G12 - FFA3 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G12/13

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 85.6

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.8
iPTM Score: 0.8
PAE mean: 13.4


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL2 L 121 34x51 G.H5 K 367 G.H5.12
Polar H8 G 282 8x49 G.H5 L 380 G.H5.25
Van-der-waals H8 G 282 8x49 G.H5 L 380 G.H5.25
Hydrophobic ICL2 P 120 34x50 G.H5 L 371 G.H5.16
Hydrophobic TM6 R 219 6x30 G.H5 L 375 G.H5.20
Van-der-waals TM6 R 219 6x30 G.H5 L 375 G.H5.20
Hydrophobic TM5 L 211 5x65 G.H5 L 375 G.H5.20
Polar ICL2 T 125 34x55 G.hns1 R 56 G.hns1.03
Hydrophobic ICL2 T 125 34x55 G.hns1 R 56 G.hns1.03
Van-der-waals ICL2 T 125 34x55 G.hns1 R 56 G.hns1.03
Hydrophobic TM3 S 116 3x53 G.H5 I 378 G.H5.23
Van-der-waals TM3 S 116 3x53 G.H5 I 378 G.H5.23
Ionic ICL1 R 46 - G.H5 D 377 G.H5.22
Polar ICL1 R 46 - G.H5 D 377 G.H5.22
Hydrophobic ICL1 R 46 - G.H5 D 377 G.H5.22
Van-der-waals ICL1 R 46 - G.H5 D 377 G.H5.22
Hydrophobic ICL2 L 121 34x51 G.S3 I 221 G.S3.01
Van-der-waals ICL2 L 121 34x51 G.S3 I 221 G.S3.01
Hydrophobic TM3 V 117 3x54 G.H5 L 375 G.H5.20
Van-der-waals TM3 V 117 3x54 G.H5 L 375 G.H5.20
Van-der-waals TM4 L 129 4x39 G.hns1 R 55 G.hns1.02
Hydrophobic ICL2 P 120 34x50 G.H5 K 367 G.H5.12
Polar ICL2 K 124 34x54 G.S1 L 57 G.S1.01
Hydrophobic ICL2 K 124 34x54 G.S1 L 57 G.S1.01
Van-der-waals ICL2 K 124 34x54 G.S1 L 57 G.S1.01
Hydrophobic ICL2 K 124 34x54 G.H5 I 370 G.H5.15
Hydrophobic TM6 R 219 6x30 G.H5 M 379 G.H5.24
Van-der-waals TM6 R 219 6x30 G.H5 M 379 G.H5.24
Hydrophobic TM6 R 222 6x33 G.H5 M 379 G.H5.24
Van-der-waals TM6 R 222 6x33 G.H5 M 379 G.H5.24
Polar H8 S 281 8x48 G.H5 L 380 G.H5.25
Van-der-waals H8 S 281 8x48 G.H5 L 380 G.H5.25
Polar TM3 R 113 3x50 G.H5 I 378 G.H5.23
Hydrophobic TM3 R 113 3x50 G.H5 I 378 G.H5.23
Van-der-waals TM3 R 113 3x50 G.H5 I 378 G.H5.23
Hydrophobic ICL2 L 121 34x51 G.H5 F 363 G.H5.08
Van-der-waals ICL2 L 121 34x51 G.H5 F 363 G.H5.08
Polar ICL2 K 124 34x54 G.h2s4 T 246 G.h2s4.05
Van-der-waals ICL2 K 124 34x54 G.h2s4 T 246 G.h2s4.05
Polar TM3 S 116 3x53 G.H5 N 374 G.H5.19
Hydrophobic TM3 S 116 3x53 G.H5 N 374 G.H5.19
Van-der-waals TM3 S 116 3x53 G.H5 N 374 G.H5.19
Hydrophobic TM3 V 117 3x54 G.H5 I 378 G.H5.23
Van-der-waals TM3 V 117 3x54 G.H5 I 378 G.H5.23
Hydrophobic ICL2 P 120 34x50 G.H5 I 370 G.H5.15
Polar H8 S 280 8x47 G.H5 L 380 G.H5.25
Hydrophobic H8 S 280 8x47 G.H5 L 380 G.H5.25
Van-der-waals H8 S 280 8x47 G.H5 L 380 G.H5.25
Hydrophobic ICL2 Y 123 34x53 G.H5 N 374 G.H5.19
Hydrophobic ICL2 L 121 34x51 G.H5 V 366 G.H5.11
Polar TM6 R 219 6x30 G.H5 Q 372 G.H5.17
Hydrophobic TM6 R 219 6x30 G.H5 Q 372 G.H5.17
Van-der-waals TM6 R 219 6x30 G.H5 Q 372 G.H5.17
Ionic ICL1 R 46 - G.H5 E 373 G.H5.18
Polar ICL1 R 46 - G.H5 E 373 G.H5.18
Van-der-waals ICL1 R 46 - G.H5 E 373 G.H5.18
Hydrophobic ICL2 L 121 34x51 G.H5 I 370 G.H5.15
Van-der-waals ICL2 L 121 34x51 G.H5 I 370 G.H5.15
Hydrophobic ICL2 T 125 34x55 G.S3 I 221 G.S3.01
Hydrophobic TM3 V 117 3x54 G.H5 L 371 G.H5.16
Van-der-waals TM3 V 117 3x54 G.H5 L 371 G.H5.16
Polar H8 S 281 8x48 G.H5 Q 381 G.H5.26
Van-der-waals H8 S 281 8x48 G.H5 Q 381 G.H5.26
Van-der-waals TM1 K 42 1x60 G.H5 L 380 G.H5.25
Van-der-waals ICL2 P 120 34x50 G.H5 N 374 G.H5.19
Polar TM6 R 222 6x33 G.H5 Q 381 G.H5.26
Van-der-waals TM6 R 222 6x33 G.H5 Q 381 G.H5.26
Van-der-waals TM7 S 279 7x56 G.H5 M 379 G.H5.24
Hydrophobic TM6 V 223 6x34 G.H5 M 379 G.H5.24