Gi2 -
FFA4 receptor complex model
GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 87.6
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.8
iPTM Score: 0.8
PAE mean: 11.9
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
Gβ,
Gγ,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Hydrophobic | TM6 | L | 262 | 6x34 | G.H5 | L | 354 | G.H5.25 |
Hydrophobic | TM6 | L | 266 | 6x38 | G.H5 | L | 354 | G.H5.25 |
Polar | ICL2 | R | 145 | 34x52 | G.h2s4 | T | 220 | G.h2s4.05 |
Hydrophobic | ICL2 | R | 145 | 34x52 | G.h2s4 | T | 220 | G.h2s4.05 |
Van-der-waals | ICL2 | R | 145 | 34x52 | G.h2s4 | T | 220 | G.h2s4.05 |
Polar | TM3 | R | 136 | 3x50 | G.H5 | C | 352 | G.H5.23 |
Hydrophobic | TM3 | R | 136 | 3x50 | G.H5 | C | 352 | G.H5.23 |
Van-der-waals | TM3 | R | 136 | 3x50 | G.H5 | C | 352 | G.H5.23 |
Hydrophobic | TM5 | L | 241 | 5x72 | G.H5 | A | 339 | G.H5.10 |
Ionic | TM6 | R | 254 | 6x26 | G.h4s6 | D | 316 | G.h4s6.09 |
Polar | TM6 | R | 254 | 6x26 | G.h4s6 | D | 316 | G.h4s6.09 |
Hydrophobic | TM6 | R | 254 | 6x26 | G.h4s6 | D | 316 | G.h4s6.09 |
Van-der-waals | TM6 | R | 254 | 6x26 | G.h4s6 | D | 316 | G.h4s6.09 |
Hydrophobic | C-term | G | 361 | - | G.H2 | R | 206 | G.H2.01 |
Van-der-waals | C-term | G | 361 | - | G.H2 | R | 206 | G.H2.01 |
Polar | ICL3 | Y | 247 | - | G.h4s6 | E | 319 | G.h4s6.12 |
Ionic | TM5 | R | 238 | 5x69 | G.H5 | D | 342 | G.H5.13 |
Hydrophobic | TM5 | S | 244 | 5x75 | G.H5 | F | 335 | G.H5.06 |
Van-der-waals | TM5 | S | 244 | 5x75 | G.H5 | F | 335 | G.H5.06 |
Hydrophobic | C-term | L | 356 | - | G.H3 | S | 253 | G.H3.11 |
Van-der-waals | C-term | L | 356 | - | G.H3 | S | 253 | G.H3.11 |
Polar | C-term | S | 360 | - | G.s4h3 | E | 237 | G.s4h3.10 |
Hydrophobic | C-term | S | 360 | - | G.s4h3 | E | 237 | G.s4h3.10 |
Van-der-waals | C-term | S | 360 | - | G.s4h3 | E | 237 | G.s4h3.10 |
Hydrophobic | ICL2 | R | 145 | 34x52 | G.H5 | I | 344 | G.H5.15 |
Hydrophobic | TM5 | L | 245 | 5x76 | G.S6 | T | 322 | G.S6.03 |
Van-der-waals | TM5 | L | 245 | 5x76 | G.S6 | T | 322 | G.S6.03 |
Hydrophobic | TM5 | L | 241 | 5x72 | G.S6 | Y | 321 | G.S6.02 |
Van-der-waals | TM5 | L | 241 | 5x72 | G.S6 | Y | 321 | G.S6.02 |
Hydrophobic | TM5 | L | 245 | 5x76 | G.S6 | H | 323 | G.S6.04 |
Van-der-waals | TM5 | L | 245 | 5x76 | G.S6 | H | 323 | G.S6.04 |
Hydrophobic | TM6 | L | 269 | 6x41 | G.H5 | L | 354 | G.H5.25 |
Ionic | TM5 | R | 240 | 5x71 | G.H5 | D | 338 | G.H5.09 |
Polar | TM5 | R | 240 | 5x71 | G.H5 | D | 338 | G.H5.09 |
Hydrophobic | TM5 | R | 240 | 5x71 | G.H5 | D | 338 | G.H5.09 |
Hydrophobic | TM5 | L | 245 | 5x76 | G.S6 | Y | 321 | G.S6.02 |
Van-der-waals | TM5 | L | 245 | 5x76 | G.S6 | Y | 321 | G.S6.02 |
Hydrophobic | ICL3 | A | 246 | - | G.S6 | F | 324 | G.S6.05 |
Van-der-waals | ICL3 | A | 246 | - | G.S6 | F | 324 | G.S6.05 |
Hydrophobic | TM5 | L | 241 | 5x72 | G.H5 | D | 342 | G.H5.13 |
Van-der-waals | TM5 | L | 241 | 5x72 | G.H5 | D | 342 | G.H5.13 |
Hydrophobic | TM5 | I | 233 | 5x64 | G.H5 | I | 345 | G.H5.16 |
Hydrophobic | C-term | I | 359 | - | G.H2 | R | 209 | G.H2.04 |
Van-der-waals | C-term | I | 359 | - | G.H2 | R | 209 | G.H2.04 |
Hydrophobic | TM3 | I | 140 | 3x54 | G.H5 | I | 345 | G.H5.16 |
Polar | ICL2 | R | 145 | 34x52 | G.h2s4 | V | 219 | G.h2s4.04 |
Hydrophobic | ICL2 | R | 145 | 34x52 | G.h2s4 | V | 219 | G.h2s4.04 |
Hydrophobic | ICL2 | V | 147 | 34x54 | G.hns1 | A | 31 | G.hns1.02 |
Van-der-waals | ICL2 | V | 147 | 34x54 | G.hns1 | A | 31 | G.hns1.02 |
Hydrophobic | TM6 | L | 262 | 6x34 | G.H5 | L | 349 | G.H5.20 |
Ionic | TM6 | H | 251 | 6x23 | G.h4s6 | E | 319 | G.h4s6.12 |
Polar | TM6 | H | 251 | 6x23 | G.h4s6 | E | 319 | G.h4s6.12 |
Hydrophobic | TM6 | H | 251 | 6x23 | G.h4s6 | E | 319 | G.h4s6.12 |
Van-der-waals | TM6 | H | 251 | 6x23 | G.h4s6 | E | 319 | G.h4s6.12 |
Hydrophobic | TM3 | C | 139 | 3x53 | G.H5 | C | 352 | G.H5.23 |
Hydrophobic | ICL2 | V | 147 | 34x54 | G.hns1 | R | 32 | G.hns1.03 |
Polar | TM5 | S | 244 | 5x75 | G.S6 | H | 323 | G.S6.04 |
Hydrophobic | TM5 | S | 244 | 5x75 | G.S6 | H | 323 | G.S6.04 |
Van-der-waals | TM5 | S | 244 | 5x75 | G.S6 | H | 323 | G.S6.04 |
Hydrophobic | TM3 | I | 140 | 3x54 | G.H5 | N | 348 | G.H5.19 |
Hydrophobic | TM5 | T | 234 | 5x65 | G.H5 | I | 345 | G.H5.16 |
Van-der-waals | ICL2 | R | 145 | 34x52 | G.hns1 | A | 31 | G.hns1.02 |
Polar | TM5 | S | 237 | 5x68 | G.H5 | D | 342 | G.H5.13 |
Van-der-waals | TM5 | S | 237 | 5x68 | G.H5 | D | 342 | G.H5.13 |
Van-der-waals | ICL3 | Y | 247 | - | G.S6 | Y | 321 | G.S6.02 |
Hydrophobic | TM5 | S | 237 | 5x68 | G.H5 | I | 345 | G.H5.16 |
Van-der-waals | TM5 | S | 237 | 5x68 | G.H5 | I | 345 | G.H5.16 |
Hydrophobic | ICL2 | L | 143 | 34x50 | G.H5 | T | 341 | G.H5.12 |
Hydrophobic | TM5 | I | 230 | 5x61 | G.H5 | L | 349 | G.H5.20 |
Polar | TM6 | R | 254 | 6x26 | G.h4s6 | K | 315 | G.h4s6.08 |
Hydrophobic | TM6 | R | 254 | 6x26 | G.h4s6 | K | 315 | G.h4s6.08 |
Van-der-waals | TM6 | R | 254 | 6x26 | G.h4s6 | K | 315 | G.h4s6.08 |
Polar | ICL2 | Q | 144 | 34x51 | G.H5 | N | 348 | G.H5.19 |
Van-der-waals | ICL2 | Q | 144 | 34x51 | G.H5 | N | 348 | G.H5.19 |
Hydrophobic | ICL2 | L | 143 | 34x50 | G.H5 | I | 344 | G.H5.15 |
Van-der-waals | ICL2 | L | 143 | 34x50 | G.H5 | I | 344 | G.H5.15 |
Polar | ICL3 | A | 246 | - | G.S6 | T | 322 | G.S6.03 |
Polar | ICL3 | A | 246 | - | G.H4 | Q | 305 | G.H4.12 |
Hydrophobic | ICL3 | A | 246 | - | G.H4 | Q | 305 | G.H4.12 |
Van-der-waals | ICL3 | A | 246 | - | G.H4 | Q | 305 | G.H4.12 |
Hydrophobic | TM3 | I | 140 | 3x54 | G.H5 | L | 349 | G.H5.20 |
Van-der-waals | TM3 | I | 140 | 3x54 | G.H5 | L | 349 | G.H5.20 |
Hydrophobic | TM3 | R | 136 | 3x50 | G.H5 | L | 354 | G.H5.25 |
Hydrophobic | TM5 | I | 230 | 5x61 | G.H5 | L | 354 | G.H5.25 |
Hydrophobic | TM6 | T | 265 | 6x37 | G.H5 | L | 354 | G.H5.25 |
Hydrophobic | ICL2 | L | 143 | 34x50 | G.S3 | L | 195 | G.S3.01 |
Hydrophobic | TM7 | T | 324 | 7x56 | G.H5 | F | 355 | G.H5.26 |
Van-der-waals | TM7 | T | 324 | 7x56 | G.H5 | F | 355 | G.H5.26 |
Polar | ICL2 | R | 145 | 34x52 | G.h2s4 | G | 218 | G.h2s4.03 |
Van-der-waals | ICL2 | R | 145 | 34x52 | G.h2s4 | G | 218 | G.h2s4.03 |
Polar | C-term | G | 361 | - | G.s4h3 | E | 237 | G.s4h3.10 |
Hydrophobic | C-term | G | 361 | - | G.s4h3 | E | 237 | G.s4h3.10 |
Van-der-waals | C-term | G | 361 | - | G.s4h3 | E | 237 | G.s4h3.10 |
Polar | ICL2 | G | 146 | 34x53 | G.H5 | N | 348 | G.H5.19 |
Hydrophobic | C-term | I | 359 | - | G.H3 | L | 250 | G.H3.08 |
Polar | TM3 | C | 139 | 3x53 | G.H5 | N | 348 | G.H5.19 |
Van-der-waals | TM3 | C | 139 | 3x53 | G.H5 | N | 348 | G.H5.19 |
Polar | TM7 | T | 324 | 7x56 | G.H5 | G | 353 | G.H5.24 |
Hydrophobic | TM7 | T | 324 | 7x56 | G.H5 | G | 353 | G.H5.24 |
Van-der-waals | TM7 | T | 324 | 7x56 | G.H5 | G | 353 | G.H5.24 |
Hydrophobic | ICL2 | L | 143 | 34x50 | G.H5 | I | 345 | G.H5.16 |
Van-der-waals | ICL2 | L | 143 | 34x50 | G.H5 | I | 345 | G.H5.16 |
Hydrophobic | TM5 | L | 241 | 5x72 | G.H5 | D | 338 | G.H5.09 |
Van-der-waals | TM5 | L | 241 | 5x72 | G.H5 | D | 338 | G.H5.09 |