Gq -
ETA receptor complex model
GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 84.5
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.8
iPTM Score: 0.7
PAE mean: 10.6
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
Gβ,
Gγ,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Hydrophobic | TM6 | V | 304 | 6x33 | G.H5 | L | 353 | G.H5.20 |
Hydrophobic | TM3 | V | 187 | 3x54 | G.H5 | L | 349 | G.H5.16 |
Van-der-waals | TM3 | V | 187 | 3x54 | G.H5 | L | 349 | G.H5.16 |
Hydrophobic | ICL2 | W | 190 | 34x50 | G.H5 | I | 348 | G.H5.15 |
Hydrophobic | ICL3 | A | 293 | - | G.h4s6 | I | 323 | G.h4s6.20 |
Van-der-waals | ICL3 | A | 293 | - | G.h4s6 | I | 323 | G.h4s6.20 |
Hydrophobic | ICL2 | G | 195 | 34x55 | G.H5 | E | 355 | G.H5.22 |
Hydrophobic | TM6 | V | 304 | 6x33 | G.H5 | L | 358 | G.H5.25 |
Van-der-waals | TM6 | V | 304 | 6x33 | G.H5 | L | 358 | G.H5.25 |
Hydrophobic | TM3 | R | 183 | 3x50 | G.H5 | L | 358 | G.H5.25 |
Van-der-waals | TM3 | R | 183 | 3x50 | G.H5 | L | 358 | G.H5.25 |
Hydrophobic | TM3 | L | 179 | 3x46 | G.H5 | Y | 356 | G.H5.23 |
Polar | ICL1 | N | 113 | 12x52 | G.H5 | E | 355 | G.H5.22 |
Van-der-waals | ICL1 | N | 113 | 12x52 | G.H5 | E | 355 | G.H5.22 |
Hydrophobic | ICL2 | V | 193 | 34x53 | G.H5 | Y | 356 | G.H5.23 |
Van-der-waals | ICL2 | V | 193 | 34x53 | G.H5 | Y | 356 | G.H5.23 |
Hydrophobic | ICL2 | S | 191 | 34x51 | G.H5 | I | 348 | G.H5.15 |
Hydrophobic | ICL3 | L | 290 | - | G.H5 | A | 342 | G.H5.09 |
Van-der-waals | ICL3 | L | 290 | - | G.H5 | A | 342 | G.H5.09 |
Hydrophobic | ICL2 | W | 190 | 34x50 | G.H5 | K | 345 | G.H5.12 |
Van-der-waals | ICL2 | W | 190 | 34x50 | G.H5 | K | 345 | G.H5.12 |
Polar | ICL2 | Q | 194 | 34x54 | G.hns1 | R | 37 | G.hns1.02 |
Hydrophobic | ICL2 | Q | 194 | 34x54 | G.hns1 | R | 37 | G.hns1.02 |
Van-der-waals | ICL2 | Q | 194 | 34x54 | G.hns1 | R | 37 | G.hns1.02 |
Hydrophobic | ICL3 | L | 290 | - | G.S6 | Y | 325 | G.S6.02 |
Van-der-waals | ICL3 | L | 290 | - | G.S6 | Y | 325 | G.S6.02 |
Polar | ICL2 | R | 192 | 34x52 | G.h2s4 | T | 224 | G.h2s4.05 |
Hydrophobic | ICL2 | R | 192 | 34x52 | G.h2s4 | T | 224 | G.h2s4.05 |
Van-der-waals | ICL2 | R | 192 | 34x52 | G.h2s4 | T | 224 | G.h2s4.05 |
Hydrophobic | TM6 | H | 297 | 6x26 | G.h4s6 | I | 323 | G.h4s6.20 |
Van-der-waals | TM6 | H | 297 | 6x26 | G.h4s6 | I | 323 | G.h4s6.20 |
Hydrophobic | TM7 | V | 372 | 7x56 | G.H5 | L | 358 | G.H5.25 |
Van-der-waals | TM7 | V | 372 | 7x56 | G.H5 | L | 358 | G.H5.25 |
Hydrophobic | TM2 | I | 119 | 2x43 | G.H5 | N | 357 | G.H5.24 |
Van-der-waals | TM2 | I | 119 | 2x43 | G.H5 | N | 357 | G.H5.24 |
Hydrophobic | TM6 | V | 304 | 6x33 | G.H5 | V | 359 | G.H5.26 |
Hydrophobic | ICL2 | V | 193 | 34x53 | G.H5 | E | 355 | G.H5.22 |
Polar | ICL2 | V | 193 | 34x53 | G.H5 | N | 352 | G.H5.19 |
Hydrophobic | ICL2 | V | 193 | 34x53 | G.H5 | N | 352 | G.H5.19 |
Van-der-waals | ICL2 | V | 193 | 34x53 | G.H5 | N | 352 | G.H5.19 |
Hydrophobic | ICL3 | L | 294 | - | G.H5 | D | 346 | G.H5.13 |
Van-der-waals | ICL3 | L | 294 | - | G.H5 | D | 346 | G.H5.13 |
Hydrophobic | TM3 | A | 186 | 3x53 | G.H5 | Y | 356 | G.H5.23 |
Van-der-waals | TM3 | A | 186 | 3x53 | G.H5 | Y | 356 | G.H5.23 |
Hydrophobic | ICL3 | L | 290 | - | G.H5 | F | 339 | G.H5.06 |
Ionic | H8 | K | 374 | 8x48 | G.h4s6 | D | 321 | G.h4s6.12 |
Polar | H8 | K | 374 | 8x48 | G.h4s6 | D | 321 | G.h4s6.12 |
Polar | TM6 | H | 297 | 6x26 | G.S6 | Y | 325 | G.S6.02 |
Van-der-waals | TM6 | H | 297 | 6x26 | G.S6 | Y | 325 | G.S6.02 |
Hydrophobic | ICL2 | W | 190 | 34x50 | G.s2s3 | S | 198 | G.s2s3.02 |
Hydrophobic | TM5 | S | 289 | 5x72 | G.H5 | F | 339 | G.H5.06 |
Polar | TM3 | R | 183 | 3x50 | G.H5 | Y | 356 | G.H5.23 |
Hydrophobic | TM3 | R | 183 | 3x50 | G.H5 | Y | 356 | G.H5.23 |
Van-der-waals | TM3 | R | 183 | 3x50 | G.H5 | Y | 356 | G.H5.23 |
Hydrophobic | ICL2 | R | 192 | 34x52 | G.H5 | I | 348 | G.H5.15 |
Hydrophobic | TM5 | M | 282 | 5x65 | G.H5 | L | 349 | G.H5.16 |
Hydrophobic | TM6 | R | 301 | 6x30 | G.H5 | L | 349 | G.H5.16 |
Van-der-waals | TM6 | R | 301 | 6x30 | G.H5 | L | 349 | G.H5.16 |
Ionic | TM6 | R | 301 | 6x30 | G.H5 | D | 346 | G.H5.13 |
Polar | TM6 | R | 301 | 6x30 | G.H5 | D | 346 | G.H5.13 |
Van-der-waals | TM6 | R | 301 | 6x30 | G.H5 | D | 346 | G.H5.13 |
Polar | H8 | S | 373 | 8x47 | G.H5 | V | 359 | G.H5.26 |
Hydrophobic | H8 | S | 373 | 8x47 | G.H5 | V | 359 | G.H5.26 |
Van-der-waals | H8 | S | 373 | 8x47 | G.H5 | V | 359 | G.H5.26 |
Polar | TM3 | A | 186 | 3x53 | G.H5 | N | 352 | G.H5.19 |
Hydrophobic | TM3 | A | 186 | 3x53 | G.H5 | N | 352 | G.H5.19 |
Van-der-waals | TM3 | A | 186 | 3x53 | G.H5 | N | 352 | G.H5.19 |
Hydrophobic | ICL3 | A | 293 | - | G.S6 | Y | 325 | G.S6.02 |
Ionic | TM6 | H | 297 | 6x26 | G.H5 | D | 346 | G.H5.13 |
Polar | TM6 | H | 297 | 6x26 | G.H5 | D | 346 | G.H5.13 |
Hydrophobic | TM6 | H | 297 | 6x26 | G.H5 | D | 346 | G.H5.13 |
Van-der-waals | TM6 | H | 297 | 6x26 | G.H5 | D | 346 | G.H5.13 |
Hydrophobic | TM7 | L | 369 | 7x53 | G.H5 | N | 357 | G.H5.24 |
Aromatic | ICL2 | W | 190 | 34x50 | G.H5 | F | 341 | G.H5.08 |
Hydrophobic | ICL2 | W | 190 | 34x50 | G.H5 | F | 341 | G.H5.08 |
Van-der-waals | ICL2 | W | 190 | 34x50 | G.H5 | F | 341 | G.H5.08 |
Ionic | TM5 | E | 281 | 5x64 | G.H5 | K | 345 | G.H5.12 |
Polar | TM5 | E | 281 | 5x64 | G.H5 | K | 345 | G.H5.12 |
Van-der-waals | TM5 | E | 281 | 5x64 | G.H5 | K | 345 | G.H5.12 |
Polar | TM6 | Q | 300 | 6x29 | G.H5 | Q | 350 | G.H5.17 |
Van-der-waals | TM6 | Q | 300 | 6x29 | G.H5 | Q | 350 | G.H5.17 |
Hydrophobic | TM7 | V | 372 | 7x56 | G.H5 | V | 359 | G.H5.26 |
Van-der-waals | TM7 | V | 372 | 7x56 | G.H5 | V | 359 | G.H5.26 |
Polar | H8 | K | 374 | 8x48 | G.H5 | V | 359 | G.H5.26 |
Hydrophobic | TM2 | P | 115 | 2x39 | G.H5 | Y | 356 | G.H5.23 |
Van-der-waals | TM2 | P | 115 | 2x39 | G.H5 | Y | 356 | G.H5.23 |
Polar | ICL2 | S | 191 | 34x51 | G.H5 | N | 352 | G.H5.19 |
Van-der-waals | ICL2 | S | 191 | 34x51 | G.H5 | N | 352 | G.H5.19 |
Hydrophobic | ICL3 | L | 294 | - | G.S6 | Y | 325 | G.S6.02 |
Hydrophobic | TM6 | Q | 300 | 6x29 | G.H5 | V | 359 | G.H5.26 |
Van-der-waals | TM6 | Q | 300 | 6x29 | G.H5 | V | 359 | G.H5.26 |
Polar | H8 | S | 373 | 8x47 | G.H5 | N | 357 | G.H5.24 |
Hydrophobic | H8 | S | 373 | 8x47 | G.H5 | N | 357 | G.H5.24 |
Hydrophobic | TM3 | V | 187 | 3x54 | G.H5 | L | 353 | G.H5.20 |
Hydrophobic | TM6 | R | 301 | 6x30 | G.H5 | L | 353 | G.H5.20 |
Hydrophobic | TM5 | M | 282 | 5x65 | G.H5 | L | 353 | G.H5.20 |
Van-der-waals | TM5 | M | 282 | 5x65 | G.H5 | L | 353 | G.H5.20 |
Hydrophobic | TM6 | V | 308 | 6x37 | G.H5 | L | 358 | G.H5.25 |
Aromatic | C-term | W | 407 | - | G.H3 | Y | 261 | G.H3.15 |
Hydrophobic | C-term | W | 407 | - | G.H3 | Y | 261 | G.H3.15 |
Van-der-waals | C-term | W | 407 | - | G.H3 | Y | 261 | G.H3.15 |
Hydrophobic | ICL2 | W | 190 | 34x50 | G.S3 | V | 199 | G.S3.01 |
Hydrophobic | ICL2 | R | 192 | 34x52 | G.S1 | L | 40 | G.S1.02 |
Van-der-waals | ICL2 | R | 192 | 34x52 | G.S1 | L | 40 | G.S1.02 |
Hydrophobic | C-term | W | 407 | - | G.H3 | T | 257 | G.H3.11 |
Van-der-waals | C-term | W | 407 | - | G.H3 | T | 257 | G.H3.11 |
Hydrophobic | ICL3 | L | 290 | - | G.H5 | A | 343 | G.H5.10 |
Polar | TM2 | N | 116 | 2x40 | G.H5 | N | 357 | G.H5.24 |
Van-der-waals | TM2 | N | 116 | 2x40 | G.H5 | N | 357 | G.H5.24 |
Hydrophobic | TM7 | V | 372 | 7x56 | G.H5 | N | 357 | G.H5.24 |
Polar | TM3 | D | 182 | 3x49 | G.H5 | Y | 356 | G.H5.23 |
Hydrophobic | TM3 | D | 182 | 3x49 | G.H5 | Y | 356 | G.H5.23 |
Polar | TM6 | H | 297 | 6x26 | G.H5 | Q | 350 | G.H5.17 |
Hydrophobic | TM6 | H | 297 | 6x26 | G.H5 | Q | 350 | G.H5.17 |
Van-der-waals | TM6 | H | 297 | 6x26 | G.H5 | Q | 350 | G.H5.17 |
Hydrophobic | TM2 | P | 115 | 2x39 | G.H5 | E | 355 | G.H5.22 |
Hydrophobic | C-term | T | 403 | - | G.H3 | W | 263 | G.H3.17 |
Van-der-waals | C-term | T | 403 | - | G.H3 | W | 263 | G.H3.17 |
Hydrophobic | H8 | F | 376 | 8x50 | G.H5 | N | 357 | G.H5.24 |
Van-der-waals | H8 | F | 376 | 8x50 | G.H5 | N | 357 | G.H5.24 |