G12 - ETA receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G12/13

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 82.5

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.8
iPTM Score: 0.7
PAE mean: 13.7


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar ICL2 V 193 34x53 G.H5 N 374 G.H5.19
Hydrophobic ICL2 V 193 34x53 G.H5 N 374 G.H5.19
Van-der-waals ICL2 V 193 34x53 G.H5 N 374 G.H5.19
Polar ICL2 R 192 34x52 G.h2s4 T 246 G.h2s4.05
Hydrophobic ICL2 R 192 34x52 G.h2s4 T 246 G.h2s4.05
Van-der-waals ICL2 R 192 34x52 G.h2s4 T 246 G.h2s4.05
Polar H8 S 373 8x47 G.H5 L 380 G.H5.25
Hydrophobic H8 S 373 8x47 G.H5 L 380 G.H5.25
Hydrophobic TM6 H 297 6x26 G.h4s6 P 345 G.h4s6.20
Van-der-waals TM6 H 297 6x26 G.h4s6 P 345 G.h4s6.20
Hydrophobic ICL3 A 293 - G.S6 L 346 G.S6.01
Van-der-waals ICL3 A 293 - G.S6 L 346 G.S6.01
Hydrophobic ICL3 L 290 - G.S6 F 347 G.S6.02
Van-der-waals ICL3 L 290 - G.S6 F 347 G.S6.02
Hydrophobic TM3 R 183 3x50 G.H5 I 378 G.H5.23
Van-der-waals TM3 R 183 3x50 G.H5 I 378 G.H5.23
Hydrophobic ICL3 A 293 - G.S6 F 347 G.S6.02
Polar TM6 H 297 6x26 G.H5 Q 372 G.H5.17
Hydrophobic TM6 H 297 6x26 G.H5 Q 372 G.H5.17
Van-der-waals TM6 H 297 6x26 G.H5 Q 372 G.H5.17
Hydrophobic ICL2 W 190 34x50 G.H5 V 366 G.H5.11
Polar TM6 R 301 6x30 G.H5 Q 372 G.H5.17
Hydrophobic TM6 R 301 6x30 G.H5 Q 372 G.H5.17
Van-der-waals TM6 R 301 6x30 G.H5 Q 372 G.H5.17
Hydrophobic TM6 V 308 6x37 G.H5 M 379 G.H5.24
Hydrophobic C-term W 407 - G.H3 T 279 G.H3.11
Van-der-waals C-term W 407 - G.H3 T 279 G.H3.11
Hydrophobic ICL2 V 193 34x53 G.H5 I 378 G.H5.23
Hydrophobic TM3 R 183 3x50 G.H5 M 379 G.H5.24
Van-der-waals TM3 R 183 3x50 G.H5 M 379 G.H5.24
Hydrophobic H8 K 375 8x49 G.H5 Q 381 G.H5.26
Van-der-waals H8 K 375 8x49 G.H5 Q 381 G.H5.26
Polar ICL2 S 191 34x51 G.H5 N 374 G.H5.19
Van-der-waals ICL2 S 191 34x51 G.H5 N 374 G.H5.19
Polar ICL2 R 192 34x52 G.h2s4 G 244 G.h2s4.03
Van-der-waals ICL2 R 192 34x52 G.h2s4 G 244 G.h2s4.03
Hydrophobic TM6 V 304 6x33 G.H5 M 379 G.H5.24
Van-der-waals TM6 V 304 6x33 G.H5 M 379 G.H5.24
Hydrophobic ICL3 L 294 - G.H5 D 368 G.H5.13
Van-der-waals ICL3 L 294 - G.H5 D 368 G.H5.13
Polar ICL2 R 192 34x52 G.h2s4 I 245 G.h2s4.04
Hydrophobic ICL2 R 192 34x52 G.h2s4 I 245 G.h2s4.04
Hydrophobic TM7 V 372 7x56 G.H5 M 379 G.H5.24
Van-der-waals TM7 V 372 7x56 G.H5 M 379 G.H5.24
Hydrophobic ICL2 R 192 34x52 G.H5 N 374 G.H5.19
Van-der-waals ICL2 R 192 34x52 G.H5 N 374 G.H5.19
Hydrophobic C-term T 403 - G.H3 K 284 G.H3.16
Van-der-waals C-term T 403 - G.H3 K 284 G.H3.16
Hydrophobic TM2 P 115 2x39 G.H5 I 378 G.H5.23
Polar C-term G 402 - G.H3 K 284 G.H3.16
Hydrophobic C-term G 402 - G.H3 K 284 G.H3.16
Van-der-waals C-term G 402 - G.H3 K 284 G.H3.16
Polar TM6 Q 300 6x29 G.H5 Q 372 G.H5.17
Van-der-waals TM6 Q 300 6x29 G.H5 Q 372 G.H5.17
Polar H8 S 373 8x47 G.H5 Q 381 G.H5.26
Hydrophobic H8 S 373 8x47 G.H5 Q 381 G.H5.26
Van-der-waals H8 S 373 8x47 G.H5 Q 381 G.H5.26
Hydrophobic ICL3 L 290 - G.H5 H 364 G.H5.09
Polar TM3 A 186 3x53 G.H5 N 374 G.H5.19
Hydrophobic TM3 A 186 3x53 G.H5 N 374 G.H5.19
Van-der-waals TM3 A 186 3x53 G.H5 N 374 G.H5.19
Hydrophobic ICL3 A 293 - G.h4s6 P 345 G.h4s6.20
Van-der-waals ICL3 A 293 - G.h4s6 P 345 G.h4s6.20
Hydrophobic C-term I 405 - G.H3 K 284 G.H3.16
Van-der-waals C-term I 405 - G.H3 K 284 G.H3.16
Polar N-term Y 26 - G.HN R 6 G.HN.06
Hydrophobic N-term Y 26 - G.HN R 6 G.HN.06
Van-der-waals N-term Y 26 - G.HN R 6 G.HN.06
Hydrophobic ICL3 L 290 - G.H5 A 365 G.H5.10
Ionic TM6 R 301 6x30 G.H5 D 368 G.H5.13
Polar TM6 R 301 6x30 G.H5 D 368 G.H5.13
Hydrophobic TM6 R 301 6x30 G.H5 D 368 G.H5.13
Van-der-waals TM6 R 301 6x30 G.H5 D 368 G.H5.13
Hydrophobic ICL2 S 191 34x51 G.hns1 R 56 G.hns1.03
Hydrophobic TM3 V 187 3x54 G.H5 L 371 G.H5.16
Hydrophobic ICL3 L 290 - G.H5 F 361 G.H5.06
Hydrophobic TM5 M 282 5x65 G.H5 L 371 G.H5.16
Ionic ICL2 R 192 34x52 G.H5 E 373 G.H5.18
Hydrophobic TM6 V 304 6x33 G.H5 L 375 G.H5.20
Polar N-term T 28 - G.HN R 6 G.HN.06
Van-der-waals N-term T 28 - G.HN R 6 G.HN.06
Hydrophobic C-term T 403 - G.H3 L 285 G.H3.17
Polar C-term S 404 - G.H3 K 284 G.H3.16
Polar H8 K 374 8x48 G.H5 L 380 G.H5.25
Van-der-waals H8 K 374 8x48 G.H5 L 380 G.H5.25
Hydrophobic ICL2 S 191 34x51 G.hns1 R 55 G.hns1.02
Van-der-waals ICL2 S 191 34x51 G.hns1 R 55 G.hns1.02
Polar ICL1 N 113 12x52 G.H5 D 377 G.H5.22
Hydrophobic ICL2 W 190 34x50 G.H5 I 370 G.H5.15
Hydrophobic ICL2 S 191 34x51 G.H5 I 370 G.H5.15
Hydrophobic ICL2 W 190 34x50 G.S3 F 223 G.S3.03
Polar N-term S 27 - G.HN R 6 G.HN.06
Van-der-waals N-term S 27 - G.HN R 6 G.HN.06
Hydrophobic TM6 V 304 6x33 G.H5 L 380 G.H5.25
Van-der-waals TM6 V 304 6x33 G.H5 L 380 G.H5.25
Hydrophobic TM6 R 301 6x30 G.H5 L 371 G.H5.16
Van-der-waals TM6 R 301 6x30 G.H5 L 371 G.H5.16
Hydrophobic TM7 V 372 7x56 G.H5 L 380 G.H5.25
Ionic TM6 H 297 6x26 G.H5 D 368 G.H5.13
Polar TM6 H 297 6x26 G.H5 D 368 G.H5.13
Polar ICL2 R 192 34x52 G.hns1 R 55 G.hns1.02
Van-der-waals ICL2 R 192 34x52 G.hns1 R 55 G.hns1.02
Hydrophobic TM3 V 187 3x54 G.H5 L 375 G.H5.20
Hydrophobic ICL2 W 190 34x50 G.H5 K 367 G.H5.12
Van-der-waals ICL2 W 190 34x50 G.H5 K 367 G.H5.12
Polar ICL2 Q 194 34x54 G.hns1 R 55 G.hns1.02
Hydrophobic ICL2 Q 194 34x54 G.hns1 R 55 G.hns1.02
Van-der-waals ICL2 Q 194 34x54 G.hns1 R 55 G.hns1.02
Hydrophobic TM5 M 278 5x61 G.H5 M 379 G.H5.24
Hydrophobic TM5 M 282 5x65 G.H5 L 375 G.H5.20
Van-der-waals TM5 M 282 5x65 G.H5 L 375 G.H5.20
Hydrophobic ICL3 L 294 - G.h4s6 P 345 G.h4s6.20
Aromatic ICL2 W 190 34x50 G.H5 F 363 G.H5.08
Hydrophobic ICL2 W 190 34x50 G.H5 F 363 G.H5.08
Van-der-waals ICL2 W 190 34x50 G.H5 F 363 G.H5.08
Ionic TM5 E 281 5x64 G.H5 K 367 G.H5.12
Polar TM5 E 281 5x64 G.H5 K 367 G.H5.12
Van-der-waals TM5 E 281 5x64 G.H5 K 367 G.H5.12
Polar H8 S 373 8x47 G.H5 M 379 G.H5.24
Hydrophobic H8 S 373 8x47 G.H5 M 379 G.H5.24
Hydrophobic ICL3 L 294 - G.S6 F 347 G.S6.02
Van-der-waals ICL3 L 294 - G.S6 F 347 G.S6.02
Hydrophobic TM3 A 186 3x53 G.H5 I 378 G.H5.23
Van-der-waals TM3 A 186 3x53 G.H5 I 378 G.H5.23
Hydrophobic ICL2 W 190 34x50 G.S3 I 221 G.S3.01
Van-der-waals ICL2 W 190 34x50 G.S3 I 221 G.S3.01
Hydrophobic TM6 R 301 6x30 G.H5 L 375 G.H5.20
Van-der-waals TM6 R 301 6x30 G.H5 L 375 G.H5.20