Gz - FFA1 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 87.8

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 14.3


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM5 L 209 5x65 G.H5 L 349 G.H5.20
Hydrophobic ICL2 L 112 34x51 G.S1 E 33 G.S1.01
Hydrophobic ICL2 P 111 34x50 G.S3 L 195 G.S3.01
Van-der-waals ICL2 P 111 34x50 G.S3 L 195 G.S3.01
Polar TM2 S 41 2x39 G.H5 I 352 G.H5.23
Hydrophobic TM2 S 41 2x39 G.H5 I 352 G.H5.23
Hydrophobic TM2 P 40 2x38 G.H5 Y 351 G.H5.22
Van-der-waals TM2 P 40 2x38 G.H5 Y 351 G.H5.22
Hydrophobic ICL3 L 214 - G.H5 Q 346 G.H5.17
Polar TM6 A 222 6x34 G.H5 L 354 G.H5.25
Hydrophobic TM6 A 222 6x34 G.H5 L 354 G.H5.25
Van-der-waals TM6 A 222 6x34 G.H5 L 354 G.H5.25
Hydrophobic TM3 A 108 3x54 G.H5 L 354 G.H5.25
Hydrophobic TM3 G 107 3x53 G.H5 I 352 G.H5.23
Polar TM3 R 104 3x50 G.H5 G 353 G.H5.24
Polar ICL2 Q 115 34x54 G.h2s4 T 220 G.h2s4.05
Hydrophobic ICL3 L 214 - G.H5 L 349 G.H5.20
Van-der-waals ICL3 L 214 - G.H5 L 349 G.H5.20
Hydrophobic TM3 R 104 3x50 G.H5 L 354 G.H5.25
Van-der-waals TM3 R 104 3x50 G.H5 L 354 G.H5.25
Hydrophobic TM3 A 108 3x54 G.H5 I 352 G.H5.23
Hydrophobic ICL3 L 214 - G.H5 I 345 G.H5.16
Polar TM6 R 218 6x30 G.H5 Q 346 G.H5.17
Hydrophobic TM6 R 218 6x30 G.H5 Q 346 G.H5.17
Van-der-waals TM6 R 218 6x30 G.H5 Q 346 G.H5.17
Polar TM3 G 107 3x53 G.H5 N 348 G.H5.19
Van-der-waals TM3 G 107 3x53 G.H5 N 348 G.H5.19
Polar TM3 R 104 3x50 G.H5 I 352 G.H5.23
Hydrophobic TM3 R 104 3x50 G.H5 I 352 G.H5.23
Van-der-waals TM3 R 104 3x50 G.H5 I 352 G.H5.23
Hydrophobic TM7 L 279 7x56 G.H5 G 353 G.H5.24
Van-der-waals TM7 L 279 7x56 G.H5 G 353 G.H5.24
Polar ICL2 G 113 34x52 G.hns1 R 31 G.hns1.02
Hydrophobic ICL2 G 113 34x52 G.hns1 R 31 G.hns1.02
Van-der-waals ICL2 G 113 34x52 G.hns1 R 31 G.hns1.02
Hydrophobic ICL2 L 112 34x51 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 L 112 34x51 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 G 113 34x52 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 L 112 34x51 G.S1 I 34 G.S1.02
Van-der-waals ICL2 L 112 34x51 G.S1 I 34 G.S1.02
Polar TM1 R 37 1x64 G.h3s5 N 262 G.h3s5.02
Hydrophobic TM1 R 37 1x64 G.h3s5 N 262 G.h3s5.02
Van-der-waals TM1 R 37 1x64 G.h3s5 N 262 G.h3s5.02
Polar ICL3 G 213 - G.H5 D 342 G.H5.13
Hydrophobic ICL3 G 213 - G.H5 D 342 G.H5.13
Van-der-waals ICL3 G 213 - G.H5 D 342 G.H5.13
Hydrophobic ICL2 Y 114 34x53 G.H5 I 352 G.H5.23
Polar ICL2 R 118 34x57 G.H5 N 348 G.H5.19
Van-der-waals ICL2 R 118 34x57 G.H5 N 348 G.H5.19
Polar TM2 S 41 2x39 G.H5 Y 351 G.H5.22
Hydrophobic TM6 V 225 6x37 G.H5 G 353 G.H5.24
Van-der-waals TM6 V 225 6x37 G.H5 G 353 G.H5.24
Polar TM2 T 39 2x37 G.H5 Y 351 G.H5.22
Hydrophobic TM2 T 39 2x37 G.H5 Y 351 G.H5.22
Van-der-waals TM2 T 39 2x37 G.H5 Y 351 G.H5.22
Hydrophobic TM3 A 108 3x54 G.H5 L 349 G.H5.20
Hydrophobic TM6 A 226 6x38 G.H5 L 354 G.H5.25
Polar ICL2 A 116 34x55 G.hns1 R 31 G.hns1.02
Hydrophobic ICL2 A 116 34x55 G.hns1 R 31 G.hns1.02
Van-der-waals ICL2 A 116 34x55 G.hns1 R 31 G.hns1.02
Hydrophobic ICL2 P 111 34x50 G.H5 N 348 G.H5.19
Van-der-waals ICL2 P 111 34x50 G.H5 N 348 G.H5.19
Hydrophobic TM6 A 222 6x34 G.H5 C 355 G.H5.26
Ionic TM5 R 211 5x67 G.s2s3 E 194 G.s2s3.02
Polar TM5 R 211 5x67 G.s2s3 E 194 G.s2s3.02
Hydrophobic TM5 R 211 5x67 G.s2s3 E 194 G.s2s3.02
Van-der-waals TM5 R 211 5x67 G.s2s3 E 194 G.s2s3.02
Van-der-waals TM6 R 221 6x33 G.H5 C 355 G.H5.26
Aromatic ICL2 R 118 34x57 G.H5 Y 351 G.H5.22
Hydrophobic ICL2 R 118 34x57 G.H5 Y 351 G.H5.22
Van-der-waals ICL2 R 118 34x57 G.H5 Y 351 G.H5.22
Hydrophobic TM1 R 37 1x64 G.H5 Y 351 G.H5.22
Van-der-waals TM1 R 37 1x64 G.H5 Y 351 G.H5.22
Hydrophobic ICL2 L 112 34x51 G.hns1 R 31 G.hns1.02
Van-der-waals ICL2 L 112 34x51 G.hns1 R 31 G.hns1.02
Hydrophobic TM6 V 225 6x37 G.H5 L 354 G.H5.25
Hydrophobic ICL2 L 112 34x51 G.S3 L 195 G.S3.01