x50 G.H5 I 383 G.H5.15
Ionic TM5 R 273 5x86 G.H4 E 344 G.H4.14
Polar TM5 R 273 5x86 G.H4 E 344 G.H4.14
Hydrophobic TM5 R 273 5x86 G.H4 E 344 G.H4.14
Van-der-waals TM5 R 273 5x86 G.H4 E 344 G.H4.14
Hydrophobic TM5 I 256 5x69 G.H5 L 394 G.H5.26
Polar TM6 K 293 6x32 G.H5 L 394 G.H5.26
Hydrophobic TM6 K 293 6x32 G.H5 L 394 G.H5.26
Van-der-waals TM6 K 293 6x32 G.H5 L 394 G.H5.26
Hydrophobic TM5 I 251 5x64 G.H5 Q 384 G.H5.16
Van-der-waals TM5 I 251 5x64 G.H5 Q 384 G.H5.16
Ionic C-term E 392 - G.h4s6 R 356 G.h4s6.12
Polar C-term E 392 - G.h4s6 R 356 G.h4s6.12
Van-der-waals C-term E 392 - G.h4s6 R 356 G.h4s6.12
Hydrophobic TM5 C 272 5x85 G.hgh4 Y 318 G.hgh4.08
Hydrophobic TM5 R 273 5x86 G.H4 R 347 G.H4.17
Van-der-waals TM5 R 273 5x86 G.H4 R 347 G.H4.17
Hydrophobic C-term I 394 - G.H5 M 386 G.H5.18
Van-der-waals C-term I 394 - G.H5 M 386 G.H5.18
Hydrophobic TM5 L 262 5x75 G.S6 P 361 G.S6.03
Polar C-term S 390 - G.h2s4 N 239 G.h2s4.02
Van-der-waals C-term S 390 - G.h2s4 N 239 G.h2s4.02
Hydrophobic TM5 A 269 5x82 G.H4 D 343 G.H4.13
Van-der-waals TM5 A 269 5x82 G.H4 D 343 G.H4.13
Polar TM5 C 272 5x85 G.hgh4 T 319 G.hgh4.09
Aromatic ICL2 F 146 34x51 G.S1 H 41 G.S1.02
Hydrophobic ICL2 F 146 34x51 G.S1 H 41 G.S1.02
Van-der-waals ICL2 F 146 34x51 G.S1 H 41 G.S1.02
Hydrophobic TM5 A 265 5x78 G.H4 D 343 G.H4.13
Hydrophobic TM5 A 269 5x82 G.hgh4 Y 318 G.hgh4.08
Hydrophobic TM6 T 297 6x36 G.H5 L 393 G.H5.25
Van-der-waals TM6 T 297 6x36 G.H5 L 393 G.H5.25
Hydrophobic TM5 E 263 5x76 G.h4s6 T 350 G.h4s6.03
Polar C-term N 397 - G.h4s6 D 354 G.h4s6.10
Polar C-term N 388 - G.h2s4 N 239 G.h2s4.02
Hydrophobic C-term N 388 - G.h2s4 N 239 G.h2s4.02
Van-der-waals C-term N 388 - G.h2s4 N 239 G.h2s4.02
Hydrophobic TM5 A 265 5x78 G.H4 L 346 G.H4.16
Ionic TM6 K 293 6x32 G.H5 E 392 G.H5.24
Polar TM6 K 293 6x32 G.H5 E 392 G.H5.24
Van-der-waals TM6 K 293 6x32 G.H5 E 392 G.H5.24
Hydrophobic TM3 A 141 3x53 G.H5 Y 391 G.H5.23
Hydrophobic C-term L 393 - G.H5 Q 390 G.H5.22
Hydrophobic TM5 I 248 5x61 G.H5 L 393 G.H5.25
Van-der-waals TM5 I 248 5x61 G.H5 L 393 G.H5.25
Hydrophobic ICL2 P 145 34x50 G.H5 H 387 G.H5.19
Hydrophobic C-term N 388 - G.H3 W 281 G.H3.17
Van-der-waals C-term N 388 - G.H3 W 281 G.H3.17
Polar ICL2 R 150 34x55 G.s2s3 K 216 G.s2s3.02
Hydrophobic ICL2 R 150 34x55 G.s2s3 K 216 G.s2s3.02
Van-der-waals ICL2 R 150 34x55 G.s2s3 K 216 G.s2s3.02
Hydrophobic TM5 A 266 5x79 G.H4 L 346 G.H4.16
Polar TM5 S 261 5x74 G.hgh4 D 323 G.hgh4.13
Van-der-waals TM5 S 261 5x74 G.hgh4 D 323 G.hgh4.13
Hydrophobic ICL2 R 150 34x55 G.hns1 A 39 G.hns1.03
Hydrophobic TM3 I 142 3x54 G.H5 L 388 G.H5.20
Van-der-waals TM3 I 142 3x54 G.H5 L 388 G.H5.20
Hydrophobic TM5 H 268 5x81 G.hgh4 P 321 G.hgh4.11
Polar H8 N 362 8x47 G.H5 Q 390 G.H5.22
Hydrophobic TM5 L 262 5x75 G.H4 L 346 G.H4.16
Polar C-term Y 410 - G.H3 K 274 G.H3.10
Hydrophobic TM5 H 268 5x81 G.hgh4 Y 318 G.hgh4.08
Hydrophobic C-term I 394 - G.H5 R 389 G.H5.21
Van-der-waals C-term I 394 - G.H5 R 389 G.H5.21
Hydrophobic ICL2 F 146 34x51 G.S3 F 219 G.S3.03
Hydrophobic C-term M 414 - G.H3 E 268 G.H3.04
Van-der-waals C-term M 414 - G.H3 E 268 G.H3.04
Hydrophobic TM5 A 266 5x79 G.h4s6 T 350 G.h4s6.03
Van-der-waals TM5 A 266 5x79 G.h4s6 T 350 G.h4s6.03
Polar TM5 Q 255 5x68 G.H5 D 381 G.H5.13
Hydrophobic TM5 Q 255 5x68 G.H5 D 381 G.H5.13
Van-der-waals TM5 Q 255 5x68 G.H5 D 381 G.H5.13
Ionic TM5 R 258 5x71 G.H5 D 381 G.H5.13
Polar TM5 R 258 5x71 G.H5 D 381 G.H5.13
Van-der-waals TM5 R 258 5x71 G.H5 D 381 G.H5.13
Polar C-term N 391 - G.h2s4 V 241 G.h2s4.04
Van-der-waals C-term N 391 - G.h2s4 V 241 G.h2s4.04
Hydrophobic TM5 I 259 5x72 G.H5 L 394 G.H5.26
Polar TM5 H 268 5x81 G.hgh4 T 319 G.hgh4.09
Van-der-waals TM5 H 268 5x81 G.hgh4 T 319 G.hgh4.09
Polar TM3 A 141 3x53 G.H5 H 387 G.H5.19
Hydrophobic TM3 A 141 3x53 G.H5 H 387 G.H5.19
Van-der-waals TM3 A 141 3x53 G.H5 H 387 G.H5.19
Hydrophobic C-term E 392 - G.h3s5 T 284 G.h3s5.02
Van-der-waals C-term E 392 - G.h3s5 T 284 G.h3s5.02
Polar C-term N 391 - G.h2s4 D 240 G.h2s4.03
Hydrophobic C-term N 391 - G.h2s4 D 240 G.h2s4.03
Van-der-waals C-term N 391 - G.h2s4 D 240 G.h2s4.03
Ionic C-term E 385 - G.h4s6 R 356 G.h4s6.12
Hydrophobic TM6 L 298 6x37 G.H5 L 393 G.H5.25
Van-der-waals TM6 L 298 6x37 G.H5 L 393 G.H5.25
Hydrophobic C-term S 390 - G.h2s4 D 240 G.h2s4.03
Van-der-waals C-term S 390 - G.h2s4 D 240 G.h2s4.03
Ionic TM5 R 273 5x86 G.hgh4 E 314 G.hgh4.04
Polar TM5 R 273 5x86 G.hgh4 E 314 G.hgh4.04
Hydrophobic TM5 R 273 5x86 G.hgh4 E 314 G.hgh4.04
Van-der-waals TM5 R 273 5x86 G.hgh4 E 314 G.hgh4.04
Polar ICL1 A 73 12x52 G.hns1 R 38 G.hns1.02
Hydrophobic TM5 Q 255 5x68 G.H5 L 394 G.H5.26
Hydrophobic ICL2 P 145 34x50 G.H5 R 380 G.H5.12
Van-der-waals ICL2 P 145 34x50 G.H5 R 380 G.H5.12
Polar TM5 Q 255 5x68 G.H5 R 385 G.H5.17
Hydrophobic TM5 Q 255 5x68 G.H5 R 385 G.H5.17
Van-der-waals TM5 Q 255 5x68 G.H5 R 385 G.H5.17