GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 72.0
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.5
iPTM Score: 0.4
PAE mean: 23.2
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Hydrophobic | C-term | L | 536 | - | G.H3 | M | 249 | G.H3.07 |
Van-der-waals | C-term | L | 536 | - | G.H3 | M | 249 | G.H3.07 |
Hydrophobic | TM5 | V | 400 | 5x72 | G.H5 | I | 344 | G.H5.16 |
Van-der-waals | TM5 | V | 400 | 5x72 | G.H5 | I | 344 | G.H5.16 |
Hydrophobic | TM6 | F | 417 | 6x29 | G.H5 | C | 351 | G.H5.23 |
Van-der-waals | TM6 | F | 417 | 6x29 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | TM2 | E | 235 | 2x41 | G.H5 | G | 350 | G.H5.22 |
Ionic | C-term | R | 549 | - | G.h4s6 | E | 318 | G.h4s6.12 |
Polar | C-term | R | 549 | - | G.h4s6 | E | 318 | G.h4s6.12 |
Hydrophobic | C-term | R | 549 | - | G.h4s6 | E | 318 | G.h4s6.12 |
Van-der-waals | C-term | R | 549 | - | G.h4s6 | E | 318 | G.h4s6.12 |
Polar | TM4 | K | 326 | 4x40 | G.HN | G | 27 | G.HN.51 |
Hydrophobic | TM4 | K | 326 | 4x40 | G.HN | G | 27 | G.HN.51 |
Van-der-waals | TM4 | K | 326 | 4x40 | G.HN | G | 27 | G.HN.51 |
Polar | C-term | V | 526 | - | G.H3 | K | 258 | G.H3.16 |
Hydrophobic | C-term | V | 526 | - | G.H3 | K | 258 | G.H3.16 |
Van-der-waals | C-term | V | 526 | - | G.H3 | K | 258 | G.H3.16 |
Hydrophobic | C-term | F | 532 | - | G.H3 | S | 253 | G.H3.11 |
Polar | C-term | R | 546 | - | G.h4s6 | K | 311 | G.h4s6.01 |
Hydrophobic | C-term | R | 546 | - | G.h4s6 | K | 311 | G.h4s6.01 |
Van-der-waals | C-term | R | 546 | - | G.h4s6 | K | 311 | G.h4s6.01 |
Hydrophobic | ICL3 | L | 406 | - | G.H5 | D | 341 | G.H5.13 |
Van-der-waals | ICL3 | L | 406 | - | G.H5 | D | 341 | G.H5.13 |
Hydrophobic | ICL2 | W | 319 | - | G.HN | I | 28 | G.HN.52 |
Polar | TM4 | S | 321 | 4x35 | G.H5 | N | 347 | G.H5.19 |
Hydrophobic | TM5 | V | 400 | 5x72 | G.H5 | T | 340 | G.H5.12 |
Hydrophobic | C-term | T | 553 | - | G.S6 | H | 322 | G.S6.04 |
Hydrophobic | TM6 | L | 414 | 6x26 | G.H5 | L | 348 | G.H5.20 |
Hydrophobic | ICL2 | K | 318 | - | G.H5 | I | 343 | G.H5.15 |
Van-der-waals | ICL2 | K | 318 | - | G.H5 | I | 343 | G.H5.15 |
Polar | ICL2 | W | 319 | - | G.H5 | N | 347 | G.H5.19 |
Van-der-waals | ICL2 | W | 319 | - | G.H5 | N | 347 | G.H5.19 |
Hydrophobic | C-term | G | 550 | - | G.H4 | Q | 305 | G.H4.12 |
Van-der-waals | C-term | G | 550 | - | G.H4 | Q | 305 | G.H4.12 |
Hydrophobic | ICL3 | E | 407 | - | G.S6 | Y | 320 | G.S6.02 |
Van-der-waals | ICL3 | E | 407 | - | G.S6 | Y | 320 | G.S6.02 |
Polar | C-term | R | 549 | - | G.H4 | Q | 305 | G.H4.12 |
Polar | C-term | S | 548 | - | G.H4 | Q | 305 | G.H4.12 |
Polar | ICL2 | K | 318 | - | G.H5 | T | 340 | G.H5.12 |
Hydrophobic | ICL2 | K | 318 | - | G.H5 | T | 340 | G.H5.12 |
Van-der-waals | ICL2 | K | 318 | - | G.H5 | T | 340 | G.H5.12 |
Hydrophobic | TM6 | F | 417 | 6x29 | G.H5 | L | 353 | G.H5.25 |
Van-der-waals | TM6 | F | 417 | 6x29 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | TM4 | K | 326 | 4x40 | G.hns1 | A | 31 | G.hns1.02 |
Hydrophobic | TM7 | W | 497 | 7x55 | G.H5 | L | 353 | G.H5.25 |
Polar | C-term | R | 546 | - | G.h4s6 | N | 312 | G.h4s6.02 |
Hydrophobic | C-term | R | 546 | - | G.h4s6 | N | 312 | G.h4s6.02 |
Van-der-waals | C-term | R | 546 | - | G.h4s6 | N | 312 | G.h4s6.02 |
Hydrophobic | TM5 | P | 405 | 5x77 | G.H5 | D | 337 | G.H5.09 |
Hydrophobic | TM5 | I | 404 | 5x76 | G.H5 | D | 337 | G.H5.09 |
Van-der-waals | TM5 | I | 404 | 5x76 | G.H5 | D | 337 | G.H5.09 |
Hydrophobic | TM6 | R | 420 | 6x32 | G.H5 | L | 353 | G.H5.25 |
Van-der-waals | TM6 | R | 420 | 6x32 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | C-term | R | 546 | - | G.h4s6 | R | 313 | G.h4s6.03 |
Hydrophobic | ICL3 | L | 406 | - | G.H5 | I | 344 | G.H5.16 |
Hydrophobic | TM5 | I | 404 | 5x76 | G.H5 | F | 336 | G.H5.08 |
Van-der-waals | TM5 | I | 404 | 5x76 | G.H5 | F | 336 | G.H5.08 |
Polar | ICL3 | E | 407 | - | G.H5 | D | 341 | G.H5.13 |
Polar | C-term | T | 551 | - | G.S6 | C | 321 | G.S6.03 |
Polar | C-term | R | 546 | - | G.H4 | S | 310 | G.H4.17 |
Hydrophobic | C-term | R | 546 | - | G.H4 | S | 310 | G.H4.17 |
Van-der-waals | C-term | R | 546 | - | G.H4 | S | 310 | G.H4.17 |
Polar | TM6 | N | 410 | 6x22 | G.H5 | Y | 354 | G.H5.26 |
Hydrophobic | TM6 | N | 410 | 6x22 | G.H5 | Y | 354 | G.H5.26 |
Van-der-waals | TM6 | N | 410 | 6x22 | G.H5 | Y | 354 | G.H5.26 |
Hydrophobic | TM4 | K | 327 | 4x41 | G.HN | I | 28 | G.HN.52 |
Van-der-waals | TM4 | K | 327 | 4x41 | G.HN | I | 28 | G.HN.52 |
Polar | C-term | S | 523 | - | G.H3 | K | 258 | G.H3.16 |
Hydrophobic | C-term | S | 523 | - | G.H3 | K | 258 | G.H3.16 |
Van-der-waals | C-term | S | 523 | - | G.H3 | K | 258 | G.H3.16 |
Hydrophobic | ICL2 | W | 319 | - | G.hns1 | K | 32 | G.hns1.03 |
Hydrophobic | TM6 | L | 414 | 6x26 | G.H5 | I | 344 | G.H5.16 |
Polar | TM3 | A | 314 | 3x53 | G.H5 | N | 347 | G.H5.19 |
Hydrophobic | TM3 | A | 314 | 3x53 | G.H5 | N | 347 | G.H5.19 |
Van-der-waals | ICL2 | K | 318 | - | G.H5 | F | 336 | G.H5.08 |
Hydrophobic | TM5 | I | 404 | 5x76 | G.H5 | T | 340 | G.H5.12 |
Van-der-waals | TM5 | I | 404 | 5x76 | G.H5 | T | 340 | G.H5.12 |
Polar | ICL1 | R | 232 | 12x51 | G.H5 | G | 350 | G.H5.22 |
Hydrophobic | ICL1 | R | 232 | 12x51 | G.H5 | G | 350 | G.H5.22 |
Hydrophobic | TM6 | F | 417 | 6x29 | G.H5 | L | 348 | G.H5.20 |
Van-der-waals | TM6 | F | 417 | 6x29 | G.H5 | L | 348 | G.H5.20 |
Hydrophobic | C-term | L | 527 | - | G.H3 | K | 258 | G.H3.16 |
Van-der-waals | C-term | L | 527 | - | G.H3 | K | 258 | G.H3.16 |
Hydrophobic | TM2 | P | 234 | 2x40 | G.H5 | C | 351 | G.H5.23 |
Van-der-waals | TM2 | P | 234 | 2x40 | G.H5 | C | 351 | G.H5.23 |
Polar | TM6 | N | 410 | 6x22 | G.h4s6 | E | 318 | G.h4s6.12 |
Hydrophobic | TM6 | N | 410 | 6x22 | G.h4s6 | E | 318 | G.h4s6.12 |
Van-der-waals | TM6 | N | 410 | 6x22 | G.h4s6 | E | 318 | G.h4s6.12 |
Polar | TM6 | N | 410 | 6x22 | G.H5 | D | 341 | G.H5.13 |
Hydrophobic | TM6 | N | 410 | 6x22 | G.H5 | D | 341 | G.H5.13 |
Van-der-waals | TM6 | N | 410 | 6x22 | G.H5 | D | 341 | G.H5.13 |
Polar | TM4 | K | 326 | 4x40 | G.hns1 | A | 30 | G.hns1.01 |
Van-der-waals | TM4 | K | 326 | 4x40 | G.hns1 | A | 30 | G.hns1.01 |
Hydrophobic | TM4 | A | 323 | 4x37 | G.hns1 | A | 31 | G.hns1.02 |
Van-der-waals | TM4 | A | 323 | 4x37 | G.hns1 | A | 31 | G.hns1.02 |
Polar | TM6 | K | 413 | 6x25 | G.H5 | Y | 354 | G.H5.26 |
Hydrophobic | TM6 | K | 413 | 6x25 | G.H5 | Y | 354 | G.H5.26 |
Van-der-waals | TM6 | K | 413 | 6x25 | G.H5 | Y | 354 | G.H5.26 |
Ionic | C-term | E | 529 | - | G.H2 | K | 210 | G.H2.05 |
Polar | C-term | T | 551 | - | G.S6 | H | 322 | G.S6.04 |
Polar | C-term | R | 546 | - | G.H4 | E | 309 | G.H4.16 |
Hydrophobic | C-term | R | 546 | - | G.H4 | E | 309 | G.H4.16 |
Van-der-waals | C-term | R | 546 | - | G.H4 | E | 309 | G.H4.16 |
Polar | C-term | R | 549 | - | G.H4 | E | 309 | G.H4.16 |
Van-der-waals | C-term | R | 549 | - | G.H4 | E | 309 | G.H4.16 |
Polar | TM6 | N | 410 | 6x22 | G.S6 | Y | 320 | G.S6.02 |
Polar | C-term | S | 548 | - | G.H4 | E | 309 | G.H4.16 |
Hydrophobic | C-term | S | 548 | - | G.H4 | E | 309 | G.H4.16 |
Van-der-waals | C-term | S | 548 | - | G.H4 | E | 309 | G.H4.16 |
Hydrophobic | ICL2 | K | 318 | - | G.S3 | L | 195 | G.S3.01 |
Polar | TM2 | E | 235 | 2x41 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | TM2 | E | 235 | 2x41 | G.H5 | C | 351 | G.H5.23 |
Van-der-waals | TM2 | E | 235 | 2x41 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | TM6 | K | 413 | 6x25 | G.H5 | L | 348 | G.H5.20 |
Ionic | TM6 | K | 413 | 6x25 | G.h4s6 | E | 318 | G.h4s6.12 |