Gz -
FFA2 receptor complex model
GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 87.0
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.8
iPTM Score: 0.8
PAE mean: 12.6
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
Gβ,
Gγ,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Polar | C-term | D | 326 | - | G.H3 | R | 249 | G.H3.07 |
Hydrophobic | C-term | D | 326 | - | G.H3 | R | 249 | G.H3.07 |
Van-der-waals | C-term | D | 326 | - | G.H3 | R | 249 | G.H3.07 |
Polar | TM4 | R | 122 | 4x38 | G.HN | Q | 28 | G.HN.52 |
Van-der-waals | TM4 | R | 122 | 4x38 | G.HN | Q | 28 | G.HN.52 |
Hydrophobic | ICL2 | P | 114 | 34x50 | G.H5 | I | 344 | G.H5.15 |
Van-der-waals | ICL2 | P | 114 | 34x50 | G.H5 | I | 344 | G.H5.15 |
Polar | C-term | E | 330 | - | G.H2 | R | 206 | G.H2.01 |
Hydrophobic | C-term | E | 330 | - | G.H2 | R | 206 | G.H2.01 |
Van-der-waals | C-term | E | 330 | - | G.H2 | R | 206 | G.H2.01 |
Hydrophobic | ICL2 | L | 119 | 34x55 | G.hns1 | R | 32 | G.hns1.03 |
Van-der-waals | ICL2 | L | 119 | 34x55 | G.hns1 | R | 32 | G.hns1.03 |
Aromatic | C-term | F | 327 | - | G.H3 | R | 249 | G.H3.07 |
Hydrophobic | C-term | F | 327 | - | G.H3 | R | 249 | G.H3.07 |
Van-der-waals | C-term | F | 327 | - | G.H3 | R | 249 | G.H3.07 |
Polar | ICL3 | V | 212 | - | G.H5 | D | 342 | G.H5.13 |
Hydrophobic | ICL3 | V | 212 | - | G.H5 | D | 342 | G.H5.13 |
Van-der-waals | ICL3 | V | 212 | - | G.H5 | D | 342 | G.H5.13 |
Polar | TM6 | Q | 215 | 6x29 | G.h4s6 | E | 316 | G.h4s6.09 |
Hydrophobic | TM6 | Q | 215 | 6x29 | G.h4s6 | E | 316 | G.h4s6.09 |
Van-der-waals | TM6 | Q | 215 | 6x29 | G.h4s6 | E | 316 | G.h4s6.09 |
Hydrophobic | TM3 | V | 111 | 3x54 | G.H5 | L | 349 | G.H5.20 |
Hydrophobic | TM3 | R | 107 | 3x50 | G.H5 | L | 354 | G.H5.25 |
Van-der-waals | TM3 | R | 107 | 3x50 | G.H5 | L | 354 | G.H5.25 |
Polar | ICL2 | R | 121 | 34x57 | G.hns1 | R | 31 | G.hns1.02 |
Hydrophobic | TM3 | V | 111 | 3x54 | G.H5 | I | 345 | G.H5.16 |
Polar | TM6 | R | 219 | 6x33 | G.H5 | C | 355 | G.H5.26 |
Hydrophobic | TM6 | R | 219 | 6x33 | G.H5 | C | 355 | G.H5.26 |
Van-der-waals | TM6 | R | 219 | 6x33 | G.H5 | C | 355 | G.H5.26 |
Polar | TM7 | S | 276 | 7x56 | G.H5 | C | 355 | G.H5.26 |
Hydrophobic | ICL2 | P | 114 | 34x50 | G.H5 | T | 341 | G.H5.12 |
Hydrophobic | ICL2 | V | 115 | 34x51 | G.S3 | L | 195 | G.S3.01 |
Van-der-waals | ICL2 | V | 115 | 34x51 | G.S3 | L | 195 | G.S3.01 |
Hydrophobic | TM6 | L | 223 | 6x37 | G.H5 | L | 354 | G.H5.25 |
Van-der-waals | TM6 | L | 223 | 6x37 | G.H5 | L | 354 | G.H5.25 |
Hydrophobic | ICL3 | L | 211 | - | G.S6 | Y | 321 | G.S6.02 |
Polar | TM6 | G | 213 | 6x27 | G.h4s6 | E | 319 | G.h4s6.12 |
Hydrophobic | TM6 | G | 213 | 6x27 | G.h4s6 | E | 319 | G.h4s6.12 |
Van-der-waals | TM6 | G | 213 | 6x27 | G.h4s6 | E | 319 | G.h4s6.12 |
Hydrophobic | TM5 | M | 206 | 5x65 | G.H5 | L | 349 | G.H5.20 |
Polar | C-term | T | 329 | - | G.H2 | R | 209 | G.H2.04 |
Van-der-waals | C-term | T | 329 | - | G.H2 | R | 209 | G.H2.04 |
Hydrophobic | TM3 | R | 107 | 3x50 | G.H5 | I | 352 | G.H5.23 |
Van-der-waals | TM3 | R | 107 | 3x50 | G.H5 | I | 352 | G.H5.23 |
Polar | TM6 | R | 216 | 6x30 | G.h4s6 | T | 317 | G.h4s6.10 |
Hydrophobic | TM6 | R | 216 | 6x30 | G.h4s6 | T | 317 | G.h4s6.10 |
Van-der-waals | TM6 | R | 216 | 6x30 | G.h4s6 | T | 317 | G.h4s6.10 |
Hydrophobic | TM6 | A | 220 | 6x34 | G.H5 | L | 349 | G.H5.20 |
Hydrophobic | TM3 | E | 106 | 3x49 | G.H5 | I | 352 | G.H5.23 |
Polar | ICL2 | P | 114 | 34x50 | G.H5 | N | 348 | G.H5.19 |
Van-der-waals | ICL2 | P | 114 | 34x50 | G.H5 | N | 348 | G.H5.19 |
Ionic | TM6 | R | 216 | 6x30 | G.h4s6 | E | 319 | G.h4s6.12 |
Polar | TM6 | R | 216 | 6x30 | G.h4s6 | E | 319 | G.h4s6.12 |
Hydrophobic | TM6 | R | 216 | 6x30 | G.h4s6 | E | 319 | G.h4s6.12 |
Van-der-waals | TM6 | R | 216 | 6x30 | G.h4s6 | E | 319 | G.h4s6.12 |
Hydrophobic | ICL2 | K | 118 | 34x54 | G.H5 | I | 344 | G.H5.15 |
Hydrophobic | ICL3 | Q | 209 | - | G.H5 | I | 345 | G.H5.16 |
Hydrophobic | ICL2 | V | 115 | 34x51 | G.H5 | I | 344 | G.H5.15 |
Polar | TM3 | R | 107 | 3x50 | G.H5 | G | 353 | G.H5.24 |
Van-der-waals | TM3 | R | 107 | 3x50 | G.H5 | G | 353 | G.H5.24 |
Hydrophobic | TM5 | F | 202 | 5x61 | G.H5 | L | 349 | G.H5.20 |
Polar | C-term | S | 325 | - | G.H3 | R | 249 | G.H3.07 |
Van-der-waals | C-term | S | 325 | - | G.H3 | R | 249 | G.H3.07 |
Hydrophobic | TM5 | F | 202 | 5x61 | G.H5 | L | 354 | G.H5.25 |
Van-der-waals | TM5 | F | 202 | 5x61 | G.H5 | L | 354 | G.H5.25 |
Hydrophobic | ICL2 | P | 114 | 34x50 | G.H5 | I | 345 | G.H5.16 |
Van-der-waals | ICL2 | P | 114 | 34x50 | G.H5 | I | 345 | G.H5.16 |
Polar | ICL2 | R | 121 | 34x57 | G.H5 | Y | 351 | G.H5.22 |
Aromatic | ICL2 | R | 121 | 34x57 | G.H5 | Y | 351 | G.H5.22 |
Hydrophobic | ICL2 | R | 121 | 34x57 | G.H5 | Y | 351 | G.H5.22 |
Van-der-waals | ICL2 | R | 121 | 34x57 | G.H5 | Y | 351 | G.H5.22 |
Polar | ICL1 | Q | 40 | - | G.hns1 | R | 31 | G.hns1.02 |
Hydrophobic | ICL1 | Q | 40 | - | G.hns1 | R | 31 | G.hns1.02 |
Van-der-waals | ICL1 | Q | 40 | - | G.hns1 | R | 31 | G.hns1.02 |
Hydrophobic | ICL2 | L | 119 | 34x55 | G.hns1 | R | 31 | G.hns1.02 |
Polar | TM6 | R | 216 | 6x30 | G.h4s6 | E | 316 | G.h4s6.09 |
Hydrophobic | TM6 | R | 216 | 6x30 | G.h4s6 | E | 316 | G.h4s6.09 |
Van-der-waals | TM6 | R | 216 | 6x30 | G.h4s6 | E | 316 | G.h4s6.09 |
Polar | TM3 | G | 110 | 3x53 | G.H5 | N | 348 | G.H5.19 |
Hydrophobic | TM3 | G | 110 | 3x53 | G.H5 | N | 348 | G.H5.19 |
Van-der-waals | TM3 | G | 110 | 3x53 | G.H5 | N | 348 | G.H5.19 |
Hydrophobic | C-term | E | 330 | - | G.s4h3 | E | 237 | G.s4h3.10 |
Van-der-waals | C-term | E | 330 | - | G.s4h3 | E | 237 | G.s4h3.10 |
Hydrophobic | ICL3 | L | 211 | - | G.H5 | D | 342 | G.H5.13 |
Van-der-waals | ICL3 | L | 211 | - | G.H5 | D | 342 | G.H5.13 |
Polar | TM7 | S | 276 | 7x56 | G.H5 | L | 354 | G.H5.25 |
Polar | TM6 | R | 216 | 6x30 | G.H5 | Q | 346 | G.H5.17 |
Van-der-waals | TM6 | R | 216 | 6x30 | G.H5 | Q | 346 | G.H5.17 |
Hydrophobic | ICL3 | L | 211 | - | G.H5 | D | 338 | G.H5.09 |
Hydrophobic | TM6 | A | 220 | 6x34 | G.H5 | L | 354 | G.H5.25 |
Polar | H8 | R | 281 | 8x51 | G.H5 | C | 355 | G.H5.26 |
Van-der-waals | H8 | R | 281 | 8x51 | G.H5 | C | 355 | G.H5.26 |
Hydrophobic | ICL2 | Y | 117 | 34x53 | G.H5 | N | 348 | G.H5.19 |
Van-der-waals | ICL2 | Y | 117 | 34x53 | G.H5 | N | 348 | G.H5.19 |
Hydrophobic | TM2 | V | 44 | 2x39 | G.H5 | I | 352 | G.H5.23 |
Hydrophobic | ICL2 | Y | 117 | 34x53 | G.H5 | I | 352 | G.H5.23 |
Hydrophobic | TM3 | G | 110 | 3x53 | G.H5 | I | 352 | G.H5.23 |
Polar | TM7 | S | 276 | 7x56 | G.H5 | G | 353 | G.H5.24 |
Hydrophobic | TM7 | S | 276 | 7x56 | G.H5 | G | 353 | G.H5.24 |
Van-der-waals | TM7 | S | 276 | 7x56 | G.H5 | G | 353 | G.H5.24 |
Hydrophobic | C-term | T | 329 | - | G.H3 | E | 246 | G.H3.04 |
Van-der-waals | C-term | T | 329 | - | G.H3 | E | 246 | G.H3.04 |