G15 -
ETB receptor complex model
GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 78.0
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 14.2
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Hydrophobic | TM5 | M | 300 | 5x65 | G.H5 | L | 368 | G.H5.20 |
Hydrophobic | C-term | F | 433 | - | G.H3 | T | 260 | G.H3.11 |
Hydrophobic | TM3 | A | 202 | 3x53 | G.H5 | I | 371 | G.H5.23 |
Hydrophobic | TM6 | V | 321 | 6x33 | G.H5 | L | 373 | G.H5.25 |
Van-der-waals | TM6 | V | 321 | 6x33 | G.H5 | L | 373 | G.H5.25 |
Hydrophobic | C-term | F | 433 | - | G.H2 | W | 219 | G.H2.07 |
Hydrophobic | C-term | A | 425 | - | G.H3 | P | 265 | G.H3.16 |
Polar | ICL1 | N | 134 | 12x52 | G.H5 | E | 370 | G.H5.22 |
Van-der-waals | ICL1 | N | 134 | 12x52 | G.H5 | E | 370 | G.H5.22 |
Aromatic | C-term | Y | 430 | - | G.H3 | W | 266 | G.H3.17 |
Hydrophobic | C-term | Y | 430 | - | G.H3 | W | 266 | G.H3.17 |
Hydrophobic | H8 | F | 393 | 8x50 | G.H5 | N | 372 | G.H5.24 |
Van-der-waals | H8 | F | 393 | 8x50 | G.H5 | N | 372 | G.H5.24 |
Aromatic | ICL2 | W | 206 | 34x50 | G.H5 | R | 360 | G.H5.12 |
Hydrophobic | ICL2 | W | 206 | 34x50 | G.H5 | R | 360 | G.H5.12 |
Van-der-waals | ICL2 | W | 206 | 34x50 | G.H5 | R | 360 | G.H5.12 |
Hydrophobic | ICL2 | I | 209 | 34x53 | G.H5 | V | 363 | G.H5.15 |
Van-der-waals | ICL2 | I | 209 | 34x53 | G.H5 | V | 363 | G.H5.15 |
Polar | H8 | S | 390 | 8x47 | G.H5 | L | 374 | G.H5.26 |
Hydrophobic | H8 | S | 390 | 8x47 | G.H5 | L | 374 | G.H5.26 |
Van-der-waals | H8 | S | 390 | 8x47 | G.H5 | L | 374 | G.H5.26 |
Hydrophobic | TM6 | T | 324 | 6x36 | G.H5 | L | 373 | G.H5.25 |
Aromatic | TM6 | H | 314 | 6x26 | G.S6 | F | 340 | G.S6.02 |
Hydrophobic | TM6 | H | 314 | 6x26 | G.S6 | F | 340 | G.S6.02 |
Van-der-waals | TM6 | H | 314 | 6x26 | G.S6 | F | 340 | G.S6.02 |
Hydrophobic | C-term | F | 433 | - | G.H3 | L | 264 | G.H3.15 |
Hydrophobic | TM3 | A | 202 | 3x53 | G.H5 | Y | 367 | G.H5.19 |
Polar | TM3 | R | 199 | 3x50 | G.H5 | I | 371 | G.H5.23 |
Hydrophobic | TM3 | R | 199 | 3x50 | G.H5 | I | 371 | G.H5.23 |
Van-der-waals | TM3 | R | 199 | 3x50 | G.H5 | I | 371 | G.H5.23 |
Hydrophobic | TM5 | M | 300 | 5x65 | G.H5 | L | 364 | G.H5.16 |
Hydrophobic | TM6 | V | 321 | 6x33 | G.H5 | L | 374 | G.H5.26 |
Polar | H8 | K | 391 | 8x48 | G.h4s6 | K | 332 | G.h4s6.14 |
Hydrophobic | H8 | K | 391 | 8x48 | G.h4s6 | K | 332 | G.h4s6.14 |
Van-der-waals | H8 | K | 391 | 8x48 | G.h4s6 | K | 332 | G.h4s6.14 |
Hydrophobic | TM5 | M | 296 | 5x61 | G.H5 | L | 373 | G.H5.25 |
Polar | ICL2 | S | 207 | 34x51 | G.S3 | T | 202 | G.S3.01 |
Hydrophobic | ICL2 | S | 207 | 34x51 | G.S3 | T | 202 | G.S3.01 |
Van-der-waals | ICL2 | S | 207 | 34x51 | G.S3 | T | 202 | G.S3.01 |
Hydrophobic | TM7 | L | 386 | 7x53 | G.H5 | N | 372 | G.H5.24 |
Van-der-waals | TM7 | L | 386 | 7x53 | G.H5 | N | 372 | G.H5.24 |
Hydrophobic | ICL2 | I | 209 | 34x53 | G.h2s4 | I | 227 | G.h2s4.05 |
Polar | TM6 | Q | 317 | 6x29 | G.h4s6 | R | 335 | G.h4s6.17 |
Van-der-waals | TM6 | Q | 317 | 6x29 | G.h4s6 | R | 335 | G.h4s6.17 |
Hydrophobic | ICL2 | W | 206 | 34x50 | G.H5 | V | 363 | G.H5.15 |
Van-der-waals | ICL2 | W | 206 | 34x50 | G.H5 | V | 363 | G.H5.15 |
Hydrophobic | TM7 | V | 389 | 7x56 | G.H5 | L | 373 | G.H5.25 |
Van-der-waals | TM7 | V | 389 | 7x56 | G.H5 | L | 373 | G.H5.25 |
Polar | TM3 | R | 199 | 3x50 | G.H5 | N | 372 | G.H5.24 |
Hydrophobic | ICL3 | L | 311 | - | G.H5 | K | 357 | G.H5.09 |
Van-der-waals | ICL3 | L | 311 | - | G.H5 | K | 357 | G.H5.09 |
Polar | ICL2 | K | 210 | 34x54 | G.H5 | Y | 367 | G.H5.19 |
Van-der-waals | ICL2 | K | 210 | 34x54 | G.H5 | Y | 367 | G.H5.19 |
Polar | TM6 | H | 314 | 6x26 | G.h4s6 | R | 338 | G.h4s6.20 |
Aromatic | TM6 | H | 314 | 6x26 | G.h4s6 | R | 338 | G.h4s6.20 |
Hydrophobic | TM6 | H | 314 | 6x26 | G.h4s6 | R | 338 | G.h4s6.20 |
Van-der-waals | TM6 | H | 314 | 6x26 | G.h4s6 | R | 338 | G.h4s6.20 |
Polar | H8 | K | 391 | 8x48 | G.H5 | L | 374 | G.H5.26 |
Hydrophobic | H8 | K | 391 | 8x48 | G.H5 | L | 374 | G.H5.26 |
Van-der-waals | H8 | K | 391 | 8x48 | G.H5 | L | 374 | G.H5.26 |
Polar | TM5 | K | 304 | 5x69 | G.s2s3 | Q | 200 | G.s2s3.01 |
Van-der-waals | TM5 | K | 304 | 5x69 | G.s2s3 | Q | 200 | G.s2s3.01 |
Hydrophobic | H8 | S | 390 | 8x47 | G.H5 | N | 372 | G.H5.24 |
Hydrophobic | C-term | N | 437 | - | G.H2 | R | 216 | G.H2.04 |
Hydrophobic | ICL2 | W | 206 | 34x50 | G.H5 | Y | 367 | G.H5.19 |
Van-der-waals | TM2 | I | 140 | 2x43 | G.H5 | N | 372 | G.H5.24 |
Polar | ICL2 | I | 209 | 34x53 | G.hns1 | R | 40 | G.hns1.02 |
Hydrophobic | ICL2 | I | 209 | 34x53 | G.hns1 | R | 40 | G.hns1.02 |
Van-der-waals | ICL2 | I | 209 | 34x53 | G.hns1 | R | 40 | G.hns1.02 |
Hydrophobic | C-term | G | 429 | - | G.H3 | W | 266 | G.H3.17 |
Hydrophobic | C-term | Y | 430 | - | G.H2 | I | 220 | G.H2.08 |
Van-der-waals | C-term | Y | 430 | - | G.H2 | I | 220 | G.H2.08 |
Polar | ICL2 | G | 211 | 34x55 | G.hns1 | R | 40 | G.hns1.02 |
Hydrophobic | ICL2 | G | 211 | 34x55 | G.hns1 | R | 40 | G.hns1.02 |
Polar | TM2 | N | 137 | 2x40 | G.H5 | N | 372 | G.H5.24 |
Hydrophobic | TM2 | N | 137 | 2x40 | G.H5 | N | 372 | G.H5.24 |
Van-der-waals | TM2 | N | 137 | 2x40 | G.H5 | N | 372 | G.H5.24 |
Ionic | TM6 | E | 320 | 6x32 | G.h4s6 | R | 335 | G.h4s6.17 |
Polar | TM6 | E | 320 | 6x32 | G.h4s6 | R | 335 | G.h4s6.17 |
Hydrophobic | TM6 | E | 320 | 6x32 | G.h4s6 | R | 335 | G.h4s6.17 |
Van-der-waals | TM6 | E | 320 | 6x32 | G.h4s6 | R | 335 | G.h4s6.17 |
Polar | TM6 | Q | 317 | 6x29 | G.h4s6 | R | 338 | G.h4s6.20 |
Van-der-waals | TM6 | Q | 317 | 6x29 | G.h4s6 | R | 338 | G.h4s6.20 |
Polar | TM5 | M | 307 | 5x72 | G.H5 | K | 357 | G.H5.09 |
Van-der-waals | TM5 | M | 307 | 5x72 | G.H5 | K | 357 | G.H5.09 |
Hydrophobic | C-term | F | 423 | - | G.h3s5 | K | 268 | G.h3s5.01 |
Van-der-waals | C-term | F | 423 | - | G.h3s5 | K | 268 | G.h3s5.01 |
Hydrophobic | TM5 | M | 307 | 5x72 | G.H5 | K | 354 | G.H5.06 |
Hydrophobic | TM5 | M | 307 | 5x72 | G.S6 | H | 342 | G.S6.04 |
Van-der-waals | TM5 | M | 307 | 5x72 | G.S6 | H | 342 | G.S6.04 |
Hydrophobic | TM3 | R | 199 | 3x50 | G.H5 | L | 373 | G.H5.25 |
Van-der-waals | TM3 | R | 199 | 3x50 | G.H5 | L | 373 | G.H5.25 |
Hydrophobic | TM6 | R | 318 | 6x30 | G.H5 | L | 364 | G.H5.16 |
Van-der-waals | TM6 | R | 318 | 6x30 | G.H5 | L | 364 | G.H5.16 |
Hydrophobic | ICL2 | I | 209 | 34x53 | G.H5 | Y | 367 | G.H5.19 |
Van-der-waals | ICL2 | I | 209 | 34x53 | G.H5 | Y | 367 | G.H5.19 |
Hydrophobic | ICL2 | I | 209 | 34x53 | G.S1 | L | 43 | G.S1.02 |
Van-der-waals | ICL2 | I | 209 | 34x53 | G.S1 | L | 43 | G.S1.02 |
Hydrophobic | TM3 | V | 203 | 3x54 | G.H5 | L | 364 | G.H5.16 |
Hydrophobic | TM6 | Q | 317 | 6x29 | G.H5 | L | 374 | G.H5.26 |
Van-der-waals | TM6 | Q | 317 | 6x29 | G.H5 | L | 374 | G.H5.26 |
Polar | H8 | K | 391 | 8x48 | G.h4s6 | G | 333 | G.h4s6.15 |
Van-der-waals | H8 | K | 391 | 8x48 | G.h4s6 | G | 333 | G.h4s6.15 |
Hydrophobic | ICL2 | W | 206 | 34x50 | G.S1 | L | 43 | G.S1.02 |
Polar | ICL2 | R | 208 | 34x52 | G.H5 | Y | 367 | G.H5.19 |
Hydrophobic | TM6 | V | 325 | 6x37 | G.H5 | L | 373 | G.H5.25 |
Van-der-waals | ICL2 | I | 209 | 34x53 | G.H5 | R | 366 | G.H5.18 |
Hydrophobic | TM2 | P | 136 | 2x39 | G.H5 | I | 371 | G.H5.23 |
Hydrophobic | TM6 | V | 321 | 6x33 | G.H5 | L | 368 | G.H5.20 |
Polar | TM7 | V | 389 | 7x56 | G.h4s6 | R | 335 | G.h4s6.17 |
Polar | C-term | S | 440 | - | G.H2 | K | 213 | G.H2.01 |
Hydrophobic | C-term | S | 440 | - | G.H2 | K | 213 | G.H2.01 |
Van-der-waals | C-term | S | 440 | - | G.H2 | K | 213 | G.H2.01 |
Polar | H8 | K | 391 | 8x48 | G.h4s6 | K | 331 | G.h4s6.13 |
Van-der-waals | H8 | K | 391 | 8x48 | G.h4s6 | K | 331 | G.h4s6.13 |
Hydrophobic | TM3 | V | 203 | 3x54 | G.H5 | L | 368 | G.H5.20 |
Hydrophobic | ICL2 | W | 206 | 34x50 | G.H5 | F | 356 | G.H5.08 |
Van-der-waals | ICL2 | W | 206 | 34x50 | G.H5 | F | 356 | G.H5.08 |
Ionic | TM6 | R | 318 | 6x30 | G.H5 | D | 361 | G.H5.13 |
Polar | TM6 | R | 318 | 6x30 | G.H5 | D | 361 | G.H5.13 |
Hydrophobic | TM6 | R | 318 | 6x30 | G.H5 | D | 361 | G.H5.13 |
Van-der-waals | TM6 | R | 318 | 6x30 | G.H5 | D | 361 | G.H5.13 |
Hydrophobic | TM7 | V | 389 | 7x56 | G.H5 | L | 374 | G.H5.26 |
Hydrophobic | C-term | F | 433 | - | G.H2 | R | 216 | G.H2.04 |