Gs -
ETA receptor complex model
GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 83.5
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.8
iPTM Score: 0.7
PAE mean: 14.2
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
Gβ,
Gγ,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Polar | ICL3 | R | 291 | - | G.hgh4 | A | 324 | G.hgh4.14 |
Van-der-waals | ICL3 | R | 291 | - | G.hgh4 | A | 324 | G.hgh4.14 |
Hydrophobic | ICL2 | W | 190 | 34x50 | G.S3 | V | 217 | G.S3.01 |
Polar | ICL2 | Q | 194 | 34x54 | G.hns1 | R | 38 | G.hns1.02 |
Hydrophobic | ICL2 | Q | 194 | 34x54 | G.hns1 | R | 38 | G.hns1.02 |
Polar | C-term | D | 418 | - | G.H3 | N | 279 | G.H3.15 |
Ionic | TM5 | E | 281 | 5x64 | G.H5 | R | 380 | G.H5.12 |
Polar | TM5 | E | 281 | 5x64 | G.H5 | R | 380 | G.H5.12 |
Hydrophobic | TM5 | E | 281 | 5x64 | G.H5 | R | 380 | G.H5.12 |
Van-der-waals | TM5 | E | 281 | 5x64 | G.H5 | R | 380 | G.H5.12 |
Polar | ICL2 | Q | 194 | 34x54 | G.H5 | Q | 390 | G.H5.22 |
Hydrophobic | ICL2 | Q | 194 | 34x54 | G.H5 | Q | 390 | G.H5.22 |
Van-der-waals | ICL2 | Q | 194 | 34x54 | G.H5 | Q | 390 | G.H5.22 |
Hydrophobic | TM6 | V | 304 | 6x33 | G.H5 | L | 393 | G.H5.25 |
Van-der-waals | TM6 | V | 304 | 6x33 | G.H5 | L | 393 | G.H5.25 |
Van-der-waals | ICL3 | A | 293 | - | G.S6 | C | 359 | G.S6.01 |
Polar | C-term | H | 422 | - | G.H2 | R | 231 | G.H2.04 |
Van-der-waals | C-term | H | 422 | - | G.H2 | R | 231 | G.H2.04 |
Hydrophobic | ICL2 | G | 195 | 34x55 | G.hns1 | R | 38 | G.hns1.02 |
Van-der-waals | ICL2 | G | 195 | 34x55 | G.hns1 | R | 38 | G.hns1.02 |
Hydrophobic | TM6 | V | 304 | 6x33 | G.H5 | L | 394 | G.H5.26 |
Hydrophobic | ICL2 | W | 190 | 34x50 | G.H5 | C | 379 | G.H5.11 |
Hydrophobic | TM7 | V | 372 | 7x56 | G.H5 | L | 393 | G.H5.25 |
Van-der-waals | TM7 | V | 372 | 7x56 | G.H5 | L | 393 | G.H5.25 |
Hydrophobic | C-term | S | 425 | - | G.s1h1 | A | 48 | G.s1h1.02 |
Van-der-waals | C-term | S | 425 | - | G.s1h1 | A | 48 | G.s1h1.02 |
Polar | C-term | S | 425 | - | G.s1h1 | G | 49 | G.s1h1.03 |
Van-der-waals | C-term | S | 425 | - | G.s1h1 | G | 49 | G.s1h1.03 |
Hydrophobic | TM5 | R | 286 | 5x69 | G.S6 | Y | 360 | G.S6.02 |
Van-der-waals | TM5 | R | 286 | 5x69 | G.S6 | Y | 360 | G.S6.02 |
Hydrophobic | ICL2 | W | 190 | 34x50 | G.H5 | I | 383 | G.H5.15 |
Hydrophobic | TM7 | L | 369 | 7x53 | G.H5 | E | 392 | G.H5.24 |
Hydrophobic | H8 | S | 373 | 8x47 | G.H5 | L | 394 | G.H5.26 |
Polar | TM6 | H | 297 | 6x26 | G.S6 | Y | 360 | G.S6.02 |
Hydrophobic | TM6 | H | 297 | 6x26 | G.S6 | Y | 360 | G.S6.02 |
Hydrophobic | ICL3 | L | 290 | - | G.S6 | Y | 360 | G.S6.02 |
Polar | H8 | S | 373 | 8x47 | G.H5 | E | 392 | G.H5.24 |
Hydrophobic | H8 | S | 373 | 8x47 | G.H5 | E | 392 | G.H5.24 |
Van-der-waals | H8 | S | 373 | 8x47 | G.H5 | E | 392 | G.H5.24 |
Hydrophobic | TM3 | R | 183 | 3x50 | G.H5 | L | 393 | G.H5.25 |
Van-der-waals | TM3 | R | 183 | 3x50 | G.H5 | L | 393 | G.H5.25 |
Hydrophobic | TM2 | P | 115 | 2x39 | G.H5 | Q | 390 | G.H5.22 |
Hydrophobic | TM6 | V | 304 | 6x33 | G.H5 | L | 388 | G.H5.20 |
Hydrophobic | C-term | M | 426 | - | G.H2 | W | 234 | G.H2.07 |
Hydrophobic | C-term | I | 405 | - | G.H3 | R | 280 | G.H3.16 |
Van-der-waals | C-term | I | 405 | - | G.H3 | R | 280 | G.H3.16 |
Hydrophobic | TM6 | V | 308 | 6x37 | G.H5 | L | 393 | G.H5.25 |
Aromatic | ICL2 | W | 190 | 34x50 | G.H5 | R | 380 | G.H5.12 |
Hydrophobic | ICL2 | W | 190 | 34x50 | G.H5 | R | 380 | G.H5.12 |
Van-der-waals | ICL2 | W | 190 | 34x50 | G.H5 | R | 380 | G.H5.12 |
Hydrophobic | C-term | M | 426 | - | G.H2 | R | 231 | G.H2.04 |
Van-der-waals | C-term | M | 426 | - | G.H2 | R | 231 | G.H2.04 |
Polar | C-term | S | 425 | - | G.H2 | R | 231 | G.H2.04 |
Hydrophobic | C-term | S | 425 | - | G.H2 | R | 231 | G.H2.04 |
Van-der-waals | C-term | S | 425 | - | G.H2 | R | 231 | G.H2.04 |
Hydrophobic | C-term | M | 426 | - | G.S1 | L | 46 | G.S1.07 |
Aromatic | TM6 | H | 297 | 6x26 | G.h4s6 | Y | 358 | G.h4s6.20 |
Hydrophobic | TM6 | H | 297 | 6x26 | G.h4s6 | Y | 358 | G.h4s6.20 |
Van-der-waals | TM6 | H | 297 | 6x26 | G.h4s6 | Y | 358 | G.h4s6.20 |
Polar | C-term | D | 424 | - | G.H2 | D | 229 | G.H2.02 |
Polar | C-term | N | 427 | - | G.s3h2 | G | 226 | G.s3h2.02 |
Hydrophobic | C-term | N | 427 | - | G.s3h2 | G | 226 | G.s3h2.02 |
Van-der-waals | C-term | N | 427 | - | G.s3h2 | G | 226 | G.s3h2.02 |
Polar | C-term | N | 427 | - | G.s1h1 | G | 49 | G.s1h1.03 |
Hydrophobic | C-term | N | 427 | - | G.s1h1 | G | 49 | G.s1h1.03 |
Van-der-waals | C-term | N | 427 | - | G.s1h1 | G | 49 | G.s1h1.03 |
Polar | TM3 | R | 183 | 3x50 | G.H5 | Y | 391 | G.H5.23 |
Hydrophobic | TM3 | R | 183 | 3x50 | G.H5 | Y | 391 | G.H5.23 |
Van-der-waals | TM3 | R | 183 | 3x50 | G.H5 | Y | 391 | G.H5.23 |
Aromatic | ICL2 | W | 190 | 34x50 | G.H5 | F | 376 | G.H5.08 |
Hydrophobic | ICL2 | W | 190 | 34x50 | G.H5 | F | 376 | G.H5.08 |
Van-der-waals | ICL2 | W | 190 | 34x50 | G.H5 | F | 376 | G.H5.08 |
Polar | TM2 | N | 116 | 2x40 | G.H5 | E | 392 | G.H5.24 |
Hydrophobic | TM2 | N | 116 | 2x40 | G.H5 | E | 392 | G.H5.24 |
Polar | TM3 | D | 182 | 3x49 | G.H5 | Y | 391 | G.H5.23 |
Hydrophobic | TM3 | D | 182 | 3x49 | G.H5 | Y | 391 | G.H5.23 |
Hydrophobic | ICL3 | L | 290 | - | G.H5 | D | 378 | G.H5.10 |
Van-der-waals | ICL3 | L | 290 | - | G.H5 | D | 378 | G.H5.10 |
Polar | C-term | D | 418 | - | G.H3 | S | 275 | G.H3.11 |
Van-der-waals | C-term | D | 418 | - | G.H3 | S | 275 | G.H3.11 |
Polar | TM3 | S | 189 | 3x56 | G.H5 | H | 387 | G.H5.19 |
Van-der-waals | TM3 | S | 189 | 3x56 | G.H5 | H | 387 | G.H5.19 |
Polar | C-term | S | 404 | - | G.H3 | R | 280 | G.H3.16 |
Hydrophobic | ICL3 | L | 290 | - | G.S6 | H | 362 | G.S6.04 |
Van-der-waals | ICL3 | L | 290 | - | G.S6 | H | 362 | G.S6.04 |
Polar | C-term | N | 427 | - | G.H1 | K | 53 | G.H1.01 |
Hydrophobic | C-term | N | 427 | - | G.H1 | K | 53 | G.H1.01 |
Van-der-waals | C-term | N | 427 | - | G.H1 | K | 53 | G.H1.01 |
Hydrophobic | TM5 | M | 278 | 5x61 | G.H5 | L | 393 | G.H5.25 |
Polar | ICL3 | R | 291 | - | G.hgh4 | D | 323 | G.hgh4.13 |
Van-der-waals | ICL3 | R | 291 | - | G.hgh4 | D | 323 | G.hgh4.13 |
Hydrophobic | TM5 | R | 285 | 5x68 | G.H5 | R | 380 | G.H5.12 |
Van-der-waals | TM5 | R | 285 | 5x68 | G.H5 | R | 380 | G.H5.12 |
Ionic | TM6 | R | 301 | 6x30 | G.H5 | D | 381 | G.H5.13 |
Polar | TM6 | R | 301 | 6x30 | G.H5 | D | 381 | G.H5.13 |
Hydrophobic | TM6 | R | 301 | 6x30 | G.H5 | D | 381 | G.H5.13 |
Van-der-waals | TM6 | R | 301 | 6x30 | G.H5 | D | 381 | G.H5.13 |
Polar | TM3 | V | 187 | 3x54 | G.H5 | Q | 384 | G.H5.16 |
Hydrophobic | TM3 | V | 187 | 3x54 | G.H5 | Q | 384 | G.H5.16 |
Van-der-waals | TM3 | V | 187 | 3x54 | G.H5 | Q | 384 | G.H5.16 |
Hydrophobic | ICL3 | I | 292 | - | G.H4 | R | 342 | G.H4.12 |
Van-der-waals | ICL3 | I | 292 | - | G.H4 | R | 342 | G.H4.12 |
Polar | TM6 | Q | 300 | 6x29 | G.H5 | R | 385 | G.H5.17 |
Van-der-waals | TM6 | Q | 300 | 6x29 | G.H5 | R | 385 | G.H5.17 |
Hydrophobic | C-term | M | 426 | - | G.s1h1 | G | 47 | G.s1h1.01 |
Van-der-waals | C-term | M | 426 | - | G.s1h1 | G | 47 | G.s1h1.01 |
Polar | C-term | N | 427 | - | G.s1h1 | E | 50 | G.s1h1.04 |
Hydrophobic | C-term | M | 426 | - | G.H3 | L | 272 | G.H3.08 |
Van-der-waals | C-term | M | 426 | - | G.H3 | L | 272 | G.H3.08 |
Polar | C-term | T | 403 | - | G.H3 | R | 280 | G.H3.16 |
Hydrophobic | TM5 | M | 282 | 5x65 | G.H5 | L | 388 | G.H5.20 |
Hydrophobic | C-term | M | 426 | - | G.H3 | I | 276 | G.H3.12 |
Van-der-waals | C-term | M | 426 | - | G.H3 | I | 276 | G.H3.12 |
Ionic | H8 | K | 375 | 8x49 | G.H5 | E | 392 | G.H5.24 |
Hydrophobic | H8 | K | 375 | 8x49 | G.H5 | E | 392 | G.H5.24 |
Hydrophobic | C-term | T | 403 | - | G.H3 | W | 281 | G.H3.17 |
Van-der-waals | C-term | T | 403 | - | G.H3 | W | 281 | G.H3.17 |
Polar | C-term | S | 425 | - | G.H3 | E | 268 | G.H3.04 |
Hydrophobic | C-term | S | 425 | - | G.H3 | E | 268 | G.H3.04 |
Van-der-waals | C-term | S | 425 | - | G.H3 | E | 268 | G.H3.04 |
Polar | TM6 | R | 301 | 6x30 | G.H5 | Q | 384 | G.H5.16 |
Van-der-waals | TM6 | R | 301 | 6x30 | G.H5 | Q | 384 | G.H5.16 |
Polar | C-term | S | 425 | - | G.s4h3 | E | 259 | G.s4h3.10 |
Van-der-waals | C-term | S | 425 | - | G.s4h3 | E | 259 | G.s4h3.10 |
Hydrophobic | TM2 | P | 115 | 2x39 | G.H5 | Y | 391 | G.H5.23 |
Van-der-waals | TM2 | P | 115 | 2x39 | G.H5 | Y | 391 | G.H5.23 |
Polar | C-term | N | 414 | - | G.h3s5 | R | 283 | G.h3s5.01 |
Polar | C-term | M | 426 | - | G.H1 | K | 53 | G.H1.01 |
Van-der-waals | C-term | M | 426 | - | G.H1 | K | 53 | G.H1.01 |
Polar | C-term | D | 424 | - | G.s4h3 | E | 259 | G.s4h3.10 |
Hydrophobic | C-term | D | 424 | - | G.s4h3 | E | 259 | G.s4h3.10 |
Van-der-waals | C-term | D | 424 | - | G.s4h3 | E | 259 | G.s4h3.10 |
Hydrophobic | TM3 | V | 187 | 3x54 | G.H5 | L | 388 | G.H5.20 |
Hydrophobic | H8 | F | 376 | 8x50 | G.H5 | E | 392 | G.H5.24 |
Van-der-waals | H8 | F | 376 | 8x50 | G.H5 | E | 392 | G.H5.24 |
Polar | ICL2 | V | 193 | 34x53 | G.hns1 | R | 38 | G.hns1.02 |
Hydrophobic | ICL2 | V | 193 | 34x53 | G.hns1 | R | 38 | G.hns1.02 |
Van-der-waals | ICL2 | V | 193 | 34x53 | G.hns1 | R | 38 | G.hns1.02 |
Hydrophobic | ICL3 | I | 292 | - | G.hgh4 | D | 323 | G.hgh4.13 |
Van-der-waals | ICL3 | I | 292 | - | G.hgh4 | D | 323 | G.hgh4.13 |
Polar | TM3 | A | 186 | 3x53 | G.H5 | H | 387 | G.H5.19 |
Hydrophobic | TM3 | A | 186 | 3x53 | G.H5 | H | 387 | G.H5.19 |
Van-der-waals | TM3 | A | 186 | 3x53 | G.H5 | H | 387 | G.H5.19 |
Hydrophobic | C-term | D | 418 | - | G.H2 | R | 232 | G.H2.05 |
Van-der-waals | C-term | D | 418 | - | G.H2 | R | 232 | G.H2.05 |
Hydrophobic | TM3 | A | 186 | 3x53 | G.H5 | Y | 391 | G.H5.23 |
Van-der-waals | TM3 | A | 186 | 3x53 | G.H5 | Y | 391 | G.H5.23 |
Polar | C-term | K | 423 | - | G.H2 | R | 231 | G.H2.04 |
Van-der-waals | C-term | K | 423 | - | G.H2 | R | 231 | G.H2.04 |
Ionic | TM5 | R | 286 | 5x69 | G.H5 | D | 378 | G.H5.10 |
Hydrophobic | ICL3 | R | 291 | - | G.hgh4 | T | 325 | G.hgh4.15 |
Van-der-waals | ICL3 | R | 291 | - | G.hgh4 | T | 325 | G.hgh4.15 |
Ionic | TM6 | H | 297 | 6x26 | G.H5 | D | 381 | G.H5.13 |
Polar | TM6 | H | 297 | 6x26 | G.H5 | D | 381 | G.H5.13 |
Hydrophobic | TM6 | H | 297 | 6x26 | G.H5 | D | 381 | G.H5.13 |
Van-der-waals | TM6 | H | 297 | 6x26 | G.H5 | D | 381 | G.H5.13 |
Polar | C-term | N | 427 | - | G.s3h2 | Q | 227 | G.s3h2.03 |
Ionic | C-term | H | 422 | - | G.s4h3 | D | 260 | G.s4h3.11 |
Polar | C-term | H | 422 | - | G.s4h3 | D | 260 | G.s4h3.11 |
Polar | ICL2 | W | 190 | 34x50 | G.S1 | H | 41 | G.S1.02 |
Hydrophobic | ICL2 | W | 190 | 34x50 | G.S1 | H | 41 | G.S1.02 |
Van-der-waals | ICL2 | W | 190 | 34x50 | G.S1 | H | 41 | G.S1.02 |
Polar | ICL2 | R | 192 | 34x52 | G.H5 | Y | 391 | G.H5.23 |
Van-der-waals | ICL2 | R | 192 | 34x52 | G.H5 | Y | 391 | G.H5.23 |
Hydrophobic | ICL2 | S | 191 | 34x51 | G.hns1 | A | 39 | G.hns1.03 |
Ionic | TM5 | R | 286 | 5x69 | G.H5 | D | 381 | G.H5.13 |
Polar | TM5 | R | 286 | 5x69 | G.H5 | D | 381 | G.H5.13 |
Hydrophobic | TM5 | R | 286 | 5x69 | G.H5 | D | 381 | G.H5.13 |
Van-der-waals | TM5 | R | 286 | 5x69 | G.H5 | D | 381 | G.H5.13 |
Polar | ICL2 | R | 192 | 34x52 | G.H5 | H | 387 | G.H5.19 |
Hydrophobic | ICL2 | R | 192 | 34x52 | G.H5 | H | 387 | G.H5.19 |
Van-der-waals | ICL2 | R | 192 | 34x52 | G.H5 | H | 387 | G.H5.19 |
Hydrophobic | TM6 | Q | 300 | 6x29 | G.H5 | L | 394 | G.H5.26 |
Van-der-waals | TM6 | Q | 300 | 6x29 | G.H5 | L | 394 | G.H5.26 |
Polar | TM5 | E | 281 | 5x64 | G.H5 | Q | 384 | G.H5.16 |
Hydrophobic | C-term | R | 419 | - | G.H2 | R | 232 | G.H2.05 |
Van-der-waals | C-term | R | 419 | - | G.H2 | R | 232 | G.H2.05 |
Ionic | C-term | K | 423 | - | G.H2 | D | 229 | G.H2.02 |
Polar | C-term | K | 423 | - | G.H2 | D | 229 | G.H2.02 |
Hydrophobic | C-term | K | 423 | - | G.H2 | D | 229 | G.H2.02 |
Van-der-waals | C-term | K | 423 | - | G.H2 | D | 229 | G.H2.02 |
Polar | TM6 | H | 297 | 6x26 | G.H5 | R | 385 | G.H5.17 |
Aromatic | TM6 | H | 297 | 6x26 | G.H5 | R | 385 | G.H5.17 |
Hydrophobic | TM6 | H | 297 | 6x26 | G.H5 | R | 385 | G.H5.17 |
Van-der-waals | TM6 | H | 297 | 6x26 | G.H5 | R | 385 | G.H5.17 |