GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 76.0
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.5
iPTM Score: 0.2
PAE mean: 28.4
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Ionic | TM4 | E | 352 | 4x39 | G.h4s6 | R | 356 | G.h4s6.12 |
Hydrophobic | N-term | E | 157 | - | G.H3 | W | 281 | G.H3.17 |
Hydrophobic | TM2 | E | 264 | 2x41 | G.H5 | L | 393 | G.H5.25 |
Van-der-waals | TM2 | E | 264 | 2x41 | G.H5 | L | 393 | G.H5.25 |
Polar | ICL1 | Q | 261 | 12x51 | G.h4s6 | G | 355 | G.h4s6.11 |
Van-der-waals | ICL1 | Q | 261 | 12x51 | G.h4s6 | G | 355 | G.h4s6.11 |
Polar | N-term | T | 160 | - | G.h2s4 | N | 239 | G.h2s4.02 |
Hydrophobic | N-term | T | 160 | - | G.h2s4 | N | 239 | G.h2s4.02 |
Van-der-waals | N-term | T | 160 | - | G.h2s4 | N | 239 | G.h2s4.02 |
Van-der-waals | N-term | L | 173 | - | G.HN | R | 20 | G.HN.37 |
Polar | ICL2 | W | 346 | - | G.H5 | H | 387 | G.H5.19 |
Hydrophobic | ICL2 | W | 346 | - | G.H5 | H | 387 | G.H5.19 |
Van-der-waals | ICL2 | W | 346 | - | G.H5 | H | 387 | G.H5.19 |
Polar | TM4 | G | 347 | 4x34 | G.H5 | Q | 390 | G.H5.22 |
Hydrophobic | TM4 | G | 347 | 4x34 | G.H5 | Q | 390 | G.H5.22 |
Van-der-waals | TM4 | G | 347 | 4x34 | G.H5 | Q | 390 | G.H5.22 |
Hydrophobic | TM2 | E | 264 | 2x41 | G.H5 | Y | 391 | G.H5.23 |
Van-der-waals | TM2 | E | 264 | 2x41 | G.H5 | Y | 391 | G.H5.23 |
Hydrophobic | N-term | L | 170 | - | G.HN | K | 24 | G.HN.41 |
Van-der-waals | N-term | L | 170 | - | G.HN | K | 24 | G.HN.41 |
Polar | TM3 | L | 340 | 3x52 | G.H5 | H | 387 | G.H5.19 |
Polar | ICL2 | K | 344 | - | G.HN | Q | 35 | G.HN.52 |
Van-der-waals | ICL2 | K | 344 | - | G.HN | Q | 35 | G.HN.52 |
Hydrophobic | N-term | H | 167 | - | G.HN | L | 30 | G.HN.47 |
Polar | TM2 | E | 264 | 2x41 | G.H5 | E | 392 | G.H5.24 |
Hydrophobic | TM2 | E | 264 | 2x41 | G.H5 | E | 392 | G.H5.24 |
Van-der-waals | TM2 | E | 264 | 2x41 | G.H5 | E | 392 | G.H5.24 |
Polar | ICL3 | T | 436 | - | G.H5 | R | 380 | G.H5.12 |
Hydrophobic | TM4 | G | 347 | 4x34 | G.H5 | M | 386 | G.H5.18 |
Van-der-waals | TM4 | G | 347 | 4x34 | G.H5 | M | 386 | G.H5.18 |
Hydrophobic | TM2 | P | 263 | 2x40 | G.H5 | Y | 391 | G.H5.23 |
Van-der-waals | TM2 | P | 263 | 2x40 | G.H5 | Y | 391 | G.H5.23 |
Polar | N-term | G | 171 | - | G.HN | R | 20 | G.HN.37 |
Hydrophobic | N-term | G | 171 | - | G.HN | R | 20 | G.HN.37 |
Van-der-waals | N-term | G | 171 | - | G.HN | R | 20 | G.HN.37 |
Polar | N-term | K | 168 | - | G.HN | N | 23 | G.HN.40 |
Hydrophobic | N-term | K | 168 | - | G.HN | N | 23 | G.HN.40 |
Van-der-waals | N-term | K | 168 | - | G.HN | N | 23 | G.HN.40 |
Hydrophobic | TM2 | P | 263 | 2x40 | G.H5 | Q | 390 | G.H5.22 |
Van-der-waals | TM2 | P | 263 | 2x40 | G.H5 | Q | 390 | G.H5.22 |
Hydrophobic | N-term | E | 165 | - | G.HN | L | 30 | G.HN.47 |
Van-der-waals | N-term | E | 165 | - | G.HN | L | 30 | G.HN.47 |
Van-der-waals | TM4 | E | 349 | 4x36 | G.h3s5 | R | 283 | G.h3s5.01 |
Polar | TM3 | A | 342 | 3x54 | G.H5 | H | 387 | G.H5.19 |
Hydrophobic | TM3 | A | 342 | 3x54 | G.H5 | H | 387 | G.H5.19 |
Van-der-waals | TM3 | A | 342 | 3x54 | G.H5 | H | 387 | G.H5.19 |
Hydrophobic | N-term | G | 162 | - | G.h2s4 | N | 239 | G.h2s4.02 |
Van-der-waals | N-term | G | 162 | - | G.h2s4 | N | 239 | G.h2s4.02 |
Hydrophobic | N-term | E | 165 | - | G.HN | D | 33 | G.HN.50 |
Polar | TM4 | H | 348 | 4x35 | G.H5 | M | 386 | G.H5.18 |
Van-der-waals | TM4 | H | 348 | 4x35 | G.H5 | M | 386 | G.H5.18 |
Hydrophobic | ICL2 | K | 345 | - | G.H5 | I | 383 | G.H5.15 |
Van-der-waals | ICL2 | K | 345 | - | G.H5 | I | 383 | G.H5.15 |
Polar | ICL2 | W | 346 | - | G.H5 | Q | 390 | G.H5.22 |
Hydrophobic | ICL2 | W | 346 | - | G.H5 | Q | 390 | G.H5.22 |
Van-der-waals | ICL2 | W | 346 | - | G.H5 | Q | 390 | G.H5.22 |
Hydrophobic | N-term | P | 166 | - | G.HN | L | 30 | G.HN.47 |
Van-der-waals | TM3 | L | 340 | 3x52 | G.H5 | Q | 390 | G.H5.22 |
Polar | ICL1 | Q | 261 | 12x51 | G.H5 | R | 389 | G.H5.21 |
Hydrophobic | ICL1 | Q | 261 | 12x51 | G.H5 | R | 389 | G.H5.21 |
Van-der-waals | ICL1 | Q | 261 | 12x51 | G.H5 | R | 389 | G.H5.21 |
Polar | TM4 | H | 348 | 4x35 | G.H5 | R | 389 | G.H5.21 |
Hydrophobic | TM4 | H | 348 | 4x35 | G.H5 | R | 389 | G.H5.21 |
Van-der-waals | TM4 | H | 348 | 4x35 | G.H5 | R | 389 | G.H5.21 |
Hydrophobic | ICL1 | F | 260 | 12x50 | G.H5 | E | 392 | G.H5.24 |
Van-der-waals | ICL1 | F | 260 | 12x50 | G.H5 | E | 392 | G.H5.24 |
Polar | TM3 | A | 341 | 3x53 | G.H5 | Y | 391 | G.H5.23 |
Hydrophobic | TM3 | A | 341 | 3x53 | G.H5 | Y | 391 | G.H5.23 |
Van-der-waals | TM3 | A | 341 | 3x53 | G.H5 | Y | 391 | G.H5.23 |
Polar | TM3 | F | 339 | 3x51 | G.H5 | Y | 391 | G.H5.23 |
Polar | ICL2 | K | 345 | - | G.S1 | H | 41 | G.S1.02 |
Hydrophobic | ICL2 | K | 345 | - | G.S1 | H | 41 | G.S1.02 |
Van-der-waals | ICL2 | K | 345 | - | G.S1 | H | 41 | G.S1.02 |
Polar | TM4 | H | 348 | 4x35 | G.h4s6 | G | 355 | G.h4s6.11 |
Polar | TM2 | Y | 262 | 2x39 | G.H5 | Y | 391 | G.H5.23 |
Hydrophobic | TM2 | Y | 262 | 2x39 | G.H5 | Y | 391 | G.H5.23 |
Van-der-waals | TM2 | Y | 262 | 2x39 | G.H5 | Y | 391 | G.H5.23 |
Polar | TM3 | A | 341 | 3x53 | G.H5 | Q | 390 | G.H5.22 |
Hydrophobic | TM3 | A | 341 | 3x53 | G.H5 | Q | 390 | G.H5.22 |
Van-der-waals | TM3 | A | 341 | 3x53 | G.H5 | Q | 390 | G.H5.22 |
Polar | TM4 | E | 349 | 4x36 | G.h3s5 | T | 284 | G.h3s5.02 |
Hydrophobic | TM4 | E | 349 | 4x36 | G.h3s5 | T | 284 | G.h3s5.02 |
Van-der-waals | TM4 | E | 349 | 4x36 | G.h3s5 | T | 284 | G.h3s5.02 |
Polar | TM2 | P | 263 | 2x40 | G.H5 | E | 392 | G.H5.24 |
Hydrophobic | TM2 | P | 263 | 2x40 | G.H5 | E | 392 | G.H5.24 |
Van-der-waals | TM2 | P | 263 | 2x40 | G.H5 | E | 392 | G.H5.24 |
Polar | TM4 | H | 348 | 4x35 | G.h4s6 | R | 356 | G.h4s6.12 |
Hydrophobic | TM4 | H | 348 | 4x35 | G.h4s6 | R | 356 | G.h4s6.12 |
Van-der-waals | TM4 | H | 348 | 4x35 | G.h4s6 | R | 356 | G.h4s6.12 |
Hydrophobic | N-term | L | 170 | - | G.HN | R | 20 | G.HN.37 |
Van-der-waals | N-term | L | 170 | - | G.HN | R | 20 | G.HN.37 |
Polar | TM2 | Y | 262 | 2x39 | G.H5 | Q | 390 | G.H5.22 |
Hydrophobic | TM2 | Y | 262 | 2x39 | G.H5 | Q | 390 | G.H5.22 |
Van-der-waals | TM2 | Y | 262 | 2x39 | G.H5 | Q | 390 | G.H5.22 |
Polar | TM3 | T | 337 | 3x49 | G.H5 | Y | 391 | G.H5.23 |
Hydrophobic | TM3 | T | 337 | 3x49 | G.H5 | Y | 391 | G.H5.23 |
Van-der-waals | TM3 | T | 337 | 3x49 | G.H5 | Y | 391 | G.H5.23 |
Van-der-waals | TM2 | Y | 262 | 2x39 | G.H5 | R | 389 | G.H5.21 |
Polar | TM2 | R | 265 | 2x42 | G.H5 | E | 392 | G.H5.24 |
Hydrophobic | TM2 | R | 265 | 2x42 | G.H5 | E | 392 | G.H5.24 |
Van-der-waals | TM2 | R | 265 | 2x42 | G.H5 | E | 392 | G.H5.24 |
Hydrophobic | TM5 | M | 431 | 5x76 | G.H5 | R | 380 | G.H5.12 |
Hydrophobic | TM4 | I | 351 | 4x38 | G.H5 | Q | 390 | G.H5.22 |
Van-der-waals | TM4 | I | 351 | 4x38 | G.H5 | Q | 390 | G.H5.22 |
Polar | ICL2 | K | 345 | - | G.H5 | H | 387 | G.H5.19 |
Hydrophobic | ICL2 | K | 345 | - | G.H5 | H | 387 | G.H5.19 |
Van-der-waals | ICL2 | K | 345 | - | G.H5 | H | 387 | G.H5.19 |
Van-der-waals | N-term | P | 174 | - | G.HN | R | 20 | G.HN.37 |
Polar | TM3 | W | 338 | 3x50 | G.H5 | Y | 391 | G.H5.23 |
Aromatic | TM3 | W | 338 | 3x50 | G.H5 | Y | 391 | G.H5.23 |
Hydrophobic | TM3 | W | 338 | 3x50 | G.H5 | Y | 391 | G.H5.23 |
Van-der-waals | TM3 | W | 338 | 3x50 | G.H5 | Y | 391 | G.H5.23 |
Hydrophobic | ICL2 | W | 346 | - | G.H5 | M | 386 | G.H5.18 |
Van-der-waals | ICL2 | W | 346 | - | G.H5 | M | 386 | G.H5.18 |
Polar | N-term | L | 170 | - | G.HN | N | 23 | G.HN.40 |
Hydrophobic | N-term | L | 170 | - | G.HN | N | 23 | G.HN.40 |
Van-der-waals | N-term | L | 170 | - | G.HN | N | 23 | G.HN.40 |
Hydrophobic | N-term | A | 161 | - | G.h2s4 | N | 239 | G.h2s4.02 |
Van-der-waals | N-term | A | 161 | - | G.h2s4 | N | 239 | G.h2s4.02 |
Polar | N-term | G | 169 | - | G.HN | N | 23 | G.HN.40 |
Hydrophobic | N-term | G | 169 | - | G.HN | N | 23 | G.HN.40 |
Van-der-waals | N-term | G | 169 | - | G.HN | N | 23 | G.HN.40 |
Polar | TM4 | E | 349 | 4x36 | G.h4s6 | H | 357 | G.h4s6.13 |
Van-der-waals | TM4 | E | 349 | 4x36 | G.h4s6 | H | 357 | G.h4s6.13 |
Hydrophobic | N-term | P | 163 | - | G.S1 | R | 42 | G.S1.03 |
Polar | N-term | A | 159 | - | G.h2s4 | N | 239 | G.h2s4.02 |
Polar | TM3 | A | 342 | 3x54 | G.H5 | Y | 391 | G.H5.23 |
Hydrophobic | TM3 | A | 342 | 3x54 | G.H5 | Y | 391 | G.H5.23 |
Van-der-waals | TM3 | A | 342 | 3x54 | G.H5 | Y | 391 | G.H5.23 |
Hydrophobic | N-term | A | 161 | - | G.H2 | Q | 236 | G.H2.09 |
Polar | TM2 | Y | 262 | 2x39 | G.H5 | E | 392 | G.H5.24 |
Hydrophobic | TM2 | Y | 262 | 2x39 | G.H5 | E | 392 | G.H5.24 |
Van-der-waals | TM2 | Y | 262 | 2x39 | G.H5 | E | 392 | G.H5.24 |
Hydrophobic | ICL2 | K | 344 | - | G.hns1 | R | 38 | G.hns1.02 |
Van-der-waals | ICL2 | K | 344 | - | G.hns1 | R | 38 | G.hns1.02 |
Van-der-waals | ICL1 | R | 259 | 12x49 | G.H5 | E | 392 | G.H5.24 |
Hydrophobic | ICL2 | W | 346 | - | G.hns1 | R | 38 | G.hns1.02 |
Hydrophobic | N-term | K | 168 | - | G.HN | I | 26 | G.HN.43 |
Van-der-waals | N-term | K | 168 | - | G.HN | I | 26 | G.HN.43 |
Polar | TM3 | A | 341 | 3x53 | G.H5 | H | 387 | G.H5.19 |
Hydrophobic | TM3 | A | 341 | 3x53 | G.H5 | H | 387 | G.H5.19 |
Van-der-waals | TM3 | A | 341 | 3x53 | G.H5 | H | 387 | G.H5.19 |
Polar | N-term | M | 172 | - | G.HN | R | 20 | G.HN.37 |
Hydrophobic | N-term | M | 172 | - | G.HN | R | 20 | G.HN.37 |
Van-der-waals | N-term | M | 172 | - | G.HN | R | 20 | G.HN.37 |
Hydrophobic | N-term | A | 159 | - | G.H3 | W | 281 | G.H3.17 |
Van-der-waals | N-term | A | 159 | - | G.H3 | W | 281 | G.H3.17 |
Van-der-waals | TM5 | I | 427 | 5x72 | G.H5 | Q | 384 | G.H5.16 |
Hydrophobic | N-term | L | 170 | - | G.HN | E | 27 | G.HN.44 |
Van-der-waals | N-term | L | 170 | - | G.HN | E | 27 | G.HN.44 |
Hydrophobic | TM4 | H | 348 | 4x35 | G.H5 | Q | 390 | G.H5.22 |
Van-der-waals | TM4 | H | 348 | 4x35 | G.H5 | Q | 390 | G.H5.22 |
Polar | ICL1 | Q | 261 | 12x51 | G.H5 | E | 392 | G.H5.24 |
Hydrophobic | ICL1 | Q | 261 | 12x51 | G.H5 | E | 392 | G.H5.24 |
Van-der-waals | ICL1 | Q | 261 | 12x51 | G.H5 | E | 392 | G.H5.24 |
Hydrophobic | TM6 | L | 444 | 6x29 | G.H5 | L | 388 | G.H5.20 |
Van-der-waals | TM6 | L | 444 | 6x29 | G.H5 | L | 388 | G.H5.20 |
Hydrophobic | TM4 | E | 349 | 4x36 | G.h4s6 | R | 356 | G.h4s6.12 |
Van-der-waals | TM4 | E | 349 | 4x36 | G.h4s6 | R | 356 | G.h4s6.12 |
Hydrophobic | N-term | A | 159 | - | G.h2s4 | F | 238 | G.h2s4.01 |
Van-der-waals | N-term | A | 159 | - | G.h2s4 | F | 238 | G.h2s4.01 |
Hydrophobic | TM5 | M | 431 | 5x76 | G.H5 | Q | 384 | G.H5.16 |
Van-der-waals | TM5 | M | 431 | 5x76 | G.H5 | Q | 384 | G.H5.16 |
Hydrophobic | TM6 | L | 444 | 6x29 | G.H5 | L | 393 | G.H5.25 |
Van-der-waals | TM6 | L | 444 | 6x29 | G.H5 | L | 393 | G.H5.25 |
Hydrophobic | N-term | P | 163 | - | G.hns1 | Y | 37 | G.hns1.01 |
Hydrophobic | N-term | N | 158 | - | G.H3 | W | 281 | G.H3.17 |
Van-der-waals | N-term | N | 158 | - | G.H3 | W | 281 | G.H3.17 |