GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 77.2
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.5
iPTM Score: 0.3
PAE mean: 27.1
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Hydrophobic | TM2 | P | 263 | 2x40 | G.H5 | G | 348 | G.H5.24 |
Van-der-waals | TM2 | P | 263 | 2x40 | G.H5 | G | 348 | G.H5.24 |
Hydrophobic | ICL3 | L | 441 | - | G.H5 | F | 350 | G.H5.26 |
Van-der-waals | ICL3 | L | 441 | - | G.H5 | F | 350 | G.H5.26 |
Hydrophobic | TM5 | L | 424 | 5x69 | G.H5 | L | 344 | G.H5.20 |
Polar | ICL1 | Q | 261 | 12x51 | G.h3s5 | T | 257 | G.h3s5.02 |
Hydrophobic | ICL1 | Q | 261 | 12x51 | G.h3s5 | T | 257 | G.h3s5.02 |
Van-der-waals | ICL1 | Q | 261 | 12x51 | G.h3s5 | T | 257 | G.h3s5.02 |
Polar | TM4 | G | 347 | 4x34 | G.H5 | N | 343 | G.H5.19 |
Hydrophobic | TM4 | G | 347 | 4x34 | G.H5 | N | 343 | G.H5.19 |
Van-der-waals | TM4 | G | 347 | 4x34 | G.H5 | N | 343 | G.H5.19 |
Hydrophobic | C-term | L | 576 | - | G.H3 | H | 240 | G.H3.03 |
Polar | TM2 | Y | 262 | 2x39 | G.H5 | D | 346 | G.H5.22 |
Hydrophobic | TM2 | Y | 262 | 2x39 | G.H5 | D | 346 | G.H5.22 |
Van-der-waals | TM2 | Y | 262 | 2x39 | G.H5 | D | 346 | G.H5.22 |
Hydrophobic | ICL1 | Q | 261 | 12x51 | G.H5 | D | 346 | G.H5.22 |
Polar | TM4 | E | 349 | 4x36 | G.h2s4 | T | 215 | G.h2s4.05 |
Hydrophobic | TM4 | E | 349 | 4x36 | G.h2s4 | T | 215 | G.h2s4.05 |
Van-der-waals | TM4 | E | 349 | 4x36 | G.h2s4 | T | 215 | G.h2s4.05 |
Hydrophobic | TM4 | H | 354 | 4x41 | G.hns1 | A | 27 | G.hns1.02 |
Van-der-waals | TM4 | H | 354 | 4x41 | G.hns1 | A | 27 | G.hns1.02 |
Hydrophobic | TM4 | I | 351 | 4x38 | G.H5 | C | 347 | G.H5.23 |
Van-der-waals | TM4 | I | 351 | 4x38 | G.H5 | C | 347 | G.H5.23 |
Van-der-waals | ICL2 | K | 344 | - | G.S3 | L | 190 | G.S3.01 |
Hydrophobic | ICL3 | K | 440 | - | G.H5 | F | 350 | G.H5.26 |
Van-der-waals | ICL3 | K | 440 | - | G.H5 | F | 350 | G.H5.26 |
Hydrophobic | TM5 | L | 424 | 5x69 | G.H5 | L | 349 | G.H5.25 |
Hydrophobic | TM2 | P | 263 | 2x40 | G.H5 | C | 347 | G.H5.23 |
Van-der-waals | TM2 | P | 263 | 2x40 | G.H5 | C | 347 | G.H5.23 |
Polar | H8 | K | 532 | 8x49 | G.h4s6 | D | 311 | G.h4s6.09 |
Van-der-waals | H8 | K | 532 | 8x49 | G.h4s6 | D | 311 | G.h4s6.09 |
Hydrophobic | TM6 | L | 444 | 6x29 | G.H5 | G | 348 | G.H5.24 |
Polar | TM3 | W | 338 | 3x50 | G.H5 | C | 347 | G.H5.23 |
Polar | TM4 | G | 347 | 4x34 | G.H5 | C | 347 | G.H5.23 |
Hydrophobic | TM4 | G | 347 | 4x34 | G.H5 | C | 347 | G.H5.23 |
Van-der-waals | TM4 | G | 347 | 4x34 | G.H5 | C | 347 | G.H5.23 |
Polar | TM4 | E | 349 | 4x36 | G.h2s4 | V | 214 | G.h2s4.04 |
Hydrophobic | TM4 | E | 349 | 4x36 | G.h2s4 | V | 214 | G.h2s4.04 |
Van-der-waals | TM4 | E | 349 | 4x36 | G.h2s4 | V | 214 | G.h2s4.04 |
Hydrophobic | TM5 | I | 427 | 5x72 | G.H5 | I | 340 | G.H5.16 |
Polar | ICL2 | W | 346 | - | G.hns1 | A | 27 | G.hns1.02 |
Hydrophobic | ICL2 | W | 346 | - | G.hns1 | A | 27 | G.hns1.02 |
Van-der-waals | ICL2 | W | 346 | - | G.hns1 | A | 27 | G.hns1.02 |
Hydrophobic | ICL2 | K | 344 | - | G.hns1 | R | 28 | G.hns1.03 |
Hydrophobic | C-term | L | 591 | - | G.H2 | R | 201 | G.H2.01 |
Van-der-waals | C-term | L | 591 | - | G.H2 | R | 201 | G.H2.01 |
Hydrophobic | ICL2 | K | 345 | - | G.S3 | L | 190 | G.S3.01 |
Hydrophobic | TM6 | I | 448 | 6x33 | G.H5 | L | 349 | G.H5.25 |
Van-der-waals | TM6 | I | 448 | 6x33 | G.H5 | L | 349 | G.H5.25 |
Polar | TM2 | P | 263 | 2x40 | G.H5 | D | 346 | G.H5.22 |
Hydrophobic | TM2 | P | 263 | 2x40 | G.H5 | D | 346 | G.H5.22 |
Van-der-waals | TM2 | P | 263 | 2x40 | G.H5 | D | 346 | G.H5.22 |
Hydrophobic | TM3 | A | 341 | 3x53 | G.H5 | L | 344 | G.H5.20 |
Van-der-waals | TM3 | A | 341 | 3x53 | G.H5 | L | 344 | G.H5.20 |
Hydrophobic | TM2 | E | 264 | 2x41 | G.H5 | G | 348 | G.H5.24 |
Van-der-waals | TM2 | E | 264 | 2x41 | G.H5 | G | 348 | G.H5.24 |
Hydrophobic | TM3 | A | 341 | 3x53 | G.H5 | C | 347 | G.H5.23 |
Van-der-waals | TM3 | A | 341 | 3x53 | G.H5 | C | 347 | G.H5.23 |
Hydrophobic | TM4 | A | 350 | 4x37 | G.hns1 | A | 27 | G.hns1.02 |
Van-der-waals | TM4 | A | 350 | 4x37 | G.hns1 | A | 27 | G.hns1.02 |
Polar | TM4 | H | 354 | 4x41 | G.HN | A | 23 | G.HN.51 |
Hydrophobic | TM4 | H | 354 | 4x41 | G.HN | A | 23 | G.HN.51 |
Van-der-waals | TM4 | H | 354 | 4x41 | G.HN | A | 23 | G.HN.51 |
Hydrophobic | TM7 | W | 527 | 7x55 | G.H5 | G | 348 | G.H5.24 |
Van-der-waals | TM7 | W | 527 | 7x55 | G.H5 | G | 348 | G.H5.24 |
Hydrophobic | TM3 | A | 342 | 3x54 | G.H5 | L | 344 | G.H5.20 |
Van-der-waals | TM3 | A | 342 | 3x54 | G.H5 | L | 344 | G.H5.20 |
Ionic | TM4 | H | 348 | 4x35 | G.H5 | D | 346 | G.H5.22 |
Polar | TM4 | H | 348 | 4x35 | G.H5 | D | 346 | G.H5.22 |
Hydrophobic | TM4 | H | 348 | 4x35 | G.H5 | D | 346 | G.H5.22 |
Van-der-waals | TM4 | H | 348 | 4x35 | G.H5 | D | 346 | G.H5.22 |
Polar | ICL2 | K | 345 | - | G.H5 | N | 343 | G.H5.19 |
Hydrophobic | ICL2 | K | 345 | - | G.H5 | N | 343 | G.H5.19 |
Van-der-waals | ICL2 | K | 345 | - | G.H5 | N | 343 | G.H5.19 |
Polar | TM2 | Y | 262 | 2x39 | G.H5 | C | 347 | G.H5.23 |
Hydrophobic | TM2 | Y | 262 | 2x39 | G.H5 | C | 347 | G.H5.23 |
Van-der-waals | TM2 | Y | 262 | 2x39 | G.H5 | C | 347 | G.H5.23 |
Hydrophobic | C-term | V | 574 | - | G.hgh4 | D | 285 | G.hgh4.04 |
Van-der-waals | C-term | V | 574 | - | G.hgh4 | D | 285 | G.hgh4.04 |
Polar | TM3 | W | 338 | 3x50 | G.H5 | G | 348 | G.H5.24 |
Hydrophobic | C-term | T | 589 | - | G.H2 | K | 205 | G.H2.05 |
Van-der-waals | C-term | T | 589 | - | G.H2 | K | 205 | G.H2.05 |
Hydrophobic | ICL2 | W | 346 | - | G.HN | E | 24 | G.HN.52 |
Hydrophobic | ICL2 | W | 346 | - | G.hns1 | R | 28 | G.hns1.03 |
Van-der-waals | ICL2 | W | 346 | - | G.hns1 | R | 28 | G.hns1.03 |
Hydrophobic | TM4 | E | 349 | 4x36 | G.h2s4 | G | 213 | G.h2s4.03 |
Van-der-waals | TM4 | E | 349 | 4x36 | G.h2s4 | G | 213 | G.h2s4.03 |
Ionic | ICL3 | K | 440 | - | G.h4s6 | E | 314 | G.h4s6.12 |
Polar | ICL3 | K | 440 | - | G.h4s6 | E | 314 | G.h4s6.12 |
Van-der-waals | ICL3 | K | 440 | - | G.h4s6 | E | 314 | G.h4s6.12 |
Hydrophobic | TM6 | L | 444 | 6x29 | G.H5 | L | 349 | G.H5.25 |
Van-der-waals | TM6 | L | 444 | 6x29 | G.H5 | L | 349 | G.H5.25 |
Hydrophobic | C-term | L | 585 | - | G.H3 | H | 244 | G.H3.07 |
Van-der-waals | C-term | L | 585 | - | G.H3 | H | 244 | G.H3.07 |
Polar | TM4 | H | 348 | 4x35 | G.H5 | C | 347 | G.H5.23 |
Hydrophobic | TM4 | H | 348 | 4x35 | G.H5 | C | 347 | G.H5.23 |
Van-der-waals | TM4 | H | 348 | 4x35 | G.H5 | C | 347 | G.H5.23 |
Hydrophobic | ICL2 | W | 346 | - | G.H5 | N | 343 | G.H5.19 |
Van-der-waals | ICL2 | W | 346 | - | G.H5 | N | 343 | G.H5.19 |
Hydrophobic | TM3 | A | 341 | 3x53 | G.H5 | L | 349 | G.H5.25 |
Van-der-waals | TM3 | A | 341 | 3x53 | G.H5 | L | 349 | G.H5.25 |
Hydrophobic | ICL2 | K | 345 | - | G.H5 | I | 340 | G.H5.16 |
Van-der-waals | ICL2 | K | 345 | - | G.H5 | I | 340 | G.H5.16 |
Hydrophobic | TM5 | I | 427 | 5x72 | G.H5 | L | 344 | G.H5.20 |
Polar | ICL2 | W | 346 | - | G.H5 | C | 347 | G.H5.23 |
Hydrophobic | ICL2 | W | 346 | - | G.H5 | C | 347 | G.H5.23 |
Van-der-waals | ICL2 | W | 346 | - | G.H5 | C | 347 | G.H5.23 |
Hydrophobic | TM3 | W | 338 | 3x50 | G.H5 | L | 349 | G.H5.25 |
Van-der-waals | TM3 | W | 338 | 3x50 | G.H5 | L | 349 | G.H5.25 |
Hydrophobic | TM6 | L | 444 | 6x29 | G.H5 | F | 350 | G.H5.26 |
Van-der-waals | TM6 | L | 444 | 6x29 | G.H5 | F | 350 | G.H5.26 |