GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 75.5
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.5
iPTM Score: 0.2
PAE mean: 28.4
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Hydrophobic | TM6 | I | 444 | 6x33 | G.H5 | G | 352 | G.H5.24 |
Van-der-waals | TM6 | I | 444 | 6x33 | G.H5 | G | 352 | G.H5.24 |
Hydrophobic | TM2 | P | 259 | 2x40 | G.H5 | C | 351 | G.H5.23 |
Van-der-waals | TM2 | P | 259 | 2x40 | G.H5 | C | 351 | G.H5.23 |
Ionic | TM4 | H | 344 | 4x35 | G.H5 | E | 350 | G.H5.22 |
Polar | TM4 | H | 344 | 4x35 | G.H5 | E | 350 | G.H5.22 |
Hydrophobic | TM4 | H | 344 | 4x35 | G.H5 | E | 350 | G.H5.22 |
Van-der-waals | TM4 | H | 344 | 4x35 | G.H5 | E | 350 | G.H5.22 |
Hydrophobic | TM3 | A | 337 | 3x53 | G.H5 | L | 353 | G.H5.25 |
Van-der-waals | TM3 | A | 337 | 3x53 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | TM4 | E | 345 | 4x36 | G.h2s4 | G | 217 | G.h2s4.03 |
Van-der-waals | TM4 | E | 345 | 4x36 | G.h2s4 | G | 217 | G.h2s4.03 |
Polar | ICL3 | L | 437 | - | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | ICL3 | L | 437 | - | G.H5 | L | 353 | G.H5.25 |
Van-der-waals | ICL3 | L | 437 | - | G.H5 | L | 353 | G.H5.25 |
Polar | ICL2 | W | 342 | - | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | ICL2 | W | 342 | - | G.H5 | C | 351 | G.H5.23 |
Van-der-waals | ICL2 | W | 342 | - | G.H5 | C | 351 | G.H5.23 |
Polar | ICL3 | T | 434 | - | G.H5 | Y | 354 | G.H5.26 |
Hydrophobic | ICL3 | T | 434 | - | G.H5 | Y | 354 | G.H5.26 |
Van-der-waals | ICL3 | T | 434 | - | G.H5 | Y | 354 | G.H5.26 |
Hydrophobic | TM6 | L | 440 | 6x29 | G.H5 | G | 352 | G.H5.24 |
Van-der-waals | TM6 | L | 440 | 6x29 | G.H5 | G | 352 | G.H5.24 |
Polar | TM4 | G | 343 | 4x34 | G.H5 | N | 347 | G.H5.19 |
Hydrophobic | TM4 | G | 343 | 4x34 | G.H5 | N | 347 | G.H5.19 |
Van-der-waals | TM4 | G | 343 | 4x34 | G.H5 | N | 347 | G.H5.19 |
Hydrophobic | ICL3 | K | 436 | - | G.H5 | L | 353 | G.H5.25 |
Van-der-waals | ICL3 | K | 436 | - | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | ICL2 | K | 341 | - | G.H5 | I | 344 | G.H5.16 |
Hydrophobic | TM3 | A | 338 | 3x54 | G.H5 | L | 348 | G.H5.20 |
Van-der-waals | TM3 | A | 338 | 3x54 | G.H5 | L | 348 | G.H5.20 |
Ionic | ICL1 | R | 257 | 12x51 | G.h3s5 | E | 261 | G.h3s5.02 |
Polar | ICL1 | R | 257 | 12x51 | G.h3s5 | E | 261 | G.h3s5.02 |
Hydrophobic | ICL1 | R | 257 | 12x51 | G.h3s5 | E | 261 | G.h3s5.02 |
Van-der-waals | ICL1 | R | 257 | 12x51 | G.h3s5 | E | 261 | G.h3s5.02 |
Hydrophobic | ICL2 | W | 342 | - | G.hns1 | K | 32 | G.hns1.03 |
Van-der-waals | ICL2 | W | 342 | - | G.hns1 | K | 32 | G.hns1.03 |
Hydrophobic | TM6 | L | 440 | 6x29 | G.H5 | Y | 354 | G.H5.26 |
Van-der-waals | TM6 | L | 440 | 6x29 | G.H5 | Y | 354 | G.H5.26 |
Polar | ICL2 | K | 341 | - | G.H5 | N | 347 | G.H5.19 |
Van-der-waals | ICL2 | K | 341 | - | G.H5 | N | 347 | G.H5.19 |
Polar | TM4 | H | 344 | 4x35 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | TM4 | H | 344 | 4x35 | G.H5 | C | 351 | G.H5.23 |
Van-der-waals | TM4 | H | 344 | 4x35 | G.H5 | C | 351 | G.H5.23 |
Polar | TM6 | M | 441 | 6x30 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | TM6 | M | 441 | 6x30 | G.H5 | L | 353 | G.H5.25 |
Van-der-waals | TM6 | M | 441 | 6x30 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | TM3 | A | 337 | 3x53 | G.H5 | C | 351 | G.H5.23 |
Van-der-waals | TM3 | A | 337 | 3x53 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | ICL3 | L | 437 | - | G.H5 | L | 348 | G.H5.20 |
Van-der-waals | ICL3 | L | 437 | - | G.H5 | L | 348 | G.H5.20 |
Hydrophobic | TM6 | I | 444 | 6x33 | G.H5 | C | 351 | G.H5.23 |
Van-der-waals | TM6 | I | 444 | 6x33 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | TM3 | W | 334 | 3x50 | G.H5 | L | 353 | G.H5.25 |
Polar | ICL2 | K | 341 | - | G.s2s3 | K | 192 | G.s2s3.01 |
Hydrophobic | TM4 | G | 343 | 4x34 | G.H5 | C | 351 | G.H5.23 |
Van-der-waals | TM4 | G | 343 | 4x34 | G.H5 | C | 351 | G.H5.23 |
Polar | TM4 | E | 345 | 4x36 | G.h2s4 | T | 219 | G.h2s4.05 |
Hydrophobic | TM4 | E | 345 | 4x36 | G.h2s4 | T | 219 | G.h2s4.05 |
Polar | TM2 | P | 259 | 2x40 | G.H5 | E | 350 | G.H5.22 |
Hydrophobic | TM2 | P | 259 | 2x40 | G.H5 | E | 350 | G.H5.22 |
Polar | ICL3 | D | 435 | - | G.H5 | Y | 354 | G.H5.26 |
Hydrophobic | ICL3 | D | 435 | - | G.H5 | Y | 354 | G.H5.26 |
Van-der-waals | ICL3 | D | 435 | - | G.H5 | Y | 354 | G.H5.26 |
Polar | TM4 | E | 345 | 4x36 | G.h2s4 | V | 218 | G.h2s4.04 |
Hydrophobic | TM4 | E | 345 | 4x36 | G.h2s4 | V | 218 | G.h2s4.04 |
Van-der-waals | TM4 | E | 345 | 4x36 | G.h2s4 | V | 218 | G.h2s4.04 |
Polar | TM6 | L | 440 | 6x29 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | TM6 | L | 440 | 6x29 | G.H5 | L | 353 | G.H5.25 |
Van-der-waals | TM6 | L | 440 | 6x29 | G.H5 | L | 353 | G.H5.25 |
Polar | TM4 | H | 344 | 4x35 | G.H5 | N | 347 | G.H5.19 |
Hydrophobic | TM2 | P | 259 | 2x40 | G.H5 | G | 352 | G.H5.24 |
Ionic | TM4 | H | 344 | 4x35 | G.h3s5 | E | 261 | G.h3s5.02 |
Polar | TM4 | H | 344 | 4x35 | G.h3s5 | E | 261 | G.h3s5.02 |
Hydrophobic | TM4 | H | 344 | 4x35 | G.h3s5 | E | 261 | G.h3s5.02 |
Van-der-waals | TM4 | H | 344 | 4x35 | G.h3s5 | E | 261 | G.h3s5.02 |
Hydrophobic | TM4 | I | 347 | 4x38 | G.H5 | C | 351 | G.H5.23 |
Van-der-waals | TM4 | I | 347 | 4x38 | G.H5 | C | 351 | G.H5.23 |
Polar | ICL3 | K | 436 | - | G.H5 | Y | 354 | G.H5.26 |
Hydrophobic | ICL3 | K | 436 | - | G.H5 | Y | 354 | G.H5.26 |
Van-der-waals | ICL3 | K | 436 | - | G.H5 | Y | 354 | G.H5.26 |
Hydrophobic | ICL3 | L | 437 | - | G.H5 | K | 349 | G.H5.21 |
Van-der-waals | ICL3 | L | 437 | - | G.H5 | K | 349 | G.H5.21 |
Hydrophobic | TM6 | M | 441 | 6x30 | G.H5 | L | 348 | G.H5.20 |
Hydrophobic | ICL2 | K | 341 | - | G.S3 | L | 194 | G.S3.01 |
Hydrophobic | TM2 | E | 260 | 2x41 | G.H5 | G | 352 | G.H5.24 |
Van-der-waals | TM2 | E | 260 | 2x41 | G.H5 | G | 352 | G.H5.24 |
Polar | ICL3 | L | 437 | - | G.H5 | Y | 354 | G.H5.26 |
Hydrophobic | ICL3 | L | 437 | - | G.H5 | Y | 354 | G.H5.26 |
Van-der-waals | ICL3 | L | 437 | - | G.H5 | Y | 354 | G.H5.26 |
Hydrophobic | ICL2 | K | 341 | - | G.H5 | L | 348 | G.H5.20 |
Ionic | ICL1 | R | 257 | 12x51 | G.H5 | E | 350 | G.H5.22 |
Polar | ICL1 | R | 257 | 12x51 | G.H5 | E | 350 | G.H5.22 |
Hydrophobic | ICL1 | R | 257 | 12x51 | G.H5 | E | 350 | G.H5.22 |
Van-der-waals | ICL1 | R | 257 | 12x51 | G.H5 | E | 350 | G.H5.22 |
Hydrophobic | TM2 | Y | 258 | 2x39 | G.H5 | E | 350 | G.H5.22 |
Van-der-waals | TM2 | Y | 258 | 2x39 | G.H5 | E | 350 | G.H5.22 |
Hydrophobic | TM6 | I | 444 | 6x33 | G.H5 | L | 353 | G.H5.25 |
Polar | ICL2 | W | 342 | - | G.hns1 | A | 31 | G.hns1.02 |
Hydrophobic | ICL2 | W | 342 | - | G.hns1 | A | 31 | G.hns1.02 |
Van-der-waals | ICL2 | W | 342 | - | G.hns1 | A | 31 | G.hns1.02 |
Hydrophobic | ICL2 | W | 342 | - | G.H5 | N | 347 | G.H5.19 |
Van-der-waals | ICL2 | W | 342 | - | G.H5 | N | 347 | G.H5.19 |
Hydrophobic | ICL2 | K | 340 | - | G.hns1 | K | 32 | G.hns1.03 |
Van-der-waals | ICL2 | K | 340 | - | G.hns1 | K | 32 | G.hns1.03 |
Hydrophobic | TM3 | A | 337 | 3x53 | G.H5 | L | 348 | G.H5.20 |
Van-der-waals | TM3 | A | 337 | 3x53 | G.H5 | L | 348 | G.H5.20 |
Hydrophobic | ICL3 | E | 432 | - | G.H5 | D | 341 | G.H5.13 |
Van-der-waals | ICL3 | E | 432 | - | G.H5 | D | 341 | G.H5.13 |
Hydrophobic | ICL3 | L | 437 | - | G.H5 | K | 345 | G.H5.17 |
Van-der-waals | ICL3 | L | 437 | - | G.H5 | K | 345 | G.H5.17 |
Hydrophobic | N-term | E | 76 | - | G.H2 | I | 212 | G.H2.08 |
Van-der-waals | N-term | E | 76 | - | G.H2 | I | 212 | G.H2.08 |
Polar | ICL3 | N | 433 | - | G.H5 | K | 345 | G.H5.17 |
Van-der-waals | ICL3 | N | 433 | - | G.H5 | K | 345 | G.H5.17 |
Polar | TM2 | Y | 258 | 2x39 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | TM2 | Y | 258 | 2x39 | G.H5 | C | 351 | G.H5.23 |
Van-der-waals | TM2 | Y | 258 | 2x39 | G.H5 | C | 351 | G.H5.23 |
Polar | ICL3 | N | 433 | - | G.H5 | Y | 354 | G.H5.26 |
Van-der-waals | ICL3 | N | 433 | - | G.H5 | Y | 354 | G.H5.26 |
Polar | ICL1 | R | 257 | 12x51 | G.h3s5 | T | 260 | G.h3s5.01 |
Van-der-waals | ICL1 | R | 257 | 12x51 | G.h3s5 | T | 260 | G.h3s5.01 |
Ionic | ICL2 | K | 340 | - | G.HN | E | 28 | G.HN.52 |
Polar | ICL2 | K | 340 | - | G.HN | E | 28 | G.HN.52 |
Hydrophobic | ICL2 | K | 340 | - | G.HN | E | 28 | G.HN.52 |
Van-der-waals | ICL2 | K | 340 | - | G.HN | E | 28 | G.HN.52 |
Polar | TM4 | E | 345 | 4x36 | G.h3s5 | T | 262 | G.h3s5.03 |
Hydrophobic | TM4 | E | 345 | 4x36 | G.h3s5 | T | 262 | G.h3s5.03 |
Van-der-waals | TM4 | E | 345 | 4x36 | G.h3s5 | T | 262 | G.h3s5.03 |