GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 76.2
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.4
iPTM Score: 0.5
PAE mean: 29.0
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Polar | TM4 | H | 348 | 4x35 | G.h3s5 | V | 284 | G.h3s5.03 |
Hydrophobic | TM4 | H | 348 | 4x35 | G.h3s5 | V | 284 | G.h3s5.03 |
Hydrophobic | C-term | L | 591 | - | H.HA | L | 106 | H.HA.29 |
Van-der-waals | C-term | L | 591 | - | H.HA | L | 106 | H.HA.29 |
Hydrophobic | ICL2 | K | 345 | - | G.H5 | L | 374 | G.H5.23 |
Van-der-waals | ICL2 | K | 345 | - | G.H5 | L | 374 | G.H5.23 |
Polar | TM4 | H | 348 | 4x35 | G.h3s5 | N | 283 | G.h3s5.02 |
Hydrophobic | TM4 | H | 348 | 4x35 | G.h3s5 | N | 283 | G.h3s5.02 |
Van-der-waals | TM4 | H | 348 | 4x35 | G.h3s5 | N | 283 | G.h3s5.02 |
Polar | TM3 | G | 343 | 3x55 | G.hns1 | K | 46 | G.hns1.02 |
Hydrophobic | TM3 | G | 343 | 3x55 | G.hns1 | K | 46 | G.hns1.02 |
Van-der-waals | TM3 | G | 343 | 3x55 | G.hns1 | K | 46 | G.hns1.02 |
Polar | TM3 | A | 341 | 3x53 | G.H5 | Q | 377 | G.H5.26 |
Hydrophobic | TM3 | A | 341 | 3x53 | G.H5 | Q | 377 | G.H5.26 |
Van-der-waals | TM3 | A | 341 | 3x53 | G.H5 | Q | 377 | G.H5.26 |
Aromatic | C-term | H | 590 | - | H.HA | K | 105 | H.HA.28 |
Polar | ICL2 | W | 346 | - | G.H5 | L | 374 | G.H5.23 |
Hydrophobic | ICL2 | W | 346 | - | G.H5 | L | 374 | G.H5.23 |
Hydrophobic | C-term | C | 567 | - | G.H3 | L | 269 | G.H3.06 |
Hydrophobic | TM4 | G | 347 | 4x34 | G.H5 | Q | 373 | G.H5.22 |
Van-der-waals | TM4 | G | 347 | 4x34 | G.H5 | Q | 373 | G.H5.22 |
Hydrophobic | C-term | T | 565 | - | G.hgh4 | E | 311 | G.hgh4.04 |
Van-der-waals | C-term | T | 565 | - | G.hgh4 | E | 311 | G.hgh4.04 |
Polar | ICL2 | W | 346 | - | G.H5 | Q | 377 | G.H5.26 |
Hydrophobic | ICL2 | W | 346 | - | G.H5 | Q | 377 | G.H5.26 |
Van-der-waals | ICL2 | W | 346 | - | G.H5 | Q | 377 | G.H5.26 |
Ionic | C-term | E | 586 | - | H.hbhc | R | 128 | H.hbhc.01 |
Polar | C-term | E | 586 | - | H.hbhc | R | 128 | H.hbhc.01 |
Hydrophobic | C-term | E | 586 | - | H.hbhc | R | 128 | H.hbhc.01 |
Van-der-waals | C-term | E | 586 | - | H.hbhc | R | 128 | H.hbhc.01 |
Hydrophobic | C-term | P | 588 | - | H.HA | V | 98 | H.HA.21 |
Ionic | ICL1 | H | 258 | 12x48 | G.h4s6 | D | 336 | G.h4s6.10 |
Polar | ICL1 | H | 258 | 12x48 | G.h4s6 | D | 336 | G.h4s6.10 |
Hydrophobic | ICL1 | H | 258 | 12x48 | G.h4s6 | D | 336 | G.h4s6.10 |
Van-der-waals | ICL1 | H | 258 | 12x48 | G.h4s6 | D | 336 | G.h4s6.10 |
Polar | TM4 | E | 352 | 4x39 | G.h3s5 | N | 283 | G.h3s5.02 |
Hydrophobic | TM4 | E | 352 | 4x39 | G.h3s5 | N | 283 | G.h3s5.02 |
Van-der-waals | TM4 | E | 352 | 4x39 | G.h3s5 | N | 283 | G.h3s5.02 |
Polar | C-term | H | 568 | - | G.hgh4 | E | 311 | G.hgh4.04 |
Hydrophobic | C-term | Y | 569 | - | G.hgh4 | Y | 308 | G.hgh4.01 |
Van-der-waals | C-term | Y | 569 | - | G.hgh4 | Y | 308 | G.hgh4.01 |
Hydrophobic | TM3 | A | 341 | 3x53 | G.H5 | M | 375 | G.H5.24 |
Van-der-waals | TM3 | A | 341 | 3x53 | G.H5 | M | 375 | G.H5.24 |
Polar | TM3 | W | 338 | 3x50 | G.H5 | Q | 377 | G.H5.26 |
Hydrophobic | TM3 | W | 338 | 3x50 | G.H5 | Q | 377 | G.H5.26 |
Van-der-waals | TM3 | W | 338 | 3x50 | G.H5 | Q | 377 | G.H5.26 |
Hydrophobic | TM3 | L | 340 | 3x52 | G.H5 | Q | 377 | G.H5.26 |
Van-der-waals | TM3 | L | 340 | 3x52 | G.H5 | Q | 377 | G.H5.26 |
Hydrophobic | ICL1 | H | 258 | 12x48 | G.h4s6 | K | 340 | G.h4s6.19 |
Aromatic | N-term | K | 168 | - | G.HN | F | 4 | G.HN.04 |
Hydrophobic | N-term | K | 168 | - | G.HN | F | 4 | G.HN.04 |
Van-der-waals | N-term | K | 168 | - | G.HN | F | 4 | G.HN.04 |
Hydrophobic | ICL3 | L | 441 | - | G.H5 | M | 375 | G.H5.24 |
Van-der-waals | ICL3 | L | 441 | - | G.H5 | M | 375 | G.H5.24 |
Polar | C-term | K | 570 | - | G.hgh4 | Y | 308 | G.hgh4.01 |
Van-der-waals | C-term | K | 570 | - | G.hgh4 | Y | 308 | G.hgh4.01 |
Hydrophobic | TM5 | I | 430 | 5x75 | G.hns1 | R | 47 | G.hns1.03 |
Van-der-waals | TM5 | I | 430 | 5x75 | G.hns1 | R | 47 | G.hns1.03 |
Hydrophobic | ICL2 | K | 345 | - | G.hns1 | R | 47 | G.hns1.03 |
Van-der-waals | ICL2 | K | 345 | - | G.hns1 | R | 47 | G.hns1.03 |
Polar | TM4 | E | 349 | 4x36 | G.h3s5 | N | 283 | G.h3s5.02 |
Hydrophobic | TM4 | E | 349 | 4x36 | G.h3s5 | N | 283 | G.h3s5.02 |
Van-der-waals | TM4 | E | 349 | 4x36 | G.h3s5 | N | 283 | G.h3s5.02 |
Hydrophobic | TM4 | E | 349 | 4x36 | G.h2s4 | V | 240 | G.h2s4.04 |
Van-der-waals | TM4 | E | 349 | 4x36 | G.h2s4 | V | 240 | G.h2s4.04 |
Polar | TM4 | H | 348 | 4x35 | G.h4s6 | K | 340 | G.h4s6.19 |
Hydrophobic | TM4 | H | 348 | 4x35 | G.h4s6 | K | 340 | G.h4s6.19 |
Van-der-waals | TM4 | H | 348 | 4x35 | G.h4s6 | K | 340 | G.h4s6.19 |
Hydrophobic | ICL3 | T | 436 | - | G.s2s3 | K | 214 | G.s2s3.01 |
Polar | TM3 | W | 338 | 3x50 | G.H5 | M | 375 | G.H5.24 |
Hydrophobic | TM3 | W | 338 | 3x50 | G.H5 | M | 375 | G.H5.24 |
Van-der-waals | TM3 | W | 338 | 3x50 | G.H5 | M | 375 | G.H5.24 |
Hydrophobic | C-term | C | 567 | - | G.H4 | F | 325 | G.H4.10 |
Van-der-waals | C-term | C | 567 | - | G.H4 | F | 325 | G.H4.10 |
Hydrophobic | ICL1 | Q | 261 | 12x51 | G.H5 | L | 376 | G.H5.25 |
Van-der-waals | ICL1 | Q | 261 | 12x51 | G.H5 | L | 376 | G.H5.25 |
Ionic | C-term | E | 586 | - | H.HA | R | 97 | H.HA.20 |
Hydrophobic | C-term | L | 591 | - | H.hdhe | F | 168 | H.hdhe.01 |
Hydrophobic | C-term | P | 588 | - | H.HA | R | 97 | H.HA.20 |
Van-der-waals | C-term | P | 588 | - | H.HA | R | 97 | H.HA.20 |
Hydrophobic | C-term | P | 572 | - | G.hgh4 | Y | 308 | G.hgh4.01 |
Hydrophobic | C-term | Y | 569 | - | G.s4h3 | N | 263 | G.s4h3.15 |
Van-der-waals | C-term | Y | 569 | - | G.s4h3 | N | 263 | G.s4h3.15 |
Polar | C-term | C | 567 | - | G.H4 | C | 329 | G.H4.14 |
Hydrophobic | C-term | C | 567 | - | G.H4 | C | 329 | G.H4.14 |
Van-der-waals | C-term | C | 567 | - | G.H4 | C | 329 | G.H4.14 |
Polar | ICL1 | P | 257 | 12x47 | G.h4s6 | Q | 339 | G.h4s6.13 |
Hydrophobic | ICL1 | P | 257 | 12x47 | G.h4s6 | Q | 339 | G.h4s6.13 |
Van-der-waals | ICL1 | P | 257 | 12x47 | G.h4s6 | Q | 339 | G.h4s6.13 |
Hydrophobic | TM4 | H | 348 | 4x35 | G.H5 | Q | 377 | G.H5.26 |
Polar | TM4 | E | 349 | 4x36 | G.h2s4 | T | 241 | G.h2s4.05 |
Hydrophobic | TM4 | E | 349 | 4x36 | G.h2s4 | T | 241 | G.h2s4.05 |
Polar | C-term | T | 589 | - | H.HA | V | 98 | H.HA.21 |
Hydrophobic | C-term | T | 589 | - | H.HA | V | 98 | H.HA.21 |
Van-der-waals | C-term | T | 589 | - | H.HA | V | 98 | H.HA.21 |
Polar | TM4 | G | 347 | 4x34 | G.H5 | Q | 377 | G.H5.26 |
Hydrophobic | TM4 | G | 347 | 4x34 | G.H5 | Q | 377 | G.H5.26 |
Van-der-waals | TM4 | G | 347 | 4x34 | G.H5 | Q | 377 | G.H5.26 |
Hydrophobic | C-term | P | 588 | - | H.HB | M | 123 | H.HB.10 |
Hydrophobic | C-term | M | 578 | - | G.s4h3 | R | 260 | G.s4h3.12 |
Van-der-waals | C-term | M | 578 | - | G.s4h3 | R | 260 | G.s4h3.12 |
Polar | C-term | T | 589 | - | H.HA | K | 105 | H.HA.28 |
Van-der-waals | C-term | T | 589 | - | H.HA | K | 105 | H.HA.28 |
Hydrophobic | ICL1 | Q | 261 | 12x51 | G.h4s6 | K | 340 | G.h4s6.19 |
Van-der-waals | ICL1 | Q | 261 | 12x51 | G.h4s6 | K | 340 | G.h4s6.19 |
Hydrophobic | TM2 | E | 264 | 2x41 | G.H5 | L | 376 | G.H5.25 |
Van-der-waals | TM2 | E | 264 | 2x41 | G.H5 | L | 376 | G.H5.25 |
Polar | TM3 | A | 342 | 3x54 | G.H5 | L | 374 | G.H5.23 |
Hydrophobic | TM3 | A | 342 | 3x54 | G.H5 | L | 374 | G.H5.23 |
Van-der-waals | TM3 | A | 342 | 3x54 | G.H5 | L | 374 | G.H5.23 |
Polar | TM4 | E | 349 | 4x36 | G.h3s5 | V | 284 | G.h3s5.03 |
Hydrophobic | TM4 | E | 349 | 4x36 | G.h3s5 | V | 284 | G.h3s5.03 |
Van-der-waals | TM4 | E | 349 | 4x36 | G.h3s5 | V | 284 | G.h3s5.03 |
Hydrophobic | TM5 | L | 424 | 5x69 | G.H5 | M | 375 | G.H5.24 |
Polar | C-term | N | 587 | - | H.HA | D | 101 | H.HA.24 |
Hydrophobic | C-term | N | 587 | - | H.HA | D | 101 | H.HA.24 |
Van-der-waals | C-term | N | 587 | - | H.HA | D | 101 | H.HA.24 |
Hydrophobic | TM2 | P | 263 | 2x40 | G.H5 | M | 375 | G.H5.24 |
Polar | C-term | P | 588 | - | H.HA | D | 101 | H.HA.24 |
Hydrophobic | C-term | P | 588 | - | H.HA | D | 101 | H.HA.24 |
Van-der-waals | C-term | P | 588 | - | H.HA | D | 101 | H.HA.24 |
Hydrophobic | C-term | Y | 569 | - | G.hgh4 | F | 309 | G.hgh4.02 |
Polar | C-term | T | 565 | - | G.H4 | N | 332 | G.H4.17 |
Polar | TM4 | E | 349 | 4x36 | G.H5 | Q | 373 | G.H5.22 |
Van-der-waals | TM4 | E | 349 | 4x36 | G.H5 | Q | 373 | G.H5.22 |
Polar | TM4 | E | 352 | 4x39 | G.h3s5 | S | 282 | G.h3s5.01 |
Hydrophobic | TM4 | E | 352 | 4x39 | G.h3s5 | S | 282 | G.h3s5.01 |
Van-der-waals | TM4 | E | 352 | 4x39 | G.h3s5 | S | 282 | G.h3s5.01 |
Aromatic | ICL3 | K | 440 | - | G.H5 | H | 368 | G.H5.17 |
Hydrophobic | ICL3 | K | 440 | - | G.H5 | H | 368 | G.H5.17 |
Polar | C-term | C | 567 | - | G.hgh4 | E | 311 | G.hgh4.04 |
Hydrophobic | C-term | C | 567 | - | G.hgh4 | E | 311 | G.hgh4.04 |
Van-der-waals | C-term | C | 567 | - | G.hgh4 | E | 311 | G.hgh4.04 |
Polar | ICL1 | H | 258 | 12x48 | G.h4s6 | Q | 339 | G.h4s6.13 |
Hydrophobic | ICL1 | H | 258 | 12x48 | G.h4s6 | Q | 339 | G.h4s6.13 |
Van-der-waals | ICL1 | H | 258 | 12x48 | G.h4s6 | Q | 339 | G.h4s6.13 |
Hydrophobic | TM2 | P | 263 | 2x40 | G.H5 | Q | 377 | G.H5.26 |
Van-der-waals | TM2 | P | 263 | 2x40 | G.H5 | Q | 377 | G.H5.26 |
Polar | C-term | E | 586 | - | H.HB | T | 127 | H.HB.14 |
Hydrophobic | C-term | T | 589 | - | H.hdhe | F | 168 | H.hdhe.01 |
Van-der-waals | C-term | T | 589 | - | H.hdhe | F | 168 | H.hdhe.01 |
Hydrophobic | TM2 | Y | 262 | 2x39 | G.H5 | L | 376 | G.H5.25 |
Van-der-waals | TM2 | Y | 262 | 2x39 | G.H5 | L | 376 | G.H5.25 |
Polar | TM2 | P | 263 | 2x40 | G.H5 | L | 376 | G.H5.25 |
Hydrophobic | TM2 | P | 263 | 2x40 | G.H5 | L | 376 | G.H5.25 |
Van-der-waals | TM2 | P | 263 | 2x40 | G.H5 | L | 376 | G.H5.25 |
Hydrophobic | C-term | C | 567 | - | G.hgh4 | F | 309 | G.hgh4.02 |
Van-der-waals | C-term | C | 567 | - | G.hgh4 | F | 309 | G.hgh4.02 |
Hydrophobic | C-term | K | 570 | - | G.hgh4 | L | 310 | G.hgh4.03 |
Van-der-waals | C-term | K | 570 | - | G.hgh4 | L | 310 | G.hgh4.03 |
Polar | C-term | T | 589 | - | H.HA | A | 102 | H.HA.25 |
Hydrophobic | C-term | T | 589 | - | H.HA | A | 102 | H.HA.25 |
Van-der-waals | C-term | T | 589 | - | H.HA | A | 102 | H.HA.25 |
Hydrophobic | C-term | L | 591 | - | H.HD | E | 167 | H.HD.12 |
Van-der-waals | C-term | L | 591 | - | H.HD | E | 167 | H.HD.12 |
Hydrophobic | TM4 | I | 351 | 4x38 | G.H5 | Q | 377 | G.H5.26 |
Van-der-waals | TM4 | I | 351 | 4x38 | G.H5 | Q | 377 | G.H5.26 |
Hydrophobic | TM3 | T | 337 | 3x49 | G.H5 | Q | 377 | G.H5.26 |
Van-der-waals | TM3 | T | 337 | 3x49 | G.H5 | Q | 377 | G.H5.26 |
Hydrophobic | C-term | H | 568 | - | G.hgh4 | F | 309 | G.hgh4.02 |
Hydrophobic | ICL2 | K | 345 | - | G.hns1 | K | 46 | G.hns1.02 |
Van-der-waals | ICL2 | K | 345 | - | G.hns1 | K | 46 | G.hns1.02 |
Polar | ICL1 | R | 259 | 12x49 | G.h4s6 | Q | 339 | G.h4s6.13 |
Hydrophobic | TM3 | A | 341 | 3x53 | G.H5 | L | 374 | G.H5.23 |
Van-der-waals | TM3 | A | 341 | 3x53 | G.H5 | L | 374 | G.H5.23 |
Hydrophobic | ICL2 | K | 344 | - | G.hns1 | K | 46 | G.hns1.02 |
Van-der-waals | ICL2 | K | 344 | - | G.hns1 | K | 46 | G.hns1.02 |
Polar | TM4 | H | 348 | 4x35 | G.H5 | Q | 373 | G.H5.22 |
Hydrophobic | TM4 | H | 348 | 4x35 | G.H5 | Q | 373 | G.H5.22 |
Van-der-waals | TM4 | H | 348 | 4x35 | G.H5 | Q | 373 | G.H5.22 |
Polar | C-term | H | 566 | - | G.hgh4 | E | 311 | G.hgh4.04 |
Hydrophobic | C-term | H | 566 | - | G.hgh4 | E | 311 | G.hgh4.04 |
Van-der-waals | C-term | H | 566 | - | G.hgh4 | E | 311 | G.hgh4.04 |
Polar | C-term | H | 590 | - | G.s4h3 | R | 260 | G.s4h3.12 |
Aromatic | C-term | H | 590 | - | G.s4h3 | R | 260 | G.s4h3.12 |
Hydrophobic | C-term | H | 590 | - | G.s4h3 | R | 260 | G.s4h3.12 |
Van-der-waals | C-term | H | 590 | - | G.s4h3 | R | 260 | G.s4h3.12 |
Hydrophobic | C-term | N | 587 | - | H.HA | K | 105 | H.HA.28 |
Van-der-waals | C-term | N | 587 | - | H.HA | K | 105 | H.HA.28 |
Hydrophobic | N-term | H | 167 | - | G.HN | L | 5 | G.HN.05 |
Van-der-waals | N-term | H | 167 | - | G.HN | L | 5 | G.HN.05 |
Hydrophobic | ICL2 | W | 346 | - | G.H5 | Q | 373 | G.H5.22 |
Van-der-waals | ICL2 | W | 346 | - | G.H5 | Q | 373 | G.H5.22 |
Van-der-waals | TM4 | A | 350 | 4x37 | G.H5 | Q | 377 | G.H5.26 |
Hydrophobic | C-term | L | 591 | - | H.HA | K | 105 | H.HA.28 |
Van-der-waals | C-term | L | 591 | - | H.HA | K | 105 | H.HA.28 |
Hydrophobic | C-term | Y | 569 | - | G.H3 | T | 266 | G.H3.03 |
Van-der-waals | C-term | Y | 569 | - | G.H3 | T | 266 | G.H3.03 |
Hydrophobic | TM6 | L | 444 | 6x29 | G.H5 | M | 375 | G.H5.24 |
Van-der-waals | TM6 | L | 444 | 6x29 | G.H5 | M | 375 | G.H5.24 |
Hydrophobic | ICL2 | W | 346 | - | G.hns1 | K | 46 | G.hns1.02 |
Hydrophobic | TM3 | A | 341 | 3x53 | G.H5 | L | 376 | G.H5.25 |
Polar | C-term | T | 589 | - | H.HA | D | 101 | H.HA.24 |
Hydrophobic | C-term | T | 589 | - | H.HA | D | 101 | H.HA.24 |
Van-der-waals | C-term | T | 589 | - | H.HA | D | 101 | H.HA.24 |