Gs - FZD10 complex model

GPCR CLASS (FAMILY)

F (Frizzled)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gs

DATE

2023-09-15

3D VIEW

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Tertiary structure confidence

(pLDDT score) avg.: 76.9

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.5
iPTM Score: 0.2
PAE mean: 27.2


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar ICL1 R 257 12x51 G.H5 Y 391 G.H5.23
Hydrophobic ICL1 R 257 12x51 G.H5 Y 391 G.H5.23
Van-der-waals ICL1 R 257 12x51 G.H5 Y 391 G.H5.23
Polar TM2 Y 258 2x39 G.H5 Q 390 G.H5.22
Van-der-waals TM2 Y 258 2x39 G.H5 Q 390 G.H5.22
Hydrophobic TM6 L 440 6x29 G.H5 L 388 G.H5.20
Polar TM2 R 261 2x42 G.H5 Y 391 G.H5.23
Van-der-waals TM2 R 261 2x42 G.H5 Y 391 G.H5.23
Polar TM2 P 259 2x40 G.H5 Y 391 G.H5.23
Hydrophobic TM2 P 259 2x40 G.H5 Y 391 G.H5.23
Van-der-waals TM2 P 259 2x40 G.H5 Y 391 G.H5.23
Hydrophobic TM2 E 260 2x41 G.H5 L 393 G.H5.25
Hydrophobic TM6 L 440 6x29 G.H5 L 393 G.H5.25
Hydrophobic TM3 A 337 3x53 G.H5 H 387 G.H5.19
Van-der-waals TM3 A 337 3x53 G.H5 H 387 G.H5.19
Polar TM3 A 337 3x53 G.H5 Q 384 G.H5.16
Van-der-waals TM3 A 337 3x53 G.H5 Q 384 G.H5.16
Polar ICL1 R 257 12x51 G.H5 Q 390 G.H5.22
Hydrophobic ICL1 R 257 12x51 G.H5 Q 390 G.H5.22
Van-der-waals ICL1 R 257 12x51 G.H5 Q 390 G.H5.22
Polar TM4 Y 353 4x44 G.HN Q 31 G.HN.48
Hydrophobic TM4 Y 353 4x44 G.HN Q 31 G.HN.48
Van-der-waals TM4 Y 353 4x44 G.HN Q 31 G.HN.48
Polar ICL1 R 257 12x51 G.H5 R 389 G.H5.21
Polar TM2 Y 258 2x39 G.H5 H 387 G.H5.19
Hydrophobic TM2 Y 258 2x39 G.H5 H 387 G.H5.19
Van-der-waals TM2 Y 258 2x39 G.H5 H 387 G.H5.19
Polar TM2 E 260 2x41 G.H5 Y 391 G.H5.23
Hydrophobic TM2 E 260 2x41 G.H5 Y 391 G.H5.23
Van-der-waals TM2 E 260 2x41 G.H5 Y 391 G.H5.23
Polar TM2 Y 258 2x39 G.H5 Y 391 G.H5.23
Hydrophobic TM2 Y 258 2x39 G.H5 Y 391 G.H5.23
Van-der-waals TM2 Y 258 2x39 G.H5 Y 391 G.H5.23
Polar TM2 P 259 2x40 G.H5 H 387 G.H5.19
Hydrophobic TM2 P 259 2x40 G.H5 H 387 G.H5.19
Van-der-waals TM2 P 259 2x40 G.H5 H 387 G.H5.19
Ionic ICL1 R 255 12x49 G.H5 E 392 G.H5.24
Polar ICL1 R 255 12x49 G.H5 E 392 G.H5.24
Hydrophobic ICL1 R 255 12x49 G.H5 E 392 G.H5.24
Van-der-waals ICL1 R 255 12x49 G.H5 E 392 G.H5.24
Hydrophobic ICL2 K 341 - G.H5 R 380 G.H5.12
Van-der-waals ICL2 K 341 - G.H5 R 380 G.H5.12
Van-der-waals TM4 A 346 4x37 G.hns1 R 38 G.hns1.02
Hydrophobic ICL2 W 342 - G.H5 I 383 G.H5.15
Van-der-waals ICL2 W 342 - G.H5 I 383 G.H5.15
Hydrophobic TM4 E 345 4x36 G.H5 M 386 G.H5.18
Van-der-waals TM4 E 345 4x36 G.H5 M 386 G.H5.18
Ionic H8 K 526 8x49 G.H5 E 392 G.H5.24
Polar H8 K 526 8x49 G.H5 E 392 G.H5.24
Hydrophobic H8 K 526 8x49 G.H5 E 392 G.H5.24
Van-der-waals H8 K 526 8x49 G.H5 E 392 G.H5.24
Polar TM4 H 344 4x35 G.H5 Q 390 G.H5.22
Hydrophobic TM4 H 344 4x35 G.H5 Q 390 G.H5.22
Van-der-waals TM4 H 344 4x35 G.H5 Q 390 G.H5.22
Polar TM4 A 349 4x40 G.hns1 R 38 G.hns1.02
Hydrophobic TM4 A 349 4x40 G.hns1 R 38 G.hns1.02
Van-der-waals TM4 A 349 4x40 G.hns1 R 38 G.hns1.02
Polar TM4 Y 353 4x44 G.HN Q 35 G.HN.52
Van-der-waals TM4 Y 353 4x44 G.HN Q 35 G.HN.52
Polar ICL1 R 255 12x49 G.H5 Y 391 G.H5.23
Hydrophobic ICL1 R 255 12x49 G.H5 Y 391 G.H5.23
Van-der-waals ICL1 R 255 12x49 G.H5 Y 391 G.H5.23
Hydrophobic TM4 G 343 4x34 G.H5 I 383 G.H5.15
Van-der-waals TM4 G 343 4x34 G.H5 I 383 G.H5.15
Polar TM4 H 344 4x35 G.H5 H 387 G.H5.19
Hydrophobic TM4 H 344 4x35 G.H5 H 387 G.H5.19
Van-der-waals TM4 H 344 4x35 G.H5 H 387 G.H5.19
Polar TM4 E 348 4x39 G.H5 Q 390 G.H5.22
Van-der-waals TM4 E 348 4x39 G.H5 Q 390 G.H5.22
Polar ICL1 F 256 12x50 G.H5 Q 390 G.H5.22
Polar TM4 H 344 4x35 G.H5 M 386 G.H5.18
Hydrophobic TM4 H 344 4x35 G.H5 M 386 G.H5.18
Van-der-waals TM4 H 344 4x35 G.H5 M 386 G.H5.18
Hydrophobic ICL2 K 341 - G.H5 I 383 G.H5.15
Van-der-waals ICL2 K 341 - G.H5 I 383 G.H5.15
Polar ICL2 W 342 - G.H5 H 387 G.H5.19
Hydrophobic ICL2 W 342 - G.H5 H 387 G.H5.19
Van-der-waals ICL2 W 342 - G.H5 H 387 G.H5.19
Hydrophobic ICL1 F 256 12x50 G.H5 Y 391 G.H5.23
Van-der-waals ICL1 F 256 12x50 G.H5 Y 391 G.H5.23
Hydrophobic TM4 I 347 4x38 G.H5 H 387 G.H5.19
Van-der-waals TM4 I 347 4x38 G.H5 H 387 G.H5.19
Polar H8 K 526 8x49 G.H5 L 394 G.H5.26
Van-der-waals H8 K 526 8x49 G.H5 L 394 G.H5.26
Hydrophobic ICL2 K 341 - G.H5 F 376 G.H5.08
Polar TM4 G 343 4x34 G.H5 H 387 G.H5.19
Hydrophobic TM4 G 343 4x34 G.H5 H 387 G.H5.19
Van-der-waals TM4 G 343 4x34 G.H5 H 387 G.H5.19