Gi1 - FZD10 complex model

GPCR CLASS (FAMILY)

F (Frizzled)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

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Tertiary structure confidence

(pLDDT score) avg.: 76.9

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.5
iPTM Score: 0.2
PAE mean: 27.4


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM6 L 440 6x29 G.H5 L 353 G.H5.25
Van-der-waals TM6 L 440 6x29 G.H5 L 353 G.H5.25
Polar TM3 W 334 3x50 G.H5 G 352 G.H5.24
Hydrophobic TM5 I 423 5x72 G.H5 I 344 G.H5.16
Hydrophobic ICL2 W 342 - G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 W 342 - G.hns1 R 32 G.hns1.03
Hydrophobic TM6 I 444 6x33 G.H5 G 352 G.H5.24
Van-der-waals TM6 I 444 6x33 G.H5 G 352 G.H5.24
Hydrophobic TM5 L 420 5x69 G.H5 L 353 G.H5.25
Van-der-waals TM5 L 420 5x69 G.H5 L 353 G.H5.25
Hydrophobic N-term E 76 - G.h2s4 E 216 G.h2s4.02
Van-der-waals N-term E 76 - G.h2s4 E 216 G.h2s4.02
Hydrophobic TM3 A 337 3x53 G.H5 L 353 G.H5.25
Van-der-waals TM3 A 337 3x53 G.H5 L 353 G.H5.25
Polar TM4 G 343 4x34 G.hns1 A 31 G.hns1.02
Polar N-term H 69 - G.H2 H 213 G.H2.09
Aromatic N-term H 69 - G.H2 H 213 G.H2.09
Hydrophobic N-term H 69 - G.H2 H 213 G.H2.09
Van-der-waals N-term H 69 - G.H2 H 213 G.H2.09
Hydrophobic TM4 G 343 4x34 G.H5 N 347 G.H5.19
Van-der-waals TM4 G 343 4x34 G.H5 N 347 G.H5.19
Polar ICL2 W 342 - G.H5 C 351 G.H5.23
Van-der-waals ICL2 W 342 - G.H5 C 351 G.H5.23
Ionic ICL1 R 257 12x51 G.h3s5 D 261 G.h3s5.02
Polar ICL1 R 257 12x51 G.h3s5 D 261 G.h3s5.02
Hydrophobic ICL1 R 257 12x51 G.h3s5 D 261 G.h3s5.02
Van-der-waals ICL1 R 257 12x51 G.h3s5 D 261 G.h3s5.02
Hydrophobic TM4 H 344 4x35 G.H5 C 351 G.H5.23
Polar ICL2 K 340 - G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 K 340 - G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 K 340 - G.hns1 R 32 G.hns1.03
Hydrophobic TM4 H 344 4x35 G.h3s5 D 261 G.h3s5.02
Polar TM4 E 345 4x36 G.h2s4 G 217 G.h2s4.03
Hydrophobic TM4 E 345 4x36 G.h2s4 G 217 G.h2s4.03
Van-der-waals TM4 E 345 4x36 G.h2s4 G 217 G.h2s4.03
Ionic ICL3 K 436 - G.h4s6 E 318 G.h4s6.12
Polar ICL3 K 436 - G.h4s6 E 318 G.h4s6.12
Hydrophobic TM5 M 427 5x76 G.H5 F 354 G.H5.26
Van-der-waals TM5 M 427 5x76 G.H5 F 354 G.H5.26
Polar ICL2 W 342 - G.HN E 28 G.HN.52
Hydrophobic ICL2 W 342 - G.HN E 28 G.HN.52
Hydrophobic TM2 P 259 2x40 G.H5 D 350 G.H5.22
Ionic ICL3 E 432 - G.H5 K 345 G.H5.17
Polar ICL3 E 432 - G.H5 K 345 G.H5.17
Polar ICL2 K 341 - G.s2s3 K 192 G.s2s3.01
Hydrophobic TM2 P 259 2x40 G.H5 C 351 G.H5.23
Van-der-waals TM2 P 259 2x40 G.H5 C 351 G.H5.23
Hydrophobic ICL3 K 436 - G.H5 F 354 G.H5.26
Van-der-waals ICL3 K 436 - G.H5 F 354 G.H5.26
Hydrophobic ICL2 W 342 - G.H5 N 347 G.H5.19
Ionic ICL2 K 340 - G.HN E 28 G.HN.52
Polar ICL2 K 340 - G.HN E 28 G.HN.52
Hydrophobic TM3 W 334 3x50 G.H5 L 353 G.H5.25
Van-der-waals TM3 W 334 3x50 G.H5 L 353 G.H5.25
Hydrophobic ICL2 K 341 - G.H5 I 344 G.H5.16
Van-der-waals ICL2 K 341 - G.H5 I 344 G.H5.16
Polar ICL2 K 341 - G.H5 N 347 G.H5.19
Ionic TM4 H 344 4x35 G.H5 D 350 G.H5.22
Polar TM4 H 344 4x35 G.H5 D 350 G.H5.22
Hydrophobic TM4 H 344 4x35 G.H5 D 350 G.H5.22
Van-der-waals TM4 H 344 4x35 G.H5 D 350 G.H5.22
Hydrophobic TM3 A 338 3x54 G.H5 L 353 G.H5.25
Hydrophobic TM6 L 440 6x29 G.H5 F 354 G.H5.26
Van-der-waals TM6 L 440 6x29 G.H5 F 354 G.H5.26
Polar TM2 E 260 2x41 G.H5 G 352 G.H5.24
Hydrophobic TM2 E 260 2x41 G.H5 G 352 G.H5.24
Van-der-waals TM2 E 260 2x41 G.H5 G 352 G.H5.24
Hydrophobic TM3 A 337 3x53 G.H5 C 351 G.H5.23
Van-der-waals TM3 A 337 3x53 G.H5 C 351 G.H5.23
Hydrophobic TM4 I 347 4x38 G.H5 C 351 G.H5.23
Van-der-waals TM4 I 347 4x38 G.H5 C 351 G.H5.23
Hydrophobic TM6 I 444 6x33 G.H5 L 353 G.H5.25
Van-der-waals TM6 I 444 6x33 G.H5 L 353 G.H5.25
Polar TM3 W 334 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 W 334 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 A 338 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 A 338 3x54 G.H5 L 348 G.H5.20
Hydrophobic TM4 G 343 4x34 G.H5 C 351 G.H5.23
Van-der-waals TM2 Y 258 2x39 G.H5 D 350 G.H5.22
Polar TM4 E 345 4x36 G.h2s4 V 218 G.h2s4.04
Hydrophobic TM4 E 345 4x36 G.h2s4 V 218 G.h2s4.04
Van-der-waals TM4 E 345 4x36 G.h2s4 V 218 G.h2s4.04
Hydrophobic TM5 M 427 5x76 G.H5 K 345 G.H5.17
Van-der-waals TM5 M 427 5x76 G.H5 K 345 G.H5.17
Polar TM4 E 345 4x36 G.h2s4 T 219 G.h2s4.05
Hydrophobic TM4 E 345 4x36 G.h2s4 T 219 G.h2s4.05
Van-der-waals TM4 E 345 4x36 G.h2s4 T 219 G.h2s4.05
Polar ICL2 W 342 - G.hns1 A 31 G.hns1.02
Hydrophobic ICL2 W 342 - G.hns1 A 31 G.hns1.02
Van-der-waals ICL2 W 342 - G.hns1 A 31 G.hns1.02
Hydrophobic TM6 L 440 6x29 G.H5 G 352 G.H5.24
Van-der-waals TM6 L 440 6x29 G.H5 G 352 G.H5.24
Hydrophobic TM2 Y 258 2x39 G.H5 C 351 G.H5.23
Hydrophobic TM5 I 423 5x72 G.H5 L 348 G.H5.20
Hydrophobic TM7 W 521 7x55 G.H5 G 352 G.H5.24
Hydrophobic ICL2 K 341 - G.S3 L 194 G.S3.01
Van-der-waals ICL2 K 341 - G.S3 L 194 G.S3.01
Hydrophobic ICL3 L 437 - G.H5 F 354 G.H5.26
Van-der-waals ICL3 L 437 - G.H5 F 354 G.H5.26
Hydrophobic TM5 L 420 5x69 G.H5 L 348 G.H5.20
Hydrophobic TM3 A 337 3x53 G.H5 L 348 G.H5.20
Van-der-waals TM3 A 337 3x53 G.H5 L 348 G.H5.20
Hydrophobic TM4 A 346 4x37 G.hns1 A 31 G.hns1.02
Van-der-waals TM4 A 346 4x37 G.hns1 A 31 G.hns1.02
Polar ICL3 N 433 - G.H5 K 345 G.H5.17