GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 75.5
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.4
iPTM Score: 0.4
PAE mean: 29.4
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Polar | TM4 | H | 348 | 4x35 | G.H3 | K | 284 | G.H3.16 |
Hydrophobic | C-term | T | 589 | - | H.hdhe | F | 173 | H.hdhe.01 |
Hydrophobic | ICL2 | K | 345 | - | G.H5 | N | 374 | G.H5.19 |
Van-der-waals | ICL2 | K | 345 | - | G.H5 | N | 374 | G.H5.19 |
Hydrophobic | C-term | P | 588 | - | H.HA | R | 106 | H.HA.20 |
Hydrophobic | C-term | L | 591 | - | H.HA | K | 114 | H.HA.28 |
Van-der-waals | C-term | L | 591 | - | H.HA | K | 114 | H.HA.28 |
Polar | TM4 | H | 348 | 4x35 | G.H3 | F | 286 | G.H3.18 |
Hydrophobic | TM4 | H | 348 | 4x35 | G.H3 | F | 286 | G.H3.18 |
Polar | ICL2 | K | 344 | - | G.hns1 | R | 55 | G.hns1.02 |
Hydrophobic | ICL2 | K | 344 | - | G.hns1 | R | 55 | G.hns1.02 |
Van-der-waals | ICL2 | K | 344 | - | G.hns1 | R | 55 | G.hns1.02 |
Hydrophobic | TM5 | M | 431 | 5x76 | G.H5 | K | 376 | G.H5.21 |
Van-der-waals | TM5 | M | 431 | 5x76 | G.H5 | K | 376 | G.H5.21 |
Hydrophobic | TM5 | L | 424 | 5x69 | G.H5 | M | 379 | G.H5.24 |
Van-der-waals | TM5 | L | 424 | 5x69 | G.H5 | M | 379 | G.H5.24 |
Hydrophobic | C-term | L | 591 | - | H.HA | L | 115 | H.HA.29 |
Van-der-waals | C-term | L | 591 | - | H.HA | L | 115 | H.HA.29 |
Hydrophobic | TM4 | A | 350 | 4x37 | G.h2s4 | D | 243 | G.h2s4.02 |
Hydrophobic | TM5 | I | 427 | 5x72 | G.H5 | I | 378 | G.H5.23 |
Van-der-waals | TM5 | I | 427 | 5x72 | G.H5 | I | 378 | G.H5.23 |
Hydrophobic | C-term | P | 588 | - | H.HA | V | 107 | H.HA.21 |
Hydrophobic | TM4 | A | 353 | 4x40 | G.h2s4 | D | 243 | G.h2s4.02 |
Van-der-waals | TM4 | A | 353 | 4x40 | G.h2s4 | D | 243 | G.h2s4.02 |
Hydrophobic | TM5 | L | 424 | 5x69 | G.H5 | I | 378 | G.H5.23 |
Van-der-waals | TM5 | L | 424 | 5x69 | G.H5 | I | 378 | G.H5.23 |
Hydrophobic | ICL3 | L | 441 | - | G.H5 | L | 375 | G.H5.20 |
Van-der-waals | ICL3 | L | 441 | - | G.H5 | L | 375 | G.H5.20 |
Polar | TM6 | M | 445 | 6x30 | G.H5 | M | 379 | G.H5.24 |
Hydrophobic | TM6 | M | 445 | 6x30 | G.H5 | M | 379 | G.H5.24 |
Van-der-waals | TM6 | M | 445 | 6x30 | G.H5 | M | 379 | G.H5.24 |
Hydrophobic | TM5 | M | 431 | 5x76 | G.H5 | L | 375 | G.H5.20 |
Van-der-waals | TM5 | M | 431 | 5x76 | G.H5 | L | 375 | G.H5.20 |
Polar | ICL3 | N | 437 | - | G.H5 | Q | 372 | G.H5.17 |
Hydrophobic | ICL3 | N | 437 | - | G.H5 | Q | 372 | G.H5.17 |
Van-der-waals | ICL3 | N | 437 | - | G.H5 | Q | 372 | G.H5.17 |
Hydrophobic | TM6 | I | 448 | 6x33 | G.H5 | L | 380 | G.H5.25 |
Hydrophobic | TM4 | H | 348 | 4x35 | G.h3s5 | N | 288 | G.h3s5.02 |
Polar | ICL2 | K | 345 | - | G.hns1 | R | 56 | G.hns1.03 |
Hydrophobic | ICL2 | K | 345 | - | G.hns1 | R | 56 | G.hns1.03 |
Van-der-waals | ICL2 | K | 345 | - | G.hns1 | R | 56 | G.hns1.03 |
Hydrophobic | TM5 | I | 430 | 5x75 | G.H5 | L | 371 | G.H5.16 |
Hydrophobic | TM3 | G | 343 | 3x55 | G.hns1 | R | 55 | G.hns1.02 |
Van-der-waals | TM3 | G | 343 | 3x55 | G.hns1 | R | 55 | G.hns1.02 |
Polar | TM4 | G | 347 | 4x34 | G.h2s4 | I | 245 | G.h2s4.04 |
Hydrophobic | TM4 | G | 347 | 4x34 | G.h2s4 | I | 245 | G.h2s4.04 |
Van-der-waals | TM4 | G | 347 | 4x34 | G.h2s4 | I | 245 | G.h2s4.04 |
Polar | ICL3 | T | 436 | - | G.H5 | Q | 372 | G.H5.17 |
Hydrophobic | ICL3 | T | 436 | - | G.H5 | Q | 372 | G.H5.17 |
Van-der-waals | ICL3 | T | 436 | - | G.H5 | Q | 372 | G.H5.17 |
Hydrophobic | C-term | L | 591 | - | H.HD | E | 172 | H.HD.12 |
Polar | C-term | P | 588 | - | H.HA | D | 110 | H.HA.24 |
Hydrophobic | C-term | P | 588 | - | H.HA | D | 110 | H.HA.24 |
Van-der-waals | C-term | P | 588 | - | H.HA | D | 110 | H.HA.24 |
Polar | C-term | N | 587 | - | H.HA | K | 114 | H.HA.28 |
Hydrophobic | C-term | N | 587 | - | H.HA | K | 114 | H.HA.28 |
Van-der-waals | C-term | N | 587 | - | H.HA | K | 114 | H.HA.28 |
Polar | TM5 | H | 426 | 5x71 | G.hns1 | R | 56 | G.hns1.03 |
Aromatic | TM5 | H | 426 | 5x71 | G.hns1 | R | 56 | G.hns1.03 |
Van-der-waals | TM5 | H | 426 | 5x71 | G.hns1 | R | 56 | G.hns1.03 |
Hydrophobic | ICL2 | K | 345 | - | G.H5 | I | 378 | G.H5.23 |
Van-der-waals | ICL2 | K | 345 | - | G.H5 | I | 378 | G.H5.23 |
Polar | C-term | T | 589 | - | H.HA | D | 110 | H.HA.24 |
Hydrophobic | C-term | T | 589 | - | H.HA | D | 110 | H.HA.24 |
Van-der-waals | C-term | T | 589 | - | H.HA | D | 110 | H.HA.24 |
Hydrophobic | ICL2 | K | 345 | - | G.S1 | L | 57 | G.S1.01 |
Van-der-waals | ICL2 | K | 345 | - | G.S1 | L | 57 | G.S1.01 |
Hydrophobic | TM3 | A | 341 | 3x53 | G.H5 | I | 378 | G.H5.23 |
Van-der-waals | TM3 | A | 341 | 3x53 | G.H5 | I | 378 | G.H5.23 |
Hydrophobic | TM6 | I | 448 | 6x33 | G.H5 | Q | 381 | G.H5.26 |
Van-der-waals | TM6 | I | 448 | 6x33 | G.H5 | Q | 381 | G.H5.26 |
Hydrophobic | TM4 | E | 349 | 4x36 | G.h2s4 | D | 243 | G.h2s4.02 |
Van-der-waals | TM4 | E | 349 | 4x36 | G.h2s4 | D | 243 | G.h2s4.02 |
Hydrophobic | TM5 | R | 428 | 5x73 | G.H5 | M | 379 | G.H5.24 |
Hydrophobic | TM6 | L | 444 | 6x29 | G.H5 | L | 380 | G.H5.25 |
Van-der-waals | TM6 | L | 444 | 6x29 | G.H5 | L | 380 | G.H5.25 |
Hydrophobic | ICL3 | L | 441 | - | G.H5 | K | 376 | G.H5.21 |
Van-der-waals | ICL3 | L | 441 | - | G.H5 | K | 376 | G.H5.21 |
Hydrophobic | C-term | L | 576 | - | G.H2 | Q | 236 | G.H2.05 |
Van-der-waals | C-term | L | 576 | - | G.H2 | Q | 236 | G.H2.05 |
Hydrophobic | TM5 | I | 427 | 5x72 | G.H5 | L | 375 | G.H5.20 |
Van-der-waals | TM5 | I | 427 | 5x72 | G.H5 | L | 375 | G.H5.20 |
Polar | ICL3 | N | 437 | - | G.H5 | K | 376 | G.H5.21 |
Hydrophobic | ICL3 | N | 437 | - | G.H5 | K | 376 | G.H5.21 |
Van-der-waals | ICL3 | N | 437 | - | G.H5 | K | 376 | G.H5.21 |
Hydrophobic | C-term | L | 591 | - | H.hdhe | F | 173 | H.hdhe.01 |
Polar | ICL1 | H | 258 | 12x48 | G.H3 | K | 284 | G.H3.16 |
Aromatic | ICL1 | H | 258 | 12x48 | G.H3 | K | 284 | G.H3.16 |
Hydrophobic | ICL1 | H | 258 | 12x48 | G.H3 | K | 284 | G.H3.16 |
Van-der-waals | ICL1 | H | 258 | 12x48 | G.H3 | K | 284 | G.H3.16 |
Polar | TM3 | A | 342 | 3x54 | G.H5 | I | 378 | G.H5.23 |
Hydrophobic | TM3 | A | 342 | 3x54 | G.H5 | I | 378 | G.H5.23 |
Van-der-waals | TM3 | A | 342 | 3x54 | G.H5 | I | 378 | G.H5.23 |
Hydrophobic | ICL2 | W | 346 | - | G.h2s4 | G | 244 | G.h2s4.03 |
Hydrophobic | TM3 | A | 341 | 3x53 | G.H5 | Q | 381 | G.H5.26 |
Van-der-waals | TM3 | A | 341 | 3x53 | G.H5 | Q | 381 | G.H5.26 |
Van-der-waals | C-term | L | 591 | - | G.s4h3 | R | 265 | G.s4h3.12 |
Hydrophobic | TM6 | I | 448 | 6x33 | G.H5 | M | 379 | G.H5.24 |
Van-der-waals | TM6 | I | 448 | 6x33 | G.H5 | M | 379 | G.H5.24 |
Polar | C-term | T | 589 | - | H.HA | V | 107 | H.HA.21 |
Hydrophobic | C-term | T | 589 | - | H.HA | V | 107 | H.HA.21 |
Van-der-waals | C-term | T | 589 | - | H.HA | V | 107 | H.HA.21 |
Polar | TM2 | Y | 262 | 2x39 | G.h3s5 | N | 288 | G.h3s5.02 |
Hydrophobic | C-term | M | 578 | - | G.H2 | Q | 236 | G.H2.05 |
Polar | TM2 | Y | 262 | 2x39 | G.H5 | Q | 381 | G.H5.26 |
Van-der-waals | TM2 | Y | 262 | 2x39 | G.H5 | Q | 381 | G.H5.26 |
Hydrophobic | TM5 | R | 428 | 5x73 | G.H5 | L | 375 | G.H5.20 |
Van-der-waals | TM5 | R | 428 | 5x73 | G.H5 | L | 375 | G.H5.20 |
Hydrophobic | TM6 | L | 444 | 6x29 | G.H5 | K | 376 | G.H5.21 |
Van-der-waals | TM6 | L | 444 | 6x29 | G.H5 | K | 376 | G.H5.21 |
Polar | C-term | T | 589 | - | H.HA | A | 111 | H.HA.25 |
Hydrophobic | C-term | T | 589 | - | H.HA | A | 111 | H.HA.25 |
Van-der-waals | C-term | T | 589 | - | H.HA | A | 111 | H.HA.25 |
Polar | TM4 | H | 348 | 4x35 | G.H3 | L | 285 | G.H3.17 |
Hydrophobic | TM4 | H | 348 | 4x35 | G.H3 | L | 285 | G.H3.17 |
Van-der-waals | TM4 | H | 348 | 4x35 | G.H3 | L | 285 | G.H3.17 |
Polar | ICL2 | K | 345 | - | G.hns1 | R | 55 | G.hns1.02 |
Hydrophobic | ICL2 | K | 345 | - | G.hns1 | R | 55 | G.hns1.02 |
Van-der-waals | ICL2 | K | 345 | - | G.hns1 | R | 55 | G.hns1.02 |
Polar | C-term | H | 590 | - | G.s4h3 | R | 265 | G.s4h3.12 |
Hydrophobic | C-term | H | 590 | - | G.s4h3 | R | 265 | G.s4h3.12 |
Van-der-waals | C-term | H | 590 | - | G.s4h3 | R | 265 | G.s4h3.12 |
Hydrophobic | TM5 | I | 430 | 5x75 | G.S3 | I | 221 | G.S3.01 |
Hydrophobic | TM4 | E | 349 | 4x36 | G.H3 | L | 285 | G.H3.17 |
Van-der-waals | TM4 | E | 349 | 4x36 | G.H3 | L | 285 | G.H3.17 |
Hydrophobic | C-term | P | 588 | - | H.HB | M | 132 | H.HB.10 |
Polar | ICL2 | K | 345 | - | G.h2s4 | T | 246 | G.h2s4.05 |
Hydrophobic | TM6 | L | 444 | 6x29 | G.H5 | M | 379 | G.H5.24 |
Van-der-waals | TM6 | L | 444 | 6x29 | G.H5 | M | 379 | G.H5.24 |
Van-der-waals | ICL2 | W | 346 | - | G.H5 | Q | 381 | G.H5.26 |
Hydrophobic | ICL2 | K | 345 | - | G.S1 | V | 58 | G.S1.02 |
Hydrophobic | TM4 | E | 349 | 4x36 | G.H3 | F | 286 | G.H3.18 |
Van-der-waals | TM4 | E | 349 | 4x36 | G.H3 | F | 286 | G.H3.18 |
Polar | ICL2 | K | 344 | - | G.HN | R | 51 | G.HN.51 |
Van-der-waals | ICL2 | K | 344 | - | G.HN | R | 51 | G.HN.51 |
Hydrophobic | TM4 | H | 348 | 4x35 | G.h3s5 | V | 289 | G.h3s5.03 |
Van-der-waals | TM4 | H | 348 | 4x35 | G.h3s5 | V | 289 | G.h3s5.03 |
Polar | H8 | K | 532 | 8x49 | G.h4s6 | S | 343 | G.h4s6.12 |
Hydrophobic | H8 | K | 532 | 8x49 | G.h4s6 | S | 343 | G.h4s6.12 |
Van-der-waals | H8 | K | 532 | 8x49 | G.h4s6 | S | 343 | G.h4s6.12 |
Hydrophobic | TM2 | P | 263 | 2x40 | G.H5 | Q | 381 | G.H5.26 |
Van-der-waals | TM2 | P | 263 | 2x40 | G.H5 | Q | 381 | G.H5.26 |
Hydrophobic | C-term | N | 587 | - | H.HA | D | 110 | H.HA.24 |
Van-der-waals | C-term | N | 587 | - | H.HA | D | 110 | H.HA.24 |
Polar | TM3 | F | 339 | 3x51 | G.hns1 | R | 55 | G.hns1.02 |
Aromatic | TM3 | F | 339 | 3x51 | G.hns1 | R | 55 | G.hns1.02 |
Hydrophobic | TM3 | F | 339 | 3x51 | G.hns1 | R | 55 | G.hns1.02 |
Van-der-waals | TM3 | F | 339 | 3x51 | G.hns1 | R | 55 | G.hns1.02 |
Polar | C-term | T | 589 | - | H.HA | K | 114 | H.HA.28 |
Hydrophobic | C-term | T | 589 | - | H.HA | K | 114 | H.HA.28 |
Van-der-waals | C-term | T | 589 | - | H.HA | K | 114 | H.HA.28 |
Polar | TM3 | W | 338 | 3x50 | G.H5 | Q | 381 | G.H5.26 |
Hydrophobic | TM3 | W | 338 | 3x50 | G.H5 | Q | 381 | G.H5.26 |
Van-der-waals | TM3 | W | 338 | 3x50 | G.H5 | Q | 381 | G.H5.26 |
Van-der-waals | ICL2 | K | 344 | - | G.hns1 | V | 54 | G.hns1.01 |
Polar | ICL1 | Q | 261 | 12x51 | G.h3s5 | F | 287 | G.h3s5.01 |
Hydrophobic | ICL1 | Q | 261 | 12x51 | G.h3s5 | F | 287 | G.h3s5.01 |
Van-der-waals | ICL1 | Q | 261 | 12x51 | G.h3s5 | F | 287 | G.h3s5.01 |
Polar | TM4 | G | 347 | 4x34 | G.h2s4 | G | 244 | G.h2s4.03 |
Hydrophobic | TM4 | G | 347 | 4x34 | G.h2s4 | G | 244 | G.h2s4.03 |
Van-der-waals | TM4 | G | 347 | 4x34 | G.h2s4 | G | 244 | G.h2s4.03 |
Polar | ICL1 | Q | 261 | 12x51 | G.H3 | K | 284 | G.H3.16 |
Hydrophobic | ICL1 | Q | 261 | 12x51 | G.H3 | K | 284 | G.H3.16 |
Van-der-waals | ICL1 | Q | 261 | 12x51 | G.H3 | K | 284 | G.H3.16 |
Hydrophobic | TM4 | A | 350 | 4x37 | G.h2s4 | G | 244 | G.h2s4.03 |
Van-der-waals | TM4 | A | 350 | 4x37 | G.h2s4 | G | 244 | G.h2s4.03 |
Hydrophobic | TM4 | E | 349 | 4x36 | G.h2s4 | F | 242 | G.h2s4.01 |
Van-der-waals | TM4 | E | 349 | 4x36 | G.h2s4 | F | 242 | G.h2s4.01 |
Hydrophobic | ICL3 | T | 436 | - | G.H5 | D | 368 | G.H5.13 |
Hydrophobic | TM5 | M | 431 | 5x76 | G.H5 | Q | 372 | G.H5.17 |
Van-der-waals | TM5 | M | 431 | 5x76 | G.H5 | Q | 372 | G.H5.17 |
Hydrophobic | ICL3 | L | 441 | - | G.H5 | M | 379 | G.H5.24 |
Van-der-waals | ICL3 | L | 441 | - | G.H5 | M | 379 | G.H5.24 |
Hydrophobic | ICL3 | K | 440 | - | G.H5 | K | 376 | G.H5.21 |
Van-der-waals | ICL3 | K | 440 | - | G.H5 | K | 376 | G.H5.21 |