GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 72.5
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.6
iPTM Score: 0.7
PAE mean: 14.5
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Polar | TM4 | Q | 322 | 4x40 | G.HN | A | 27 | G.HN.51 |
Hydrophobic | TM4 | Q | 322 | 4x40 | G.HN | A | 27 | G.HN.51 |
Van-der-waals | TM4 | Q | 322 | 4x40 | G.HN | A | 27 | G.HN.51 |
Hydrophobic | TM5 | I | 400 | 5x76 | G.H5 | I | 344 | G.H5.16 |
Hydrophobic | TM5 | V | 396 | 5x72 | G.H5 | L | 348 | G.H5.20 |
Hydrophobic | C-term | I | 554 | - | H.hdhe | Y | 146 | H.hdhe.01 |
Ionic | ICL2 | K | 314 | - | G.s2s3 | D | 193 | G.s2s3.02 |
Polar | ICL2 | K | 314 | - | G.s2s3 | D | 193 | G.s2s3.02 |
Van-der-waals | ICL2 | K | 314 | - | G.s2s3 | D | 193 | G.s2s3.02 |
Hydrophobic | TM3 | A | 310 | 3x53 | G.H5 | L | 348 | G.H5.20 |
Hydrophobic | C-term | F | 530 | - | G.H2 | R | 208 | G.H2.04 |
Van-der-waals | C-term | F | 530 | - | G.H2 | R | 208 | G.H2.04 |
Hydrophobic | TM5 | L | 393 | 5x69 | G.H5 | L | 348 | G.H5.20 |
Van-der-waals | C-term | T | 570 | - | G.S2 | E | 186 | G.S2.03 |
Polar | C-term | S | 555 | - | G.s4h3 | V | 235 | G.s4h3.09 |
Hydrophobic | C-term | S | 555 | - | G.s4h3 | V | 235 | G.s4h3.09 |
Van-der-waals | C-term | S | 555 | - | G.s4h3 | V | 235 | G.s4h3.09 |
Ionic | C-term | H | 568 | - | H.HA | E | 68 | H.HA.06 |
Polar | C-term | H | 568 | - | H.HA | E | 68 | H.HA.06 |
Hydrophobic | C-term | H | 568 | - | H.HA | E | 68 | H.HA.06 |
Van-der-waals | C-term | H | 568 | - | H.HA | E | 68 | H.HA.06 |
Ionic | TM4 | K | 323 | 4x41 | G.HN | D | 28 | G.HN.52 |
Polar | TM4 | K | 323 | 4x41 | G.HN | D | 28 | G.HN.52 |
Hydrophobic | TM4 | K | 323 | 4x41 | G.HN | D | 28 | G.HN.52 |
Van-der-waals | TM4 | K | 323 | 4x41 | G.HN | D | 28 | G.HN.52 |
Polar | C-term | T | 560 | - | G.hfs2 | K | 180 | G.hfs2.04 |
Hydrophobic | C-term | T | 560 | - | G.hfs2 | K | 180 | G.hfs2.04 |
Van-der-waals | C-term | T | 560 | - | G.hfs2 | K | 180 | G.hfs2.04 |
Hydrophobic | C-term | V | 573 | - | G.S2 | E | 186 | G.S2.03 |
Hydrophobic | C-term | S | 557 | - | G.s4h3 | V | 235 | G.s4h3.09 |
Van-der-waals | C-term | S | 557 | - | G.s4h3 | V | 235 | G.s4h3.09 |
Polar | TM4 | Q | 322 | 4x40 | G.HN | D | 28 | G.HN.52 |
Polar | TM4 | S | 316 | 4x34 | G.hns1 | A | 31 | G.hns1.02 |
Van-der-waals | TM4 | S | 316 | 4x34 | G.hns1 | A | 31 | G.hns1.02 |
Hydrophobic | C-term | V | 522 | - | G.h4s6 | M | 312 | G.h4s6.03 |
Hydrophobic | ICL2 | K | 314 | - | G.S3 | L | 194 | G.S3.01 |
Van-der-waals | ICL2 | K | 314 | - | G.S3 | L | 194 | G.S3.01 |
Hydrophobic | C-term | T | 562 | - | G.hfs2 | V | 179 | G.hfs2.03 |
Van-der-waals | C-term | T | 562 | - | G.hfs2 | V | 179 | G.hfs2.03 |
Hydrophobic | C-term | I | 554 | - | H.HA | T | 90 | H.HA.28 |
Van-der-waals | C-term | I | 554 | - | H.HA | T | 90 | H.HA.28 |
Hydrophobic | TM3 | A | 311 | 3x54 | G.H5 | L | 348 | G.H5.20 |
Hydrophobic | C-term | V | 573 | - | G.S3 | F | 199 | G.S3.06 |
Hydrophobic | TM6 | F | 413 | 6x29 | G.H5 | G | 352 | G.H5.24 |
Van-der-waals | TM6 | F | 413 | 6x29 | G.H5 | G | 352 | G.H5.24 |
Hydrophobic | TM4 | E | 318 | 4x36 | G.hns1 | A | 31 | G.hns1.02 |
Hydrophobic | TM6 | I | 417 | 6x33 | G.H5 | L | 353 | G.H5.25 |
Van-der-waals | TM6 | I | 417 | 6x33 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | C-term | L | 523 | - | G.H3 | H | 256 | G.H3.15 |
Van-der-waals | C-term | L | 523 | - | G.H3 | H | 256 | G.H3.15 |
Polar | C-term | S | 557 | - | G.s1h1 | E | 43 | G.s1h1.04 |
Polar | C-term | S | 555 | - | G.s4h3 | L | 234 | G.s4h3.08 |
Van-der-waals | C-term | S | 555 | - | G.s4h3 | L | 234 | G.s4h3.08 |
Hydrophobic | C-term | G | 559 | - | G.hfs2 | K | 180 | G.hfs2.04 |
Hydrophobic | TM3 | A | 310 | 3x53 | G.H5 | C | 351 | G.H5.23 |
Van-der-waals | TM3 | A | 310 | 3x53 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | C-term | V | 553 | - | H.hdhe | Y | 146 | H.hdhe.01 |
Hydrophobic | TM2 | E | 231 | 2x41 | G.H5 | G | 352 | G.H5.24 |
Hydrophobic | TM2 | P | 230 | 2x40 | G.H5 | C | 351 | G.H5.23 |
Van-der-waals | TM2 | P | 230 | 2x40 | G.H5 | C | 351 | G.H5.23 |
Ionic | ICL1 | R | 228 | 12x51 | G.H5 | D | 350 | G.H5.22 |
Polar | ICL1 | R | 228 | 12x51 | G.H5 | D | 350 | G.H5.22 |
Hydrophobic | ICL1 | R | 228 | 12x51 | G.H5 | D | 350 | G.H5.22 |
Van-der-waals | ICL1 | R | 228 | 12x51 | G.H5 | D | 350 | G.H5.22 |
Polar | C-term | I | 516 | - | G.H3 | K | 257 | G.H3.16 |
Van-der-waals | C-term | I | 516 | - | G.H3 | K | 257 | G.H3.16 |
Polar | C-term | V | 553 | - | H.HD | E | 145 | H.HD.12 |
Hydrophobic | C-term | V | 553 | - | H.HD | E | 145 | H.HD.12 |
Van-der-waals | C-term | V | 553 | - | H.HD | E | 145 | H.HD.12 |
Hydrophobic | TM3 | A | 310 | 3x53 | G.H5 | L | 353 | G.H5.25 |
Van-der-waals | TM3 | A | 310 | 3x53 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | C-term | I | 554 | - | H.HA | R | 86 | H.HA.24 |
Ionic | C-term | K | 550 | - | G.s4h3 | E | 239 | G.s4h3.13 |
Polar | C-term | K | 550 | - | G.s4h3 | E | 239 | G.s4h3.13 |
Van-der-waals | C-term | K | 550 | - | G.s4h3 | E | 239 | G.s4h3.13 |
Polar | C-term | S | 519 | - | G.H3 | K | 257 | G.H3.16 |
Hydrophobic | C-term | S | 519 | - | G.H3 | K | 257 | G.H3.16 |
Van-der-waals | C-term | S | 519 | - | G.H3 | K | 257 | G.H3.16 |
Polar | C-term | T | 560 | - | H.HA | N | 76 | H.HA.14 |
Hydrophobic | TM4 | A | 319 | 4x37 | G.hns1 | A | 31 | G.hns1.02 |
Van-der-waals | TM4 | A | 319 | 4x37 | G.hns1 | A | 31 | G.hns1.02 |
Polar | ICL2 | K | 314 | - | G.s2s3 | K | 192 | G.s2s3.01 |
Van-der-waals | ICL2 | K | 314 | - | G.s2s3 | K | 192 | G.s2s3.01 |
Hydrophobic | TM4 | Q | 322 | 4x40 | G.hns1 | A | 31 | G.hns1.02 |
Van-der-waals | TM4 | Q | 322 | 4x40 | G.hns1 | A | 31 | G.hns1.02 |
Hydrophobic | C-term | V | 553 | - | H.hdhe | Q | 147 | H.hdhe.02 |
Van-der-waals | C-term | V | 553 | - | H.hdhe | Q | 147 | H.hdhe.02 |
Hydrophobic | C-term | T | 562 | - | H.HA | I | 72 | H.HA.10 |
Hydrophobic | TM5 | V | 396 | 5x72 | G.H5 | I | 344 | G.H5.16 |
Van-der-waals | TM5 | V | 396 | 5x72 | G.H5 | I | 344 | G.H5.16 |
Hydrophobic | TM6 | L | 410 | 6x26 | G.H5 | F | 354 | G.H5.26 |
Hydrophobic | TM5 | V | 399 | 5x75 | G.s2s3 | K | 192 | G.s2s3.01 |
Van-der-waals | TM5 | V | 399 | 5x75 | G.s2s3 | K | 192 | G.s2s3.01 |
Polar | C-term | T | 560 | - | G.hfs2 | R | 178 | G.hfs2.02 |
Hydrophobic | C-term | F | 530 | - | G.H3 | L | 249 | G.H3.08 |
Van-der-waals | C-term | F | 530 | - | G.H3 | L | 249 | G.H3.08 |
Hydrophobic | TM4 | A | 319 | 4x37 | G.hns1 | K | 32 | G.hns1.03 |
Polar | ICL2 | K | 314 | - | G.H5 | N | 347 | G.H5.19 |
Van-der-waals | ICL2 | K | 314 | - | G.H5 | N | 347 | G.H5.19 |
Hydrophobic | ICL2 | K | 314 | - | G.H5 | I | 344 | G.H5.16 |
Hydrophobic | C-term | T | 560 | - | H.hbhc | E | 116 | H.hbhc.04 |
Van-der-waals | C-term | T | 560 | - | H.hbhc | E | 116 | H.hbhc.04 |
Ionic | TM6 | K | 409 | 6x25 | G.h4s6 | E | 318 | G.h4s6.12 |
Polar | TM6 | K | 409 | 6x25 | G.h4s6 | E | 318 | G.h4s6.12 |
Hydrophobic | C-term | I | 554 | - | H.HA | A | 87 | H.HA.25 |
Van-der-waals | C-term | I | 554 | - | H.HA | A | 87 | H.HA.25 |
Hydrophobic | TM4 | S | 316 | 4x34 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | TM6 | N | 406 | 6x22 | G.H5 | F | 354 | G.H5.26 |
Hydrophobic | C-term | F | 530 | - | G.H3 | S | 252 | G.H3.11 |
Polar | C-term | N | 534 | - | G.H2 | R | 205 | G.H2.01 |
Hydrophobic | TM6 | F | 413 | 6x29 | G.H5 | L | 353 | G.H5.25 |
Van-der-waals | TM6 | F | 413 | 6x29 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | TM4 | C | 317 | 4x35 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | C-term | S | 557 | - | H.hdhe | Q | 147 | H.hdhe.02 |
Polar | C-term | S | 555 | - | H.hdhe | Q | 147 | H.hdhe.02 |
Hydrophobic | C-term | S | 555 | - | H.hdhe | Q | 147 | H.hdhe.02 |
Van-der-waals | C-term | S | 555 | - | H.hdhe | Q | 147 | H.hdhe.02 |
Hydrophobic | ICL3 | H | 402 | - | G.H5 | D | 337 | G.H5.09 |
Hydrophobic | C-term | T | 570 | - | G.S2 | I | 185 | G.S2.02 |
Hydrophobic | TM6 | L | 410 | 6x26 | G.H5 | L | 348 | G.H5.20 |
Hydrophobic | ICL3 | H | 402 | - | G.H5 | A | 338 | G.H5.10 |
Hydrophobic | C-term | L | 551 | - | H.HD | E | 145 | H.HD.12 |
Van-der-waals | C-term | L | 551 | - | H.HD | E | 145 | H.HD.12 |
Hydrophobic | C-term | R | 520 | - | G.H3 | K | 257 | G.H3.16 |
Van-der-waals | C-term | R | 520 | - | G.H3 | K | 257 | G.H3.16 |
Polar | C-term | S | 555 | - | G.s4h3 | D | 238 | G.s4h3.12 |
Hydrophobic | C-term | S | 555 | - | G.s4h3 | D | 238 | G.s4h3.12 |
Van-der-waals | C-term | S | 555 | - | G.s4h3 | D | 238 | G.s4h3.12 |
Hydrophobic | C-term | V | 553 | - | G.s4h3 | V | 233 | G.s4h3.07 |
Van-der-waals | C-term | V | 553 | - | G.s4h3 | V | 233 | G.s4h3.07 |
Polar | ICL3 | H | 402 | - | G.H5 | F | 334 | G.H5.06 |
Aromatic | ICL3 | H | 402 | - | G.H5 | F | 334 | G.H5.06 |
Hydrophobic | ICL3 | H | 402 | - | G.H5 | F | 334 | G.H5.06 |
Van-der-waals | ICL3 | H | 402 | - | G.H5 | F | 334 | G.H5.06 |
Polar | TM6 | N | 406 | 6x22 | G.H5 | K | 345 | G.H5.17 |
Hydrophobic | TM6 | N | 406 | 6x22 | G.H5 | K | 345 | G.H5.17 |
Van-der-waals | TM6 | N | 406 | 6x22 | G.H5 | K | 345 | G.H5.17 |
Polar | C-term | K | 552 | - | H.HA | T | 90 | H.HA.28 |
Hydrophobic | C-term | K | 552 | - | H.HA | T | 90 | H.HA.28 |
Hydrophobic | TM5 | I | 400 | 5x76 | G.H5 | D | 341 | G.H5.13 |
Van-der-waals | TM5 | I | 400 | 5x76 | G.H5 | D | 341 | G.H5.13 |
Polar | C-term | M | 558 | - | H.HA | Q | 79 | H.HA.17 |
Hydrophobic | C-term | M | 558 | - | H.HA | Q | 79 | H.HA.17 |
Van-der-waals | C-term | M | 558 | - | H.HA | Q | 79 | H.HA.17 |
Polar | C-term | I | 554 | - | H.hdhe | Q | 147 | H.hdhe.02 |
Hydrophobic | C-term | I | 554 | - | H.hdhe | Q | 147 | H.hdhe.02 |
Hydrophobic | C-term | L | 523 | - | G.H3 | K | 257 | G.H3.16 |
Van-der-waals | C-term | L | 523 | - | G.H3 | K | 257 | G.H3.16 |
Polar | C-term | S | 571 | - | G.S2 | E | 186 | G.S2.03 |
Van-der-waals | C-term | S | 571 | - | G.S2 | E | 186 | G.S2.03 |
Hydrophobic | TM6 | F | 413 | 6x29 | G.H5 | F | 354 | G.H5.26 |
Van-der-waals | TM6 | F | 413 | 6x29 | G.H5 | F | 354 | G.H5.26 |
Hydrophobic | C-term | S | 561 | - | G.hfs2 | K | 180 | G.hfs2.04 |
Polar | C-term | Y | 544 | - | G.s4h3 | E | 239 | G.s4h3.13 |
Hydrophobic | C-term | Y | 544 | - | G.s4h3 | E | 239 | G.s4h3.13 |
Van-der-waals | C-term | Y | 544 | - | G.s4h3 | E | 239 | G.s4h3.13 |
Ionic | C-term | H | 568 | - | H.HA | E | 65 | H.HA.03 |
Polar | C-term | H | 568 | - | H.HA | E | 65 | H.HA.03 |
Hydrophobic | C-term | H | 568 | - | H.HA | E | 65 | H.HA.03 |
Van-der-waals | C-term | H | 568 | - | H.HA | E | 65 | H.HA.03 |
Hydrophobic | TM3 | W | 307 | 3x50 | G.H5 | L | 353 | G.H5.25 |
Van-der-waals | TM3 | W | 307 | 3x50 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | TM4 | I | 320 | 4x38 | G.H5 | C | 351 | G.H5.23 |
Aromatic | C-term | F | 529 | - | G.H3 | H | 248 | G.H3.07 |
Hydrophobic | C-term | F | 529 | - | G.H3 | H | 248 | G.H3.07 |
Van-der-waals | C-term | F | 529 | - | G.H3 | H | 248 | G.H3.07 |
Hydrophobic | C-term | I | 575 | - | G.H2 | K | 210 | G.H2.06 |
Aromatic | ICL2 | W | 315 | - | G.hns1 | K | 32 | G.hns1.03 |
Hydrophobic | ICL2 | W | 315 | - | G.hns1 | K | 32 | G.hns1.03 |
Van-der-waals | ICL2 | W | 315 | - | G.hns1 | K | 32 | G.hns1.03 |
Polar | TM5 | Q | 401 | 5x77 | G.H5 | D | 341 | G.H5.13 |
Hydrophobic | C-term | I | 575 | - | G.H2 | H | 213 | G.H2.09 |
Hydrophobic | C-term | T | 560 | - | H.HA | Q | 79 | H.HA.17 |
Polar | C-term | V | 573 | - | G.S2 | I | 184 | G.S2.01 |
Hydrophobic | C-term | V | 573 | - | G.S2 | I | 184 | G.S2.01 |
Van-der-waals | C-term | V | 573 | - | G.S2 | I | 184 | G.S2.01 |
Hydrophobic | TM6 | K | 409 | 6x25 | G.H5 | F | 354 | G.H5.26 |
Van-der-waals | TM6 | K | 409 | 6x25 | G.H5 | F | 354 | G.H5.26 |
Polar | C-term | S | 526 | - | G.H3 | S | 252 | G.H3.11 |
Hydrophobic | C-term | S | 526 | - | G.H3 | S | 252 | G.H3.11 |
Van-der-waals | C-term | S | 526 | - | G.H3 | S | 252 | G.H3.11 |
Hydrophobic | C-term | I | 575 | - | G.S2 | I | 184 | G.S2.01 |
Van-der-waals | C-term | I | 575 | - | G.S2 | I | 184 | G.S2.01 |
Polar | ICL2 | W | 315 | - | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | TM3 | A | 311 | 3x54 | G.H5 | L | 353 | G.H5.25 |