GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 78.3
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.5
iPTM Score: 0.5
PAE mean: 27.1
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Polar | TM3 | A | 337 | 3x53 | G.H5 | Y | 356 | G.H5.23 |
Hydrophobic | TM3 | A | 337 | 3x53 | G.H5 | Y | 356 | G.H5.23 |
Van-der-waals | TM3 | A | 337 | 3x53 | G.H5 | Y | 356 | G.H5.23 |
Hydrophobic | TM6 | L | 440 | 6x29 | G.H5 | L | 358 | G.H5.25 |
Van-der-waals | TM6 | L | 440 | 6x29 | G.H5 | L | 358 | G.H5.25 |
Hydrophobic | TM2 | P | 259 | 2x40 | G.H5 | Y | 356 | G.H5.23 |
Van-der-waals | TM2 | P | 259 | 2x40 | G.H5 | Y | 356 | G.H5.23 |
Polar | C-term | V | 581 | - | G.s6h5 | T | 332 | G.s6h5.04 |
Hydrophobic | C-term | V | 581 | - | G.s6h5 | T | 332 | G.s6h5.04 |
Van-der-waals | C-term | V | 581 | - | G.s6h5 | T | 332 | G.s6h5.04 |
Hydrophobic | C-term | Y | 557 | - | G.H5 | R | 338 | G.H5.05 |
Van-der-waals | C-term | Y | 557 | - | G.H5 | R | 338 | G.H5.05 |
Hydrophobic | C-term | I | 551 | - | G.S6 | Y | 325 | G.S6.02 |
Polar | C-term | Y | 557 | - | G.H5 | F | 339 | G.H5.06 |
Hydrophobic | C-term | Y | 557 | - | G.H5 | F | 339 | G.H5.06 |
Van-der-waals | C-term | Y | 557 | - | G.H5 | F | 339 | G.H5.06 |
Polar | TM2 | E | 260 | 2x41 | G.H5 | N | 357 | G.H5.24 |
Hydrophobic | TM2 | E | 260 | 2x41 | G.H5 | N | 357 | G.H5.24 |
Van-der-waals | TM2 | E | 260 | 2x41 | G.H5 | N | 357 | G.H5.24 |
Polar | C-term | S | 553 | - | G.S6 | S | 326 | G.S6.03 |
Van-der-waals | C-term | S | 553 | - | G.S6 | S | 326 | G.S6.03 |
Polar | TM4 | H | 344 | 4x35 | G.h3s5 | N | 266 | G.h3s5.02 |
Hydrophobic | TM4 | H | 344 | 4x35 | G.h3s5 | N | 266 | G.h3s5.02 |
Van-der-waals | TM4 | H | 344 | 4x35 | G.h3s5 | N | 266 | G.h3s5.02 |
Polar | C-term | V | 581 | - | G.HG | D | 277 | G.HG.02 |
Ionic | ICL3 | K | 436 | - | G.H5 | D | 346 | G.H5.13 |
Polar | ICL3 | K | 436 | - | G.H5 | D | 346 | G.H5.13 |
Van-der-waals | ICL3 | K | 436 | - | G.H5 | D | 346 | G.H5.13 |
Van-der-waals | TM2 | Y | 258 | 2x39 | G.H5 | K | 354 | G.H5.21 |
Polar | ICL2 | W | 342 | - | G.H5 | E | 355 | G.H5.22 |
Hydrophobic | ICL2 | W | 342 | - | G.H5 | E | 355 | G.H5.22 |
Van-der-waals | ICL2 | W | 342 | - | G.H5 | E | 355 | G.H5.22 |
Hydrophobic | TM5 | L | 420 | 5x69 | G.H5 | Y | 356 | G.H5.23 |
Van-der-waals | TM5 | L | 420 | 5x69 | G.H5 | Y | 356 | G.H5.23 |
Hydrophobic | TM6 | I | 444 | 6x33 | G.H5 | L | 358 | G.H5.25 |
Van-der-waals | TM6 | I | 444 | 6x33 | G.H5 | L | 358 | G.H5.25 |
Hydrophobic | ICL2 | K | 341 | - | G.H5 | E | 355 | G.H5.22 |
Van-der-waals | ICL2 | K | 341 | - | G.H5 | E | 355 | G.H5.22 |
Polar | TM4 | G | 343 | 4x34 | G.H5 | E | 355 | G.H5.22 |
Hydrophobic | TM4 | G | 343 | 4x34 | G.H5 | E | 355 | G.H5.22 |
Van-der-waals | TM4 | G | 343 | 4x34 | G.H5 | E | 355 | G.H5.22 |
Polar | C-term | I | 551 | - | G.S6 | I | 324 | G.S6.01 |
Van-der-waals | C-term | I | 551 | - | G.S6 | I | 324 | G.S6.01 |
Polar | TM3 | A | 338 | 3x54 | G.H5 | Y | 356 | G.H5.23 |
Hydrophobic | TM3 | A | 338 | 3x54 | G.H5 | Y | 356 | G.H5.23 |
Van-der-waals | TM3 | A | 338 | 3x54 | G.H5 | Y | 356 | G.H5.23 |
Hydrophobic | TM4 | H | 344 | 4x35 | G.H5 | K | 354 | G.H5.21 |
Van-der-waals | TM4 | H | 344 | 4x35 | G.H5 | K | 354 | G.H5.21 |
Hydrophobic | C-term | V | 550 | - | G.H4 | V | 314 | G.H4.16 |
Van-der-waals | C-term | V | 550 | - | G.H4 | V | 314 | G.H4.16 |
Hydrophobic | C-term | V | 550 | - | G.S6 | S | 326 | G.S6.03 |
Van-der-waals | C-term | V | 550 | - | G.S6 | S | 326 | G.S6.03 |
Hydrophobic | ICL2 | K | 341 | - | G.H5 | Y | 356 | G.H5.23 |
Van-der-waals | ICL2 | K | 341 | - | G.H5 | Y | 356 | G.H5.23 |
Polar | C-term | T | 579 | - | H.HF | Q | 177 | H.HF.02 |
Van-der-waals | C-term | T | 579 | - | H.HF | Q | 177 | H.HF.02 |
Hydrophobic | TM3 | W | 334 | 3x50 | G.H5 | L | 358 | G.H5.25 |
Hydrophobic | C-term | I | 556 | - | G.H5 | F | 339 | G.H5.06 |
Van-der-waals | C-term | I | 556 | - | G.H5 | F | 339 | G.H5.06 |
Hydrophobic | TM2 | P | 259 | 2x40 | G.H5 | E | 355 | G.H5.22 |
Van-der-waals | TM2 | P | 259 | 2x40 | G.H5 | E | 355 | G.H5.22 |
Polar | TM3 | W | 334 | 3x50 | G.H5 | N | 357 | G.H5.24 |
Van-der-waals | TM3 | W | 334 | 3x50 | G.H5 | N | 357 | G.H5.24 |
Hydrophobic | C-term | C | 580 | - | G.HG | D | 277 | G.HG.02 |
Van-der-waals | C-term | C | 580 | - | G.HG | D | 277 | G.HG.02 |
Hydrophobic | C-term | I | 556 | - | G.H5 | A | 342 | G.H5.09 |
Van-der-waals | C-term | I | 556 | - | G.H5 | A | 342 | G.H5.09 |
Hydrophobic | C-term | I | 556 | - | G.S6 | Y | 325 | G.S6.02 |
Van-der-waals | C-term | I | 556 | - | G.S6 | Y | 325 | G.S6.02 |
Ionic | ICL1 | R | 257 | 12x51 | G.h4s6 | D | 321 | G.h4s6.12 |
Polar | ICL1 | R | 257 | 12x51 | G.h4s6 | D | 321 | G.h4s6.12 |
Hydrophobic | ICL1 | R | 257 | 12x51 | G.h4s6 | D | 321 | G.h4s6.12 |
Van-der-waals | ICL1 | R | 257 | 12x51 | G.h4s6 | D | 321 | G.h4s6.12 |
Hydrophobic | C-term | T | 552 | - | G.H4 | L | 310 | G.H4.12 |
Polar | C-term | T | 552 | - | G.S6 | S | 326 | G.S6.03 |
Van-der-waals | C-term | T | 552 | - | G.S6 | S | 326 | G.S6.03 |
Hydrophobic | TM4 | H | 344 | 4x35 | G.H5 | E | 355 | G.H5.22 |
Polar | C-term | C | 580 | - | G.s6h5 | C | 330 | G.s6h5.02 |
Hydrophobic | C-term | C | 580 | - | G.s6h5 | C | 330 | G.s6h5.02 |
Van-der-waals | C-term | C | 580 | - | G.s6h5 | C | 330 | G.s6h5.02 |
Polar | ICL1 | R | 257 | 12x51 | G.H5 | N | 357 | G.H5.24 |
Hydrophobic | ICL1 | R | 257 | 12x51 | G.H5 | N | 357 | G.H5.24 |
Van-der-waals | ICL1 | R | 257 | 12x51 | G.H5 | N | 357 | G.H5.24 |
Polar | TM2 | E | 260 | 2x41 | G.H5 | V | 359 | G.H5.26 |
Van-der-waals | TM2 | E | 260 | 2x41 | G.H5 | V | 359 | G.H5.26 |
Hydrophobic | C-term | A | 548 | - | G.H4 | V | 314 | G.H4.16 |
Polar | TM4 | E | 345 | 4x36 | G.h3s5 | N | 266 | G.h3s5.02 |
Hydrophobic | TM4 | E | 345 | 4x36 | G.h3s5 | N | 266 | G.h3s5.02 |
Van-der-waals | TM4 | E | 345 | 4x36 | G.h3s5 | N | 266 | G.h3s5.02 |
Hydrophobic | ICL3 | K | 436 | - | G.H5 | L | 349 | G.H5.16 |
Hydrophobic | C-term | I | 551 | - | G.h4s6 | I | 323 | G.h4s6.20 |
Van-der-waals | C-term | I | 551 | - | G.h4s6 | I | 323 | G.h4s6.20 |
Polar | C-term | S | 553 | - | G.S6 | H | 327 | G.S6.04 |
Hydrophobic | C-term | S | 553 | - | G.S6 | H | 327 | G.S6.04 |
Van-der-waals | C-term | S | 553 | - | G.S6 | H | 327 | G.S6.04 |
Hydrophobic | C-term | C | 580 | - | G.HG | K | 276 | G.HG.01 |
Hydrophobic | C-term | S | 553 | - | G.H5 | F | 339 | G.H5.06 |
Polar | C-term | V | 581 | - | G.s6h5 | A | 331 | G.s6h5.03 |
Polar | C-term | I | 551 | - | G.S6 | S | 326 | G.S6.03 |
Van-der-waals | C-term | I | 551 | - | G.S6 | S | 326 | G.S6.03 |
Hydrophobic | C-term | V | 581 | - | H.HF | R | 181 | H.HF.06 |
Van-der-waals | C-term | V | 581 | - | H.HF | R | 181 | H.HF.06 |
Polar | TM3 | W | 334 | 3x50 | G.H5 | Y | 356 | G.H5.23 |
Hydrophobic | TM3 | W | 334 | 3x50 | G.H5 | Y | 356 | G.H5.23 |
Van-der-waals | TM3 | W | 334 | 3x50 | G.H5 | Y | 356 | G.H5.23 |
Hydrophobic | TM4 | I | 347 | 4x38 | G.H5 | E | 355 | G.H5.22 |
Van-der-waals | TM4 | I | 347 | 4x38 | G.H5 | E | 355 | G.H5.22 |
Polar | TM2 | P | 259 | 2x40 | G.H5 | N | 357 | G.H5.24 |
Hydrophobic | TM2 | P | 259 | 2x40 | G.H5 | N | 357 | G.H5.24 |
Van-der-waals | TM2 | P | 259 | 2x40 | G.H5 | N | 357 | G.H5.24 |
Hydrophobic | TM5 | M | 427 | 5x76 | G.H5 | L | 349 | G.H5.16 |
Ionic | ICL1 | R | 257 | 12x51 | G.h4s6 | D | 319 | G.h4s6.10 |
Polar | ICL1 | R | 257 | 12x51 | G.h4s6 | D | 319 | G.h4s6.10 |
Polar | TM2 | Y | 258 | 2x39 | G.H5 | N | 357 | G.H5.24 |
Hydrophobic | TM2 | Y | 258 | 2x39 | G.H5 | N | 357 | G.H5.24 |
Van-der-waals | TM2 | Y | 258 | 2x39 | G.H5 | N | 357 | G.H5.24 |
Hydrophobic | TM4 | H | 344 | 4x35 | G.H5 | L | 351 | G.H5.18 |
Hydrophobic | TM2 | P | 259 | 2x40 | G.H5 | K | 354 | G.H5.21 |
Van-der-waals | TM2 | P | 259 | 2x40 | G.H5 | K | 354 | G.H5.21 |
Polar | C-term | Y | 557 | - | G.H5 | E | 335 | G.H5.02 |
Van-der-waals | C-term | Y | 557 | - | G.H5 | E | 335 | G.H5.02 |
Hydrophobic | TM3 | A | 337 | 3x53 | G.H5 | E | 355 | G.H5.22 |
Van-der-waals | TM3 | A | 337 | 3x53 | G.H5 | E | 355 | G.H5.22 |
Ionic | ICL3 | E | 432 | - | G.H5 | K | 345 | G.H5.12 |
Polar | ICL3 | E | 432 | - | G.H5 | K | 345 | G.H5.12 |
Hydrophobic | ICL3 | E | 432 | - | G.H5 | K | 345 | G.H5.12 |
Van-der-waals | ICL3 | E | 432 | - | G.H5 | K | 345 | G.H5.12 |
Hydrophobic | TM6 | L | 440 | 6x29 | G.H5 | L | 353 | G.H5.20 |
Van-der-waals | TM6 | L | 440 | 6x29 | G.H5 | L | 353 | G.H5.20 |
Hydrophobic | C-term | V | 550 | - | G.H4 | L | 310 | G.H4.12 |
Hydrophobic | TM5 | I | 423 | 5x72 | G.H5 | Y | 356 | G.H5.23 |
Van-der-waals | TM5 | I | 423 | 5x72 | G.H5 | Y | 356 | G.H5.23 |
Polar | TM2 | E | 260 | 2x41 | G.H5 | L | 358 | G.H5.25 |
Van-der-waals | TM2 | E | 260 | 2x41 | G.H5 | L | 358 | G.H5.25 |
Hydrophobic | ICL1 | R | 257 | 12x51 | G.H5 | K | 354 | G.H5.21 |
Van-der-waals | ICL1 | R | 257 | 12x51 | G.H5 | K | 354 | G.H5.21 |
Polar | C-term | T | 579 | - | H.HF | R | 181 | H.HF.06 |
Van-der-waals | C-term | T | 579 | - | H.HF | R | 181 | H.HF.06 |
Hydrophobic | C-term | V | 581 | - | H.HF | Q | 177 | H.HF.02 |
Van-der-waals | C-term | V | 581 | - | H.HF | Q | 177 | H.HF.02 |
Polar | C-term | C | 580 | - | H.HF | R | 181 | H.HF.06 |
Hydrophobic | C-term | C | 580 | - | H.HF | R | 181 | H.HF.06 |
Van-der-waals | C-term | C | 580 | - | H.HF | R | 181 | H.HF.06 |