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ETB receptor complex model
GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 78.6
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 14.0
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Polar | N-term | E | 27 | - | G.HN | G | 2 | G.HN.02 |
Hydrophobic | N-term | E | 27 | - | G.HN | G | 2 | G.HN.02 |
Van-der-waals | N-term | E | 27 | - | G.HN | G | 2 | G.HN.02 |
Ionic | TM6 | H | 314 | 6x26 | G.h4s6 | E | 318 | G.h4s6.12 |
Polar | TM6 | H | 314 | 6x26 | G.h4s6 | E | 318 | G.h4s6.12 |
Hydrophobic | TM6 | H | 314 | 6x26 | G.h4s6 | E | 318 | G.h4s6.12 |
Van-der-waals | TM6 | H | 314 | 6x26 | G.h4s6 | E | 318 | G.h4s6.12 |
Hydrophobic | ICL3 | I | 309 | - | G.S6 | Y | 320 | G.S6.02 |
Hydrophobic | N-term | G | 26 | - | G.HN | G | 2 | G.HN.02 |
Hydrophobic | ICL2 | I | 209 | 34x53 | G.H5 | C | 351 | G.H5.23 |
Van-der-waals | ICL2 | I | 209 | 34x53 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | TM2 | P | 136 | 2x39 | G.H5 | C | 351 | G.H5.23 |
Van-der-waals | TM2 | P | 136 | 2x39 | G.H5 | C | 351 | G.H5.23 |
Polar | TM3 | R | 199 | 3x50 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | TM3 | R | 199 | 3x50 | G.H5 | C | 351 | G.H5.23 |
Van-der-waals | TM3 | R | 199 | 3x50 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | ICL2 | K | 210 | 34x54 | G.hns1 | A | 31 | G.hns1.02 |
Hydrophobic | TM6 | V | 325 | 6x37 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | TM6 | V | 321 | 6x33 | G.H5 | L | 348 | G.H5.20 |
Hydrophobic | TM3 | R | 199 | 3x50 | G.H5 | L | 353 | G.H5.25 |
Van-der-waals | TM3 | R | 199 | 3x50 | G.H5 | L | 353 | G.H5.25 |
Polar | H8 | S | 390 | 8x47 | G.H5 | Y | 354 | G.H5.26 |
Hydrophobic | H8 | S | 390 | 8x47 | G.H5 | Y | 354 | G.H5.26 |
Hydrophobic | TM4 | W | 217 | 4x41 | G.HN | K | 24 | G.HN.48 |
Van-der-waals | TM4 | W | 217 | 4x41 | G.HN | K | 24 | G.HN.48 |
Aromatic | ICL2 | W | 206 | 34x50 | G.H5 | F | 336 | G.H5.08 |
Hydrophobic | ICL2 | W | 206 | 34x50 | G.H5 | F | 336 | G.H5.08 |
Van-der-waals | ICL2 | W | 206 | 34x50 | G.H5 | F | 336 | G.H5.08 |
Hydrophobic | TM5 | M | 300 | 5x65 | G.H5 | L | 348 | G.H5.20 |
Van-der-waals | TM5 | M | 300 | 5x65 | G.H5 | L | 348 | G.H5.20 |
Hydrophobic | ICL2 | R | 208 | 34x52 | G.H5 | N | 347 | G.H5.19 |
Polar | ICL2 | K | 210 | 34x54 | G.HN | D | 26 | G.HN.50 |
Hydrophobic | ICL2 | K | 210 | 34x54 | G.hns1 | A | 30 | G.hns1.01 |
Hydrophobic | TM5 | M | 307 | 5x72 | G.S5 | I | 266 | G.S5.03 |
Hydrophobic | TM5 | M | 307 | 5x72 | G.S6 | Y | 320 | G.S6.02 |
Van-der-waals | TM5 | M | 307 | 5x72 | G.S6 | Y | 320 | G.S6.02 |
Hydrophobic | ICL2 | R | 208 | 34x52 | G.H5 | I | 343 | G.H5.15 |
Ionic | TM5 | K | 304 | 5x69 | G.H5 | D | 341 | G.H5.13 |
Polar | TM5 | K | 304 | 5x69 | G.H5 | D | 341 | G.H5.13 |
Van-der-waals | TM5 | K | 304 | 5x69 | G.H5 | D | 341 | G.H5.13 |
Polar | ICL2 | R | 208 | 34x52 | G.S1 | D | 33 | G.S1.01 |
Hydrophobic | ICL2 | R | 208 | 34x52 | G.S1 | D | 33 | G.S1.01 |
Van-der-waals | ICL2 | R | 208 | 34x52 | G.S1 | D | 33 | G.S1.01 |
Hydrophobic | TM3 | V | 203 | 3x54 | G.H5 | I | 344 | G.H5.16 |
Polar | TM6 | Q | 317 | 6x29 | G.H5 | Y | 354 | G.H5.26 |
Hydrophobic | TM6 | Q | 317 | 6x29 | G.H5 | Y | 354 | G.H5.26 |
Van-der-waals | TM6 | Q | 317 | 6x29 | G.H5 | Y | 354 | G.H5.26 |
Hydrophobic | ICL2 | S | 207 | 34x51 | G.H5 | I | 343 | G.H5.15 |
Hydrophobic | N-term | W | 25 | - | G.HN | G | 2 | G.HN.02 |
Hydrophobic | ICL2 | W | 206 | 34x50 | G.S3 | L | 195 | G.S3.01 |
Polar | ICL2 | S | 207 | 34x51 | G.H5 | N | 347 | G.H5.19 |
Van-der-waals | ICL2 | S | 207 | 34x51 | G.H5 | N | 347 | G.H5.19 |
Hydrophobic | TM5 | M | 300 | 5x65 | G.H5 | I | 344 | G.H5.16 |
Hydrophobic | TM6 | V | 321 | 6x33 | G.H5 | Y | 354 | G.H5.26 |
Hydrophobic | TM7 | V | 389 | 7x56 | G.H5 | L | 353 | G.H5.25 |
Polar | H8 | K | 391 | 8x48 | G.H5 | Y | 354 | G.H5.26 |
Hydrophobic | N-term | W | 25 | - | G.HN | M | 1 | G.HN.01 |
Van-der-waals | N-term | W | 25 | - | G.HN | M | 1 | G.HN.01 |
Hydrophobic | ICL3 | I | 309 | - | G.H5 | D | 341 | G.H5.13 |
Polar | TM3 | A | 202 | 3x53 | G.H5 | N | 347 | G.H5.19 |
Hydrophobic | TM3 | A | 202 | 3x53 | G.H5 | N | 347 | G.H5.19 |
Van-der-waals | TM3 | A | 202 | 3x53 | G.H5 | N | 347 | G.H5.19 |
Hydrophobic | H8 | F | 393 | 8x50 | G.H5 | G | 352 | G.H5.24 |
Hydrophobic | N-term | R | 29 | - | G.HN | T | 4 | G.HN.10 |
Van-der-waals | N-term | R | 29 | - | G.HN | T | 4 | G.HN.10 |
Hydrophobic | TM5 | M | 307 | 5x72 | G.H5 | A | 338 | G.H5.10 |
Van-der-waals | TM5 | M | 307 | 5x72 | G.H5 | A | 338 | G.H5.10 |
Ionic | TM6 | R | 318 | 6x30 | G.H5 | D | 341 | G.H5.13 |
Polar | TM6 | R | 318 | 6x30 | G.H5 | D | 341 | G.H5.13 |
Hydrophobic | TM6 | R | 318 | 6x30 | G.H5 | D | 341 | G.H5.13 |
Van-der-waals | TM6 | R | 318 | 6x30 | G.H5 | D | 341 | G.H5.13 |
Polar | TM5 | K | 304 | 5x69 | G.H5 | D | 337 | G.H5.09 |
Hydrophobic | TM5 | K | 304 | 5x69 | G.H5 | D | 337 | G.H5.09 |
Van-der-waals | TM5 | K | 304 | 5x69 | G.H5 | D | 337 | G.H5.09 |
Hydrophobic | TM5 | M | 307 | 5x72 | G.H5 | V | 334 | G.H5.06 |
Van-der-waals | TM5 | M | 307 | 5x72 | G.H5 | V | 334 | G.H5.06 |
Polar | C-term | Y | 430 | - | G.H2 | C | 215 | G.H2.10 |
Hydrophobic | C-term | Y | 430 | - | G.H2 | C | 215 | G.H2.10 |
Van-der-waals | C-term | Y | 430 | - | G.H2 | C | 215 | G.H2.10 |
Hydrophobic | TM3 | A | 202 | 3x53 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | ICL2 | R | 208 | 34x52 | G.S1 | V | 34 | G.S1.02 |
Van-der-waals | ICL2 | R | 208 | 34x52 | G.S1 | V | 34 | G.S1.02 |
Hydrophobic | ICL2 | W | 206 | 34x50 | G.H5 | I | 343 | G.H5.15 |
Van-der-waals | ICL2 | W | 206 | 34x50 | G.H5 | I | 343 | G.H5.15 |
Hydrophobic | H8 | S | 390 | 8x47 | G.H5 | G | 352 | G.H5.24 |
Van-der-waals | H8 | S | 390 | 8x47 | G.H5 | G | 352 | G.H5.24 |
Polar | N-term | W | 25 | - | G.HN | C | 3 | G.HN.09 |
Hydrophobic | N-term | W | 25 | - | G.HN | C | 3 | G.HN.09 |
Van-der-waals | N-term | W | 25 | - | G.HN | C | 3 | G.HN.09 |
Polar | ICL2 | K | 210 | 34x54 | G.HN | G | 27 | G.HN.51 |
Hydrophobic | ICL2 | K | 210 | 34x54 | G.HN | G | 27 | G.HN.51 |
Van-der-waals | ICL2 | K | 210 | 34x54 | G.HN | G | 27 | G.HN.51 |
Polar | TM2 | N | 137 | 2x40 | G.H5 | G | 350 | G.H5.22 |
Polar | N-term | E | 27 | - | G.HN | M | 1 | G.HN.01 |
Hydrophobic | N-term | E | 27 | - | G.HN | M | 1 | G.HN.01 |
Van-der-waals | N-term | E | 27 | - | G.HN | M | 1 | G.HN.01 |
Polar | ICL2 | R | 208 | 34x52 | G.hns1 | A | 31 | G.hns1.02 |
Van-der-waals | ICL2 | R | 208 | 34x52 | G.hns1 | A | 31 | G.hns1.02 |
Hydrophobic | TM3 | V | 203 | 3x54 | G.H5 | L | 348 | G.H5.20 |
Polar | ICL2 | R | 208 | 34x52 | G.h2s4 | T | 220 | G.h2s4.05 |
Hydrophobic | ICL2 | R | 208 | 34x52 | G.h2s4 | T | 220 | G.h2s4.05 |
Van-der-waals | ICL2 | R | 208 | 34x52 | G.h2s4 | T | 220 | G.h2s4.05 |
Polar | ICL2 | I | 209 | 34x53 | G.H5 | N | 347 | G.H5.19 |
Hydrophobic | ICL2 | I | 209 | 34x53 | G.H5 | N | 347 | G.H5.19 |
Van-der-waals | ICL2 | I | 209 | 34x53 | G.H5 | N | 347 | G.H5.19 |
Hydrophobic | TM6 | R | 318 | 6x30 | G.H5 | I | 344 | G.H5.16 |
Hydrophobic | TM6 | V | 321 | 6x33 | G.H5 | L | 353 | G.H5.25 |
Van-der-waals | TM6 | V | 321 | 6x33 | G.H5 | L | 353 | G.H5.25 |
Polar | TM5 | K | 304 | 5x69 | G.H5 | T | 340 | G.H5.12 |
Hydrophobic | TM5 | K | 304 | 5x69 | G.H5 | T | 340 | G.H5.12 |
Van-der-waals | TM5 | K | 304 | 5x69 | G.H5 | T | 340 | G.H5.12 |
Hydrophobic | ICL2 | S | 207 | 34x51 | G.hns1 | A | 31 | G.hns1.02 |
Van-der-waals | ICL2 | S | 207 | 34x51 | G.hns1 | A | 31 | G.hns1.02 |
Hydrophobic | ICL2 | W | 206 | 34x50 | G.s2s3 | K | 193 | G.s2s3.01 |
Van-der-waals | ICL2 | W | 206 | 34x50 | G.s2s3 | K | 193 | G.s2s3.01 |
Ionic | TM4 | K | 216 | 4x40 | G.HN | E | 20 | G.HN.44 |
Polar | TM4 | K | 216 | 4x40 | G.HN | E | 20 | G.HN.44 |
Hydrophobic | TM4 | K | 216 | 4x40 | G.HN | E | 20 | G.HN.44 |
Van-der-waals | TM4 | K | 216 | 4x40 | G.HN | E | 20 | G.HN.44 |
Polar | H8 | K | 391 | 8x48 | G.h4s6 | N | 316 | G.h4s6.10 |
Hydrophobic | ICL2 | W | 206 | 34x50 | G.H5 | T | 340 | G.H5.12 |
Polar | ICL1 | N | 134 | 12x52 | G.H5 | G | 350 | G.H5.22 |
Van-der-waals | ICL1 | N | 134 | 12x52 | G.H5 | G | 350 | G.H5.22 |
Polar | C-term | Y | 430 | - | G.H2 | H | 214 | G.H2.09 |
Aromatic | C-term | Y | 430 | - | G.H2 | H | 214 | G.H2.09 |
Hydrophobic | C-term | Y | 430 | - | G.H2 | H | 214 | G.H2.09 |
Van-der-waals | C-term | Y | 430 | - | G.H2 | H | 214 | G.H2.09 |
Polar | N-term | G | 26 | - | G.HN | M | 1 | G.HN.01 |
Hydrophobic | N-term | G | 26 | - | G.HN | M | 1 | G.HN.01 |
Van-der-waals | N-term | G | 26 | - | G.HN | M | 1 | G.HN.01 |