GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 76.4
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.5
iPTM Score: 0.2
PAE mean: 28.1
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Polar | TM2 | P | 263 | 2x40 | G.H5 | Y | 351 | G.H5.22 |
Hydrophobic | TM2 | P | 263 | 2x40 | G.H5 | Y | 351 | G.H5.22 |
Van-der-waals | TM2 | P | 263 | 2x40 | G.H5 | Y | 351 | G.H5.22 |
Hydrophobic | TM6 | I | 448 | 6x33 | G.H5 | L | 354 | G.H5.25 |
Van-der-waals | TM6 | I | 448 | 6x33 | G.H5 | L | 354 | G.H5.25 |
Polar | ICL1 | H | 258 | 12x48 | G.h3s5 | N | 262 | G.h3s5.02 |
Polar | TM2 | Y | 262 | 2x39 | G.H5 | I | 352 | G.H5.23 |
Hydrophobic | TM2 | Y | 262 | 2x39 | G.H5 | I | 352 | G.H5.23 |
Van-der-waals | TM2 | Y | 262 | 2x39 | G.H5 | I | 352 | G.H5.23 |
Hydrophobic | TM6 | L | 444 | 6x29 | G.H5 | L | 354 | G.H5.25 |
Van-der-waals | TM6 | L | 444 | 6x29 | G.H5 | L | 354 | G.H5.25 |
Hydrophobic | ICL2 | K | 345 | - | G.S3 | L | 195 | G.S3.01 |
Van-der-waals | ICL2 | K | 345 | - | G.S3 | L | 195 | G.S3.01 |
Aromatic | TM4 | H | 348 | 4x35 | G.H5 | Y | 351 | G.H5.22 |
Hydrophobic | TM4 | H | 348 | 4x35 | G.H5 | Y | 351 | G.H5.22 |
Van-der-waals | TM4 | H | 348 | 4x35 | G.H5 | Y | 351 | G.H5.22 |
Hydrophobic | ICL2 | K | 345 | - | G.H5 | I | 345 | G.H5.16 |
Van-der-waals | ICL2 | K | 345 | - | G.H5 | I | 345 | G.H5.16 |
Hydrophobic | TM4 | H | 354 | 4x41 | G.hns1 | R | 32 | G.hns1.03 |
Hydrophobic | TM3 | A | 341 | 3x53 | G.H5 | I | 352 | G.H5.23 |
Van-der-waals | TM3 | A | 341 | 3x53 | G.H5 | I | 352 | G.H5.23 |
Hydrophobic | TM4 | G | 347 | 4x34 | G.H5 | N | 348 | G.H5.19 |
Van-der-waals | TM4 | G | 347 | 4x34 | G.H5 | N | 348 | G.H5.19 |
Polar | ICL1 | Q | 261 | 12x51 | G.H5 | Y | 351 | G.H5.22 |
Hydrophobic | ICL1 | Q | 261 | 12x51 | G.H5 | Y | 351 | G.H5.22 |
Van-der-waals | ICL1 | Q | 261 | 12x51 | G.H5 | Y | 351 | G.H5.22 |
Hydrophobic | TM4 | A | 350 | 4x37 | G.hns1 | R | 31 | G.hns1.02 |
Van-der-waals | TM4 | A | 350 | 4x37 | G.hns1 | R | 31 | G.hns1.02 |
Polar | TM4 | A | 353 | 4x40 | G.hns1 | R | 31 | G.hns1.02 |
Hydrophobic | TM4 | A | 353 | 4x40 | G.hns1 | R | 31 | G.hns1.02 |
Van-der-waals | TM4 | A | 353 | 4x40 | G.hns1 | R | 31 | G.hns1.02 |
Hydrophobic | TM2 | P | 263 | 2x40 | G.H5 | I | 352 | G.H5.23 |
Van-der-waals | TM2 | P | 263 | 2x40 | G.H5 | I | 352 | G.H5.23 |
Polar | H8 | K | 532 | 8x49 | G.h4s6 | E | 316 | G.h4s6.09 |
Van-der-waals | H8 | K | 532 | 8x49 | G.h4s6 | E | 316 | G.h4s6.09 |
Ionic | ICL2 | K | 344 | - | G.s2s3 | E | 194 | G.s2s3.02 |
Polar | ICL2 | K | 344 | - | G.s2s3 | E | 194 | G.s2s3.02 |
Hydrophobic | ICL2 | K | 344 | - | G.s2s3 | E | 194 | G.s2s3.02 |
Van-der-waals | ICL2 | K | 344 | - | G.s2s3 | E | 194 | G.s2s3.02 |
Ionic | ICL3 | K | 440 | - | G.h4s6 | E | 319 | G.h4s6.12 |
Polar | ICL3 | K | 440 | - | G.h4s6 | E | 319 | G.h4s6.12 |
Hydrophobic | ICL2 | W | 346 | - | G.H5 | N | 348 | G.H5.19 |
Van-der-waals | ICL2 | W | 346 | - | G.H5 | N | 348 | G.H5.19 |
Polar | TM2 | Y | 262 | 2x39 | G.H5 | Y | 351 | G.H5.22 |
Hydrophobic | TM2 | Y | 262 | 2x39 | G.H5 | Y | 351 | G.H5.22 |
Van-der-waals | TM2 | Y | 262 | 2x39 | G.H5 | Y | 351 | G.H5.22 |
Polar | TM2 | E | 264 | 2x41 | G.H5 | I | 352 | G.H5.23 |
Hydrophobic | TM2 | E | 264 | 2x41 | G.H5 | I | 352 | G.H5.23 |
Van-der-waals | TM2 | E | 264 | 2x41 | G.H5 | I | 352 | G.H5.23 |
Hydrophobic | TM2 | P | 263 | 2x40 | G.H5 | L | 354 | G.H5.25 |
Van-der-waals | TM2 | P | 263 | 2x40 | G.H5 | L | 354 | G.H5.25 |
Hydrophobic | TM3 | A | 341 | 3x53 | G.H5 | L | 354 | G.H5.25 |
Van-der-waals | TM3 | A | 341 | 3x53 | G.H5 | L | 354 | G.H5.25 |
Hydrophobic | TM2 | P | 263 | 2x40 | G.H5 | L | 349 | G.H5.20 |
Van-der-waals | TM2 | P | 263 | 2x40 | G.H5 | L | 349 | G.H5.20 |
Van-der-waals | ICL2 | W | 346 | - | G.H5 | I | 352 | G.H5.23 |
Polar | TM4 | E | 349 | 4x36 | G.h2s4 | V | 219 | G.h2s4.04 |
Hydrophobic | TM4 | E | 349 | 4x36 | G.h2s4 | V | 219 | G.h2s4.04 |
Van-der-waals | TM4 | E | 349 | 4x36 | G.h2s4 | V | 219 | G.h2s4.04 |
Hydrophobic | TM3 | A | 342 | 3x54 | G.H5 | L | 349 | G.H5.20 |
Van-der-waals | TM3 | A | 342 | 3x54 | G.H5 | L | 349 | G.H5.20 |
Polar | TM2 | E | 264 | 2x41 | G.H5 | Y | 351 | G.H5.22 |
Van-der-waals | TM2 | E | 264 | 2x41 | G.H5 | Y | 351 | G.H5.22 |
Hydrophobic | TM4 | I | 351 | 4x38 | G.H5 | I | 352 | G.H5.23 |
Van-der-waals | TM4 | I | 351 | 4x38 | G.H5 | I | 352 | G.H5.23 |
Hydrophobic | TM3 | T | 337 | 3x49 | G.H5 | I | 352 | G.H5.23 |
Van-der-waals | TM3 | T | 337 | 3x49 | G.H5 | I | 352 | G.H5.23 |
Polar | TM4 | E | 349 | 4x36 | G.H5 | N | 348 | G.H5.19 |
Polar | N-term | Q | 81 | - | G.H2 | H | 214 | G.H2.09 |
Hydrophobic | N-term | Q | 81 | - | G.H2 | H | 214 | G.H2.09 |
Van-der-waals | N-term | Q | 81 | - | G.H2 | H | 214 | G.H2.09 |
Polar | TM4 | E | 349 | 4x36 | G.h2s4 | T | 220 | G.h2s4.05 |
Hydrophobic | TM4 | E | 349 | 4x36 | G.h2s4 | T | 220 | G.h2s4.05 |
Van-der-waals | TM4 | E | 349 | 4x36 | G.h2s4 | T | 220 | G.h2s4.05 |
Polar | TM4 | S | 356 | 4x43 | G.hns1 | R | 31 | G.hns1.02 |
Van-der-waals | TM4 | S | 356 | 4x43 | G.hns1 | R | 31 | G.hns1.02 |
Polar | ICL1 | Q | 261 | 12x51 | G.h3s5 | N | 262 | G.h3s5.02 |
Hydrophobic | ICL1 | Q | 261 | 12x51 | G.h3s5 | N | 262 | G.h3s5.02 |
Van-der-waals | ICL1 | Q | 261 | 12x51 | G.h3s5 | N | 262 | G.h3s5.02 |
Polar | TM4 | E | 352 | 4x39 | G.h3s5 | N | 262 | G.h3s5.02 |
Polar | TM4 | H | 348 | 4x35 | G.H5 | N | 348 | G.H5.19 |
Hydrophobic | TM4 | H | 348 | 4x35 | G.H5 | N | 348 | G.H5.19 |
Van-der-waals | TM4 | H | 348 | 4x35 | G.H5 | N | 348 | G.H5.19 |
Polar | TM4 | H | 354 | 4x41 | G.hns1 | R | 31 | G.hns1.02 |
Aromatic | TM4 | H | 354 | 4x41 | G.hns1 | R | 31 | G.hns1.02 |
Hydrophobic | TM4 | H | 354 | 4x41 | G.hns1 | R | 31 | G.hns1.02 |
Van-der-waals | TM4 | H | 354 | 4x41 | G.hns1 | R | 31 | G.hns1.02 |
Hydrophobic | TM2 | E | 264 | 2x41 | G.H5 | G | 353 | G.H5.24 |
Van-der-waals | TM2 | E | 264 | 2x41 | G.H5 | G | 353 | G.H5.24 |
Hydrophobic | TM3 | T | 337 | 3x49 | G.H5 | L | 354 | G.H5.25 |
Polar | TM4 | H | 348 | 4x35 | G.H5 | N | 347 | G.H5.18 |
Hydrophobic | TM4 | H | 348 | 4x35 | G.H5 | N | 347 | G.H5.18 |
Van-der-waals | TM4 | H | 348 | 4x35 | G.H5 | N | 347 | G.H5.18 |
Polar | TM4 | H | 348 | 4x35 | G.h3s5 | N | 262 | G.h3s5.02 |
Van-der-waals | TM4 | H | 348 | 4x35 | G.h3s5 | N | 262 | G.h3s5.02 |
Hydrophobic | TM4 | G | 347 | 4x34 | G.H5 | I | 352 | G.H5.23 |
Van-der-waals | TM4 | G | 347 | 4x34 | G.H5 | I | 352 | G.H5.23 |
Hydrophobic | TM3 | A | 341 | 3x53 | G.H5 | L | 349 | G.H5.20 |
Van-der-waals | TM3 | A | 341 | 3x53 | G.H5 | L | 349 | G.H5.20 |
Hydrophobic | ICL2 | W | 346 | - | G.S3 | L | 195 | G.S3.01 |
Van-der-waals | ICL2 | W | 346 | - | G.S3 | L | 195 | G.S3.01 |
Hydrophobic | ICL2 | W | 346 | - | G.hns1 | R | 32 | G.hns1.03 |
Van-der-waals | ICL2 | W | 346 | - | G.hns1 | R | 32 | G.hns1.03 |
Hydrophobic | TM6 | L | 444 | 6x29 | G.H5 | C | 355 | G.H5.26 |
Van-der-waals | TM6 | L | 444 | 6x29 | G.H5 | C | 355 | G.H5.26 |
Hydrophobic | TM7 | W | 527 | 7x55 | G.H5 | G | 353 | G.H5.24 |
Van-der-waals | TM7 | W | 527 | 7x55 | G.H5 | G | 353 | G.H5.24 |
Ionic | ICL2 | K | 345 | - | G.H5 | D | 342 | G.H5.13 |
Polar | ICL2 | K | 345 | - | G.H5 | D | 342 | G.H5.13 |
Hydrophobic | ICL2 | K | 345 | - | G.H5 | D | 342 | G.H5.13 |
Van-der-waals | ICL2 | K | 345 | - | G.H5 | D | 342 | G.H5.13 |
Hydrophobic | TM3 | W | 338 | 3x50 | G.H5 | L | 354 | G.H5.25 |
Van-der-waals | TM3 | W | 338 | 3x50 | G.H5 | L | 354 | G.H5.25 |
Polar | TM4 | E | 349 | 4x36 | G.h3s5 | T | 263 | G.h3s5.03 |
Van-der-waals | TM4 | E | 349 | 4x36 | G.h3s5 | T | 263 | G.h3s5.03 |
Polar | TM4 | Y | 357 | 4x44 | G.hns1 | R | 31 | G.hns1.02 |
Hydrophobic | TM4 | Y | 357 | 4x44 | G.hns1 | R | 31 | G.hns1.02 |
Van-der-waals | TM4 | Y | 357 | 4x44 | G.hns1 | R | 31 | G.hns1.02 |
Van-der-waals | TM4 | H | 348 | 4x35 | G.S5 | S | 264 | G.S5.01 |
Hydrophobic | ICL1 | H | 258 | 12x48 | G.h3s5 | I | 261 | G.h3s5.01 |
Hydrophobic | N-term | Q | 81 | - | G.H2 | I | 213 | G.H2.08 |
Van-der-waals | N-term | Q | 81 | - | G.H2 | I | 213 | G.H2.08 |
Polar | TM3 | W | 338 | 3x50 | G.H5 | I | 352 | G.H5.23 |
Hydrophobic | TM2 | P | 263 | 2x40 | G.H5 | N | 348 | G.H5.19 |
Van-der-waals | TM2 | P | 263 | 2x40 | G.H5 | N | 348 | G.H5.19 |